公开(公告)号：US20210228703A1

公开(公告)日：2021-07-29

申请号：US15734670

申请日：2019-06-04

Applicant: XIAMEN UNIVERSITY ,  XIAMEN INNOVAX BIOTECH CO., LTD.

Inventor： Shaowei LI ,  Shuo SONG ,  Maozhou HE ,  Jingjie SHI ,  Ying GU ,  Ningshao XIA

IPC: A61K39/12 ,  C12N7/00

Abstract: The present invention relates to a mutated HPV18 L1 protein (or a variant thereof), a sequence encoding the same, a method for preparing the same, and a virus-like particle comprising the same, wherein the protein (or a variant thereof) and the virus-like particle can induce the generation of neutralizing antibodies against at least two HPV types (for example, HPV18 and HPV45, or HPV18, HPV45 and HPV59), and therefore can be used to prevent infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum. The invention further relates to the use of the protein and the virus-like particle in the manufacture of a pharmaceutical composition or a vaccine for preventing infection by said at least two HPV types, and a disease caused by said infection, such as cervical cancer and condyloma acuminatum.

公开(公告)号：US20180141978A1

公开(公告)日：2018-05-24

申请号：US15575140

申请日：2016-05-20

Applicant: XIAMEN UNIVERSITY

Inventor： Shengxiang GE ,  Tingdong LI ,  Lianzhi JIA ,  Yijian LI ,  Miaoge XUE ,  Yuanjun ZENG ,  Jun ZHANG ,  Ningshao XIA

IPC: C07K14/005 ,  C12N7/00 ,  A61K39/15 ,  A61P31/14 ,  A61P1/12 ,  A61P1/00 ,  A61P29/00

Abstract: The invention relates to a truncated rotavirus VP4 protein, a sequence encoding the same, a method for preparing the same, and a pharmaceutical composition and a vaccine comprising the protein, wherein the protein, the pharmaceutical composition and the vaccine are useful for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea. The invention further relates to use of the protein in the manufacture of a pharmaceutical composition or a vaccine for preventing, alleviating or treating rotavirus infection and a disease caused by rotavirus infection, such as rotavirus gastroenteritis and diarrhea.

公开(公告)号：US20240000813A1

公开(公告)日：2024-01-04

申请号：US18253160

申请日：2021-11-15

Applicant: XIAMEN UNIVERSITY ,  XIAMEN INNOVAX BIOTECH CO., LTD.

Inventor： Qinjian ZHAO ,  Xiaofen HUANG ,  Meifeng NIE ,  Zhigang ZHANG ,  Quan YUAN ,  Tianying ZHANG ,  Shaowei LI ,  Ningshao XIA

IPC: A61K31/663 ,  A61K33/06 ,  A61K33/30 ,  A61K39/39 ,  A61K39/215 ,  A61K39/25 ,  A61K39/145 ,  A61K39/15 ,  A61P31/22 ,  A61P31/16

CPC classification number: A61K31/663 ,  A61K33/06 ,  A61K33/30 ,  A61K39/39 ,  A61K39/215 ,  A61K39/25 ,  A61K39/145 ,  A61K39/15 ,  A61P31/22 ,  A61P31/16 ,  A61K2039/55505

Abstract: An adjuvant containing zinc aluminum risedronate, an immunogenic composition comprising the adjuvant and an immunogen, and uses of the adjuvant and the immunogenic composition.

公开(公告)号：US20230287086A1

公开(公告)日：2023-09-14

申请号：US18005543

申请日：2021-07-13

Applicant: YANG SHENG TANG COMPANY, LTD. ,  XIAMEN UNIVERSITY

Inventor： Quan YUAN ,  Shaojuan WANG ,  Sheng NIAN ,  Min WEI ,  Yali ZHANG ,  Kai WANG ,  Yixin CHEN ,  Tianying ZHANG ,  Shengxiang GE ,  Ningshao XIA

IPC: C07K16/10 ,  C07K14/005 ,  C12N15/70

CPC classification number: C07K16/10 ,  C07K14/005 ,  C12N15/70 ,  C07K2319/10 ,  C07K2319/81 ,  C12N2800/101

Abstract: Provided is a cell-penetrating peptide, which can deliver a variety of biological macromolecules, such as proteins, antibodies, nucleic acids and so on into cells across a membrane. In addition, further provided are a fusion protein, conjugate and complex containing the cell-penetrating peptide, and a use of the cell-penetrating peptide.

公开(公告)号：US20220193231A1

公开(公告)日：2022-06-23

申请号：US17602214

申请日：2020-04-10

Applicant: XIAMEN INNOVAX BIOTECH CO., LTD. ,  XIAMEN UNIVERSITY

Inventor： Qinjian ZHAO ,  Xiaofen HUANG ,  Siyi CHEN ,  Yike LI ,  Cai ZHANG ,  Ningshao XIA

IPC: A61K39/39 ,  A61K9/14 ,  A61K39/25 ,  A61K39/29 ,  A61P37/04 ,  A61P31/22

Abstract: Disclosed is a zinc zoledronate micro-nanoparticle adjuvant, which contains zinc and zoledronic acid and optionally contains a phosphate and aluminum. The preparation method therefor comprises performing mixed precipitation on a soluble salt solution containing zinc ions, zoledronic acid, and sodium hydroxide. The adjuvant can be used to prepare vaccines, etc.

公开(公告)号：US20190389939A1

公开(公告)日：2019-12-26

申请号：US15766593

申请日：2016-10-09

Applicant: XIAMEN UNIVERSITY ,  YANG SHENG TANG COMPANY, LTD.

Inventor： Wenxin LUO ,  Bing ZHOU ,  Juan ZHANG ,  Quan YUAN ,  Tianying ZHANG ,  Jun ZHANG ,  Ningshao XIA

IPC: C07K16/08

Abstract: The invention provides an antibody (in particular, a humanized antibody) against hepatitis B surface antigen (HBsAg), a nucleic acid molecule encoding the same, a method for preparing the same, and a pharmaceutical composition comprising the same. The invention also provides use of the antibody and pharmaceutical composition. The antibody and pharmaceutical composition according to the invention can be used for preventing and/or treating HBV infection or a disease associated with HBV infection (such as Hepatitis B), for neutralizing HBV virulence in a subject (such as human), or for reducing the serum level of HBV DNA and/or HBsAg in a subject.

公开(公告)号：US20190247494A1

公开(公告)日：2019-08-15

申请号：US15754766

申请日：2016-08-24

Applicant: XIAMEN UNIVERSITY ,  YANG SHENG TANG COMPANY, LTD.

Inventor： Tianying ZHANG ,  Quan YUAN ,  Xueran GUO ,  Ying ZHANG ,  Qinjian ZHAO ,  Jun ZHANG ,  Ningshao XIA

IPC: A61K39/29 ,  A61K39/385 ,  C12N15/62 ,  C12N7/00 ,  A61K39/39 ,  A61P35/00 ,  A61P31/20

Abstract: The invention relates to a polypeptide carrier for presenting a target polypeptide, and use thereof. In particular, the invention relates to a nucleic acid molecule, comprising a nucleotide sequence encoding a polypeptide carrier, and being used for insertion of a nucleotide sequence encoding a target polypeptide. In addition, the invention further relates to a recombinant protein comprising the polypeptide carrier and a target polypeptide. Furthermore, the invention further relates to use of the nucleic acid molecule and the recombinant protein. In addition, the invention further relates to a vaccine or a pharmaceutical composition useful for preventing, alleviating or treating HBV infection or a disease associated with HBV infection (e.g., hepatitis B), comprising a recombinant protein comprising the polypeptide carrier of the invention and an epitope from HBV.

公开(公告)号：US20180208905A1

公开(公告)日：2018-07-26

申请号：US15865540

申请日：2018-01-09

Applicant: Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. ,  RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY ,  Xiamen University

Inventor： Hua ZHU ,  Yimin LI ,  Ningshao XIA ,  Tong CHENG ,  Xiangzhong YE

IPC: C12N7/00 ,  C07K14/005 ,  A61K39/25 ,  A61K39/12 ,  C12N15/86 ,  A61K39/00

Abstract: Provided are an ORF7 deficient varicella virus, an vaccine comprising the virus and use thereof, as well as a method for the production the virus.

公开(公告)号：US20240123058A1

公开(公告)日：2024-04-18

申请号：US18276700

申请日：2022-01-29

Applicant: XIAMEN UNIVERSITY ,  SUN YAT-SEN UNIVERSITY CANCER CENTER (SUN YAT-SEN UNIVERSITY CANCER CENTER HOSPITAL, SUN YAT-SEN ,  SUN YAT-SEN UNIVERSITY

Inventor： Yixin CHEN ,  Xiao ZHANG ,  Junping HONG ,  Miao XU ,  Qian WU ,  Ling ZHONG ,  Ningshao XIA

IPC: A61K39/245 ,  A61P35/00 ,  C07K16/08 ,  C12N7/00

CPC classification number: A61K39/245 ,  A61P35/00 ,  C07K16/085 ,  C12N7/00 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2319/30

Abstract: Provided are an epitope peptide (or a variant thereof) that can be used for preventing or treating an EBV infection, a recombinant protein containing the epitope peptide (or variant thereof) and a carrier protein, and the use of the epitope peptide (or variant thereof) and the recombinant protein. Further provided are an antibody against the epitope peptide, and the use thereof in the detection, prevention and/or treatment of an EBV infection and/or diseases caused by the infection.

公开(公告)号：US20230358757A1

公开(公告)日：2023-11-09

申请号：US17802290

申请日：2021-01-18

Applicant: BEIJING WANTAI BIOLOGICAL PHARMACY ENTERPRISE CO., LTD. ,  XIAMEN UNIVERSITY

Inventor： Tingdong LI ,  Qiaoyun SHI ,  Jinkai REN ,  Shengxiang GE ,  Congming HONG ,  Xiaolei ZHANG ,  Dong WANG ,  Guoliang ZHOU ,  Quan YUAN ,  Xiaowei WU ,  Xuan WANG ,  Yangtao WU ,  Haifeng PAN ,  Yuting QI ,  Xuerong JIA ,  Lizhi ZHOU ,  Wangheng HOU ,  Shan QIAO ,  Shaowei LI ,  Jun ZHANG ,  Ningshao XIA

IPC: G01N33/68 ,  C07K14/165

CPC classification number: G01N33/6854 ,  C07K14/165 ,  C07K2319/40 ,  G01N2333/165 ,  G01N2469/20

Abstract: Provided are a method for assaying a specific IgM antibody and a total antibody for the 2019 novel coronavirus (2019-nCOV), a method for determining whether subjects are infected with 2019-nCOV, and a virus antigen and a kit for carrying out the above-mentioned detection.