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公开(公告)号：US5587175A
公开(公告)日：1996-12-24
申请号：US174101
申请日：1993-12-28
IPC分类号： A61F9/008 , A61K9/00 , A61L15/22 , A61L15/44 , A61L24/00 , A61L24/04 , A61L27/26 , A61L27/52 , A61L27/54 , A61L31/04 , A61L31/16 , A61K31/77 , A61K31/725 , A61K31/73 , A61K2/14
CPC分类号： A61L31/16 , A61F9/00819 , A61K9/0048 , A61L15/225 , A61L15/44 , A61L24/0015 , A61L24/0031 , A61L24/043 , A61L27/26 , A61L27/52 , A61L27/54 , A61L31/041 , A61F2009/00872 , A61L2300/00 , A61L2430/16 , Y10S514/912 , Y10S514/913 , Y10S514/914 , Y10S514/944 , Y10S514/966 , Y10S514/967 , Y10S623/905
摘要： Balanced pH, hyperosmotic, hypoosmotic, or isoosmotic gels are ideal vehicles for drug delivery. They are especially suited for topical body cavity or injection application of drugs or diagnostic agents; for drug or diagnostic agent delivery to the eye of a mammal; as protective corneal shields; or as ablatable corneal masks useful in laser reprofiling of the cornea. The compositions without the addition of a drug or diagnostic agent are useful as medical devices, for instance, in separating surgically or otherwise injured tissue as a means of preventing adhesions.
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22.发明授权Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels 失效体腔药物递送与热不可逆的聚氧化烯和离子多糖凝胶
公开(公告)号：US5346703A
公开(公告)日：1994-09-13
申请号：US939475
申请日：1992-08-31
CPC分类号： A61K9/0048 , A61K47/10 , A61K47/18 , A61K47/36 , A61K9/0014 , Y10S514/944 , Y10S514/966 , Y10S514/967
摘要： Balanced pH, thermo-irreversible gels are ideal vehicles for drug delivery to a body cavity of a mammal. The gels contain a mixture of a polyoxyalkylene block copolymer or polyether together with an ionic polysaccharide which is thermo-irreversibly gelled in the presence of a counter-ion.
摘要翻译： 平衡的pH，热不可逆凝胶是药物递送到哺乳动物体腔的理想载体。 凝胶含有聚氧化烯嵌段共聚物或聚醚与在抗衡离子存在下不可逆地凝胶化的离子多糖的混合物。
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23.发明授权Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide 失效具有聚氧亚氨基聚合物和离子多糖的热不可逆凝胶的眼药物递送
公开(公告)号：US5077033A
公开(公告)日：1991-12-31
申请号：US563638
申请日：1990-08-07
CPC分类号： A61K9/0048 , A61K47/10 , A61K47/18 , A61K47/36 , A61F9/00819 , Y10S514/912 , Y10S514/913 , Y10S514/914 , Y10S514/944 , Y10S525/916
摘要： Balanced pH, thermo-irreversible gels are ideal vehicles for drug delivery to the eye of a mammal.
摘要翻译： 平衡的pH，热不可逆凝胶是药物输送到哺乳动物眼睛的理想载体。
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公开(公告)号：US08598364B2
公开(公告)日：2013-12-03
申请号：US12530363
申请日：2008-03-12
申请人： Jennifer Riggs-Sauthier , Lin Cheng , Tacey X. Viegas , Xuyuan Gu , Franco J. Duarte , Wen Zhang
发明人： Jennifer Riggs-Sauthier , Lin Cheng , Tacey X. Viegas , Xuyuan Gu , Franco J. Duarte , Wen Zhang
IPC分类号： C07D239/02 , C07D401/00 , C07D217/00 , C07D405/00 , C07D213/00 , C07D277/30 , C07D493/00 , C07D307/02 , C07F9/28 , C07F9/06
CPC分类号： A61K47/48215 , A61K47/60
摘要： The invention provides protease inhibitors that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the protease inhibitors not attached to the water-soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学修饰的蛋白酶抑制剂。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的蛋白酶抑制剂不同的特征。
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公开(公告)号：US5593683A
公开(公告)日：1997-01-14
申请号：US205305
申请日：1994-03-03
CPC分类号： A61K47/18 , A61K47/10 , A61K9/0014 , Y10S514/912 , Y10S514/944
摘要： Compositions based upon aqueous gels for medical application, comprising polyoxyalkylene copolymers. Such gels which are isotonic, iso-osmotic, pH balanced, thermo-reversible gels are ideal vehicles for drug or diagnostic agent delivery.
摘要翻译： 基于用于医疗应用的含水凝胶的组合物，包含聚氧化烯共聚物。 这种等渗，等渗，pH平衡，热可逆凝胶的凝胶是用于药物或诊断剂递送的理想载体。
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26.发明授权Drug delivery by injection with thermoreversible gels containing polyoxyalkylene copolymers 失效通过注射含有聚氧化烯共聚物的热可逆凝胶进行药物递送
公开(公告)号：US5306501A
公开(公告)日：1994-04-26
申请号：US791119
申请日：1991-11-08
CPC分类号： A61K47/18 , A61K47/10 , A61K9/0019 , Y10S514/944
摘要： Isotonic, iso-osmotic, pH balanced thermoreversible gels are ideal medical devices or vehicles for drug injection into the body of a mammal. The osmolality in the gel state can be calculated by assuming that a polyoxyalkylene block copolymer or polyether present in said gel does not contribute to the osmolality in the gel state, although it does contribute to the osmolality in the liquid state.
摘要翻译： 等渗，等渗，pH平衡的热可逆凝胶是用于药物注射到哺乳动物体内的理想医疗装置或载体。 可以通过假设存在于所述凝胶中的聚氧化烯嵌段共聚物或聚醚在凝胶状态下不影响重量摩尔渗透压浓度来计算凝胶状态下的重量摩尔渗透压浓度，尽管它确实有助于液态渗透压。
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27.发明授权Body cavity drug delivery with thermo-irreversible polyoxyalkylene and ionic polysaccharide gels 失效体腔药物递送与热不可逆的聚氧化烯和离子多糖凝胶
公开(公告)号：US5143731A
公开(公告)日：1992-09-01
申请号：US563640
申请日：1990-08-07
CPC分类号： A61K47/36 , A61K47/10 , A61K47/18 , A61K9/0014 , A61K9/0048 , Y10S424/14 , Y10S514/944 , Y10S514/966 , Y10S514/967
摘要： Balanced pH, thermo-irreversible gels are ideal vehicles for drug delivery to a body cavity of a mammal. The gels contain a mixture of a polyoxyalkylene block copolymer or polyether together with an ionic polysaccharide which is thermo-irreversibly gelled in the presence of a counter-ion.
摘要翻译： 平衡的pH，热不可逆凝胶是药物递送到哺乳动物体腔的理想载体。 凝胶含有聚氧化烯嵌段共聚物或聚醚与在抗衡离子存在下不可逆地凝胶化的离子多糖的混合物。
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公开(公告)号：US08580919B2
公开(公告)日：2013-11-12
申请号：US13617756
申请日：2012-09-14
CPC分类号： C07K17/08 , A61K47/60 , C07K14/605
摘要： Conjugates of a GLP-1 moiety may be covalently attached to one or more water-soluble polymers. For instance, a GLP-1 polymer conjugate may include a GLP-1 moiety releasably attached at its N-terminus to a water-soluble polymer. The GLP-1 polymer conjugate may include a GLP-1 moiety covalently attached to a water-soluble polymer, wherein the GLP-1 moiety possesses an N-methyl substituent.
摘要翻译： GLP-1部分的缀合物可以共价连接到一种或多种水溶性聚合物上。 例如，GLP-1聚合物缀合物可以包括其N末端可释放地连接到水溶性聚合物上的GLP-1部分。 GLP-1聚合物缀合物可以包括共价连接到水溶性聚合物上的GLP-1部分，其中GLP-1部分具有N-甲基取代基。
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公开(公告)号：US20130096258A1
公开(公告)日：2013-04-18
申请号：US13617756
申请日：2012-09-14
IPC分类号： C07K17/08
CPC分类号： C07K17/08 , A61K47/60 , C07K14/605
摘要： Conjugates of a GLP-1 moiety may be covalently attached to one or more water-soluble polymers. For instance, a GLP-1 polymer conjugate may include a GLP-1 moiety releasably attached at its N-terminus to a water-soluble polymer. The GLP-1 polymer conjugate may include a GLP-1 moiety covalently attached to a water-soluble polymer, wherein the GLP-1 moiety possesses an N-methyl substituent.
摘要翻译： GLP-1部分的缀合物可以共价连接到一种或多种水溶性聚合物上。 例如，GLP-1聚合物缀合物可以包括其N末端可释放地连接到水溶性聚合物上的GLP-1部分。 GLP-1聚合物缀合物可以包括共价连接到水溶性聚合物上的GLP-1部分，其中GLP-1部分具有N-甲基取代基。
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公开(公告)号：US08293869B2
公开(公告)日：2012-10-23
申请号：US12086687
申请日：2006-12-18
CPC分类号： C07K17/08 , A61K47/60 , C07K14/605
摘要： Conjugates of a GLP-I moiety may be covalently attached to one or more water-soluble polymers. For instance, a GLP-I polymer conjugate may include a GLP-I moiety releasably attached at its N-terminus to a water-soluble polymer. The GLP-I polymer conjugate may include a GLP-I moiety covalently attached to a water-soluble polymer, wherein the GLP-I moiety possesses an N-methyl substituent. The GLP-I polymer conjugate may include a GLP-I moiety covalently attached at a polymer attachment site to a water-soluble polymer, wherein the GLP-I moiety is glycosylated at a site separate from the polymer attachment site.
摘要翻译： GLP-1部分的缀合物可以共价连接到一种或多种水溶性聚合物上。 例如，GLP-1聚合物缀合物可以包括其N-末端可释放地连接到水溶性聚合物上的GLP-1部分。 GLP-1聚合物缀合物可以包括与水溶性聚合物共价连接的GLP-1部分，其中GLP-1部分具有N-甲基取代基。 GLP-1聚合物缀合物可以包括在聚合物附着位点共价连接到水溶性聚合物上的GLP-1部分，其中GLP-1部分在与聚合物附着部位分开的位置被糖基化。
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