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    Absolute quantification of nucleic acids and related methods and systems
    23.
    发明授权
    Absolute quantification of nucleic acids and related methods and systems 有权

    公开(公告)号：US12173363B2

    公开(公告)日：2024-12-24

    申请号：US17863183

    申请日：2022-07-12

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

    Inventor： Rustem F. Ismagilov ,  Jacob T. Barlow ,  Said R. Bogatyrev

    IPC: C12Q1/68 ,  C12Q1/686 ,  C12Q1/6888

    Abstract: Provided herein are methods and systems for absolute quantification of a target 16S rRNA and/or of a target prokaryotic taxon, based on amplifying and sequencing a same 16S rRNA recognition segment in which target 16S rRNA conserved regions flank 16S rRNA variable regions, conserved and variable among a plurality of sample 16S rRNAs and/or of a sample prokaryotic taxon of higher taxonomic rank with respect to the target taxon. In the methods and systems, absolute abundance of the a plurality of sample 16S rRNAs and/or of the sample prokaryotic taxon detected by the amplifying, is multiplied by the relative abundance of the target 16S rRNA and/or of a target prokaryotic taxon detected by the sequencing to provide the absolute quantification in accordance with method and systems of the disclosure.

    ALL-OPTICAL ULTRAFAST NONLINEAR ACTIVATION FUNCTIONS FOR DEEP LEARNING
    24.
    发明申请
    ALL-OPTICAL ULTRAFAST NONLINEAR ACTIVATION FUNCTIONS FOR DEEP LEARNING 有权

    公开(公告)号：US20240419951A1

    公开(公告)日：2024-12-19

    申请号：US17973118

    申请日：2022-10-25

    Applicant: California Institute of Technology

    Inventor： Gordon H.Y. Li ,  Ryoto Sekine ,  Rajveer Nehra ,  Robert M. Gray ,  Alireza Marandi

    IPC: G06N3/048 ,  G06N3/067

    Abstract: A device implementing a nonlinear activation function including a material having nonlinear susceptibility phase-matching a coherent nonlinear interaction involving a signal comprising a signal wavelength and a bias comprising a bias wavelength, so that (1) a first phase difference between the signal and the bias induces the interaction comprising second harmonic generation (generating a second harmonic of the bias wavelength) or sum frequency generation (generating a sum frequency of the bias and the signal, and (2) a second phase difference between the signal and the bias induces the interaction comprising parametric amplification amplifying the bias and attenuating the signal. A positive input to the nonlinear activation function is represented by the signal having an input energy and the first phase difference. A negative input is represented by second phase difference. The output is an output energy of the signal as function of the input energy.

    HIGH TEMPERATURE SUPERCONDUCTING MATERIALS
    25.
    发明申请
    HIGH TEMPERATURE SUPERCONDUCTING MATERIALS 有权

    公开(公告)号：US20240415031A1

    公开(公告)日：2024-12-12

    申请号：US18647210

    申请日：2024-04-26

    Applicant: California Institute of Technology

    Inventor： Jamil Tahir-Kheli

    IPC: H10N60/85 ,  C04B35/45 ,  C04B35/626 ,  H10N60/01

    Abstract: A superconducting composition of matter including overlapping first and second regions. The regions comprise unit cells of a solid, the first region comprises an electrical insulator or semiconductor, and the second region comprises a metallic electrical conductor. The second region extends through the solid and a subset of said second region comprise surface metal unit cells that are adjacent to at least one unit cell from the first region. The ratio of the number of said surface metal unit cells to the total number of unit cells in the second region being at least 20 percent.

    MAMMALIAN POLYCISTRONIC EXPRESSION SYSTEM FOR DIRECT TRANSLATION FROM RNA AND SECRETION OF CARGO
    29.
    发明申请
    MAMMALIAN POLYCISTRONIC EXPRESSION SYSTEM FOR DIRECT TRANSLATION FROM RNA AND SECRETION OF CARGO 有权

    公开(公告)号：US20240366793A1

    公开(公告)日：2024-11-07

    申请号：US18653868

    申请日：2024-05-02

    Applicant: California Institute of Technology

    Inventor： Ishaan J. Dev ,  Mengtong Duan ,  Mikhail G. Shapiro

    IPC: A61K48/00 ,  C12N15/11 ,  C12N15/85

    Abstract: Disclosed herein include methods, compositions, and kits enabling expression of multiple payload proteins from a single mRNA configured to achieve a predetermined stoichiometry of first unit payload protein(s) and second unit payload protein(s) in a cell or cell-like environment. There are provided, in some embodiments, nucleic acid compositions comprising a polynucleotide comprising a first nucleic acid unit (encoding one or more first unit payload protein(s)) and a second nucleic acid unit (encoding one or more second unit payload protein(s)). The first nucleic acid unit and the second nucleic acid unit can each comprise an engineered translation initiation site (eTIS) comprising a three-nucleotide tunable element immediately upstream of a start codon. In some embodiments, the nucleic acid composition comprises at least one modified nucleotide and/or at least one nucleotide analogue or nucleotide derivative. In some embodiments, the polynucleotide comprises a disclosed eTIS combination.

    Self-calibrating phased-array transceiver
    30.
    发明授权
    Self-calibrating phased-array transceiver 有权

    公开(公告)号：US12136772B2

    公开(公告)日：2024-11-05

    申请号：US17683100

    申请日：2022-02-28

    Applicant: California Institute of Technology

    Inventor： Austin C. Fikes ,  Behrooz Abiri ,  Florian Bohn ,  Seyed Ali Hajimiri ,  Christopher Ian Walker ,  David Elliot Williams

    IPC: H01Q3/26

    Abstract: A phased-array includes, in part, N transceivers each including a receiver and a transmitter, and a controller. The phased array is configured to transmit a first radio signal from a first element of the array during a first time period, receive the first radio signal from a second element of the array, recover a first value associated with the radio signal received by the second element, transmit a second radio signal from the second element of the array during a second time period, receive the second radio signal from the first element of the array, recover a second value associated with the radio signal received by the first element, and determine a first phase of a reference signal received by the second element from the recovered first and second values. The first phase is relative to a second phase of the reference signal received by the first element.

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