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公开(公告)号：US10207269B2
公开(公告)日：2019-02-19
申请号：US15022879
申请日：2014-09-18
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY , SLIPCHIP CORPORATION
Inventor： Rustem F. Ismagilov , Feng Shen , Liang Li , David Selck , Joe Baker , Espir Kahatt , Chris Da Costa
Abstract: The present invention relates to fluidic systems for controlling one or more fluids and/or one or more reagents. These systems can be used in combination with one or more devices for assaying, processing, and/or storing samples. In particular, the systems and related methods can allow for dispensing fluid in a controlled manner and/or introducing pause(s) when implementing assays or processes.
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公开(公告)号：US09808798B2
公开(公告)日：2017-11-07
申请号：US13868009
申请日：2013-04-22
Applicant: University of Chicago , California Institute of Technology
Inventor： Rustem F. Ismagilov , Qichao Pan , Stefano Begolo
IPC: G01N21/75 , B01L3/00 , B01L7/00 , G01N33/543
CPC classification number: B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502784 , B01L7/52 , B01L2200/027 , B01L2200/0605 , B01L2200/0673 , B01L2200/0678 , B01L2300/045 , B01L2300/0681 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2400/0406 , B01L2400/0487 , B01L2400/0644 , B01L2400/065 , G01N33/54366 , Y10T436/143333 , Y10T436/2525
Abstract: The present invention relates to fluidic devices for preparing, processing, storing, preserving, and/or analyzing samples. In particular, the devices and related systems and methods allow for preservation or storage of samples (e.g., biospecimen samples) by using one or more of a bridge, a membrane, and/or a desiccant.
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3.发明申请MULTIVOLUME DEVICES, KITS AND RELATED METHODS FOR QUANTIFICATION AND DETECTION OF NUCLEIC ACIDS AND OTHER ANALYTES 审中-公开用于定量和检测核酸和其他分析物的多功能装置，试剂盒和相关方法公开(公告)号：US20150225803A1
公开(公告)日：2015-08-13
申请号：US14177194
申请日：2014-02-10
Applicant: California Institute of Technology , University of Chicago
Inventor： Rustem F. Ismagilov , Feng Shen , Jason E. Kreutz , Wenbin Du , Bing Sun
IPC: C12Q1/70
CPC classification number: C12Q1/703 , C12Q1/6851 , C12Q1/707 , C12Q2600/158 , C12Q2561/113
Abstract: Provided are devices comprising multivolume analysis regions, the devices being capable of supporting amplification, detection, and other processes. Also provided are related methods of detecting or estimating the presence nucleic acids, viral levels, and other biological markers of interest.
Abstract translation: 提供了包括多体积分析区域的装置，该装置能够支持放大，检测和其它过程。 还提供了检测或估计存在的核酸，病毒水平和感兴趣的其他生物标志物的相关方法。
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公开(公告)号：US12122996B2
公开(公告)日：2024-10-22
申请号：US16141707
申请日：2018-09-25
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Rustem F. Ismagilov , Eugenia Khorosheva , Dmitriy V. Zhukov
IPC: B01L3/00 , C12N15/10 , C12Q1/6806 , C12Q1/6855 , G01N33/58 , G01N33/68 , C40B30/04 , C40B40/08 , C40B70/00
CPC classification number: C12N15/1065 , B01L3/502715 , B01L3/502738 , C12Q1/6806 , C12Q1/6855 , G01N33/58 , G01N33/68 , B01L2200/027 , B01L2200/141 , B01L2200/16 , B01L2300/0816 , B01L2300/0861 , B01L2300/161 , B01L2400/065 , C40B30/04 , C40B40/08 , C40B70/00 , C12Q1/6806 , C12Q2523/101 , C12Q2525/191 , C12Q2565/514
Abstract: A device for allowing compartmentalized reactions with minimized cross-contamination between the compartments, utilizing a delivery of material by loading wells to pooling wells, such that the pooling wells can be additively provided with reactants while maintaining isolation between the pooling wells. The use of geometric properties is used to facilitate transmission of fluids/droplets without the need for hydrophilic surfaces.
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5.发明授权公开(公告)号：US11827944B2
公开(公告)日：2023-11-28
申请号：US16158233
申请日：2018-10-11
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Rustem F. Ismagilov , Emily S. Savela , Nathan Schoepp , Eric J. Liaw
IPC: C12Q1/689 , C12Q1/6806 , C12Q1/6851
CPC classification number: C12Q1/689 , C12Q1/6806 , C12Q1/6851 , C12Q1/6806 , C12Q2527/125 , C12Q2533/101 , C12Q2535/122
Abstract: Provided herein is an antibiotic susceptibility test and related compositions, methods and systems based on detection of a nucleic acid from a target microorganism in a sample in the presence or absence of a lysis treatment of the sample.
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Patent Agency Ranking
公开(公告)号：US11434526B2
公开(公告)日：2022-09-06
申请号：US16224617
申请日：2018-12-18
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Rustem F. Ismagilov , Bing Sun , Jesus Rodriguez Manzano , Eugenia Khorosheva , Matthew S. Curtis
IPC: C12Q1/68 , C12Q1/6848 , C12Q1/6844 , C12Q1/6851 , C12Q1/686 , C12Q1/6865 , C12Q1/70
Abstract: The present invention relates to assays, including amplification assays, conducted in the presence of modulators. These assays can be used to detect the presence of particular nucleic acid sequences. In particular, these assays can allow for genotyping or other genetic analysis.
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公开(公告)号：US11242290B2
公开(公告)日：2022-02-08
申请号：US16549954
申请日：2019-08-23
Applicant: California Institute of Technology
Inventor： Katherine T. Faber , Julia A. Kornfield , Noriaki Arai , Orland Bateman , Rustem F. Ismagilov
IPC: C04B38/06 , B01D67/00 , B01D69/02 , B01D71/02 , B01J35/04 , B01J35/10 , C04B38/00 , H01B1/14 , H01B1/16
Abstract: Provided herein are methods for making a freeze-cast material having a internal structure, the methods comprising steps of: determining the internal structure of the material, the internal structure having a plurality of pores, wherein: each of the plurality of pores has directionality; and the step of determining comprises: selecting a temperature gradient and a freezing front velocity to obtain the determined internal structure based on the selected temperature gradient and the selected freezing front velocity; directionally freezing a liquid formulation to form a frozen solid, the step of directionally freezing comprising: controlling the temperature gradient and the freezing front velocity to match the selected temperature gradient and the selected freezing front velocity during directionally freezing; wherein the liquid formulation comprises at least one solvent and at least one dispersed species; and subliming the at least one solvent out of the frozen solid to form the material.
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8.发明申请MULTIVOLUME DEVICES, KITS AND RELATED METHODS FOR QUANTIFICATION AND DETECTION OF NUCLEIC ACIDS AND OTHER ANALYTES 审中-公开用于定量和检测核酸和其他分析物的多功能装置，试剂盒和相关方法公开(公告)号：US20170051365A9
公开(公告)日：2017-02-23
申请号：US14177194
申请日：2014-02-10
Applicant: California Institute of Technology , University of Chicago
Inventor： Rustem F. Ismagilov , Feng Shen , Jason E. Kreutz , Wenbin Du , Bing Sun
IPC: C12Q1/70
CPC classification number: C12Q1/703 , C12Q1/6851 , C12Q1/707 , C12Q2600/158 , C12Q2561/113
Abstract: Provided are devices comprising multivolume analysis regions, the devices being capable of supporting amplification, detection, and other processes. Also provided are related methods of detecting or estimating the presence nucleic acids, viral levels, and other biological markers of interest.
Abstract translation: 提供了包括多体积分析区域的装置，该装置能够支持放大，检测和其它过程。 还提供了检测或估计存在的核酸，病毒水平和感兴趣的其他生物标志物的相关方法。
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9.发明授权Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes 有权用于定量和检测核酸和其他分析物的多体积仪器，试剂盒和相关方法公开(公告)号：US09493826B2
公开(公告)日：2016-11-15
申请号：US14177190
申请日：2014-02-10
Applicant: California Institute of Technology , University of Chicago
Inventor： Rustem F. Ismagilov , Feng Shen , Jason E. Kreutz , Wenbin Du , Bing Sun
CPC classification number: C12Q1/6851 , B01F5/0085 , B01F13/0094 , B01F15/0218 , B01L3/5025 , B01L3/502738 , B01L3/50851 , B01L2200/027 , B01L2200/0605 , B01L2200/0642 , B01L2300/045 , B01L2300/049 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0644 , B01L2400/065 , C12Q2531/119 , C12Q2537/149 , C12Q2563/159 , C12Q2565/629
Abstract: Provided are devices comprising multivolume analysis regions, the devices being capable of supporting amplification, detection, and other processes. Also provided are related methods of detecting or estimating the presence nucleic acids, viral levels, and other biological markers of interest.
Abstract translation: 提供了包括多体积分析区域的装置，该装置能够支持放大，检测和其它过程。 还提供了检测或估计存在的核酸，病毒水平和感兴趣的其他生物标志物的相关方法。
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10.发明申请MULTIVOLUME DEVICES, KITS AND RELATED METHODS FOR QUANTIFICATION AND DETECTION OF NUCLEIC ACIDS AND OTHER ANALYTES 有权用于定量和检测核酸和其他分析物的多功能装置，试剂盒和相关方法公开(公告)号：US20140336064A1
公开(公告)日：2014-11-13
申请号：US14177190
申请日：2014-02-10
Applicant: California Institute of Technology , University of Chicago
Inventor： Rustem F. Ismagilov , Feng Shen , Jason E. Kreutz , Wenbin Du , Bing Sun
IPC: C12Q1/68
CPC classification number: C12Q1/6851 , B01F5/0085 , B01F13/0094 , B01F15/0218 , B01L3/5025 , B01L3/502738 , B01L3/50851 , B01L2200/027 , B01L2200/0605 , B01L2200/0642 , B01L2300/045 , B01L2300/049 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0644 , B01L2400/065 , C12Q2531/119 , C12Q2537/149 , C12Q2563/159 , C12Q2565/629
Abstract: Provided are devices comprising multivolume analysis regions, the devices being capable of supporting amplification, detection, and other processes. Also provided are related methods of detecting or estimating the presence nucleic acids, viral levels, and other biological markers of interest.
Abstract translation: 提供了包括多体积分析区域的装置，该装置能够支持放大，检测和其它过程。 还提供了检测或估计存在的核酸，病毒水平和感兴趣的其他生物标志物的相关方法。
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