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公开(公告)号：US20070128667A1
公开(公告)日：2007-06-07
申请号：US10596221
申请日：2004-11-18
申请人： Jean Merrill , Zhengbin Yao , Wayne Petko , Olga Khorkova , George Keesler , Min Wang
发明人： Jean Merrill , Zhengbin Yao , Wayne Petko , Olga Khorkova , George Keesler , Min Wang
IPC分类号： G01N33/567 , A61K38/55 , A61K31/727
CPC分类号： G01N33/5011 , A61K31/727 , A61K38/1709 , C12Q1/26 , G01N33/5017 , G01N33/5047
摘要： A novel neuroprotectant was identified by microarray analysis that is differentially expressed between the ventricular zone and the cortex of human adult and fetal brain. The secreted protein antagonizes Wnt action in Xenopus embryos. Methods are described for modulating free radical neurotoxicity by contacting cells with the protein, treating neuronal diseases associated with free radical-mediated cell death by administering the protein, determining neuroprotective genomic targets associated with select free radical toxicity pathways by screening with the protein and using the protein to identify other compounds that modulate the biological activity of the secreted protein and the cell machinery that reacts to the secreted protein.
摘要翻译： 通过微阵列分析鉴定出新的神经保护剂，其在人成人和胎儿脑的心室区和皮层之间差异表达。 分泌的蛋白质拮抗非洲爪蟾胚胎中的Wnt作用。 描述了通过使细胞与蛋白质接触来治疗自由基神经毒性的方法，通过施用蛋白质治疗与自由基介导的细胞死亡相关的神经元疾病，通过用蛋白质筛选确定与选择的自由基毒性途径相关的神经保护基因组靶标，并使用 蛋白质以鉴定调节分泌蛋白质的生物活性的其他化合物和与分泌蛋白质反应的细胞机制。
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公开(公告)号：US20060100134A1
公开(公告)日：2006-05-11
申请号：US11251734
申请日：2005-10-17
申请人： Yong Guo , Clarence Morse , Zhengbin Yao , George Keesler
发明人： Yong Guo , Clarence Morse , Zhengbin Yao , George Keesler
CPC分类号： C07K14/4702 , C07K2319/00 , C07K2319/03 , C07K2319/09 , C07K2319/10 , C07K2319/43 , C07K2319/50 , C07K2319/60 , C12N15/62
摘要： The present invention is directed to membrane penetrating peptides useful as in viv, ex vivo and in vitro intracellular delivery devices for compound of interest. More particularly, the invention involves identification of membrane penetrating peptides which may be used as protein carriers for delivery of a compound of interest to cells, to methods of delivering a compound of interest attached to membrane penetrating peptides to cells.
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23.发明授权
公开(公告)号：US6100235A
公开(公告)日：2000-08-08
申请号：US22260
申请日：1998-02-11
IPC分类号： G01N33/53 , A61K38/00 , A61K38/17 , A61K48/00 , A61P29/00 , A61P37/00 , C07K14/54 , C07K14/715 , C07K16/28 , C12N5/10 , C12N15/00 , C12N15/02 , C12N15/09 , C12N15/12 , C12N15/85 , C12P21/02 , C12P21/08 , C12R1/91 , G01N33/577 , G01N33/68
CPC分类号： C07K14/54 , C07K14/7155 , A61K38/00 , A61K48/00 , C07K2319/00 , Y10S514/885 , Y10S514/886
摘要： Isolated receptors for IL-17, DNA's encoding such receptors, and pharmaceutical compositions made therefrom, and methods of treatment using the IL-17 receptors are disclosed. The isolated receptors can be used to regulate an immune response.
摘要翻译： 公开了用于IL-17的分离的受体，编码这种受体的DNA，以及由其制备的药物组合物，以及使用IL-17受体的治疗方法。 分离的受体可用于调节免疫应答。
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公开(公告)号：US6072033A
公开(公告)日：2000-06-06
申请号：US22255
申请日：1998-02-11
IPC分类号： G01N33/53 , A61K38/00 , A61K38/17 , A61K48/00 , A61P29/00 , A61P37/00 , C07K14/54 , C07K14/715 , C07K16/28 , C12N5/10 , C12N15/00 , C12N15/02 , C12N15/09 , C12N15/12 , C12N15/85 , C12P21/02 , C12P21/08 , C12R1/91 , G01N33/577 , G01N33/68 , C07K1/00
CPC分类号： C07K14/54 , C07K14/7155 , A61K38/00 , A61K48/00 , C07K2319/00 , Y10S514/885 , Y10S514/886
摘要： Isolated receptors for IL-17, DNA's encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response.
摘要翻译： 公开了用于IL-17的分离的受体，编码这种受体的DNA和由其制备的药物组合物。 分离的受体可用于调节免疫应答。
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公开(公告)号：US20090068737A1
公开(公告)日：2009-03-12
申请号：US11901904
申请日：2007-09-19
IPC分类号： C12N5/02
CPC分类号： C07K14/54 , A61K38/00 , A61K48/00 , C07K14/7155 , C07K2319/00 , Y10S514/885 , Y10S514/886
摘要： Isolated receptors for IL-17, DNA's encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response.
摘要翻译： 公开了用于IL-17的分离的受体，编码这种受体的DNA和由其制备的药物组合物。 分离的受体可用于调节免疫应答。
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26.发明授权Methods of treating autoimmune disease by administering interleukin-17 receptor 失效通过施用白细胞介素-17受体治疗自身免疫性疾病的方法公开(公告)号：US06680057B1
公开(公告)日：2004-01-20
申请号：US09549679
申请日：2000-04-14
IPC分类号： A61K3800
CPC分类号： C07K14/7155 , A61K38/00 , A61K48/00 , C07K2319/00 , Y10S514/885
摘要： Isolated receptors for IL-17, DNA's encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response.
摘要翻译： 公开了用于IL-17的分离的受体，编码这种受体的DNA和由其制备的药物组合物。 分离的受体可用于调节免疫应答。
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27.发明授权Screening methods for altering circadian rhythms and for human casein kinase I &dgr; and/or &egr; phosphorylation of human clock proteins, period 1, -2 and -3 有权用于改变昼夜节律和人类酪蛋白激酶Iδ和/或人时钟蛋白的epsi磷酸化的时间段1，-2和-3的筛选方法公开(公告)号：US06555328B1
公开(公告)日：2003-04-29
申请号：US09589462
申请日：2000-06-07
IPC分类号： C12Q148
CPC分类号： G01N33/5008 , C12Q1/48 , G01N33/502 , G01N33/68 , G01N33/6842 , G01N2500/00
摘要： The present invention is directed to methods to identify test compounds that alter circadian rhythms of mammals, and more specifically, directed to methods for determining the ability of a test compound to alter hCKI &dgr; and &egr; phosphorylation of a human Period protein. The present invention is also directed to a method for determing the ability of a test compound to selectively alter phosphorylation, interaction with, or alternatively degradation, of one or more human Period proteins relative to its ability to alter phosphorylation, interaction with, or alternatively degradation, of a different human Period protein.
摘要翻译： 本发明涉及确定改变哺乳动物昼夜节律的测试化合物的方法，更具体地，涉及确定测试化合物改变人周期蛋白的hCKIδ和epsi磷酸化能力的方法。 本发明还涉及一种用于确定测试化合物相对于其改变磷酸化，相互作用或替代降解的能力选择性地改变一种或多种人周期蛋白的磷酸化，相互作用或替代降解的能力的方法 ，不同的人类周期蛋白。
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公开(公告)号：US6096305A
公开(公告)日：2000-08-01
申请号：US22253
申请日：1998-02-11
IPC分类号： G01N33/53 , A61K38/00 , A61K38/17 , A61K48/00 , A61P29/00 , A61P37/00 , C07K14/54 , C07K14/715 , C07K16/28 , C12N5/10 , C12N15/00 , C12N15/02 , C12N15/09 , C12N15/12 , C12N15/85 , C12P21/02 , C12P21/08 , C12R1/91 , G01N33/577 , G01N33/68 , C12N15/63
CPC分类号： C07K14/54 , C07K14/7155 , A61K38/00 , A61K48/00 , C07K2319/00 , Y10S514/885 , Y10S514/886
摘要： Isolated receptors for IL-17, DNA's encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response.
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