公开(公告)号：US20070202039A1

公开(公告)日：2007-08-30

申请号：US11742687

申请日：2007-05-01

申请人： Frank Brady ,  Sajinder Luthra ,  Yongjun Zhao

发明人： Frank Brady ,  Sajinder Luthra ,  Yongjun Zhao

IPC分类号： A61K51/00 ,  C07C19/08

CPC分类号： C07C17/204 ,  C07B2200/05 ,  C07C17/093

摘要： The invention relates to a process for the production of an [18F]fluorohaloalkane which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LINKER-SO2—O—(CH2)nX  (I) wherein n is an integer of from 1 to 7 and X is chloro, bromo or iodo; with 18F− to produce the [18F]fluorohaloalkane of formula (II) 18F—(CH2)n—X  (II) wherein n and X are as defined for the compound of formula (I), optionally followed by (i) removal of excess 18F−, for example by ion-exchange chromatography; and/or (ii) removal of organic solvent.

摘要翻译： 本发明涉及一种制备[ - 18 F]氟卤代烷烃的方法，该方法包括处理式（I）的固体载体结合的前体：<β在线式描述=“In “公式”end =“lead”？>固体支持物 - SO 2 -O - （CH 2）n X（I ）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中n为1至7的整数，X为氯，溴或碘; 与
以产生式（II）的 18 F氟卤代烷烃<？in-line-formula description =“In- 线公式“end =”lead“？> （CH 2）n -X（II）<？in-line- 其中n和X如对于式（I）化合物所定义，任选地之后是（i）除去过量的18 F 例如通过离子交换色谱法; 和/或（ii）除去有机溶剂。

公开(公告)号：US20060069294A1

公开(公告)日：2006-03-30

申请号：US10539163

申请日：2003-12-19

申请人： Frank Brady ,  Sajinder Luthra ,  Yongjun Zhao

发明人： Frank Brady ,  Sajinder Luthra ,  Yongjun Zhao

IPC分类号： C07C17/093

CPC分类号： C07C17/204 ,  C07B2200/05 ,  C07C17/093

摘要： The invention relates to a process for the production of an [18F]fluorohaloalkane which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LINKER-SO2—O—(CH2)nX (I) wherein n is an integer of from (1) to (7) and X is chloro, bromo or iodo; with 18F− to produce the [18F]fluorohaloalkane of formula (II) 18F—(CH2)nX (II) wherein n and X are as defined for the compound of formula (I), optionally followed by (i) removal of excess 18F−, for example by ion-exchange chromatography; and/or (ii) removal of organic solvent.

摘要翻译： 本发明涉及一种制备[ - 18 F]氟卤代烷烃的方法，该方法包括处理式（I）的固体载体结合的前体：固体支持物 - 其中n为（1）至（7）的整数，X为氯，溴或氯，或（C 1 -C 4） 碘 以产生式（II）的[ - 18 F]氟代卤代烷基（F）（CH 3） 其中n和X如对于式（I）化合物所定义，其中任选地随后是（i）除去过量的18 例如通过离子交换色谱法; 和/或（ii）除去有机溶剂。

公开(公告)号：US20130084441A1

公开(公告)日：2013-04-04

申请号：US13248687

申请日：2011-09-29

申请人： Xiaoyue Huang ,  Lijuan Zou ,  Yongjun Zhao ,  Michael Kautzky

发明人： Xiaoyue Huang ,  Lijuan Zou ,  Yongjun Zhao ,  Michael Kautzky

IPC分类号： B32B7/02 ,  C23F1/00

CPC分类号： G02B6/136 ,  G02B6/138 ,  G11B5/3163 ,  G11B2005/0021 ,  Y10T428/24942

摘要： Disclosed herein is a method for fabricating an optical device that includes depositing an etch stop material to form an etch stop layer, wherein the etch stop material has a refractive index in the infrared wavelength range, n1; depositing a core material to form a core layer, wherein the core material has a refractive index in the infrared wavelength range, n2; and etching the core layer using a halide based etch process, wherein the etch stop material has an etch rate in the halide based etch process and the core material has an etch rate in the halide based etch process, wherein the etch rate of the core material is at least about five times higher than the etch rate of the etch stop material, and wherein n1 is not greater than n2.

摘要翻译： 本文公开了一种制造光学器件的方法，其包括沉积蚀刻停止材料以形成蚀刻停止层，其中所述蚀刻停止材料具有红外波长范围内的折射率n1; 沉积芯材以形成芯层，其中所述芯材料具有红外波长范围内的折射率n2; 以及使用基于卤化物的蚀刻工艺蚀刻所述芯层，其中所述蚀刻停止材料在所述基于卤化物的蚀刻工艺中具有蚀刻速率，并且所述芯材料在所述基于卤化物的蚀刻工艺中具有蚀刻速率，其中所述芯材料的蚀刻速率 比蚀刻停止材料的蚀刻速率高至少约五倍，其中n1不大于n2。

公开(公告)号：US20090317328A1

公开(公告)日：2009-12-24

申请号：US12302895

申请日：2007-05-31

申请人： Erik Arstad ,  Edward George Robins ,  Yongjun Zhao

发明人： Erik Arstad ,  Edward George Robins ,  Yongjun Zhao

IPC分类号： A61K51/04 ,  C07D267/14 ,  A61P25/00

CPC分类号： C07D498/04

摘要： Novel compounds of formula (I): suitable for use as in vivo imaging agents are provided as well as precursors suitable for the preparation of said compounds. The present invention also provides pharmaceuticals comprising the compounds and kits for the preparation of the pharmaceuticals. Furthermore, use of the compounds for imaging peripheral benzodiazepine receptors in a subject is provided, in particular for imaging pathological conditions in which PBR are upregulated, e.g. Parkinson's disease, multiple sclerosis, Alzheimer's disease and Huntington's disease, neuropathic pain, arthritis, asthma, atherosclerosis and cancer.

摘要翻译： 提供新的式（I）化合物：适合用作体内显像剂以及适于制备所述化合物的前体。 本发明还提供了包含用于制备药物的化合物和试剂盒的药物。 此外，提供了用于成像受试者外周苯并二氮杂受体的化合物的用途，特别是用于成像其中上调PBR的病理状况，例如， 帕金森病，多发性硬化症，阿尔茨海默病和亨廷顿病，神经性疼痛，关节炎，哮喘，动脉粥样硬化和癌症。

公开(公告)号：US07405332B2

公开(公告)日：2008-07-29

申请号：US10528645

申请日：2003-09-18

申请人： Frank Brady ,  Sajinder Luthra ,  Yongjun Zhao

发明人： Frank Brady ,  Sajinder Luthra ,  Yongjun Zhao

IPC分类号： C07C17/00 ,  C07C19/08 ,  C07C213/00 ,  C07F7/08 ,  C07D257/00

CPC分类号： C07B59/001 ,  C07C17/093 ,  C07C303/26

摘要： The invention provides a process for preparation of a fluorohaloalkane, preferably an [18F]fluorohaloalkane of formula (I) wherein X is halo and n is an integer of from 1 to 6; which comprises: reaction of the corresponding organosilicon compound of formula (II): wherein n is as defined for the compound of formula (I); and R′, R″, and R′″ are independently selected from C1-6 alkyl and C1-6 haloalkyl; and R″ may alternatively be the group: with a compound of formula (III): wherein X is as defined for the compound of formula (I) and Y is halo. Intermediates having use in such processes are also claimed.

摘要翻译： 本发明提供了制备式（I）的氟代卤代烷烃，优选其中X为卤素且n为1至6的整数的式（I）的[F 18 F]氟卤代烷烃的方法; 其包括：相应的式（II）的有机硅化合物的反应：其中n如对于式（I）的化合物所定义; 和R'，R“和R”'独立地选自C 1-6烷基和C 1-6卤代烷基; 和R“可以另选地为：与式（III）化合物：其中X如式（I）化合物所定义，Y是卤素。 也要求使用在这些方法中的中间体。

公开(公告)号：US20050203909A1

公开(公告)日：2005-09-15

申请号：US10799392

申请日：2004-03-12

申请人： Yongjun Zhao

发明人： Yongjun Zhao

IPC分类号： G06F7/00

CPC分类号： G06F16/9535

摘要： The present invention includes a device comprising a plurality of interconnected computers. Each of the plurality of interconnected computers preferably includes a storage device that is configured to store a cookie entry when the computer user visits a web page. The cookie entry preferably comprises a path name, a description of web page content, and a uniform resource locator of the web page. The device further includes at least one processor in communication with the plurality of interconnected computers. The processor is preferably configured to accept a search query from a computer user, compare the search query with the cookie entry, and provide the computer user with the uniform resource locator of the cookie entry that match the search query.

摘要翻译： 本发明包括一种包括多个相互连接的计算机的装置。 多个相互连接的计算机中的每一个优选地包括存储装置，其被配置为当计算机用户访问网页时存储cookie条目。 cookie条目优选地包括网页的路径名称，网页内容的描述和网页的统一资源定位符。 该设备还包括与多个互连计算机通信的至少一个处理器。 处理器优选地被配置为接受来自计算机用户的搜索查询，将搜索查询与cookie条目进行比较，并向计算机用户提供与搜索查询匹配的Cookie条目的统一资源定位符。

公开(公告)号：US20050173864A1

公开(公告)日：2005-08-11

申请号：US11053815

申请日：2005-02-08

申请人： Yongjun Zhao

发明人： Yongjun Zhao

IPC分类号： A63F1/00 ,  G06Q10/00 ,  G09B3/00 ,  G09B5/00 ,  G09B7/00

CPC分类号： G06Q10/10

摘要： The present invention includes a method of composing at least one literary work. The method includes establishing a story theme; providing a plurality of interconnected computers; allowing users to use the plurality of interconnected computers; forming a cast of authors from the users of the plurality of interconnected computers; and allowing the cast of authors to compose a script based on the story theme.

摘要翻译： 本发明包括组成至少一个文学作品的方法。 该方法包括建立故事主题; 提供多个互连的计算机; 允许用户使用多个互连的计算机; 从所述多个互连的计算机的用户中形成作者的演员; 并允许作者的作品组成一个基于故事主题的剧本。

公开(公告)号：US20050125544A1

公开(公告)日：2005-06-09

申请号：US11004680

申请日：2004-12-02

申请人： Yongjun Zhao

发明人： Yongjun Zhao

IPC分类号： G06F15/16 ,  H04L12/18 ,  H04L12/58

CPC分类号： H04L51/04 ,  H04L51/14

摘要： Methods and apparatuses for facilitating online communications are described. One method comprises allowing at least one message author to compose a message; allowing the message author to provide a description of the message; defining a plurality of message types, each type distinguishable by its message description; associating the author's message with a message type from the plurality of defined message types; allowing at least one potential message recipient to enter a profile, the profile comprising an indication of the type of message the potential message recipient desires to receive; and, associating the author's message with at least one potential message recipient profile based on the message type. Another method comprises publishing a first message on at least one website; allowing an online subscriber to respond to the first message; posing a question to the online subscriber; allowing the online subscriber to answer the question; evaluating the online subscriber's answer; and allowing the online subscriber to see a second message depending on the success of the subscriber's answer.

摘要翻译： 描述了用于促进在线通信的方法和装置。 一种方法包括允许至少一个消息作者撰写消息; 允许消息作者提供消息的描述; 定义多个消息类型，每种类型可由其消息描述区分; 将作者的消息与来自多个定义的消息类型的消息类型相关联; 允许至少一个潜在消息接收者进入简档，该简档包括潜在消息接收者希望接收的消息类型的指示; 并且基于消息类型将作者的消息与至少一个潜在消息接收者简档相关联。 另一种方法包括在至少一个网站上发布第一消息; 允许在线用户响应第一条消息; 向在线用户提出问题; 允许在线用户回答问题; 评估在线用户的答案; 并允许在线用户根据用户答案的​​成功来查看第二个消息。

公开(公告)号：US08958668B2

公开(公告)日：2015-02-17

申请号：US13231569

申请日：2011-09-13

申请人： Chubing Peng ,  Yongjun Zhao

发明人： Chubing Peng ,  Yongjun Zhao

IPC分类号： G02B6/26 ,  G02B6/42 ,  G11B5/31 ,  G11B5/60 ,  G02B6/28 ,  G11B7/1387 ,  G11B5/00

CPC分类号： G11B7/22 ,  G02B6/262 ,  G02B6/2817 ,  G02B6/4206 ,  G02B6/4214 ,  G02B6/4298 ,  G11B5/314 ,  G11B5/6088 ,  G11B7/1387 ,  G11B2005/0021

摘要： A plasmonic transducer includes at least two metal elements with a gap therebetween. The metal elements are elongated along a plasmon-enhanced, near-field radiation delivery axis. Cross sections of the metal elements in a plane normal to the delivery axis vary in shape along the delivery axis. A waveguide is disposed along an elongated side of the plasmonic transducer. The waveguide is optically coupled to the plasmonic transducer along the elongated side.

摘要翻译： 等离子体激元换能器包括至少两个在它们之间具有间隙的金属元件。 金属元素沿着等离子体增强的近场辐射传输轴线是细长的。 垂直于输送轴的平面中的金属元件的横截面沿着输送轴线的形状不同。 沿着等离子体激元传感器的细长侧布置波导。 波导沿着细长侧光耦合到等离子体激元传感器。

公开(公告)号：US20140004384A1

公开(公告)日：2014-01-02

申请号：US13537758

申请日：2012-06-29

申请人： Tong Zhao ,  Michael Christopher Kautzky ,  Michael Allen Seigler ,  Yongjun Zhao ,  Jay Jayashankar ,  Xiaoyue Huang

发明人： Tong Zhao ,  Michael Christopher Kautzky ,  Michael Allen Seigler ,  Yongjun Zhao ,  Jay Jayashankar ,  Xiaoyue Huang

IPC分类号： G11B13/08

CPC分类号： G11B5/314 ,  G11B5/6088 ,  G11B11/10536 ,  G11B2005/0021 ,  Y10T428/1157 ,  Y10T428/1171 ,  Y10T428/1193

摘要： A device that includes a near field transducer (NFT); at least one cladding layer adjacent the NFT; and a discontinuous metal layer positioned between the NFT and the at least one cladding layer.

摘要翻译： 包括近场换能器（NFT）的装置; 邻近NFT的至少一个覆层; 以及位于所述NFT和所述至少一个包覆层之间的不连续金属层。