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公开(公告)号：US20230218576A1
公开(公告)日：2023-07-13
申请号：US18001167
申请日：2021-06-01
发明人： Tianying ZHANG , Jiali CAO , Tianshu SHI , Jian MA , Shaojuan WANG , Quan YUAN , Jun ZHANG , Ningshao XIA
IPC分类号： A61K31/415 , A61P31/20
CPC分类号： A61K31/415 , A61P31/20
摘要： The present application relates to the field of antiviral treatment of hepatitis B, and specifically relates to the use of a compound represented by formula I in treatment against HBV virus.
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公开(公告)号：US20220110988A1
公开(公告)日：2022-04-14
申请号：US16966345
申请日：2019-02-01
发明人： Yixin CHEN , Guosong WANG , Quan YUAN , Jiali CAO , Lina LIN , Ningshao XIA
IPC分类号： A61K35/763 , C12N7/00 , A61P35/00
摘要： A pseudorabies virus (PRV) or a modified form thereof, or a genome sequence or a cDNA sequence containing the PRV or the modified form thereof, or nucleic acid molecules of a complementary sequence of the cDNA sequence, for treating tumors of subjects and/or reducing or inhibiting tumor recurrence, and for preparation of a pharmaceutical composition used for treating the tumors of the subjects and/or reducing or inhibiting the tumor recurrence. A method for treating tumors and/or reducing or inhibiting tumor recurrence, comprising a step of administering, on a subject having a need, the PRV or the modified form thereof, or nucleic acid molecules of the genome sequence containing the PRV or the modified form thereof.
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公开(公告)号：US20200147205A1
公开(公告)日：2020-05-14
申请号：US16484366
申请日：2018-02-05
发明人： Tianying ZHANG , Quan YUAN , Xueran GUO , Minxi WEI , Xiaozhen KANG , Jun ZHANG , Ningshao XIA
IPC分类号： A61K39/29 , C07K14/005 , C12N7/00 , A61P31/20
摘要： The invention relates to a polypeptide carrier for presenting a target polypeptide, and use thereof. In particular, the invention relates to a nucleic acid molecule, comprising a nucleotide sequence encoding a polypeptide carrier, and being used for insertion of a nucleotide sequence encoding a target polypeptide. In addition, the invention further relates to a recombinant protein comprising the polypeptide carrier and a target polypeptide. Furthermore, the invention further relates to use of the nucleic acid molecule and the recombinant protein. In addition, the invention further relates to a vaccine or a pharmaceutical composition useful for preventing, alleviating or treating HBV infection or a disease associated with HBV infection (e.g., hepatitis B), comprising a recombinant protein comprising the polypeptide carrier of the invention and an epitope from HBV.
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公开(公告)号：US20220251173A1
公开(公告)日：2022-08-11
申请号：US17613392
申请日：2020-05-22
发明人： Wenxin LUO , Yichao JIANG , Chao YU , Xiaoqing CHEN , Jixian TANG , Quan YUAN , Tianying ZHANG , Ningshao XIA
摘要： Antibodies (especially humanized antibodies) against the hepatitis B surface antigen (HBsAg), a nucleic acid molecule encoding same, a method for preparing same, and a pharmaceutical composition containing same. The anti-HBsAg antibodies have a higher binding affinity to HBsAg at a neutral pH than at an acidic pH, thereby significantly enhancing virus clearance efficiency and prolonging virus inhibition time. The antibodies and pharmaceutical composition may be used to prevent and/or treat HBV infections or diseases related to HBV infection (such as hepatitis B) for use in neutralizing the virulence of HBV in the body of a subject (such as a human) to reduce a serum level of HBV DNA and/or HBsAg in the body of the subject, or to activate a humoral immune response of a subject (such as a person infected with chronic HBV or a patient who has chronic hepatitis B) against HBV.
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公开(公告)号：US20230323369A1
公开(公告)日：2023-10-12
申请号：US18002988
申请日：2021-06-24
发明人： Quan YUAN , Jiali CAO , Yali ZHANG , Mingfeng WANG , Jian MA , Tianying ZHANG , Jun ZHANG , Ningshao XIA
CPC分类号： C12N15/52 , C12N9/0069 , C12N15/85 , G01N33/5023 , C12N2510/00 , C12N2730/10122 , G01N2333/02
摘要： The present invention belongs to the field of virology, in particular to the field of hepatitis B virus treatment. Provided are a model and a method for screening HBV cccDNA inhibitors. According to the screening model and the method, the detection of a split luciferase is used as an alternative index ofHBV cccDNA detection, and a cccDNA-targeted drug can be screened in high throughput.
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6.发明公开公开(公告)号：US20230174592A1
公开(公告)日：2023-06-08
申请号：US17997465
申请日：2021-04-30
发明人： Yali ZHANG , Shaojuan WANG , Yangtao WU , Wangheng HOU , Jianghui YE , Juan WANG , Tianying ZHANG , Tong CHENG , Quan YUAN , Ningshao XIA
IPC分类号： C07K14/165 , C12N15/63 , G01N33/58 , C12N5/071 , C07K14/705
CPC分类号： C07K14/165 , C12N15/63 , G01N33/582 , C12N5/0602 , C07K14/705 , C07K2319/60 , C07K2319/02
摘要： Disclosed are a fusion protein probe and a cell model for screening a blocking agent of coronavirus infections, a screening system comprising same, and a method of using the screening system for screening a blocking agent of coronavirus infections. The screening system and method do not involve live viruses, are simple and convenient to operate, have a high accuracy, are suitable for high throughput screening, and are of great significance for the development of coronavirus neutralizing antibodies, preventive vaccines, and small molecule drugs.
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公开(公告)号：US20220235117A1
公开(公告)日：2022-07-28
申请号：US17613322
申请日：2020-05-22
发明人： Wenxin LUO , Can WEN , Xinchu XIANG , Jixian TANG , Yangtao WU , Tianying ZHANG , Quan YUAN , Ningshao XIA
摘要： Disclosed are antibodies to anti-hepatitis B surface antigen (HBsAg) (especially humanized antibodies), nucleic acid molecules encoding same, methods for preparing same, and pharmaceutical compositions containing same. The antibodies have higher affinity for HBsAg at neutral pH than at acidic pH, thereby significantly enhancing the virus clearance efficiency and prolonging the virus inhibition time. The antibodies and the pharmaceutical compositions can be used for preventing and/or treating HBV infections or diseases related to HBV infections (e.g., hepatitis B), for neutralizing the virulence of HBV in a subject (e.g., a human), for reducing the serum level of HBV DNA and/or HBsAg in the body of the subject, or for activating the humoral immune response of the subject (e.g., a chronic HBV infected or chronic hepatitis B patient) against HBV.
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公开(公告)号：US20230287086A1
公开(公告)日：2023-09-14
申请号：US18005543
申请日：2021-07-13
发明人： Quan YUAN , Shaojuan WANG , Sheng NIAN , Min WEI , Yali ZHANG , Kai WANG , Yixin CHEN , Tianying ZHANG , Shengxiang GE , Ningshao XIA
IPC分类号： C07K16/10 , C07K14/005 , C12N15/70
CPC分类号： C07K16/10 , C07K14/005 , C12N15/70 , C07K2319/10 , C07K2319/81 , C12N2800/101
摘要： Provided is a cell-penetrating peptide, which can deliver a variety of biological macromolecules, such as proteins, antibodies, nucleic acids and so on into cells across a membrane. In addition, further provided are a fusion protein, conjugate and complex containing the cell-penetrating peptide, and a use of the cell-penetrating peptide.
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公开(公告)号：US20190389939A1
公开(公告)日：2019-12-26
申请号：US15766593
申请日：2016-10-09
发明人： Wenxin LUO , Bing ZHOU , Juan ZHANG , Quan YUAN , Tianying ZHANG , Jun ZHANG , Ningshao XIA
IPC分类号： C07K16/08
摘要： The invention provides an antibody (in particular, a humanized antibody) against hepatitis B surface antigen (HBsAg), a nucleic acid molecule encoding the same, a method for preparing the same, and a pharmaceutical composition comprising the same. The invention also provides use of the antibody and pharmaceutical composition. The antibody and pharmaceutical composition according to the invention can be used for preventing and/or treating HBV infection or a disease associated with HBV infection (such as Hepatitis B), for neutralizing HBV virulence in a subject (such as human), or for reducing the serum level of HBV DNA and/or HBsAg in a subject.
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公开(公告)号：US20190247494A1
公开(公告)日：2019-08-15
申请号：US15754766
申请日：2016-08-24
发明人： Tianying ZHANG , Quan YUAN , Xueran GUO , Ying ZHANG , Qinjian ZHAO , Jun ZHANG , Ningshao XIA
摘要： The invention relates to a polypeptide carrier for presenting a target polypeptide, and use thereof. In particular, the invention relates to a nucleic acid molecule, comprising a nucleotide sequence encoding a polypeptide carrier, and being used for insertion of a nucleotide sequence encoding a target polypeptide. In addition, the invention further relates to a recombinant protein comprising the polypeptide carrier and a target polypeptide. Furthermore, the invention further relates to use of the nucleic acid molecule and the recombinant protein. In addition, the invention further relates to a vaccine or a pharmaceutical composition useful for preventing, alleviating or treating HBV infection or a disease associated with HBV infection (e.g., hepatitis B), comprising a recombinant protein comprising the polypeptide carrier of the invention and an epitope from HBV.
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