公开(公告)号：US5872266A

公开(公告)日：1999-02-16

申请号：US925027

申请日：1997-09-08

申请人： Hiroyuki Nitobe ,  Masaki Takemoto ,  Takafumi Abe

发明人： Hiroyuki Nitobe ,  Masaki Takemoto ,  Takafumi Abe

IPC分类号： C07D307/06 ,  C07D307/00 ,  C07D307/02

CPC分类号： C07D307/06

摘要： There is disclosed a process for producing 3-methyltetrahydrofuran substantially free from any of an alcohol and water which comprises adding an organic solvent capable of forming an azeotropic mixture with an alcohol with an alkyl group having 1 to 3 carbon atoms to a mixed liquid containing 3-methyltetrahydrofuran, the alcohol and/or water as the principal components and, as the case may be, another substance, and distilling the resultant mixture of the mixed liquid and said organic solvent. According to the above process, it is made possible to efficiently separate a mixture of 3-methyltetrahydrofuran and an alcohol and/or water which mixture is difficult to separate with conventional distillation process alone, thereby efficiently producing the objective 3-methyltetrahydrofuran substantially free from any of an alcohol and water.

摘要翻译： 公开了一种基本上不含任何醇和水的3-甲基四氢呋喃的制备方法，该方法包括将能够与具有1至3个碳原子的烷基的醇形成共沸混合物的有机溶剂加入到含有3 甲基四氢呋喃，醇和/或水作为主要成分，视情况而定，另一种物质，并蒸馏混合液和有机溶剂的混合物。 根据上述方法，可以有效地分离3-甲基四氢呋喃与醇和/或水的混合物，该混合物难以与常规的蒸馏方法分离，从而有效地制备基本上不含任何物质的目标3-甲基四氢呋喃 的酒精和水。

公开(公告)号：US5618953A

公开(公告)日：1997-04-08

申请号：US595271

申请日：1996-02-01

申请人： Takafumi Abe ,  Fumio Tanaka ,  Hiroyuki Nitobe ,  Masaki Takemoto

发明人： Takafumi Abe ,  Fumio Tanaka ,  Hiroyuki Nitobe ,  Masaki Takemoto

IPC分类号： C07D307/06 ,  C07D307/02

CPC分类号： C07D307/06

摘要： A process for producing 3-methyltetrahydrofuran, wherein in a first step, prussic acid is reacted with methyl methacrylate to produce methyl 3-cyanoisobutyrate. The methyl 3-cyanoisobutyrate is then reacted with water and sulfuric acid to produce a resultant product which is reacted with a C.sub.1 -C.sub.8 aliphatic alcohol to produce a methylsuccinic acid ester. The methylsuccinic acid ester is catalytically hydrogenated to prepare the 3-methyltetrahydrofuran. Alternatively, the methyl 3-cyanoisobutyrate is hydrated to produce methyl 3-carbamoylisobutyrate, which is then reacted with a formic acid ester to form a methylsuccinic acid ester and formamide and the resultant methylsuccinic acid ester is catalytically hydrogenated. The 3-methyltetrahydrofuran is produced in high selectivity and in a commercially advantageous manner from inexpensive reactants. The 3-methyltetrahydrofuran is useful as a commoner for producing polyether glycol, which is utilized as starting raw material for preparing spandex fiber.

摘要翻译： 一种生产3-甲基四氢呋喃的方法，其中在第一步中，使二异丁酸与甲基丙烯酸甲酯反应产生3-氰基异丁酸甲酯。 然后使3-氰基异丁酸甲酯与水和硫酸反应，生成与C1-C8脂族醇反应生成甲基琥珀酸酯的产物。 将甲基琥珀酸酯催化氢化以制备3-甲基四氢呋喃。 或者，将3-氰基异丁酸甲酯水合，得到3-氨基甲酰基异丁酸甲酯，然后与甲酸酯反应形成甲基琥珀酸酯和甲酰胺，得到的甲基琥珀酸酯被催化氢化。 3-甲基四氢呋喃以廉价的反应物以高选择性和商业上有利的方式生产。 3-甲基四氢呋喃可用作制备聚醚二醇的通用剂，其用作制备氨纶纤维的起始原料。

公开(公告)号：US5663382A

公开(公告)日：1997-09-02

申请号：US729384

申请日：1996-10-11

申请人： Masaki Takemoto ,  Yoshikazu Shima ,  Takafumi Abe

发明人： Masaki Takemoto ,  Yoshikazu Shima ,  Takafumi Abe

IPC分类号： B01J23/86 ,  B01J31/02 ,  C07B61/00 ,  C07D307/06 ,  C07D307/08

CPC分类号： C07D307/06

摘要： A process for preparing 3-methyltetrahydrofuran is herein disclosed which comprises reacting a methacrylic acid ester with carbon monoxide and a lower aliphatic alcohol to obtain a methylsuccinic acid diester, and hydrogenating and dehydrating/cyclizing this methylsuccinic acid diester. According to this process, 3-methyltetrahydrofuran can efficiently be obtained from inexpensive starting materials.

摘要翻译： 本文公开了制备3-甲基四氢呋喃的方法，其包括使甲基丙烯酸酯与一氧化碳和低级脂族醇反应，得到甲基琥珀酸二酯，并使该甲基琥珀酸二酯氢化和脱水/环化。 根据该方法，可以从廉价的原料得到3-甲基四氢呋喃。

公开(公告)号：US5990324A

公开(公告)日：1999-11-23

申请号：US039954

申请日：1998-03-16

申请人： Masaki Takemoto ,  Takafumi Abe

发明人： Masaki Takemoto ,  Takafumi Abe

IPC分类号： B01J23/72 ,  C07B61/00 ,  C07D307/06

CPC分类号： C07D307/06

摘要： There is disclosed a process for producing 3-methyl-tetrahydrofuran which comprises the step 1 of subjecting the compound represented by the general formula [I]ROOC--CH(CH.sub.3)--CH.sub.2 --CHO [I]wherein R is an alkyl group having 1 to 3 carbon atoms and the formyl group may be present as an acetal having an alkanol with 1 to 8 carbon atoms, to hydrogenation and alcohol-eliminating cyclization to synthesize 2-methyl-.gamma.-butyrolactone; the step 2 of separating the 2-methyl-.gamma.-butyrolactone formed in the step 1 from alcohols by means of distillation, etc.; and the step 3 of hydrogenating the 2-methyl-.gamma.-butyrolactone which is formed in the step 2. The above process enables the production of the objective highly-pure 3-methyltetrahydrofuran substantially free from an alcohol in high efficiency and high conversion through simplified production steps.

摘要翻译： 公开了一种制备3-甲基 - 四氢呋喃的方法，其包括步骤1：使通式[I]表示的化合物ROOC-CH（CH 3）-CH 2 CHO [I]其中R是具有1个 至3个碳原子，甲酰基可以作为具有1至8个碳原子的链烷醇的缩醛存在，进行氢化和醇消除环化以合成2-甲基-γ-丁内酯; 通过蒸馏等将步骤1中形成的2-甲基γ-丁内酯与醇分离的步骤2; 以及氢化步骤2中形成的2-甲基-γ-丁内酯的步骤3.上述方法使得通过简化的方法能够以高效率和高转化率生产基本上不含醇的目标高纯度3-甲基四氢呋喃 生产步骤。

公开(公告)号：USD667123S1

公开(公告)日：2012-09-11

申请号：US29404537

申请日：2011-10-21

申请人： Masaki Takemoto

设计人： Masaki Takemoto

公开(公告)号：USD667122S1

公开(公告)日：2012-09-11

申请号：US29397835

申请日：2011-07-21

申请人： Masakazu Mori ,  Masaki Takemoto

设计人： Masakazu Mori ,  Masaki Takemoto

公开(公告)号：US20090030163A1

公开(公告)日：2009-01-29

申请号：US11993999

申请日：2006-06-30

申请人： Rieko Nakano ,  Masaki Takemoto ,  Yoshikazu Shima

发明人： Rieko Nakano ,  Masaki Takemoto ,  Yoshikazu Shima

IPC分类号： C07D301/12 ,  C08L63/00

CPC分类号： C07D301/12 ,  C07D303/16

摘要： An efficient process for producing glycidyl 2-hydroxyisobutyrate useful as a reactive diluent is provided. When glycidyl 2-hydroxyisobutyrate is produced by reacting allyl 2-hydroxyisobutyrate with hydrogen peroxide, a solution in which allyl 2-hydroxyisobutyrate is dissolved in an aliphatic ester as a solvent is reacted with hydrogen peroxide in the presence of a crystalline titanosilicate catalyst. Thus, a production process of glycidyl 2-hydroxyisobutyrate, which is small in degradation of purity and yield due to generation of peroxides or the like, and products thereof are provided.

摘要翻译： 提供了一种生产用作反应性稀释剂的2-羟基异丁酸缩水甘油酯的有效方法。 当2-羟基异丁酸缩水甘油酯是通过使2-羟基异丁酸烯丙酯与过氧化氢反应来制备的，其中将2-羟基异丁酸烯丙酯溶解在作为溶剂的脂肪族酯中的溶液与过氧化氢在结晶钛硅酸盐催化剂存在下反应。 因此，提供了由于产生过氧化物等而导致的纯度和产率降低小的2-羟基异丁酸缩水甘油酯的制备方法及其产物。

公开(公告)号：USD541776S1

公开(公告)日：2007-05-01

申请号：US29262126

申请日：2006-06-27

申请人： Tamotsu Senda ,  Masaki Takemoto ,  Masaaki Goto

设计人： Tamotsu Senda ,  Masaki Takemoto ,  Masaaki Goto

公开(公告)号：USD339121S

公开(公告)日：1993-09-07

申请号：US731095

申请日：1991-07-17

申请人： Masaki Takemoto ,  Norihiko Shimose

设计人： Masaki Takemoto ,  Norihiko Shimose

公开(公告)号：US08759566B2

公开(公告)日：2014-06-24

申请号：US13259156

申请日：2010-03-30

申请人： Hideho Matsuda ,  Yuuichi Sugano ,  Yoshikazu Shima ,  Masaki Takemoto ,  Genki Nogami

发明人： Hideho Matsuda ,  Yuuichi Sugano ,  Yoshikazu Shima ,  Masaki Takemoto ,  Genki Nogami

IPC分类号： C07C69/66

CPC分类号： C07C67/20 ,  B01J21/02 ,  B01J21/066 ,  B01J23/02 ,  B01J23/06 ,  B01J23/10 ,  B01J23/14 ,  B01J23/18 ,  B01J23/22 ,  B01J23/26 ,  B01J23/34 ,  B01J23/72 ,  B01J23/74 ,  B01J27/0576 ,  B01J37/08 ,  C07C69/68 ,  C07C69/675

摘要： Provided is a process for producing α-hydroxycarboxylic esters from α-hydroxycarboxylic amides and aliphatic alcohols, wherein it is a production process which is inhibited in a production cost and enhanced in a conversion rate and a selectivity and which is industrially advantageous. To be specific, it is a production process for α-hydroxycarboxylic ester characterized by subjecting α-hydroxycarboxylic amide and aliphatic alcohol to a gas phase reaction in the presence of a zirconium dioxide catalyst. A catalyst lifetime is improved to a large extent by using a zirconium dioxide catalyst containing a specific element.

摘要翻译： 本发明提供一种由α-羟基羧酸酰胺和脂肪族醇制造α-羟基羧酸酯的方法，其为生产成本抑制的生产方法，转化率和选择性提高，在工业上具有优势。 具体而言，是在二氧化锆催化剂存在下，使α-羟基羧酸酰胺和脂肪醇进行气相反应的α-羟基羧酸酯的制造方法。 通过使用含有特定元素的二氧化锆催化剂在很大程度上改善了催化剂寿命。