公开(公告)号：US12259368B2

公开(公告)日：2025-03-25

申请号：US17471393

申请日：2021-09-10

Applicant: Waters Technologies Corporation

Inventor： Amit Patel ,  Moon Chul Jung ,  Matthew A. Lauber ,  Kevin Wyndham ,  Mathew H. DeLano ,  Jennifer Simeone

IPC: G01N30/04 ,  G01N30/02

Abstract: The present disclosure is directed to methods of characterizing a system containing a chromatographic column. The methods can include introducing a sample comprising a positive control and a negative control to the system containing a chromatographic column, wherein the positive control is a sensitive probe that interacts with the system and the negative control is substantially non-interacting with the system; after passing the sample through the chromatographic column, detecting the positive control and the negative control; and determining system suitability by comparing the amount of detected positive control to negative control. In some embodiments, determining system suitability (e.g., inertness of sample to the system) is accomplished by determining a ratio of detected positive control to negative control.

公开(公告)号：US11041834B2

公开(公告)日：2021-06-22

申请号：US16292610

申请日：2019-03-05

Applicant: Waters Technologies Corporation

Inventor： Abhijit Tarafder ,  Moon Chul Jung ,  Edouard S. P. Bouvier

IPC: G01N30/60 ,  B01L3/00 ,  G01N30/02 ,  G01N30/52 ,  G01N30/88

Abstract: A chromatographic device includes a primary channel having a cross-sectional area and characteristic length such that analyte travel within the primary channel is substantially convective. A plurality of secondary channels each having a cross-sectional area and characteristic length such that analyte flow into and out of a secondary channel is substantially diffusive, each of the plurality of secondary channels having an entrance in fluidic communication with the primary channel wherein the entrance intersects the primary channel.

公开(公告)号：US20200284802A1

公开(公告)日：2020-09-10

申请号：US16808233

申请日：2020-03-03

Applicant: Waters Technologies Corporation

Inventor： Moon Chul Jung ,  Mary Elizabeth Lame ,  Caitlin Dunning ,  Christopher John Hughes ,  Xiaoxiao Liu ,  Paula Orens ,  Yun Wang Alelyunas ,  Erin E. Chambers ,  David Dao ,  Robert Birdsall

IPC: G01N33/68 ,  G01N30/72 ,  G01N30/06

Abstract: The present disclosure relates to a method of analyzing a sample comprising a hydrophobic molecule. The method includes preparing an aqueous solution comprising the sample. The method also includes placing the solution in contact with a polypropylene substrate having a deactivated surface that reduces adsorption of the hydrophobic molecule relative to a polypropylene substrate that has not been deactivated. The method also includes analyzing the sample.

公开(公告)号：US20190187109A1

公开(公告)日：2019-06-20

申请号：US16223330

申请日：2018-12-18

Applicant: Waters Technologies Corporation

Inventor： Moon Chul Jung ,  Abhijit Tarafder ,  Wade P. Leveille

IPC: G01N30/14 ,  B01D15/26 ,  B01D15/18

CPC classification number: G01N30/14 ,  B01D15/18 ,  B01D15/26 ,  G01N1/34 ,  G01N30/32 ,  G01N30/34 ,  G01N2030/143 ,  G01N2030/342

Abstract: In various aspects provided are purification media and containers for dispensing a purified liquid are provided herein where a high surface area-to-volume chemically interactive purification media positioned at the outlet of a container that purifies the liquid as it is dispensed and/or extracted.

公开(公告)号：US20180202888A1

公开(公告)日：2018-07-19

申请号：US15872755

申请日：2018-01-16

Applicant: Waters Technologies Corporation

Inventor： Abhijit Tarafder ,  Moon Chul Jung ,  Jonathan L. Belanger ,  Xiangjin Song ,  Wade P. Leveille ,  Darryl W. Brousmiche

IPC: G01M3/20 ,  G01N30/34 ,  G01N30/02

Abstract: Systems, methods, and devices for detecting leaks in chromatography systems are disclosed. A coating is disposed to conform to at least one component of a chromatography system, such as a fitting or a section of tubing. The coating is made of or contains a responsive material that can undergo a detectable change when exposed to a chromatographic fluid or mobile phase. The change of the responsive material can indicate the presence of the fluid or mobile phase, a change in at least one physical property of the coating to prevent passage of the fluid or mobile phase, or a combination thereof.

公开(公告)号：US20150047441A1

公开(公告)日：2015-02-19

申请号：US14388274

申请日：2013-03-04

Applicant: Waters Technologies Corporation

Inventor： Xin Zhang ,  Pamela C. Iraneta ,  Moon Chul Jung ,  Pamela J. Longenbach ,  Frank Marszalkowski, Jr.

IPC: G01N1/30 ,  G01N1/10

CPC classification number: G01N1/30 ,  B01L3/5088 ,  B01L2300/126 ,  B01L2300/161 ,  G01N1/10 ,  G01N33/5436 ,  G01N33/96 ,  G01N2291/02466

Abstract: Described is a biological sample carrier based on a rigid hydrophilic object fabricated from a non-absorbing inert porous material. A biological fluid sample applied to the surface of the object is absorbed into the pores and constituents of the biological fluid sample remain in the pores after drying. Unlike a disc punched from a conventional dried blood spot (DBS) card, the object is easily handled. In contrast to DBS cards containing glass fiber structures that interact with basic analytes and other DBS card having adsorbing fibers that tend to separate blood constituents as the sample spreads through the fibers, the biological sample carrier is substantially inert to drug analytes.

Abstract translation: 描述了基于由非吸收惰性多孔材料制造的刚性亲水物体的生物样品载体。 施加到物体表面的生物流体样品被吸收到孔中，并且干燥后生物流体样品的成分保留在孔中。 与传统的干血斑（DBS）卡片冲孔不同，该物体易于处理。 与含有与碱性分析物相互作用的玻璃纤维结构的DBS卡和具有吸附纤维的其它DBS卡相反，当样品扩散通过纤维时，其具有倾向于分离血液成分的生物样品载体对药物分析物基本上是惰性的。

公开(公告)号：US11874256B2

公开(公告)日：2024-01-16

申请号：US17471449

申请日：2021-09-10

Applicant: Waters Technologies Corporation

Inventor： Amit Patel ,  Moon Chul Jung ,  Thomas H. Walter ,  Matthew A. Lauber ,  Kevin Wyndham ,  Mathew DeLano ,  Jennifer Simeone

IPC: G01N30/16 ,  G01N30/72 ,  G01N30/74 ,  G01N30/86 ,  G01N30/06 ,  G01N30/02

CPC classification number: G01N30/16 ,  G01N30/72 ,  G01N30/74 ,  G01N30/8637 ,  G01N30/06 ,  G01N2030/027

Abstract: The present disclosure is directed to methods for evaluating system inertness, such as the inertness of a LC or other fluidic system. Some methods are directed to tests wherein the column has been removed prior to injecting a sample including a positive (e.g., metal reacting moiety) control into the system. Some methods can include: (1) repeatedly injecting the sample into a system, the system comprising: fluidic paths wherein interior surfaces of the fluidic paths define wetted surfaces, and wherein at least a portion of the wetted surfaces of the fluidic flow path are coated with an inert coating, wherein the inert coating is inert to at least one analyte in the sample; (2) detecting a value associated with the positive control; and (3) analyzing values associated with the detected positive control to determine system inertness.

公开(公告)号：US11747341B2

公开(公告)日：2023-09-05

申请号：US16808233

申请日：2020-03-03

Applicant: Waters Technologies Corporation

Inventor： Moon Chul Jung ,  Mary Elizabeth Lame ,  Caitlin Dunning ,  Christopher John Hughes ,  Xiaoxiao Liu ,  Paula Orens ,  Yun Wang Alelyunas ,  Erin E. Chambers ,  David Dao ,  Robert Birdsall

IPC: G01N33/68 ,  G01N30/06 ,  G01N30/72

CPC classification number: G01N33/6848 ,  G01N30/06 ,  G01N30/7233

Abstract: The present disclosure relates to a method of analyzing a sample comprising a hydrophobic molecule. The method includes preparing an aqueous solution comprising the sample. The method also includes placing the solution in contact with a polypropylene substrate having a deactivated surface that reduces adsorption of the hydrophobic molecule relative to a polypropylene substrate that has not been deactivated. The method also includes analyzing the sample.

公开(公告)号：US20230088954A1

公开(公告)日：2023-03-23

申请号：US17881175

申请日：2022-08-04

Applicant: Waters Technologies Corporation

Inventor： Joomi Ahn ,  Moon Chul Jung ,  Kevin D. Wyndham

IPC: C12Q1/37 ,  C12N11/06 ,  C12N11/14 ,  C12M1/40 ,  C12M1/34 ,  C12Q1/48

Abstract: An immobilized enzymatic reactor can include a wall defining a chamber having an inlet and an outlet; a solid stationary phase covalently linked to an enzyme and disposed within the chamber; and a pressure modulator in a fluid communication with the chamber and adapted to support continuous flow of a liquid sample comprising a polymer analyte through the inlet, over the solid stationary phase, and out of the outlet under a pressure between about 2,500 and 35,000 psi. In one example, the solid stationary phase includes inorganic/organic hybrid particles in an ultra performance liquid chromatography system, the enzyme is a protease, and the polymer analyte is a polypeptide. The immobilized enzymatic reactor can prepare an analyte for applications such as for hydrogen deuterium exchange mass spectrometry.

公开(公告)号：US11085905B2

公开(公告)日：2021-08-10

申请号：US16439484

申请日：2019-06-12

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Abhijit Tarafder ,  Jonathan Belanger ,  Moon Chul Jung ,  Wade P. Leveille

IPC: G01N30/76 ,  G01N9/32 ,  G08B3/10 ,  G08B5/36 ,  G08B21/18 ,  G01N30/02

Abstract: Various embodiments are generally directed to techniques for monitoring chromatographic fluid flows, such as the flow to and/or from one or more reservoirs used in chromatographic operations, for instance. In many embodiments, the chromatographic operations may include one or more of High Performance Liquid Chromatography (HPLC), Ultra Performance Liquid Chromatography (UPLC), Ultra Performance Convergence Chromatography (UPC2), and the like. Several embodiments are particularly directed to a chromatographic fluid flow device (CFFD) for monitoring a change in density of a chromatographic fluid in a tube, such as by detecting the presence or absence of gas in the tube with an ultrasonic bubble detector. In various embodiments, the chromatographic fluid may include a solvent, a sample, or waste associated with a chromatographic operation.