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公开(公告)号：US20190328445A1
公开(公告)日：2019-10-31
申请号：US16443351
申请日：2019-06-17
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafael V. Davalos
Abstract: The present invention relates to the field of biomedical engineering and medical treatment of diseases and disorders. Methods, devices, and systems for in vivo treatment of cell proliferative disorders are provided. In embodiments, the methods comprise the delivery of high-frequency bursts of bipolar pulses to achieve the desired modality of cell death. More specifically, embodiments of the invention relate to a device and method for destroying aberrant cells, including tumor tissues, using high-frequency, bipolar electrical pulses having a burst width on the order of microseconds and duration of single polarity on the microsecond to nanosecond scale. In embodiments, the methods rely on conventional electroporation with adjuvant drugs or irreversible electroporation to cause cell death in treated tumors. The invention can be used to treat solid tumors, such as brain tumors.
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22.发明申请公开(公告)号：US20190029749A1
公开(公告)日：2019-01-31
申请号：US16152743
申请日：2018-10-05
Applicant: Virginia Tech Intellectual Properties Inc.
Inventor： Paulo A. Garcia , Christopher B. Arena , Michael B. Sano , Rafael V. Davalos
IPC: A61B18/14
Abstract: Systems and methods are provided for modeling and for providing a graphical representation of tissue heating and electric field distributions for medical treatment devices that apply electrical treatment energy through one or a plurality of electrodes. In embodiments, methods comprise: providing one or more parameters of a treatment protocol for delivering one or more electrical pulses to tissue through a plurality of electrodes; modeling electric and heat distribution in the tissue based on the parameters; and displaying a graphical representation of the modeled electric and heat distribution. In another embodiment, a treatment planning module is adapted to generate an estimated target ablation zone based on a combination of one or more parameters for an irreversible electroporation protocol and one or more tissue-specific conductivity parameters.
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Patent Agency Ranking
公开(公告)号：US10117707B2
公开(公告)日：2018-11-06
申请号：US14558631
申请日：2014-12-02
Applicant: Virginia Tech Intellectual Properties Inc.
Inventor： Paulo A. Garcia , Christopher B. Arena , Michael B. Sano , Rafael V. Davalos
Abstract: Systems and methods are provided for modeling and for providing a graphical representation of tissue heating and electric field distributions for medical treatment devices that apply electrical treatment energy through one or a plurality of electrodes. In embodiments, methods comprise: providing one or more parameters of a treatment protocol for delivering one or more electrical pulses to tissue through a plurality of electrodes; modeling electric and heat distribution in the tissue based on the parameters; and displaying a graphical representation of the modeled electric and heat distribution. In another embodiment, a treatment planning module is adapted to generate an estimated target ablation zone based on a combination of one or more parameters for an irreversible electroporation protocol and one or more tissue-specific conductivity parameters.
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公开(公告)号：US20160287314A1
公开(公告)日：2016-10-06
申请号：US15186653
申请日：2016-06-20
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Christopher B. Arena , Rafael V. Davalos , Michael B. Sano
IPC: A61B18/14
CPC classification number: A61B18/14 , A61B2018/0016 , A61B2018/00577 , A61B2018/00613 , A61B2018/00761 , A61B2018/00767 , A61N1/327
Abstract: The present invention relates to the field of biomedical engineering and medical treatment of diseases and disorders. Methods, devices, and systems for in vivo treatment of cell proliferative disorders are provided. In embodiments, the methods comprise the delivery of high-frequency bursts of bipolar pulses to achieve the desired modality of cell death. More specifically, embodiments of the invention relate to a device and method for destroying aberrant cells, including tumor tissues, using high-frequency, bipolar electrical pulses having a burst width on the order of microseconds and duration of single polarity on the microsecond to nanosecond scale. In embodiments, the methods rely on conventional electroporation with adjuvant drugs or irreversible electroporation to cause cell death in treated tumors. The invention can be used to treat solid tumors, such as brain tumors.
Abstract translation: 本发明涉及疾病和病症的生物医学工程和医学治疗领域。 提供了体内治疗细胞增殖性疾病的方法，装置和系统。 在实施例中，这些方法包括输送高频脉冲串的双极脉冲以实现所需的细胞死亡模式。 更具体地，本发明的实施例涉及使用高频双极电脉冲来破坏包括肿瘤组织的异常细胞的装置和方法，所述高频双极电脉冲具有微秒级的微秒级和单极性的持续时间，微秒至纳秒级 。 在实施方案中，所述方法依赖于常规电穿孔辅助药物或不可逆电穿孔以在治疗的肿瘤中引起细胞死亡。 本发明可用于治疗诸如脑肿瘤的实体瘤。
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25.发明申请SYSTEM AND METHOD FOR ESTIMATING TISSUE HEATING OF A TARGET ABLATION ZONE FOR ELECTRICAL-ENERGY BASED THERAPIES 审中-公开用于评估基于电力能量治疗的目标吸收区组织加热的系统和方法公开(公告)号：US20150088120A1
公开(公告)日：2015-03-26
申请号：US14558631
申请日：2014-12-02
Applicant: Virginia Tech Intellectual Properties Inc.
Inventor： Paulo A. Garcia , Christopher B. Arena , Michael B. Sano , Rafael V. Davalos
CPC classification number: A61B18/1477 , A61B34/10 , A61B34/25 , A61B90/37 , A61B2018/0016 , A61B2018/00613 , A61B2018/00779 , A61B2018/00875 , A61B2018/00886 , A61B2018/00892 , A61B2018/1425 , A61B2034/104 , A61B2034/256 , C12N13/00
Abstract: Systems and methods are provided for modeling and for providing a graphical representation of tissue heating and electric field distributions for medical treatment devices that apply electrical treatment energy through one or a plurality of electrodes. In embodiments, methods comprise: providing one or more parameters of a treatment protocol for delivering one or more electrical pulses to tissue through a plurality of electrodes; modeling electric and heat distribution in the tissue based on the parameters; and displaying a graphical representation of the modeled electric and heat distribution. In another embodiment, a treatment planning module is adapted to generate an estimated target ablation zone based on a combination of one or more parameters for an irreversible electroporation protocol and one or more tissue-specific conductivity parameters.
Abstract translation: 提供的系统和方法用于建模并提供用于通过一个或多个电极施加电处理能量的医疗处理装置的组织加热和电场分布的图形表示。 在实施例中，方法包括：提供用于通过多个电极将一个或多个电脉冲传送到组织的治疗方案的一个或多个参数; 基于参数对组织中的电热分布进行建模; 并显示所建模的电和热分布的图形表示。 在另一个实施例中，治疗计划模块适于基于用于不可逆电穿孔方案的一个或多个参数和一个或多个组织特异性电导率参数的组合来产生估计的目标消融区域。
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公开(公告)号：US08814860B2
公开(公告)日：2014-08-26
申请号：US13919640
申请日：2013-06-17
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , Marissa N. Rylander , Christopher B. Arena , Yong Woo Lee
CPC classification number: A61B18/1477 , A61B18/1206 , A61B2018/00446 , A61B2018/00613 , A61N1/05 , A61N1/327 , C12N13/00
Abstract: The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors. In embodiments, the methods comprise the use of high aspect ratio nanoparticles with or without modified surface chemistry.
Abstract translation: 本发明提供用于体内治疗细胞增殖性疾病的方法，装置和系统。 本发明可用于治疗诸如脑肿瘤的实体瘤。 该方法依赖于非热不可逆电穿孔（IRE）在治疗的肿瘤中引起细胞死亡。 在实施方案中，所述方法包括使用具有或不具有改性表面化学性质的高纵横比纳米颗粒。
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27.发明申请SYSTEM AND METHOD FOR ESTIMATING A TREATMENT VOLUME FOR ADMINISTERING ELECTRICAL-ENERGY BASED THERAPIES 有权用于评估基于电力能量治疗的治疗体系的系统和方法公开(公告)号：US20130345697A1
公开(公告)日：2013-12-26
申请号：US14012832
申请日：2013-08-28
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Paulo A. Garcia , Christopher B. Arena , Rafael V. Davalos
CPC classification number: A61B18/1206 , A61B18/14 , A61B18/1477 , A61B18/18 , A61B34/10 , A61B2018/0016 , A61B2018/00577 , A61B2018/00613 , A61B2018/00666 , A61B2018/00672 , A61B2018/00678 , A61B2018/00767 , A61B2018/00875 , A61B2018/1425 , A61B2034/104 , C12N13/00
Abstract: The invention provides for a system for estimating a 3-dimensional treatment volume for a device that applies treatment energy through a plurality of electrodes defining a treatment area, the system comprising a memory, a display device, a processor coupled to the memory and the display device, and a treatment planning module stored in the memory and executable by the processor. In one embodiment, the treatment planning module is adapted to generate an estimated first 3-dimensional treatment volume for display in the display device based on the ratio of a maximum conductivity of the treatment area to a baseline conductivity of the treatment area. The invention also provides for a method for estimating 3-dimensional treatment volume, the steps of which are executable through the processor. In embodiments, the system and method are based on a numerical model which may be implemented in computer readable code which is executable through a processor.
Abstract translation: 本发明提供一种用于估计通过定义治疗区域的多个电极施加治疗能量的装置的三维治疗体积的系统，所述系统包括存储器，显示装置，耦合到存储器和显示器的处理器 设备和存储在存储器中并由处理器执行的治疗计划模块。 在一个实施例中，治疗计划模块适于基于治疗区域的最大电导率与治疗区域的基线电导率的比率来生成用于在显示装置中显示的估计的第一3维治疗体积。 本发明还提供了一种用于估计三维处理量的方法，该方法的步骤可通过处理器执行。 在实施例中，系统和方法基于可以在可通过处理器执行的计算机可读代码中实现的数值模型。
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