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公开(公告)号：US12214189B2
公开(公告)日：2025-02-04
申请号：US16938778
申请日：2020-07-24
Inventor： Melvin F. Lorenzo , Christopher B. Arena , Suyashree Bhonsle , Natalie White , Lucy Epshteyn , Rafael V. Davalos
Abstract: Electroporation-based therapies (EBTs) employ high voltage pulsed electric fields (PEFs) to permeabilize tumor tissue, resulting in changes in passive electrical properties detectable using electrical impedance spectroscopy (EIS). Currently, commercial potentiostats for EIS are limited by impedance spectrum acquisition time (˜10 s); this timeframe is much larger than pulse periods used with EBTs (˜1 s). Fourier Analysis SpecTroscopy (FAST) is introduced as a methodology for monitoring tissue inter-burst impedance (diagnostic FAST) and intra-burst impedance (therapeutic FAST) during EBTs. FAST is a rapid-capture (
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公开(公告)号：US11903690B2
公开(公告)日：2024-02-20
申请号：US16865031
申请日：2020-05-01
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , Mohammad Bonakdar , Eduardo L. Latouche , Roop L. Mahajan , John L. Robertson , Christopher B. Arena , Michael B. Sano
IPC: A61B5/053 , G01N33/543 , A61B5/01 , A61B5/0538
CPC classification number: A61B5/0538 , A61B5/01 , G01N33/5438
Abstract: Provided herein are devices, systems, and methods for monitoring lesion or treated area in a tissue during focal ablation or cell membrane disruption therapy.
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3.发明公开公开(公告)号：US20230355293A1
公开(公告)日：2023-11-09
申请号：US18130330
申请日：2023-04-03
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , Christopher B. Arena
IPC: A61B18/12
CPC classification number: A61B18/1206 , A61B2018/00666
Abstract: A method for treating a target tissue in a patient in need thereof is provided. The method includes the steps of identifying one or more characteristics of one or more cells of a target tissue; calculating a threshold electric field for inducing IRE in the target tissue based on the one or more characteristics; constructing a treatment protocol of one or more pulse parameters, wherein the treatment protocol is capable of inducing IRE in the target tissue; and delivering the treatment protocol to the target tissue. Systems for treatment planning for medical therapies involving administering electrical treatment energy are also provided.
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公开(公告)号：US20230248414A1
公开(公告)日：2023-08-10
申请号：US18123719
申请日：2023-03-20
Applicant: Virginia Tech Intellectual Properties Inc.
Inventor： Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafael V. Davalos
CPC classification number: A61B18/14 , A61N1/327 , A61B2018/00761
Abstract: The present invention relates to the field of biomedical engineering and medical treatment of diseases and disorders. Methods, devices, and systems for in vivo treatment of cell proliferative disorders are provided. In embodiments, the methods comprise the delivery of high-frequency bursts of bipolar pulses to achieve the desired modality of cell death. More specifically, embodiments of the invention relate to a device and method for destroying aberrant cells, including tumor tissues, using high-frequency, bipolar electrical pulses having a burst width on the order of microseconds and duration of single polarity on the microsecond to nanosecond scale. In embodiments, the methods rely on conventional electroporation with adjuvant drugs or irreversible electroporation to cause cell death in treated tumors. The invention can be used to treat solid tumors, such as brain tumors.
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公开(公告)号：US11607537B2
公开(公告)日：2023-03-21
申请号：US16210771
申请日：2018-12-05
Applicant: Virginia Tech Intellectual Properties, Inc. , VoltMed, Inc.
Inventor： Eduardo Latouche , Samuel Lesko , Lucy Epshteyn , Christopher B. Arena , John H. Rossmeisl, Jr. , Melvin Lorenzo , Rafael Davalos
Abstract: This disclosure describes the methods, devices, and systems of treating diseased tissue with integrated nanosecond pulse irreversible electroporation. Methods and systems as disclosed provide MRI compatible shielded electrodes and electrode leads to prevent emanating radiofrequency noise and improve image quality, disconnecting the electrode from the cable linkage to the pulse generator reduce electromagnetic interference and image artifacts, placing electrodes strategically within a guide cannula to minimize distortion from heterogeneities or maximize ablation within the tissue, utilizing conductive fluids, innate or external, such as cerebral spinal fluid or grounding pads to provide a pathway for current return, and for timing of the electrical waveforms with inherent brain electrical activity.
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Patent Agency Ranking
公开(公告)号：US11272979B2
公开(公告)日：2022-03-15
申请号：US16152743
申请日：2018-10-05
Applicant: Virginia Tech Intellectual Properties Inc.
Inventor： Paulo A. Garcia , Christopher B. Arena , Michael B. Sano , Rafael V. Davalos
Abstract: Systems and methods are provided for modeling and for providing a graphical representation of tissue heating and electric field distributions for medical treatment devices that apply electrical treatment energy through one or a plurality of electrodes. In embodiments, methods comprise: providing one or more parameters of a treatment protocol for delivering one or more electrical pulses to tissue through a plurality of electrodes; modeling electric and heat distribution in the tissue based on the parameters; and displaying a graphical representation of the modeled electric and heat distribution. In another embodiment, a treatment planning module is adapted to generate an estimated target ablation zone based on a combination of one or more parameters for an irreversible electroporation protocol and one or more tissue-specific conductivity parameters.
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7.发明申请公开(公告)号：US20200260987A1
公开(公告)日：2020-08-20
申请号：US16865031
申请日：2020-05-01
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Rafael V. Davalos , Mohammad Bonakdar , Eduardo L. Latouche , Roop L. Mahajan , John L. Robertson , Christopher B. Arena , Michael B. Sano
IPC: A61B5/053
Abstract: Provided herein are devices, systems, and methods for monitoring lesion or treated area in a tissue during focal ablation or cell membrane disruption therapy.
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公开(公告)号：US10471254B2
公开(公告)日：2019-11-12
申请号：US15310114
申请日：2015-05-12
Applicant: Virginia Tech Intellectual Properties, Inc. , Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafael V. Davalos
Inventor： Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafael V. Davalos
IPC: A61B18/14 , A61N1/32 , A61N1/40 , A61B90/00 , A61B18/12 , A61N1/06 , A61N1/08 , A61B18/00 , A61B17/00
Abstract: A system and method for selectively treating aberrant cells such as cancer cells through administration of a train of electrical pulses is described. The pulse length and delay between successive pulses is optimized to produce effects on intracellular membrane potentials. Therapies based on the system and method produce two treatment zones: an ablation zone surrounding the electrodes within which aberrant cells are non-selectively killed and a selective treatment zone surrounding the ablation zone within which target cells are selectively killed through effects on intracellular membrane potentials. As a result, infiltrating tumor cells within a tumor margin can be effectively treated while sparing healthy tissue. The system and method are useful for treating various cancers in which solid tumors form and have a chance of recurrence from microscopic disease surrounding the tumor.
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公开(公告)号：US11406820B2
公开(公告)日：2022-08-09
申请号：US16520901
申请日：2019-07-24
Applicant: Virginia Tech Intellectual Properties, Inc.
Inventor： Michael B. Sano , Christopher B. Arena , Scott S. Verbridge , Rafael V. Davalos
IPC: A61B18/12 , A61B18/14 , A61N1/32 , A61N1/40 , A61B90/00 , A61N1/06 , A61N1/08 , A61B18/00 , A61B17/00
Abstract: A system and method for selectively treating aberrant cells such as cancer cells through administration of a train of electrical pulses is described. The pulse length and delay between successive pulses is optimized to produce effects on intracellular membrane potentials. Therapies based on the system and method produce two treatment zones: an ablation zone surrounding the electrodes within which aberrant cells are non-selectively killed and a selective treatment zone surrounding the ablation zone within which target cells are selectively killed through effects on intracellular membrane potentials. As a result, infiltrating tumor cells within a tumor margin can be effectively treated while sparing healthy tissue. The system and method are useful for treating various cancers in which solid tumors form and have a chance of recurrence from microscopic disease surrounding the tumor.
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公开(公告)号：US20220022945A9
公开(公告)日：2022-01-27
申请号：US16152743
申请日：2018-10-05
Applicant: Virginia Tech Intellectual Properties Inc.
Inventor： Paulo A. Garcia , Christopher B. Arena , Michael B. Sano , Rafael V. Davalos
IPC: A61B18/14
Abstract: Systems and methods are provided for modeling and for providing a graphical representation of tissue heating and electric field distributions for medical treatment devices that apply electrical treatment energy through one or a plurality of electrodes. In embodiments, methods comprise: providing one or more parameters of a treatment protocol for delivering one or more electrical pulses to tissue through a plurality of electrodes; modeling electric and heat distribution in the tissue based on the parameters; and displaying a graphical representation of the modeled electric and heat distribution. In another embodiment, a treatment planning module is adapted to generate an estimated target ablation zone based on a combination of one or more parameters for an irreversible electroporation protocol and one or more tissue-specific conductivity parameters.
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