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公开(公告)号:US08431139B2
公开(公告)日:2013-04-30
申请号:US11434203
申请日:2006-05-16
申请人: John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
发明人: John Telford , Vega Masignani , Maria Scarselli , Guido Grandi , Herve Tettelin , Claire Fraser
IPC分类号: A61K39/09
CPC分类号: C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要: The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
摘要翻译: 本发明提供来自B族链球菌(无乳链球菌)和A型链球菌(化脓链球菌)的蛋白质,包括氨基酸序列和相应的核苷酸序列。 给出数据以显示蛋白质是疫苗,免疫原性组合物和/或诊断的有用抗原。 蛋白质也是抗生素的靶标。
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公开(公告)号:US20120135024A1
公开(公告)日:2012-05-31
申请号:US13070448
申请日:2011-03-23
申请人: Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
发明人: Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
CPC分类号: C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
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3.
公开(公告)号:US20120128707A1
公开(公告)日:2012-05-24
申请号:US12897952
申请日:2010-10-05
申请人: VEGA MASIGNANI , HERV¿ TETTELIN , CLAIRE FRASER
发明人: VEGA MASIGNANI , HERV¿ TETTELIN , CLAIRE FRASER
IPC分类号: A61K39/09 , A61K39/295 , C07K14/315 , A61P31/16 , A61P31/04 , A61P31/14 , A61P31/20 , A61K39/116 , A61P37/04
CPC分类号: C07K14/3156 , A61K39/00 , Y02A50/464 , Y02A50/466
摘要: The invention provides proteins and nucleic acid sequences from Streptococcus Pneumoniae, together with a genome sequence. These are useful for the development of vaccines, diagnostics, and antibiotics.
摘要翻译: 本发明提供了来自肺炎链球菌的蛋白质和核酸序列,以及基因组序列。 这些可用于开发疫苗,诊断和抗生素。
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公开(公告)号:US20090232820A1
公开(公告)日:2009-09-17
申请号:US12013047
申请日:2008-01-11
申请人: Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
发明人: Claire FRASER , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Petersen , Mariagrazia Pizza , Rino Rappuoli , Giulio Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , J. Craig Venter
IPC分类号: A61K39/395 , C07K7/06 , C07K7/08 , C07K14/00 , A61K38/08 , A61K38/10 , A61K38/16 , C07K16/00 , C07H21/04
CPC分类号: C07K14/22 , A61K38/00 , A61K39/00 , A61K39/095 , A61K2039/55505 , Y10S530/806 , Y10S530/825
摘要: The invention provides proteins from Neisseria meningitidis, including the amino acid sequences and the corresponding nucleotide sequences. The proteins are predicted to be useful antigens for vaccines and/or diagnostics.
摘要翻译: 本发明提供脑膜炎奈瑟氏球菌的蛋白质,包括氨基酸序列和相应的核苷酸序列。 蛋白质被预测为用于疫苗和/或诊断的有用的抗原。
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公开(公告)号:US20060258849A1
公开(公告)日:2006-11-16
申请号:US11434127
申请日:2006-05-16
申请人: John Telford , Vega Masignani , Immaculada Ros , Guido Grandi , Claire Fraser , Herve Tettelin
发明人: John Telford , Vega Masignani , Immaculada Ros , Guido Grandi , Claire Fraser , Herve Tettelin
CPC分类号: C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要: The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
摘要翻译: 本发明提供来自B族链球菌(无乳链球菌)和A型链球菌(化脓链球菌)的蛋白质,包括氨基酸序列和相应的核苷酸序列。 给出数据以显示蛋白质是疫苗,免疫原性组合物和/或诊断的有用抗原。 蛋白质也是抗生素的靶标。
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公开(公告)号:US20060210580A1
公开(公告)日:2006-09-21
申请号:US11434184
申请日:2006-05-16
申请人: John Telford , Vega Masignani , Immaculada Ros , Guido Grandi , Claire Fraser , Herve Tettelin
发明人: John Telford , Vega Masignani , Immaculada Ros , Guido Grandi , Claire Fraser , Herve Tettelin
CPC分类号: C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要: The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
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7.
公开(公告)号:US20120207778A1
公开(公告)日:2012-08-16
申请号:US13398079
申请日:2012-02-16
申请人: John Telford , Vega Masignani , Immaculada Margarit Y Ros , Guido Grandi , Claire Fraser , Hervé Tettelin
发明人: John Telford , Vega Masignani , Immaculada Margarit Y Ros , Guido Grandi , Claire Fraser , Hervé Tettelin
IPC分类号: A61K39/09 , C07K16/12 , C07K7/08 , A61K38/16 , A61P31/04 , C07K7/06 , C07K14/315 , C07H21/04
CPC分类号: C07K14/315 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K2319/00 , Y02A50/464 , Y02A50/466 , Y02A90/22 , Y02A90/26
摘要: The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences.
摘要翻译: 本发明提供来自B族链球菌(无乳链球菌)和A型链球菌(化脓链球菌)的蛋白质,包括氨基酸序列和相应的核苷酸序列。
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公开(公告)号:US08039007B2
公开(公告)日:2011-10-18
申请号:US12306920
申请日:2007-06-29
申请人: Rino Rappuoli , Claire Fraser , Mariagrazia Pizza , Maria Scarselli , Davide Serruto , Hervé Tettelin
发明人: Rino Rappuoli , Claire Fraser , Mariagrazia Pizza , Maria Scarselli , Davide Serruto , Hervé Tettelin
IPC分类号: A61K39/095 , C07H21/04 , C07K14/22
摘要: Various specific meningococcal proteins are disclosed. The invention provides related polypeptides, nucleic acids, antibodies and methods. These can all be used in medicine for treating or preventing disease and/or infection caused by meningococcus, such as bacterial meningitis.
摘要翻译: 公开了各种特定的脑膜炎球菌蛋白质。 本发明提供了相关多肽,核酸,抗体和方法。 这些都可以用于治疗或预防脑膜炎球菌引起的疾病和/或感染的药物,例如细菌性脑膜炎。
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公开(公告)号:US20070026021A1
公开(公告)日:2007-02-01
申请号:US11395121
申请日:2006-03-31
申请人: Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Peterson , Mariagrazia Pizza , Rino Rappuoli , Giulo Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , Craig Venter
发明人: Claire Fraser , Cesira Galeotti , Guido Grandi , Erin Hickey , Vega Masignani , Marirosa Mora , Jeremy Peterson , Mariagrazia Pizza , Rino Rappuoli , Giulo Ratti , Vincenzo Scarlato , Maria Scarselli , Herve Tettelin , Craig Venter
IPC分类号: A61K39/095 , C07K14/22 , C07K16/12
摘要: This invention provides, among other things, protein, polypeptides, and fragments thereof, derived from bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto (e.g., antisense nucleic acids). Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or fragments. This invention further provides expression vectors useful for making the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments and/or nucleic acids.
摘要翻译: 本发明尤其提供衍生自脑膜炎奈瑟氏球菌B的蛋白质,多肽和其片段。还提供编码这种蛋白质,多肽和/或片段的核酸,以及与其互补的核酸(例如, 反义核酸)。 另外,本发明提供了结合蛋白质,多肽和/或片段的抗体。 本发明进一步提供用于制备用作疫苗,诊断试剂,免疫原性组合物等的蛋白质,多肽,片段和/或核酸的表达载体。 还提供了用组合物制备组合物和处理方法的方法。 本发明还提供了检测蛋白质,多肽,片段和/或核酸的方法。
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公开(公告)号:US20050020813A1
公开(公告)日:2005-01-27
申请号:US10472928
申请日:2002-03-27
申请人: Vega Masignani , Herve Tettelin , Claire Fraser
发明人: Vega Masignani , Herve Tettelin , Claire Fraser
IPC分类号: C12N15/09 , A61K38/00 , A61K39/00 , A61K39/02 , A61K39/05 , A61K39/08 , A61K39/095 , A61K39/102 , A61K39/118 , A61K39/20 , A61K39/205 , A61K39/29 , A61K39/395 , A61P11/00 , A61P25/00 , A61P27/16 , A61P31/04 , C07K14/315 , C07K16/12 , C12N1/21 , C12N15/31 , C12R1/46 , A61K39/09 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号: C07K14/3156 , A61K39/00 , Y02A50/464 , Y02A50/466
摘要: The invention provides proteins and nucleic acid sequences from Streptococcus pneumoniae, together with a genome sequence. These are useful for the development of vaccines, diagnostics, and antibiotics.
摘要翻译: 本发明提供了来自肺炎链球菌的蛋白质和核酸序列,以及基因组序列。 这些可用于开发疫苗,诊断和抗生素。
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