公开(公告)号：US5872266A

公开(公告)日：1999-02-16

申请号：US925027

申请日：1997-09-08

申请人： Hiroyuki Nitobe ,  Masaki Takemoto ,  Takafumi Abe

发明人： Hiroyuki Nitobe ,  Masaki Takemoto ,  Takafumi Abe

IPC分类号： C07D307/06 ,  C07D307/00 ,  C07D307/02

CPC分类号： C07D307/06

摘要： There is disclosed a process for producing 3-methyltetrahydrofuran substantially free from any of an alcohol and water which comprises adding an organic solvent capable of forming an azeotropic mixture with an alcohol with an alkyl group having 1 to 3 carbon atoms to a mixed liquid containing 3-methyltetrahydrofuran, the alcohol and/or water as the principal components and, as the case may be, another substance, and distilling the resultant mixture of the mixed liquid and said organic solvent. According to the above process, it is made possible to efficiently separate a mixture of 3-methyltetrahydrofuran and an alcohol and/or water which mixture is difficult to separate with conventional distillation process alone, thereby efficiently producing the objective 3-methyltetrahydrofuran substantially free from any of an alcohol and water.

摘要翻译： 公开了一种基本上不含任何醇和水的3-甲基四氢呋喃的制备方法，该方法包括将能够与具有1至3个碳原子的烷基的醇形成共沸混合物的有机溶剂加入到含有3 甲基四氢呋喃，醇和/或水作为主要成分，视情况而定，另一种物质，并蒸馏混合液和有机溶剂的混合物。 根据上述方法，可以有效地分离3-甲基四氢呋喃与醇和/或水的混合物，该混合物难以与常规的蒸馏方法分离，从而有效地制备基本上不含任何物质的目标3-甲基四氢呋喃 的酒精和水。

公开(公告)号：US5824818A

公开(公告)日：1998-10-20

申请号：US698478

申请日：1996-08-15

申请人： Takafumi Abe ,  Toshiyuki Gotoh ,  Takako Uchiyama ,  Hirofumi Higuchi ,  Yoshikazu Shima ,  Kazuto Ikemoto

发明人： Takafumi Abe ,  Toshiyuki Gotoh ,  Takako Uchiyama ,  Hirofumi Higuchi ,  Yoshikazu Shima ,  Kazuto Ikemoto

IPC分类号： C07C67/20 ,  C07C69/66

CPC分类号： C07C67/20

摘要： A process for preparing a lactate which includes: (a) preparing lactonitrile from prussic acid and acetaldehyde, (b) hydrating the lactonitrile to form lactamide, (c) forming the desired lactate and formamide from lactamide and formate (or methanol and carbon monoxide), (d) separating and collecting components, having a lower boiling point than that of lactate from the reaction liquid in step (c), by distillation under specified conditions, and (e) dehydrating formamide from step (d) to form prussic acid and recycling the prussic acid to step (a). Heretofore, lactates had been manufactured by forming lactonitrile (cyanohydrin) from acetaldehyde and prussic acid, and then esterifying lactonitrile with a mineral acid or the like. However, in this conventional process, ammonium salts were formed as by-products in an amount equal to that of the lactate. According to the present invention, a lactate can be efficiently manufactured on a commercial scale without forming a large amount of the ammonium salts as by-products. In particular, the yield of the lactate can be increased by controlling the formation of 2-formyloxy propionate and also a dimer of a lactate.

摘要翻译： 一种制备乳酸的方法，其包括：（a）从丙二酸和乙醛制备乳腈，（b）使乳腈水合形成乳酰胺，（c）从乳酰胺和甲酸盐（或甲醇和一氧化碳）形成所需的乳酸盐和甲酰胺， ，（d）在步骤（c）中通过蒸馏从特定条件下蒸馏分离和收集沸点低于乳酸盐的组分，并且（e）从步骤（d）中将甲酰胺脱水形成二甲苯， 将重要的酸回收到步骤（a）。 迄今为止，已经通过从乙醛和氢溴酸形成乳腈（氰醇），然后用无机酸等使乳腈酯化来制造乳酸盐。 然而，在该常规方法中，形成铵盐，其量等于乳酸盐的副产物。 根据本发明，可以以商业规模有效地制造乳酸盐，而不会形成大量的作为副产物的铵盐。 特别地，通过控制2-甲酰氧基丙酸酯和乳酸二聚体的形成可以提高乳酸产率。

公开(公告)号：US5756842A

公开(公告)日：1998-05-26

申请号：US729385

申请日：1996-10-11

申请人： Fumio Tanaka ,  Tsumoru Morimoto ,  Takako Uchiyama ,  Takafumi Abe

发明人： Fumio Tanaka ,  Tsumoru Morimoto ,  Takako Uchiyama ,  Takafumi Abe

IPC分类号： C07C231/06

CPC分类号： C07C231/065

摘要： There is herein disclosed a process for preparing a lactamide by hydrating lactonitrile in the presence of a catalyst mainly comprising a manganese oxide, and a nitrogen-containing compound such as ammonia or diethylamine. According to this process, the lactamide can be obtained from lactonitrile in a high yield, while the high activity of the catalyst is maintained for a long period of time.

摘要翻译： 本文公开了一种通过在主要包含氧化锰的催化剂和含氨化合物如氨或二乙胺的存在下使乳腈水合制备乳酰胺的方法。 根据该方法，可以高产率从乳腈获得乳酰胺，同时保持催化剂的高活性长时间。

公开(公告)号：US5391813A

公开(公告)日：1995-02-21

申请号：US135247

申请日：1993-10-12

申请人： Nobuyuki Muro ,  Takafumi Abe ,  Hirofumi Higuchi

发明人： Nobuyuki Muro ,  Takafumi Abe ,  Hirofumi Higuchi

IPC分类号： C07B61/00 ,  C07C67/20 ,  C07C69/675

CPC分类号： C07C67/20

摘要： There is disclosed a process for efficiently producing methyl .alpha.-hydroxyisobutyrate from .alpha.-hydroxyisobutyramide and methyl formate by means of reaction distillation which comprises feeding .alpha.-hydroxyisobutyramide and an alkali metal hydroxide in a continuous distillation column to prepare therein the dehydrated condensate of .alpha.-hydroxyisobutyramide with the alkali metal hydroxide as the catalyst and reacting remaining .alpha.-hydroxyisobutyramide with methyl formate in the presence of the dehydrated condensate as the catalyst.According to the above process, the objective methyl .alpha.-hydroxyisobutyrate is continuously obtained in high yield and high selectivity without any operational trouble.

摘要翻译： 公开了一种通过反应蒸馏从α-羟基异丁酰胺和甲酸甲酯有效生产α-羟基异丁酸甲酯的方法，其中包括在连续蒸馏塔中加入α-羟基异丁酰胺和碱金属氢氧化物，以制备α-羟基异丁酰胺的脱水缩合物 与碱金属氢氧化物作为催化剂，并在脱水缩合物作为催化剂存在下使残余的α-羟基异丁酰胺与甲酸甲酯反应。 根据上述方法，以高产率和高选择性连续获得目标α-羟基异丁酸甲酯，没有任何操作故障。

公开(公告)号：US5312966A

公开(公告)日：1994-05-17

申请号：US944359

申请日：1992-09-14

申请人： Takafumi Abe ,  Yoshiyuki Nishide ,  Nobuyuki Muro ,  Hirofumi Higuchi

发明人： Takafumi Abe ,  Yoshiyuki Nishide ,  Nobuyuki Muro ,  Hirofumi Higuchi

IPC分类号： B01J31/08 ,  C07B61/00 ,  C07C67/20 ,  C07C67/36 ,  C07C69/14 ,  C07C69/54 ,  C07C69/675 ,  C07C231/08 ,  C07C233/03 ,  C07C69/34 ,  C07C69/68

CPC分类号： C07C67/20

摘要： There is disclosed a process for efficiently producing a carboxylic acid ester and formamide by reacting a carboxylic acid amide with a formic acid ester or with an alcohol and carbon monoxide in the presence of a strongly basic anion-exchange resin. By the use of the strongly basic anion-exchange resin as the catalyst, the process of the present invention enables the efficient production of the carboxylic acid ester as well as formamide from the Carboxylic acid amide and Formic acid ester, etc. with a high selectivity under mild reaction conditions and facilitates the separation of the catalyst from the reaction product, thereby greatly enhancing the industrial significance of itself.

摘要翻译： 公开了在强碱性阴离子交换树脂存在下，使羧酸酰胺与甲酸酯或与醇和一氧化碳反应，有效地制备羧酸酯和甲酰胺的方法。 通过使用强碱性阴离子交换树脂作为催化剂，本发明的方法能够以高选择性从羧酸酰胺和甲酸酯等有效地制备羧酸酯以及甲酰胺 在温和的反应条件下，促进了催化剂与反应产物的分离，从而大大增强了其自身的工业意义。

公开(公告)号：US07465832B2

公开(公告)日：2008-12-16

申请号：US11749787

申请日：2007-05-17

申请人： Tomohiro Sugawara ,  Takafumi Abe ,  Tatsuyuki Kumano ,  Kinji Kato

发明人： Tomohiro Sugawara ,  Takafumi Abe ,  Tatsuyuki Kumano ,  Kinji Kato

IPC分类号： C07C209/48

CPC分类号： C07C209/48 ,  C07C211/27

摘要： A method of producing xylylenediamine of the present invention includes the steps of: subjecting a liquid mixture of phthalonitriles with liquid ammonia or a mixture of liquid ammonia and an organic solvent to a first catalytic hydrogenation treatment, thereby hydrogenating the phthalonitriles to obtain a reaction product (A), wherein a content of the liquid ammonia or the mixture of liquid ammonia and an organic solvent is 80 wt % or more; removing the liquid ammonia in the reaction product (A) to obtain a reaction product (B); subjecting the reaction product (B) to a second catalytic hydrogenation treatment, thereby hydrogenating cyanobenzylamine to obtain a reaction product (C); and distilling the reaction product (C) to purify xylylenediamine.

摘要翻译： 本发明的苯二甲胺的制造方法包括以下步骤：将液氨或液态氨与有机溶剂的混合液的酞腈液进行第一次催化氢化处理，氢化二氯腈得到反应产物（ A），其中液氨或液氨和有机溶剂的混合物的含量为80重量％以上; 除去反应产物（A）中的液氨，得到反应产物（B）; 使反应产物（B）进行第二催化氢化处理，由此氢化氰基苄胺得到反应产物（C）; 并蒸馏反应产物（C）以净化苯二甲胺。

公开(公告)号：US6124501A

公开(公告)日：2000-09-26

申请号：US261858

申请日：1999-03-03

申请人： Yuichi Sugano ,  Takafumi Abe ,  Rieko Nakano

发明人： Yuichi Sugano ,  Takafumi Abe ,  Rieko Nakano

IPC分类号： C07C231/06 ,  C07C235/06

CPC分类号： C07C231/065

摘要： A process for preparing lactamide with a high conversion and a high selectivity without the deterioration of a catalytic activity in a short time, which comprises subjecting lactonitrile to a hydrating reaction in the presence of (A) a catalyst including an oxide of manganese as a main component, (B) an oxidizing agent and (C) hydrogen cyanide or hydrogen cyanide and a compound represented by the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are each a hydrogen atom, a C.sub.1 to C.sub.8 alkyl group, a C.sub.1 to C.sub.8 hyroxyalkyl group, a C.sub.1 to C.sub.8 aminoalkyl group or a C.sub.1 to C.sub.8 halogenoalkyl group.

摘要翻译： 一种制备具有高转化率和高选择性而不会在短时间内催化活性降低的乳酰胺的方法，其包括在（A）包含以锰的氧化物为主要原料的催化剂存在下，使乳腈进行水合反应 组分，（B）氧化剂和（C）氰化氢或氰化氢和由下式表示的化合物其中R1，R2和R3各自为氢原子，C1至C8烷基，C1至C8羟烷基， C1〜C8氨基烷基或C1〜C8卤代烷基。

公开(公告)号：US5703272A

公开(公告)日：1997-12-30

申请号：US707135

申请日：1996-09-03

申请人： Mariko Abe ,  Shuji Ebata ,  Takafumi Abe ,  Hirofumi Higuchi

发明人： Mariko Abe ,  Shuji Ebata ,  Takafumi Abe ,  Hirofumi Higuchi

IPC分类号： B01J21/06 ,  B01J21/08 ,  B01J37/03 ,  C07C67/08 ,  C07C69/02

CPC分类号： B01J21/063 ,  B01J21/08 ,  B01J37/03 ,  C07C67/08

摘要： A process for preparing a carboxylic acid ester which includes subjecting a carboxylic acid and an alcohol or a phenol to an esterification reaction in the presence of a silica-titania catalyst. The silica-titania catalyst is prepared by adding an acidic solution containing a silicon compound and a titanium compound dissolved therein to a solution of a basic compound to bring about co-precipitation, in which the acidic solution is a nitric acid-acidic solution or a sulfuric acid-acidic solution, a ratio of the amount (gram equivalent) of nitric acid or sulfuric acid to the amount (mol) of the silicon compound in the acidic solution is 0.5 to 50 and the amount of the titanium compound in the acidic solution is such that a ratio of titania (TiO.sub.2) in the silica-titania catalyst is 1 to 50% by weight.

摘要翻译： 一种制备羧酸酯的方法，包括在二氧化硅 - 二氧化钛催化剂的存在下使羧酸和醇或酚进行酯化反应。 二氧化硅 - 二氧化钛催化剂通过将含有硅化合物和溶解在其中的钛化合物的酸性溶液加入到碱性化合物的溶液中来进行共沉淀，其中酸性溶液是硝酸 - 酸性溶液或 硫酸 - 酸性溶液，酸性溶液中的硝酸或硫酸的量（克当量）与硅化合物的量（摩尔）的比例为0.5〜50，酸性溶液中钛化合物的量 使得二氧化硅 - 二氧化钛催化剂中的二氧化钛（TiO 2）的比例为1〜50重量％。

公开(公告)号：US5075493A

公开(公告)日：1991-12-24

申请号：US618040

申请日：1990-11-23

申请人： Yoshikazu Shima ,  Takafumi Abe ,  Hirofumi Higuchi ,  Koichi Kida

发明人： Yoshikazu Shima ,  Takafumi Abe ,  Hirofumi Higuchi ,  Koichi Kida

IPC分类号： B01J27/053 ,  B01J27/16 ,  B01J29/08 ,  C07B61/00 ,  C07C67/327 ,  C07C69/54

CPC分类号： C07C67/327

摘要： A process for producing .alpha., .beta.-unsaturated carboxylic acid ester which comprises catalytically reacting .alpha.-hydroxycarboxylic acid ester with crystalline aluminosilicate catalyst, and then catalytic reacting the resulting reaction product with solid acid catalyst.According to the process, .alpha., .beta.-unsaturated carboxylic acid ester of a high purity, and a high quality, without by-product, can be produced efficiently.

公开(公告)号：US5023390A

公开(公告)日：1991-06-11

申请号：US405966

申请日：1989-09-12

申请人： Takafumi Abe ,  Shuji Ebata ,  Hiroshi Machida ,  Koichi Kida

发明人： Takafumi Abe ,  Shuji Ebata ,  Hiroshi Machida ,  Koichi Kida

IPC分类号： B01J21/04 ,  B01J23/86 ,  B01J27/12 ,  C07B61/00 ,  C07C1/00 ,  C07C1/20 ,  C07C1/24 ,  C07C5/41 ,  C07C15/24 ,  C07C45/00 ,  C07C45/46 ,  C07C45/49 ,  C07C49/76 ,  C07C67/00

CPC分类号： C07C45/46 ,  C07C1/24 ,  C07C15/24 ,  C07C45/49 ,  C07C5/412 ,  C07C5/417 ,  C07C2521/04 ,  C07C2521/12 ,  Y02P20/52

摘要： A process for production of 2,6-dimethylnaphthalene is disclosed; comprising the steps: (1) an acylation step where 2,4-dimethylisobutyrophenone is produced from m-xylene, propylene and carbon monoxide: (2) a hydrogenation step where the carbonyl group of the above 2,4-dimethylisobutyrophenone is hydrogenated: and (3) a dehydrogenation and cyclization step where the above hydrogenated product is subjected to dehydrogenation and cyclization to produce the desired 2,6-dimethylnaphthalene. The process enables efficiently producing high quality or high purity 2,6-dimethylnaphthalene.