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30 条记录 (耗时 0.02 秒)

    Cyclobutane derivatives
    24.
    发明授权
    Cyclobutane derivatives 失效
    环丁烷衍生物

    公开(公告)号：US5250697A

    公开(公告)日：1993-10-05

    申请号：US657463

    申请日：1991-02-19

    申请人： Koichi Narasaka ,  Yujiro Hayashi

    发明人： Koichi Narasaka ,  Yujiro Hayashi

    IPC分类号： C07D263/26 ,  C07D263/04

    CPC分类号： C07D263/26

    摘要： Cyclobutane derivatives represented by the following general formula (I): ##STR1## wherein X represents a group represented by the formula ##STR2## or the formula ##STR3## which is expected to be useful as reagents, drugs, agricultural chemicals and perfumes as well as an intermediate for the preparation thereof.

    Therapeutic agent for accelerating recovery of animal under medical treatment
    25.
    发明授权
    Therapeutic agent for accelerating recovery of animal under medical treatment 有权
    用于加速医疗恢复的治疗剂

    公开(公告)号：US09078868B2

    公开(公告)日：2015-07-14

    申请号：US13522203

    申请日：2011-01-14

    申请人： Noboru Murakami ,  Keiko Nakahara ,  Kenji Kangawa ,  Yujiro Hayashi

    发明人： Noboru Murakami ,  Keiko Nakahara ,  Kenji Kangawa ,  Yujiro Hayashi

    IPC分类号： A61K38/25 ,  A61K38/00 ,  A61K38/22

    CPC分类号： A61K38/25 ,  A61K38/00 ,  A61K38/2264

    摘要： An object of the present invention is to provide a therapeutic agent for accelerating recovery to accelerate a return to normal physical conditions by administering to an animal not in good health and under medical treatment, a treatment method, and the like. There is provided a therapeutic agent for accelerating recovery for animal use to accelerate the improvement of a physical condition of an animal under medical treatment which has a decreased activity (vigor) and is exhausted, which contains ghrelin or a derivative thereof or a pharmaceutically acceptable salt thereof as an active ingredient and improves one or more of evaluation parameters consisting of activity (vigor), blood cell test values, biochemical test values, body temperature, the degree of anger or anxiety, and respiratory rate.

    摘要翻译： 本发明的目的是提供一种治疗剂，其用于加速恢复，通过给予不良健康和医疗处理的动物，治疗方法等来加速恢复正常的身体状况。 提供了用于加速动物使用恢复的治疗剂，以加速具有降低的活性（活力）并且被排出的动物的身体状况的改善，其含有生长素释放肽或其衍生物或药学上可接受的盐 作为活性成分，改善由活性（活力），血细胞试验值，生化试验值，体温，愤怒或焦虑程度和呼吸频率组成的评价参数中的一种或多种。

    SPINAL NERVE REPAIR PROMOTING THERAPEUTICS CONTAINING GHRELIN OR ITS DERIVATIVES OR SUBSTANCES THAT ACT ON GHS-R1a AS AN ACTIVE INGREDIENT
    27.
    发明申请
    SPINAL NERVE REPAIR PROMOTING THERAPEUTICS CONTAINING GHRELIN OR ITS DERIVATIVES OR SUBSTANCES THAT ACT ON GHS-R1a AS AN ACTIVE INGREDIENT 审中-公开
    含有GHRELIN或其衍生物或作为活性成分的GHS-R1a作用的物质的脊髓神经修复促进治疗

    公开(公告)号：US20100143310A1

    公开(公告)日：2010-06-10

    申请号：US12377056

    申请日：2007-08-10

    申请人： Noboru Murakami ,  Keiko Nakahara ,  Miho Hashimoto ,  Yujiro Hayashi ,  Kenji Kangawa

    发明人： Noboru Murakami ,  Keiko Nakahara ,  Miho Hashimoto ,  Yujiro Hayashi ,  Kenji Kangawa

    IPC分类号： A61K45/00 ,  C07K7/08 ,  C07K14/00 ,  C12N5/079 ,  A61P25/00

    CPC分类号： C07K14/60 ,  A61K38/00

    摘要： The invention provides a spinal neuron damage treating agent for use in the treatment of spinal neuron damage, or an agent for promoting the proliferation of spinal neuronal precursor cells in the culture of spinal neuronal precursor cells, or an agent for promoting the regeneration of spinal nerves after transplantation of cultured spinal neuronal precursor cells, and the like.The invention provides an agent that contains a substance (e.g., ghrelin) that acts on the growth hormone secretagogue-receptor as an active ingredient, the agent being a spinal neuron damage treating agent for use in the treatment of spinal neuron damage, or an agent for promoting the proliferation of cultured spinal neuronal precursor cells in the culture of spinal neuronal precursor cells, or an agent for promoting the regeneration of spinal nerves after transplantation of cultured spinal neuronal precursor cells, and the like.

    摘要翻译： 本发明提供了用于治疗脊髓神经元损伤的脊髓神经元损伤治疗剂或用于促进脊髓神经元前体细胞培养中脊髓神经元前体细胞增殖的药剂，或用于促进脊髓神经再生的药剂 移植后培养的脊髓神经元前体细胞等。 本发明提供一种包含作用于生长激素促分泌素受体作为活性成分的物质（例如生长激素释放肽）的药剂，所述药剂是用于治疗脊髓神经元损伤的脊髓神经元损伤治疗剂或药剂 用于促进脊髓神经元前体细胞培养中培养的脊髓神经元前体细胞的增殖，或用于促进培养的脊髓神经元前体细胞移植后脊髓神经再生的试剂等。

    Optically active alpha-aminooxyketone derivatives and process for production thereof
    29.
    发明申请
    Optically active alpha-aminooxyketone derivatives and process for production thereof 失效
    光学活性α-氨基氧基酮衍生物及其制备方法

    公开(公告)号：US20060293525A1

    公开(公告)日：2006-12-28

    申请号：US10569757

    申请日：2004-08-20

    申请人： Yujiro Hayashi ,  Mitsuru Shoji

    发明人： Yujiro Hayashi ,  Mitsuru Shoji

    IPC分类号： C07D335/02 ,  C07D211/54

    CPC分类号： C07D317/72 ,  C07B2200/07 ,  C07C239/20 ,  C07D211/74 ,  C07D309/30 ,  C07D319/08 ,  C07D335/02 ,  C07D339/08 ,  C07F7/1892

    摘要： The corresponding α-aminooxy ketone is manufactured with a high yield and a high enantioselectivity. A manufacturing method for an optically active α-aminooxy ketone derivative expressed by formula (1), wherein a ketone expressed by formula (2) is caused to react with a nitroso compound expressed by formula (3) in the presence of a proline derivative expressed by formula (4). In the formula, R1 and R2 respectively denote an alkyl, alkenyl or alkynyl group, and R1 and R2 may be linked to form a ring. R3 denotes an aryl, heterocyclic, alkyl, alkenyl or alkynyl group. A denotes a hydrogen atom, alkoxy group, aryloxy group, acyloxy group or silyloxy group which may have a substituent.

    摘要翻译： 相应的α-氨氧基酮以高产率和高对映选择性制造。 由式（1）表示的光学活性α-氨基氧基酮衍生物的制造方法，其中使由式（2）表示的酮与式（3）表示的亚硝基化合物在表达的脯氨酸衍生物的存在下反应 通过式（4）。 在该式中，R 1和R 2分别表示烷基，烯基或炔基，R 1和R 2可以相同或不同， / SUP>可以链接形成一个戒指。 R 3表示芳基，杂环，烷基，烯基或炔基。 A表示可以具有取代基的氢原子，烷氧基，芳氧基，酰氧基或甲硅烷氧基。