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    Attenuated Mycoplasma gallisepticum strains
    22.
    发明授权
    Attenuated Mycoplasma gallisepticum strains 有权
    减毒支原体菌株

    公开(公告)号：US08298552B2

    公开(公告)日：2012-10-30

    申请号：US13071601

    申请日：2011-03-25

    Applicant: Mahesh Kumar ,  Muhammad Ayub Khan

    Inventor： Mahesh Kumar ,  Muhammad Ayub Khan

    IPC: A61K39/02

    CPC classification number: C12N1/36 ,  A61K39/0241 ,  A61K2039/522 ,  A61K2039/552 ,  C12N1/20 ,  C12R1/35

    Abstract: The present invention provides live, attenuated Mycoplasma gallisepticum bacteria that exhibit reduced expression of a protein identified as MGA_0621. In certain embodiments, the attenuated bacteria may additionally exhibit reduced expression of one or more proteins selected from the group consisting of pyruvate dehydrogenase, phosphopyruvate hydratase, 2-deoxyribose-5-phosphate aldolase, and ribosomal protein L35, relative to a wild-type M. gallisepticum bacterium. Also provided are vaccines and vaccination methods involving the use of the live, attenuated M. gallisepticum bacteria, and methods for making live attenuated M. gallisepticum bacteria. An exemplary live, attenuated strain of M. gallisepticum is provided, designated MGx+47, which was shown by proteomics analysis to exhibit significantly reduced expression of MGA_0621, and was shown to be safe and effective when administered as a vaccine against M. gallisepticum infection in chickens.

    Abstract translation: 本发明提供活的，减毒的鸡毒支原体细菌，其表现出被鉴定为MGA_0621的蛋白质的表达降低。 在某些实施方案中，相对于野生型M，减毒细菌可另外显示出一种或多种选自丙酮酸脱氢酶，磷酸丙酮酸水合酶，2-脱氧核糖-5-磷酸醛缩酶和核糖体蛋白L35的蛋白质​​的表达降低 胆汁败霉菌 还提供了涉及使用活的，减毒的金黄色葡萄球菌细菌的疫苗和疫苗接种方法，以及用于制造活的减毒的金黄色葡萄球菌细菌的方法。 提供了一种示例性的活的减毒毒株的菌株，命名为MGx + 47，通过蛋白质组学分析显示出显着降低的MGA_0621的表达，并且当作为针对鸡链球菌毒素感染的疫苗施用时被证明是安全和有效的 在鸡中

    Attenuated Mycoplasma gallisepticum strains
    23.
    发明授权
    Attenuated Mycoplasma gallisepticum strains 有权
    减毒支原体菌株

    公开(公告)号：US07935356B2

    公开(公告)日：2011-05-03

    申请号：US12207750

    申请日：2008-09-10

    Applicant: Mahesh Kumar ,  Muhammad Ayub Khan

    Inventor： Mahesh Kumar ,  Muhammad Ayub Khan

    IPC: A61K39/02

    CPC classification number: C12N1/36 ,  A61K39/0241 ,  A61K2039/522 ,  A61K2039/552 ,  C12N1/20 ,  C12R1/35

    Abstract: The present invention provides live, attenuated Mycoplasma gallisepticum bacteria that exhibit reduced expression of a protein identified as MGA_0621. In certain embodiments, the attenuated bacteria may additionally exhibit reduced expression of one or more proteins selected from the group consisting of pyruvate dehydrogenase, phosphopyruvate hydratase, 2-deoxyribose-5-phosphate aldolase, and ribosomal protein L35, relative to a wild-type M. gallisepticum bacterium. Also provided are vaccines and vaccination methods involving the use of the live, attenuated M. gallisepticum bacteria, and methods for making live attenuated M. gallisepticum bacteria. An exemplary live, attenuated strain of M. gallisepticum is provided, designated MGx+47, which was shown by proteomics analysis to exhibit significantly reduced expression of MGA_0621, and was shown to be safe and effective when administered as a vaccine against M. gallisepticum infection in chickens.

    Abstract translation: 本发明提供活的，减毒的鸡毒支原体细菌，其表现出被鉴定为MGA_0621的蛋白质的表达降低。 在某些实施方案中，相对于野生型M，减毒细菌可另外表现出一种或多种选自丙酮酸脱氢酶，磷酸丙酮酸水合酶，2-脱氧核糖-5-磷酸醛缩酶和核糖体蛋白L35的蛋白质​​的表达降低 胆汁败霉菌 还提供了涉及使用活的，减毒的金黄色葡萄球菌细菌的疫苗和疫苗接种方法，以及用于制造活的减毒的金黄色葡萄球菌细菌的方法。 提供了一种示例性的活的减毒毒株的菌株，命名为MGx + 47，通过蛋白质组学分析显示出显着降低的MGA_0621的表达，并且当作为针对鸡链球菌毒素感染的疫苗施用时被证明是安全和有效的 在鸡中

    SWINE VACCINATION SYSTEM
    24.
    发明申请
    SWINE VACCINATION SYSTEM 审中-公开
    动物疫苗系统

    公开(公告)号：US20100310589A1

    公开(公告)日：2010-12-09

    申请号：US12864130

    申请日：2009-01-29

    Applicant: Mahesh Kumar

    Inventor： Mahesh Kumar

    IPC: A61K39/00 ,  A01K29/00

    CPC classification number: A61D1/025 ,  A61D7/04 ,  A61D2003/003 ,  A61M11/00 ,  A61M2205/13 ,  A61M2205/3379 ,  A61M2210/0606 ,  A61M2250/00

    Abstract: A system for vaccinating swine according to one embodiment includes a housing having an open first end and an open opposite second end. The housing has a pair of side walls that are angled and non-parallel to one another such that at the second end only a single piglet can exit at one time. The system also includes a vaccination station for individually vaccinating piglets. The vaccination station is located between the pair of side walls in a region thereof that is sized to only permit one piglet to stand between the side walls. The vaccination station includes at least one sensor that detects the presence of the one piglet within the vaccination station and at least one spray nozzle positioned within the vaccination station such that a vaccine dose discharged therefrom is directed upwardly into facial areas of the piglet effectively.

    Abstract translation: 根据一个实施例的用于接种猪的系统包括具有敞开的第一端和敞开的相对的第二端的壳体。 壳体具有一对侧壁，它们彼此成角度并且不平行，使得在第二端只有一只小猪可以一次离开。 该系统还包括一个单独接种仔猪的疫苗接种站。 疫苗接种站位于其一侧区域中的一对侧壁之间，其尺寸仅允许一只小猪站在侧壁之间。 疫苗接种站包括至少一个传感器，其检测疫苗接种站内的一只仔猪的存在以及位于疫苗接种站内的至少一个喷嘴，使得从其中排出的疫苗剂量有效地向上指向小猪的面部区域。

    Multi-virtual service module pinhole or connection class offload
    25.
    发明授权
    Multi-virtual service module pinhole or connection class offload 有权
    多虚拟服务模块针孔或连接类卸载

    公开(公告)号：US07738469B1

    公开(公告)日：2010-06-15

    申请号：US12132988

    申请日：2008-06-04

    Applicant: Praveen Shekokar ,  Manoj Sharma ,  Badari Narayana ,  Ratnarekha Singamsetty ,  Mahesh Kumar

    Inventor： Praveen Shekokar ,  Manoj Sharma ,  Badari Narayana ,  Ratnarekha Singamsetty ,  Mahesh Kumar

    IPC: H04L12/28

    CPC classification number: H04L63/0254 ,  H04L49/00

    Abstract: In a communications network, a virtual rack having service modules for performing network services is provided. A pinhole that corresponds to a plurality of the service modules is created. Data packets are directed to a service processor in response to matching the data packets to the pinhole. For connection class offload, using the acceleration processor to match the connection class pinhole to the data packets and creating connection class sessions that are used for processing subsequent packets of the connection.

    Abstract translation: 在通信网络中，提供了具有用于执行网络服务的服务模块的虚拟机架。 创建对应于多个服务模块的针孔。 响应于将数据分组匹配到针孔，数据分组被引导到服务处理器。 对于连接类卸载，使用加速处理器将连接类针孔与数据包匹配，并创建用于处理连接的后续数据包的连接类会话。

    Method and system for managing communication of router information
    26.
    发明授权
    Method and system for managing communication of router information 有权
    管理路由器信息通信的方法和系统

    公开(公告)号：US07643485B2

    公开(公告)日：2010-01-05

    申请号：US11227522

    申请日：2005-09-15

    Applicant: Kappagal Joish Viswanath ,  Mrityunjay Sharanappa Hubli ,  Mahesh Kumar

    Inventor： Kappagal Joish Viswanath ,  Mrityunjay Sharanappa Hubli ,  Mahesh Kumar

    IPC: H04L12/56

    CPC classification number: H04L41/08

    Abstract: A method and apparatus for managing communication of router information in a network is disclosed. Consumers of the router information are determined on an interface in the network. The interface is set as a passive interface if no consumers are present on the interface. A passive interface is an interface on which the communication of router information is disallowed.

    Abstract translation: 公开了一种用于管理网络中的路由器信息的通信的方法和装置。 路由器信息的消费者在网络中的接口上确定。 如果接口上没有消费者，该接口被设置为被动接口。 被动接口是不允许路由器信息通信的接口。

    Multivalent avian influenza vaccines and methods
    28.
    发明申请
    Multivalent avian influenza vaccines and methods 审中-公开
    多种禽流感疫苗及方法

    公开(公告)号：US20080226676A1

    公开(公告)日：2008-09-18

    申请号：US12077044

    申请日：2008-03-14

    Applicant: Joan Plana Duran ,  Mahesh Kumar

    Inventor： Joan Plana Duran ,  Mahesh Kumar

    IPC: A61K39/145

    CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/55566 ,  A61K2039/70 ,  C12N2760/16134

    Abstract: The present invention provides vaccine compositions comprising at least two strains of avian influenza virus, wherein one of the strains has an H5 hemagglutinin subtype and the other strain has an H7 hemagglutinin subtype, and wherein at least one of the strains has an N4 neuraminidase subtype and neither strain has an N1 subtype. Also provided are vaccination methods that utilize the novel vaccine compositions of the invention. The compositions and methods of the present invention provide protection against infection with H5 and H7 influenza strains (e.g., H5N1 and H7N1) while at the same time facilitating the distinction between infected and vaccinated animals.

    Abstract translation: 本发明提供了包含至少两种禽流感病毒菌株的疫苗组合物，其中一种菌株具有H5血凝素亚型，另一种菌株具有H7血凝素亚型，并且其中至少一种菌株具有N4神经氨酸酶亚型和 两个菌株都没有N1亚型。 还提供了利用本发明的新型疫苗组合物的疫苗接种方法。 本发明的组合物和方法提供了针对H5和H7流感病毒株（例如H5N1和H7N1）的感染的保护，同时有利于感染和接种疫苗的动物之间的区别。

    Method and system for managing communication of router information
    30.
    发明申请
    Method and system for managing communication of router information 有权
    管理路由器信息通信的方法和系统

    公开(公告)号：US20070076718A1

    公开(公告)日：2007-04-05

    申请号：US11227522

    申请日：2005-09-15

    Applicant: Kappagal Viswanath ,  Mrityunjay Hubli ,  Mahesh Kumar

    Inventor： Kappagal Viswanath ,  Mrityunjay Hubli ,  Mahesh Kumar

    IPC: H04L12/56

    CPC classification number: H04L41/08

    Abstract: A method and apparatus for managing communication of router information in a network is disclosed. Consumers of the router information are determined on an interface in the network. The interface is set as a passive interface if no consumers are present on the interface. A passive interface is an interface on which the communication of router information is disallowed.

    Abstract translation: 公开了一种用于管理网络中的路由器信息的通信的方法和装置。 路由器信息的消费者在网络中的接口上确定。 如果接口上没有消费者，该接口被设置为被动接口。 被动接口是不允许路由器信息通信的接口。

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