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公开(公告)号：US09040048B2
公开(公告)日：2015-05-26
申请号：US13672077
申请日：2012-11-08
Applicant: UCB PHARMA S.A.
Inventor： Ralph Adams , Pallavi Bhatta , Sam Philip Heywood , David Paul Humphreys
IPC: A61K39/395 , C07K14/705 , C07K16/28 , C07K16/18 , A61K39/00
CPC classification number: C07K16/18 , A61K39/3955 , A61K2039/505 , C07K16/2866 , C07K16/2878 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/624 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
Abstract translation: 本发明涉及对人OX40的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途以及产生所述抗体分子的方法。
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公开(公告)号：US20140194596A1
公开(公告)日：2014-07-10
申请号：US14101083
申请日：2013-12-09
Applicant: UCB Pharma S.A.
Inventor： David Paul Humphreys , Emma Dave , Laura Griffin , Sam Philip Heywood
IPC: C07K16/46
CPC classification number: C07K16/468 , C07K16/00 , C07K16/18 , C07K16/245 , C07K2317/24 , C07K2317/31 , C07K2317/522 , C07K2317/54 , C07K2317/55 , C07K2317/569 , C07K2317/64 , C07K2317/92
Abstract: The present invention provides dual specificity antibody fusion proteins comprising an antibody Fab or Fab′ fragment with specificity for an antigen of interest, said fragment being fused to at least one single domain antibody which has specificity for a second antigen of interest.
Abstract translation: 本发明提供双特异性抗体融合蛋白，其包含对感兴趣的抗原具有特异性的抗体Fab或Fab'片段，所述片段与至少一种对目的第二抗原具有特异性的单结构域抗体融合。
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公开(公告)号：US09951365B2
公开(公告)日：2018-04-24
申请号：US14400068
申请日：2013-05-13
Applicant: UCB PHARMA S.A.
CPC classification number: C12P21/00 , C07K16/283 , C07K2317/10 , C12N9/52 , C12N15/70 , C12P21/02
Abstract: The present disclosure relates to a recombinant gram-negative bacterial cell comprising: a.) a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from D133, H145, H157, N31, R62, I70, Q73, C94, S95, V98, Q99, R100, L108, Y115, V135, L136, G140, R144 and G147 and b.) a gene capable of expressing or overexpressing one or more proteins capable of facilitating protein folding, such as FkpA, Skp, SurA, PPiA and PPiD, wherein the cell has reduced Tsp protein activity compared to a wild-type cell, methods employing the cells, use of the cells in the expression of proteins in particular antibodies, such as anti Fc Rn antibodies and proteins made by the methods described herein.
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Patent Agency Ranking
公开(公告)号：US20160333105A1
公开(公告)日：2016-11-17
申请号：US15165131
申请日：2016-05-26
Applicant: UCB PHARMA S.A.
Inventor： Ralph Adams , Emma Dave , David Paul Humphreys
Abstract: The present invention provides a multivalent antibody or a heavy/light chain component thereof comprising: a heavy chain comprising a constant region fragment, said constant region fragment located between two variable domains which are not a cognate pair, the heavy chain further comprising an Fc region with at least one domain selected from CH2, CH3 and combinations thereof, with the proviso that the heavy chain contains no more than one CH1 domain and only contains two variable domains, and a light chain comprising a constant region fragment located between two variable domains which are not a cognate pair, wherein said heavy and light chains are aligned to provide a first binding site formed by a first cognate pair of variable domains and a second binding site formed by a second cognate pair of variable domains.
Abstract translation: 本发明提供了一种多价抗体或其重/轻链组分，其包含：包含恒定区片段的重链，所述恒定区片段位于不是同源对的两个可变结构域之间，所述重链还包含Fc区 其中至少一个选自CH 2，CH 3及其组合的结构域，条件是重链含有不超过一个CH1结构域并且仅含有两个可变结构域，以及包含位于两个可变结构域之间的恒定区片段的轻链， 不是同源对，其中所述重链和轻链对齐以提供由第一同源对可变结构域形成的第一结合位点和由第二同源对可变结构域形成的第二结合位点。
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公开(公告)号：US09493559B2
公开(公告)日：2016-11-15
申请号：US14633294
申请日：2015-02-27
Applicant: UCB PHARMA, S.A.
Inventor： Mark Ellis , David Paul Humphreys
IPC: C07K14/245 , C07K16/24 , C12N1/20
CPC classification number: C07K16/241 , C07K14/245 , C07K2317/14 , C12N1/20
Abstract: The present invention provides a recombinant gram-negative bacterial cell, characterized in that the cell comprises a recombinant polynucleotide encoding DsbC and has reduced Tsp protein activity compared to a wild-type cell.
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26.发明授权Bacterial host strain comprising a mutant SPR gene and a wild-type TSP gene 有权包含突变体SPR基因和野生型TSP基因的细菌宿主菌株公开(公告)号：US09493558B2
公开(公告)日：2016-11-15
申请号：US14633257
申请日：2015-02-27
Applicant: UCB PHARMA, S.A.
Inventor： Mark Ellis , David Paul Humphreys
CPC classification number: C07K16/241 , C07K2317/14 , C07K2317/55 , C12N1/20 , C12N9/52 , C12N15/70 , C12P21/02 , Y02P20/52
Abstract: The present invention provides a recombinant gram-negative bacterial cell comprising a mutant spr gene encoding a mutant spr protein and wherein the cell comprises a non-recombinant wild-type chromosomal Tsp gene.
Abstract translation: 本发明提供了一种重组革兰氏阴性细菌细胞，其包含编码突变型spr蛋白的突变型spr基因，并且其中所述细胞包含非重组野生型染色体Tsp基因。
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公开(公告)号：US20160311930A1
公开(公告)日：2016-10-27
申请号：US15058460
申请日：2016-07-06
Applicant: UCB PHARMA S.A.
Inventor： David Paul Humphreys , Emma Dave , Laura Griffin , Sam Philip Heywood
CPC classification number: C07K16/468 , C07K16/00 , C07K16/18 , C07K16/245 , C07K2317/24 , C07K2317/31 , C07K2317/522 , C07K2317/54 , C07K2317/55 , C07K2317/569 , C07K2317/64 , C07K2317/92
Abstract: The present invention provides dual specificity antibody fusion proteins comprising an antibody Fab or Fab′ fragment with specificity for an antigen of interest, said fragment being fused to at least one single domain antibody which has specificity for a second antigen of interest.
Abstract translation: 本发明提供双特异性抗体融合蛋白，其包含对感兴趣的抗原具有特异性的抗体Fab或Fab'片段，所述片段与至少一种对目的第二抗原具有特异性的单结构域抗体融合。
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公开(公告)号：US20150274810A1
公开(公告)日：2015-10-01
申请号：US14697092
申请日：2015-04-27
Applicant: UCB PHARMA S.A.
Inventor： David Paul Humphreys
IPC: C07K16/00
Abstract: The present disclosure provides an antibody or antibody fragment comprising at least one Fab molecule, wherein the light chain variable region, VL and the heavy chain region, VH of the Fab molecule are linked by one or more disulfide bonds, and use of the same in treatment or prophylaxis.
Abstract translation: 本公开内容提供了包含至少一个Fab分子的抗体或抗体片段，其中Fab分子的轻链可变区VL和重链区域VH通过一个或多个二硫键连接，并且使用它们 治疗或预防。
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