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102 条记录 (耗时 0.2 秒)

    Neisserial antigenic peptides
    21.
    发明授权
    Neisserial antigenic peptides 有权
    Neisserial抗原肽

    公开(公告)号：US08734812B1

    公开(公告)日：2014-05-27

    申请号：US10111983

    申请日：2000-10-30

    申请人： Cesira Galeotti ,  Guido Grandi ,  Vega Masignani ,  Mariarosa Mora ,  Mariagrazia Pizza ,  Rino Rappuoli ,  Guilio Ratti ,  Vincenzo Scarlato ,  Maria Scarselli

    发明人： Cesira Galeotti ,  Guido Grandi ,  Vega Masignani ,  Mariarosa Mora ,  Mariagrazia Pizza ,  Rino Rappuoli ,  Guilio Ratti ,  Vincenzo Scarlato ,  Maria Scarselli

    IPC分类号： A61K39/095 ,  A61K39/02 ,  A61K39/00 ,  A61K38/00

    CPC分类号： A61K39/095 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/55505 ,  C07K14/22

    摘要： This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto (e.g., antisense nucleic acids). Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or fragments. This invention further provides expression vectors useful for making the proteins, polypeptides, and/or fragments, as well as host cells transformed with such vectors. This invention also provides compositions of the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments, and/or nucleic acids.

    摘要翻译： 本发明尤其提供衍生自脑膜炎奈瑟氏球菌B的细菌的蛋白质，多肽和其片段。还提供了编码这种蛋白质，多肽和/或片段的核酸，以及与其互补的核酸（例如， ，反义核酸）。 另外，本发明提供了结合蛋白质，多肽和/或片段的抗体。 本发明进一步提供了可用于制备蛋白质，多肽和/或片段以及用这些载体转化的宿主细胞的表达载体。 本发明还提供用作疫苗，诊断试剂，免疫原性组合物等的蛋白质，多肽，片段和/或核酸的组合物。 还提供了用组合物制备组合物和处理方法的方法。 本发明还提供了检测蛋白质，多肽，片段和/或核酸的方法。

    Domains And Epitopes Of Meningococcal Protein NMB1870
    29.
    发明申请
    Domains And Epitopes Of Meningococcal Protein NMB1870 审中-公开
    脑膜炎球菌蛋白NMB1870的结构域和表位

    公开(公告)号：US20090285845A1

    公开(公告)日：2009-11-19

    申请号：US11661665

    申请日：2005-09-01

    申请人： Vega Masignani ,  Maria Scarselli ,  Rino Rappuoli ,  Mariagrazia Pizza ,  Marzia Giuliani ,  Federica Di Marcello ,  Daniele Veggi ,  Laura Ciucchi

    发明人： Vega Masignani ,  Maria Scarselli ,  Rino Rappuoli ,  Mariagrazia Pizza ,  Marzia Giuliani ,  Federica Di Marcello ,  Daniele Veggi ,  Laura Ciucchi

    IPC分类号： A61K39/095 ,  C07K14/22 ,  C07H21/00 ,  A61P37/02

    CPC分类号： A61K39/095 ,  A61K39/00 ,  A61K2039/55505 ,  C07K14/22

    摘要： ‘NMB1870’ is a known surface protein in Neisseria meningitidis expressed across all serogroups. It has three distinct families. Serum raised against a given family is bactericidal within the same family, but is not active against strains which express one of the other two families i.e. intra-family but not inter-family cross-protection. The inventors have found that NMB1870 can be divided into domains, and that not all domains are required for antigenicity. Antigenic domains can be taken from each of the three NMB1870 families and expressed as a single polypeptide chain. The inventors have also found that NMB1870 exposes some of its epitopes in surface loops situated between alpha helices, and that substitution of loop epitopes from one family into the loop position in another family allows chimeric NMB1870 to be produced with multi-family antigenicity. Thus chimeric NMB1870 proteins are provided that comprise portions of NMB1870 from different families.

    摘要翻译： “NMB1870”是脑膜炎奈瑟氏球菌在所有血清群中表达的已知表面蛋白质。 它有三个不同的家庭。 对同一家庭提起的血清是在同一家庭内具有杀菌作用，但对于表达其他两个家族之一，即家庭内部而不是家族间交叉保护的菌株不起作用。 发明人已经发现，NMB1870可以分为多个结构域，并不是所有的域都是抗原性所必需的。 抗原结构域可以从三个NMB1870家族中的每一个获取，并且表达为单个多肽链。 本发明人还发现NMB1870在位于α-螺旋之间的表面循环中暴露了其一些表位，并且将一个家族的环表位置换为另一家族的环位置允许以多家族抗原性产生嵌合NMB1870。 因此，提供了嵌合NMB1870蛋白，其包含来自不同家族的NMB1870的部分。