公开(公告)号：US20070135452A1

公开(公告)日：2007-06-14

申请号：US10577334

申请日：2004-10-27

申请人： Albert Gyorkos ,  Christopher Corrette ,  Suk Cho ,  Timothy Turner ,  Scott Pratt ,  Kazuyoshi Aso ,  Masakuni Kori ,  Michiyo Gyoten

发明人： Albert Gyorkos ,  Christopher Corrette ,  Suk Cho ,  Timothy Turner ,  Scott Pratt ,  Kazuyoshi Aso ,  Masakuni Kori ,  Michiyo Gyoten

IPC分类号： A61K31/519 ,  C07D471/02 ,  A61K31/4745 ,  C07D487/04

CPC分类号： C07D235/30 ,  C07D471/04

摘要： There is provided a CRF receptor antagonist comprising a compound of the formula (I): wherein, ring A is a 5-membered ring represented by the formula (A′): wherein X is a carbon and X1 is an oxygen, a sulfur or —NR5—, or formula (A″): wherein X is a nitrogen and R6 is an optionally substituted hydrocarbyl, R1 is an amino substituted by two optionally substituted hydrocarbyl groups, R2 is an phenyl, Y1 is CR3a or a nitrogen, y2 is CR3b or a nitrogen and Y3 is CR3c or a nitrogen, provided that one or less of Y1, Y2, and Y3 is nitrogen, W is a bond, —(CH2)n-, and Z is a bond, —NR4—, etc.; or a salt thereof or a prodrug thereof.

摘要翻译： 提供了包含式（I）化合物的CRF受体拮抗剂：其中环A是由式（A'）表示的5元环：其中X是碳，X 1 O >是氧，硫或-NR 5 - 或式（A“）：其中X是氮，R 6是任选取代的烃基，R 1是由两个任选取代的烃基取代的氨基，R 2是苯基，Y 1是H 3 S >或氮，Y 2是CR 3或氮和Y 3是C 3或N 3或N 3 条件是Y 1，Y 2和Y 3中的一个或多个为氮，W为键， - （CH _{2）n - ，Z为键，-NR 4 - 等; 或其盐或其前药。}

公开(公告)号：US20070102933A1

公开(公告)日：2007-05-10

申请号：US11591168

申请日：2006-11-01

申请人： Timothy Turner

发明人： Timothy Turner

IPC分类号： F03B13/00 ,  F03B13/10 ,  H02P9/04

CPC分类号： F03B13/1845 ,  F05B2220/706 ,  Y02E10/38

摘要： An electrical generator having two generator components, namely a coil and a magnet. One of the generator components is attached to a fixed or buoyant pylon, and the other of the generator components is attached to a float that rises and falls in response to changes in the water level of a body of water. This causes relative motion between the two generator components and results in electrical power being generated by the coil. The buoyant pylon may be anchored by a flexible attachment to the bottom of the body of water. The float need not be coaxial with respect to the pylon. A single float may be used with more than one pylon and generator component. More than one float may be used with a particular generator component. Fixed pylons may also be used as a breakwater or as a support for a structure.

摘要翻译： 具有两个发电机部件，即线圈和磁体的发电机。 发电机组件中的一个附接到固定的或浮力的塔架上，另一个发电机组件附接到响应于水体水位变化而上升和下降的浮子。 这导致两个发电机部件之间的相对运动并导致由线圈产生的电力。 浮力塔可以通过柔性附件锚固到水体的底部。 浮子不需要相对于塔架是同轴的。 单个浮子可以与多于一个的塔和发电机组件一起使用。 特定的发电机组件可以使用多于一个的浮子。 固定塔也可用作防波堤或作为结构的支撑。

公开(公告)号：US20060156857A1

公开(公告)日：2006-07-20

申请号：US11330978

申请日：2006-01-11

申请人： Timothy Turner ,  Gary Scott

发明人： Timothy Turner ,  Gary Scott

IPC分类号： G05G1/00

CPC分类号： G05G1/085 ,  Y10T74/20744

摘要： A retractable support crank is provided that includes a first handle piece adapted to be connected to a driving rod, and a second handle piece rotationally coupled to the first handle piece. The second handle piece being adapted to rotate from a high-speed position to a high leverage position by manipulating a releasable locking mechanism coupled to the first and second handle positions.

摘要翻译： 提供了一种可伸缩的支撑曲柄，其包括适于连接到驱动杆的第一手柄件和与第一手柄件旋转地联接的第二手柄件。 所述第二手柄件适于通过操纵联接到所述第一和第二手柄位置的可释放锁定机构从高速位置旋转到高杠杆位置。

公开(公告)号：US20050251115A1

公开(公告)日：2005-11-10

申请号：US11158365

申请日：2005-06-22

申请人： Ian Cox ,  Timothy Turner ,  Gerhard Youssefi

发明人： Ian Cox ,  Timothy Turner ,  Gerhard Youssefi

IPC分类号： A61F9/01 ,  A61F9/013 ,  A61B18/18 ,  A61B3/00 ,  A61B3/10

CPC分类号： A61F9/008 ,  A61F9/00806 ,  A61F9/013 ,  A61F2009/00846 ,  A61F2009/00857 ,  A61F2009/00859 ,  A61F2009/00872 ,  A61F2009/0088 ,  A61F2009/00882

摘要： Methods and apparatus for improving vision incorporate the effects of biodynamical and biomechanical (biological) responses of the eye. The eye produces a biological response to trauma, such as a LASIK keratectomy or other necessary traumatic procedure in preparation for refractive surgery. By observing the biological response, a prospective treatment to correct higher order aberrations is adjusted to compensate for the biological effects. An improved photorefractive surgery system incorporates one or more suitable diagnostic devices that provide biological response information in such a manner that the patient need not change position from that assumed for the surgical procedure.

摘要翻译： 用于改善视力的方法和装置包括眼睛的生物力学和生物力学（生物）反应的作用。 眼睛产生对创伤的生物反应，例如LASIK角膜切除术或其他必要的创伤手术，用于屈光手术的准备。 通过观察生物反应，调整纠正高阶像差的前瞻性治疗以补偿生物效应。 改进的光折射手术系统包括一种或多种合适的诊断装置，其提供生物反应信息，使得患者不需要改变与外科手术所假设的位置。

公开(公告)号：USD415425S

公开(公告)日：1999-10-19

申请号：US80056

申请日：1997-11-26

申请人： Timothy Turner ,  Carlton Young

设计人： Timothy Turner ,  Carlton Young

公开(公告)号：USD411107S

公开(公告)日：1999-06-15

申请号：US80031

申请日：1997-11-26

申请人： Timothy Turner ,  Carlton Young

设计人： Timothy Turner ,  Carlton Young

公开(公告)号：US5590807A

公开(公告)日：1997-01-07

申请号：US146234

申请日：1993-11-01

申请人： Randall Forrest ,  Timothy Turner ,  Don Thurman

发明人： Randall Forrest ,  Timothy Turner ,  Don Thurman

IPC分类号： B21D51/38 ,  B65D7/42

CPC分类号： B21D51/383

摘要： The present invention is a reformed container end and a method of forming the container end. The container end includes a center panel surrounded by a countersink having an inner wall, an outer wall, and a countersink bottom. The countersink bottom includes a first arcuate segment having a small radius and a second arcuate segment having a larger radius. The container end may also include a portion wherein the center panel is slightly expanded and the inner wall is further reformed to direct potential buckling away from the nose of a pour opening panel.

公开(公告)号：US08461118B2

公开(公告)日：2013-06-11

申请号：US13178042

申请日：2011-07-07

申请人： Clayton Yates ,  Jesse Jaynes ,  Timothy Turner

发明人： Clayton Yates ,  Jesse Jaynes ,  Timothy Turner

IPC分类号： A61K38/00 ,  A61K38/09 ,  A61K38/16 ,  A61K38/24

CPC分类号： C07K14/4723 ,  A61K38/00 ,  C07K7/23 ,  C07K2319/33

摘要： Lytic peptides, including fusion peptides of lytic peptides conjugated with luteinizing hormone-releasing hormone or modified versions thereof to target luteinizing hormone-releasing hormone receptors, are disclosed. The lytic peptides show anti-proliferative activity against human prostate cancer cell lines, but are nontoxic to normal primary human prostate epithelial cells or to bone marrow stromal cells in co-culture. The lytic peptides have specificity for and anti-proliferative activity against prostate cancer tumor cells, and low toxicity for normal prostate cells, making the peptides useful in therapies for prostate cancer.

摘要翻译： 公开了Lytic肽，包括与促黄体生成激素释放激素结合的裂解肽的融合肽或其修饰形式靶向促黄体生成激素释放激素受体。 裂解肽显示对人前列腺癌细胞系的抗增殖活性，但对于正常的原代人前列腺上皮细胞或共培养中的骨髓基质细胞无毒性。 溶解肽对前列腺癌肿瘤细胞具有特异性和抗增殖活性，对正常前列腺细胞具有低毒性，使得该肽可用于前列腺癌的治疗。

公开(公告)号：US20130053319A1

公开(公告)日：2013-02-28

申请号：US13219375

申请日：2011-08-26

申请人： Cecelia C. Yates-Binder ,  Jesse Jaynes ,  Timothy Turner ,  Alan Wells ,  Richard J. Bodnar

发明人： Cecelia C. Yates-Binder ,  Jesse Jaynes ,  Timothy Turner ,  Alan Wells ,  Richard J. Bodnar

IPC分类号： A61K38/19 ,  A61P9/00 ,  A61P43/00 ,  A61P35/00

CPC分类号： A61K38/195 ,  A61K47/551 ,  C07K14/522

摘要： Disclosed are peptides having activity against receptor CXCR3 are disclosed that exhibit activity in preventing the formation of new vessels and activity in mediating the dissociation of newly-formed vessels and resolving of wounds in the later stages of wound healing. Preferred peptides are derived from the α-helix portion IP-10 (CXCL10) or from IP-9 (CXCL11), are nontoxic, and smaller than naturally occurring peptides, making them useful in therapies against diseases or disease states marked by unwanted angiogenesis, including tumorogenic diseases such as cancers, and in healing of chronic wounds.

摘要翻译： 公开了具有针对受体CXCR3的活性的肽，其表现出在预防新血管形成中的活性和介导新形成的血管解离和在伤口愈合后期分解伤口的活性。 衍生自α-螺旋部分IP-10（CXCL10）或来自IP-9（CXCL11）的优选肽是无毒的且小于天然存在的肽，使得它们可用于治疗由不想要的血管发生标记的疾病或疾病状态， 包括肿瘤发生疾病如癌症，以及慢性伤口愈合。

公开(公告)号：US07909196B2

公开(公告)日：2011-03-22

申请号：US10846416

申请日：2004-05-14

申请人： Timothy Turner ,  Randall G. Forrest

发明人： Timothy Turner ,  Randall G. Forrest

IPC分类号： B65D17/34

CPC分类号： B65D17/28 ,  B65D2517/0014 ,  B65D2517/5075 ,  B65D2517/5083 ,  Y10S220/906

摘要： A can end for a container has a curl defining an outer perimeter of the can end. A chuckwall extends downwardly from the curl. A means for increasing the strength of the can end is integral with the chuckwall, and a center panel is integral with the means for increasing the strength of the can end. The center panel has a product side, a public side, a rivet, and a displaceable tear panel. A non-detachable tab is staked to the central panel wall by the rivet. First and second void regions of the tab are separated by a narrow strip of the central webbing. A portion of the narrow strip extends downwardly and approaches the public side of the central panel wherein a height of the lift end of the tab above the public side of the central panel is maintained at a predetermined height.

摘要翻译： 容器的罐端部具有限定罐端部的外周边的卷曲。 卡盘从卷曲向下延伸。 用于增加罐端部强度的装置与夹套壁是一体的，并且中心板与用于增加罐端部强度的装置成一体。 中心面板具有产品侧，公共侧，铆钉和可移动的撕裂面板。 由铆钉将不可拆卸的片材固定在中央墙壁上。 翼片的第一和第二空隙区域由中央织带的窄带分隔开。 窄条的一部分向下延伸并且接近中央面板的公共侧，其中突出部在中心面板的公共侧上方的提升端的高度保持在预定高度。