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公开(公告)号：US20090221674A1
公开(公告)日：2009-09-03
申请号：US12096216
申请日：2006-12-07
申请人： Ugur Sahin , Özlem Türeci , Michael Koslowski
发明人： Ugur Sahin , Özlem Türeci , Michael Koslowski
IPC分类号： A61K31/7105 , C12N15/11 , C12N15/00 , C12Q1/68 , G01N33/574 , C12Q1/02
CPC分类号： C12N15/1138 , C07K14/4748 , C12N15/1137 , C12N2310/14 , C12Y301/03048
摘要： The present invention is directed to siRNA molecules which specifically target and cause RNAi-induced degradation of mRNA from TPTE genes, so that the protein product of the TPTE gene is not produced or is produced in reduced amounts. The siRNA compounds and compositions of the invention are useful for treating diseases which require inhibition of TPTE expression for their treatment, in particular cancer pathologies. The present invention also includes methods which make possible to assess and/or prognose the metastatic behaviour of a cancer disease and/or the occurrence of a relapse of cancer.
摘要翻译： 本发明涉及特异性靶向并引起来自TPTE基因的mRNA的RNAi诱导的降解的siRNA分子，使得TPTE基因的蛋白质产物不被产生或以减少的量产生。 本发明的siRNA化合物和组合物可用于治疗需要抑制TPTE表达以治疗，特别是癌症病症的疾病。 本发明还包括使得有可能评估和/或预测癌症疾病的转移行为和/或癌症复发的方法。
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公开(公告)号：US20080166350A1
公开(公告)日：2008-07-10
申请号：US11596649
申请日：2005-05-18
申请人： Ozlem Tureci , Ugur Sahin , Michael Koslowski
发明人： Ozlem Tureci , Ugur Sahin , Michael Koslowski
IPC分类号： A61K39/395 , C07H21/04 , A61K39/00 , C12Q1/68 , C12N5/00 , C07K14/435 , C07K17/00 , C07K2/00 , C12N15/00 , A61P35/04 , C07K16/00
CPC分类号： A61K6/00 , A61K47/6851 , A61K49/00 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/30 , C07K16/303 , C07K16/3046 , C07K16/3076 , C07K16/44 , C07K2317/24 , C07K2317/34 , C07K2317/73 , C07K2317/75 , C12N9/88 , C12Y406/01002 , G01N33/57496
摘要： According to the invention, gene products expressed in a tumor-associated manner and the nucleic acids coding therefor were identified. The invention relates to the therapy and diagnosis of diseases wherein said gene products expressed in a tumor-associated manner are aberrantly expressed. The invention also relates to proteins, polypeptides and peptides which are expressed in a tumor associated manner and to nucleic acids coding therefor.
摘要翻译： 根据本发明，鉴定了以肿瘤相关方式表达的基因产物和其编码的核酸。 本发明涉及疾病的治疗和诊断，其中以肿瘤相关方式表达的所述基因产物被异常表达。 本发明还涉及以肿瘤相关方式表达的蛋白质，多肽和肽以及编码它们的核酸。
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公开(公告)号：US20060013817A1
公开(公告)日：2006-01-19
申请号：US10506443
申请日：2003-03-12
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski
IPC分类号： A61K48/00 , A61K39/395
CPC分类号： C07K16/30 , A61K38/00 , A61K39/00 , A61K39/39558 , A61K48/00 , C07K14/4748 , C07K16/3015 , C07K16/3023 , C07K16/3053 , C07K16/3069 , C07K2317/34 , C07K2317/76 , C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , G01N33/574
摘要： The invention relates to the identification of genetic products that are expressed in association with a tumor and the nucleic acid coding therefor. The invention relates to the therapy and diagnosis of diseases in which said genetic products that are expressed in association with a tumor are expressed in an aberrant manner. The invention also relates to proteins, polypeptides, and peptides which are expressed in association with a tumor and the nucleic acids coding therefor.
摘要翻译： 本发明涉及与肿瘤相关表达的遗传产物的鉴定及其编码的核酸。 本发明涉及以异常方式表达与肿瘤相关表达的所述遗传产物的疾病的治疗和诊断。 本发明还涉及与肿瘤相关的表达的蛋白质，多肽和肽以及编码它们的核酸。
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公开(公告)号：US09809815B2
公开(公告)日：2017-11-07
申请号：US13201702
申请日：2010-02-19
申请人： Ugur Sahin , Özlem Türeci , Michael Koslowski , Gerd Helftenbein , Korden Walter , Stefan Wöll , Gabriela-Elena Oprea
发明人： Ugur Sahin , Özlem Türeci , Michael Koslowski , Gerd Helftenbein , Korden Walter , Stefan Wöll , Gabriela-Elena Oprea
IPC分类号： G01N1/00 , G01N33/574 , C12N15/113 , A61K31/7088
CPC分类号： C12N15/113 , A61K31/7088
摘要： The present invention relates to the identification of nucleic acid and amino acid sequences that are characteristic of tumor tissues such as ovarian tumor and lung tumor tissues and which represent targets for therapy or diagnosis of tumor diseases in a subject.
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公开(公告)号：US09718886B2
公开(公告)日：2017-08-01
申请号：US13808423
申请日：2011-07-04
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Maria Kreuzberg , Sylvia Luxen
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Maria Kreuzberg , Sylvia Luxen
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/28 , C07K16/3015 , C07K16/3023 , C07K16/3038 , C07K16/3046 , C07K16/3053 , C07K16/3069 , C07K2317/24 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： The invention relates to the treatment and/or prevention of tumor diseases associated with cells expressing CLDN6, in particular cancer and cancer metastasis using antibodies which bind to CLDN6. The present application demonstrates that the binding of antibodies to CLDN6 on the surface of tumor cells is sufficient to inhibit growth of the tumor and to prolong survival and extend the lifespan of tumor patients. Furthermore, binding of antibodies to CLDN6 is efficient in inhibiting growth of CLDN6 positive germ cell tumors such as teratocarcinomas or embryonal carcinomas, in particular germ cell tumors of the testis.
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公开(公告)号：US09487584B2
公开(公告)日：2016-11-08
申请号：US13503461
申请日：2010-11-11
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Stefan Woll , Maria Kreuzberg , Bernd Hubner , Michael Erdeljan
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Stefan Woll , Maria Kreuzberg , Bernd Hubner , Michael Erdeljan
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/30 , C07K2317/14 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing Claudin-6 (CLDN6), including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达紧密连接蛋白-6（CLDN6）的细胞相关的疾病的治疗剂的抗体，包括肿瘤相关疾病如卵巢癌，肺癌，胃癌，乳腺癌，肝癌，胰腺癌 ，皮肤癌，恶性黑素瘤，头颈癌，肉瘤，胆管癌，膀胱癌，肾癌，结肠癌，胎盘绒毛膜癌，子宫颈癌，睾丸癌和子宫癌。
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公开(公告)号：US09321842B2
公开(公告)日：2016-04-26
申请号：US14117118
申请日：2012-04-20
申请人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Stefan Woll , Maria Kreuzberg , Bernd Hubner , Michael Erdeljan , Michael Weichel
发明人： Ugur Sahin , Ozlem Tureci , Michael Koslowski , Korden Walter , Stefan Woll , Maria Kreuzberg , Bernd Hubner , Michael Erdeljan , Michael Weichel
IPC分类号： C07K16/28 , C07K16/30 , A61K39/395 , A61K39/00
CPC分类号： C07K16/30 , A61K39/39591 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLDN6, including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.
摘要翻译： 本发明提供了可用作治疗和/或预防与表达CLDN6的细胞相关的疾病的治疗剂的抗体，包括肿瘤相关疾病如卵巢癌，肺癌，胃癌，乳腺癌，肝癌，胰腺癌，皮肤癌，恶性肿瘤 黑素瘤，头颈癌，肉瘤，胆管癌，膀胱癌，肾癌，结肠癌，胎盘绒毛膜癌，子宫颈癌，睾丸癌和子宫癌。
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28.发明授权公开(公告)号：US08637012B2
公开(公告)日：2014-01-28
申请号：US13296620
申请日：2011-11-15
申请人： Ugur Sahin , Özlem Türeci , Michael Koslowski
发明人： Ugur Sahin , Özlem Türeci , Michael Koslowski
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： C07K16/3076 , A61K47/48569 , A61K47/549 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K2317/30 , C07K2317/34 , G01N33/57484
摘要： The invention relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for the expressed products. An embodiment of the invention also relates to the therapy and diagnosis of disease in which the genetic products are aberrantly expressed in association with tumors, proteins, polypeptides and peptides which are expressed in association with tumors, and to the nucleic acids coding for the polypeptides, peptides and proteins.
摘要翻译： 本发明涉及与肿瘤相关表达的遗传产物的鉴定和用于表达产物的编码核酸。 本发明的一个实施方案还涉及其中遗传产物与肿瘤相关表达的肿瘤，蛋白质，多肽和肽异常表达的疾病的治疗和诊断，以及编码多肽的核酸， 肽和蛋白质。
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公开(公告)号：US20130156782A1
公开(公告)日：2013-06-20
申请号：US13710828
申请日：2012-12-11
申请人： Ugur Sahin , Michael Koslowski , Ozlem Tureci
发明人： Ugur Sahin , Michael Koslowski , Ozlem Tureci
CPC分类号： C07K16/30 , C07K16/18 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76
摘要： The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing GT468, including tumor-related diseases such as breast cancer, lung cancer, gastric cancer, ovarian cancer, and hepatocellular cancer.
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30.发明申请公开(公告)号：US20120258091A1
公开(公告)日：2012-10-11
申请号：US13296620
申请日：2011-11-15
申请人： Ugur Sahin , Özlem Türeci , Michael Koslowski
发明人： Ugur Sahin , Özlem Türeci , Michael Koslowski
IPC分类号： A61K39/395 , A61P35/00 , C07K16/30
CPC分类号： C07K16/3076 , A61K47/48569 , A61K47/549 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K16/30 , C07K16/3023 , C07K16/3046 , C07K2317/30 , C07K2317/34 , G01N33/57484
摘要： The invention relates to the identification of genetic products expressed in association with tumors and to coding nucleic acids for the expressed products. An embodiment of the invention also relates to the therapy and diagnosis of disease in which the genetic products are aberrantly expressed in association with tumors, proteins, polypeptides and peptides which are expressed in association with tumors, and to the nucleic acids coding for the polypeptides, peptides and proteins.
摘要翻译： 本发明涉及与肿瘤相关表达的遗传产物的鉴定和用于表达产物的编码核酸。 本发明的一个实施方案还涉及其中遗传产物与肿瘤相关表达的肿瘤，蛋白质，多肽和肽异常表达的疾病的治疗和诊断，以及编码多肽的核酸， 肽和蛋白质。
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