公开(公告)号：US20220091079A1

公开(公告)日：2022-03-24

申请号：US17471463

申请日：2021-09-10

Applicant: Waters Technologies Corporation

Inventor： Amit Patel ,  Moon Chul Jung ,  Susan Rzewuski ,  Matthew A. Lauber ,  Thomas H. Walter ,  Kevin Wyndham ,  Mathew DeLano ,  Jennifer Simeone

IPC: G01N30/88

Abstract: The present disclosure is directed to a kit for evaluating system inertness. The kit includes a positive control comprising a metal interacting moiety, and a negative control that does not contain a metal interacting moiety. In some embodiments the kit also includes a container to hold a system suitability solution (e.g., an equimolar mixture of the positive control and the negative control).

公开(公告)号：US20220082531A1

公开(公告)日：2022-03-17

申请号：US17471393

申请日：2021-09-10

Applicant: Waters Technologies Corporation

Inventor： Amit Patel ,  Moon Chul Jung ,  Susan Rzewuski ,  Thomas H. Walter ,  Matthew A. Lauber ,  Kevin Wyndham ,  Mathew DeLano ,  Jennifer Simeone

IPC: G01N30/04

Abstract: The present disclosure is directed to methods of characterizing a system containing a chromatographic column. The methods can include introducing a sample comprising a positive control and a negative control to the system containing a chromatographic column, wherein the positive control is a sensitive probe that interacts with the system and the negative control is substantially non-interacting with the system; after passing the sample through the chromatographic column, detecting the positive control and the negative control; and determining system suitability by comparing the amount of detected positive control to negative control. In some embodiments, determining system suitability (e.g., inertness of sample to the system) is accomplished by determining a ratio of detected positive control to negative control.

公开(公告)号：US20210164094A1

公开(公告)日：2021-06-03

申请号：US17166460

申请日：2021-02-03

Applicant: Waters Technologies Corporation

Inventor： Stephen J. Shiner ,  Cheryl Boissel ,  Matthew A. Lauber ,  Kevin Wyndham

IPC: C23C16/02 ,  C23C14/04 ,  C23C14/12 ,  C23C14/58 ,  G01N30/60 ,  C23C14/16 ,  C09D143/04

Abstract: A chromatographic device including a coated metallic frit is disclosed. The coating is provided over the fluid exposed surfaces of the frit, thereby covering metallic surfaces to prevent interaction with an analyte in the flowstream. This technology relates to the use of vapor deposition coated frit(s) in a liquid flow path for improved chromatography. More specifically, this technology relates to liquid chromatographic devices for separating analytes in a sample having coated frit(s) within an uncoated metallic fluidic flow path (i.e., the column tube or channel is formed of stainless steel, titanium (pure or alloyed), or some mixture of stainless steel and titanium) and does not include the coating applied to the frit.

公开(公告)号：US10823713B2

公开(公告)日：2020-11-03

申请号：US15847586

申请日：2017-12-19

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Wade P. Leveille ,  Jonathan L. Belanger ,  Moon Chul Jung ,  Abhijit Tarafder ,  Joseph Michienzi ,  Keith Fadgen ,  Kevin Wyndham ,  Xiangjin Song

IPC: G01N30/32 ,  B01D15/16 ,  B65D83/14 ,  G01N30/38

Abstract: The present disclosure generally relates to systems, methods and devices for providing pressurized solvent flow in chromatography systems.

公开(公告)号：US20180202980A1

公开(公告)日：2018-07-19

申请号：US15847586

申请日：2017-12-19

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Wade P. Leveille ,  Jonathan L. Belanger ,  Moon Chul Jung ,  Abhijit Tarafder ,  Joseph Michienzi ,  Keith Fadgen ,  Kevin Wyndham ,  Xiangjin Song

IPC: G01N30/32 ,  B01D15/16 ,  G01N30/38 ,  B65D83/14

Abstract: The present disclosure generally relates to systems, methods and devices for providing pressurized solvent flow in chromatography systems.