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公开(公告)号：US12216124B2
公开(公告)日：2025-02-04
申请号：US18058458
申请日：2022-11-23
Inventor： Daniel T. Chiu , Changfeng Wu , Xuanjun Zhang , Jiangbo Yu , Fangmao Ye
IPC: C09K11/06 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C08G61/12 , C08J3/11 , C09K11/02 , G01N33/58 , H10K85/10
Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
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公开(公告)号：US20240254288A1
公开(公告)日：2024-08-01
申请号：US18317288
申请日：2023-05-15
Inventor： Daniel T. Chiu , Changfeng Wu , Yu Rong , Yong Zhang , Yi-Che Wu , Yang-Hsiang Chan , Xuanjun Zhang , Jiangbo Yu , Wei Sun
IPC: C08G75/32 , A61K49/00 , B82Y30/00 , B82Y40/00 , C08G79/00 , C09B69/10 , G01N21/64 , G01N33/58 , H10K50/11 , H10K85/10
CPC classification number: C08G75/32 , A61K49/0019 , A61K49/0067 , C08G79/00 , C09B69/105 , G01N33/582 , G01N33/587 , H10K85/10 , H10K85/113 , H10K85/115 , H10K85/151 , B82Y30/00 , B82Y40/00 , G01N2021/6439 , H10K50/11
Abstract: Polymers, monomers, chromophoric polymer dots and related methods are provided. Highly fluorescent chromophoric polymer dots with narrow-band emissions are provided. Methods for synthesizing the chromophoric polymers, preparation methods for forming the chromophoric polymer dots, and biological applications using the unique properties of narrow-band emissions are also provided.
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公开(公告)号：US20220082566A1
公开(公告)日：2022-03-17
申请号：US17538447
申请日：2021-11-30
Inventor： Daniel T. Chiu , Changfeng Wu , Jiangbo Yu
Abstract: The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.
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Patent Agency Ranking
公开(公告)号：US11221336B2
公开(公告)日：2022-01-11
申请号：US16556006
申请日：2019-08-29
Inventor： Daniel T. Chiu , Changfeng Wu , Jiangbo Yu
Abstract: The present disclosure provides encoded chromophoric polymer particles that are capable of, for example, optical and/or biomolecular encoding of analytes. The present disclosure also provides suspensions comprising a plurality of encoded chromophoric polymer particles. The present disclosure also provides methods of using the encoded chromophoric polymer particles and systems for performing multiplex analysis with encoded chromophoric polymer particles.
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公开(公告)号：US20200371109A1
公开(公告)日：2020-11-26
申请号：US16989491
申请日：2020-08-10
Inventor： Daniel T. Chiu , Changfeng Wu , Xuanjun Zhang , Jiangbo Yu , Fangmao Ye
IPC: G01N33/58 , B82Y30/00 , B82Y40/00 , C08G61/12 , C08J3/11 , C09K11/02 , C09K11/06 , H01L51/00 , B82Y15/00
Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
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公开(公告)号：US10739349B2
公开(公告)日：2020-08-11
申请号：US15167513
申请日：2016-05-27
Inventor： Daniel T. Chiu , Changfeng Wu , Xuanjun Zhang , Jiangbo Yu , Fangmao Ye
IPC: C09K11/06 , G01N33/58 , B82Y30/00 , B82Y40/00 , B82Y15/00 , H01L51/00 , C08G61/12 , C08J3/11 , C09K11/02
Abstract: The present invention provides, among other aspects, stabilized chromophoric nanoparticles. In certain embodiments, the chromophoric nanoparticles provided herein are rationally functionalized with a pre-determined number of functional groups. In certain embodiments, the stable chromophoric nanoparticles provided herein are modified with a low density of functional groups. In yet other embodiments, the chromophoric nanoparticles provided herein are conjugated to one or more molecules. Also provided herein are methods for making rationally functionalized chromophoric nanoparticles.
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公开(公告)号：US09797840B2
公开(公告)日：2017-10-24
申请号：US13687813
申请日：2012-11-28
Inventor： Daniel T. Chiu , Changfeng Wu , Fangmao Ye
CPC classification number: G01N21/6486 , B82Y15/00 , G01N33/588 , Y10T428/2982
Abstract: Fluorescent nanoparticles are provided. The nanoparticles are formed from poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-(1-cyanovinylene-1,4-phenylene)]. Also provided are methods for imaging a target to which the nanoparticles are bound.
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公开(公告)号：US20130266957A1
公开(公告)日：2013-10-10
申请号：US13687813
申请日：2012-11-28
Inventor： Daniel T. Chiu , Changfeng Wu , Fangmao Ye
IPC: G01N21/64
CPC classification number: G01N21/6486 , B82Y15/00 , G01N33/588 , Y10T428/2982
Abstract: Fluorescent nanoparticles are provided. The nanoparticles are formed from poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-(1-cyanovinylene-1,4-phenylene)]. Also provided are methods for imaging a target to which the nanoparticles are bound.
Abstract translation: 提供荧光纳米粒子。 纳米颗粒由聚[2-甲氧基-5-（2-乙基己氧基）-1,4-（1-氰基亚乙烯基-1,4-亚苯基）]形成。 还提供了用于对纳米颗粒结合的靶进行成像的方法。
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