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21.发明授权Ketone compounds and compositions for cholesterol management and related uses 有权酮类化合物和胆固醇管理及相关用途的组合物公开(公告)号：US08084498B2
公开(公告)日：2011-12-27
申请号：US12492597
申请日：2009-06-26
IPC分类号： A61K31/19
CPC分类号： C07C59/353 , C07C49/17 , C07C49/185 , C07C49/215 , C07C49/245 , C07C49/258 , C07C49/507 , C07C49/723 , C07C49/743 , C07C49/747 , C07C49/784 , C07C49/82 , C07C49/86 , C07C50/30 , C07C59/347 , C07C59/82 , C07C59/84 , C07C59/90 , C07C69/716 , C07C69/738 , C07C235/74 , C07C261/04 , C07C309/07 , C07C309/24 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/16 , C07D233/72 , C07D233/84 , C07D233/86 , C07D257/04 , C07D261/12 , C07D305/12 , C07D307/33 , C07D309/12 , C07D309/30 , C07D309/40 , C07F9/093 , C07F9/2425 , C07F9/4423
摘要： The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
摘要翻译： 本发明涉及新颖的酮化合物，包含酮化合物的组合物，以及可用于治疗和预防心血管疾病，血脂异常，dysproteinemias和葡萄糖代谢紊乱的方法，包括施用包含酮化合物的组合物。 本发明的化合物，组合物和方法也可用于治疗和预防阿尔茨海默病，综合征X，过氧化物酶体增殖物激活受体相关病症，败血症，血栓形成障碍，肥胖症，胰腺炎，高血压，肾脏疾病，癌症，炎症和 阳。 在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。
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22.发明申请HYDROXYL COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES 审中-公开羟丙基化合物和组合物用于胆固醇管理和相关用途公开(公告)号：US20110003860A1
公开(公告)日：2011-01-06
申请号：US12870184
申请日：2010-08-27
IPC分类号： A61K31/4433 , A61P25/28 , A61P11/06 , A61P35/00 , A61P9/12 , A61P3/10 , A61P3/06 , A61P15/10 , A61P29/00 , A61P5/50 , A61P3/04 , A61P1/18 , A61P13/12 , A61P25/16 , A61K31/047 , A61K31/194 , A61K31/351 , A61K31/225 , A61K31/19 , A61K31/045 , A61K31/277 , A61K31/465
CPC分类号： C07C31/27 , A61K31/191 , A61K31/194 , A61K31/20 , A61K31/23 , C07C31/20 , C07C31/22 , C07C31/24 , C07C33/26 , C07C47/19 , C07C47/34 , C07C59/01 , C07C59/105 , C07C59/11 , C07C59/245 , C07C59/285 , C07C59/29 , C07C59/46 , C07C59/48 , C07C59/54 , C07C61/12 , C07C62/02 , C07C62/06 , C07C65/17 , C07C69/003 , C07C69/017 , C07C69/675 , C07C69/757 , C07C255/00 , C07C309/08 , C07C309/24 , C07C309/25 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/80 , C07D257/04 , C07D261/08 , C07D261/12 , C07D305/12 , C07D307/33 , C07D309/10 , C07D309/12 , C07D309/30 , C07D405/12 , C07D495/04 , C07F9/093 , C07F9/094 , C07F9/11 , C07F9/117 , C07F9/12 , C07F9/2408 , C07F9/2416 , C07F9/242 , C07F9/2425 , C07F9/4423
摘要： The present invention relates to novel hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, pancreatitius, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, metabolic syndrome disorders (e.g., Syndrome X), thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
摘要翻译： 本发明涉及新的羟基化合物，包含羟基化合物的组合物和可用于治疗和预防各种疾病和病症例如但不限于老化，阿尔茨海默氏病，癌症，心血管疾病，糖尿病性肾病，糖尿病性视网膜病变， 葡萄糖代谢异常，血脂异常，脂蛋白血症，高血压，阳ence，炎症，胰岛素抵抗，胆汁中的脂质清除，肥胖，胆汁中的氧固醇消除，胰腺炎，胰腺炎，帕金森病，过氧化物酶体增殖物激活受体相关病症，磷脂消除 胆汁，肾脏疾病，败血症，代谢综合症（如X综合症），血栓形成障碍。 本发明的化合物和方法也可用于调节C反应蛋白或增强患者的胆汁产生。 在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。
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23.发明申请公开(公告)号：US20080249166A1
公开(公告)日：2008-10-09
申请号：US12135504
申请日：2008-06-09
IPC分类号： A61K31/216 , A61K31/192 , A61K31/22 , C07C69/74 , C07C61/06 , A61P9/00 , C07C61/04 , C07C69/743 , A61K31/191
CPC分类号： C07C31/27 , A61K31/191 , A61K31/194 , A61K31/20 , A61K31/23 , C07C31/20 , C07C31/22 , C07C31/24 , C07C33/26 , C07C47/19 , C07C47/34 , C07C59/01 , C07C59/105 , C07C59/11 , C07C59/245 , C07C59/285 , C07C59/29 , C07C59/46 , C07C59/48 , C07C59/54 , C07C61/12 , C07C62/02 , C07C62/06 , C07C65/17 , C07C69/003 , C07C69/017 , C07C69/675 , C07C69/757 , C07C255/00 , C07C309/08 , C07C309/24 , C07C309/25 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D213/80 , C07D257/04 , C07D261/08 , C07D261/12 , C07D305/12 , C07D307/33 , C07D309/10 , C07D309/12 , C07D309/30 , C07D405/12 , C07D495/04 , C07F9/093 , C07F9/094 , C07F9/11 , C07F9/117 , C07F9/12 , C07F9/2408 , C07F9/2416 , C07F9/242 , C07F9/2425 , C07F9/4423
摘要： The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, Syndrome X, thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
摘要翻译： 本发明涉及新的环烷基 - 羟基化合物，包含羟基化合物的组合物和可用于治疗和预防各种疾病和病症例如但不限于老化，阿尔茨海默氏病，癌症，心血管疾病，糖尿病性肾病，糖尿病 视网膜病变，葡萄糖代谢紊乱，血脂异常，脂蛋白血症，高血压，阳ence，炎症，胰岛素抵抗，胆汁中的脂质消除，肥胖，胆汁中的氧固醇消除，胰腺炎，帕金森病，过氧化物酶体增殖物激活受体相关病症，磷脂消除 胆汁，肾脏疾病，败血症，X综合征，血栓形成障碍。 本发明的化合物和方法也可用于调节C反应蛋白或增强患者的胆汁产生。 在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。
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公开(公告)号：US07192940B2
公开(公告)日：2007-03-20
申请号：US10893791
申请日：2004-07-16
IPC分类号： A61K31/66 , A61K31/185 , A61K31/19
CPC分类号： C07D233/72 , C07C43/132 , C07C59/125 , C07C311/04 , C07F9/091 , Y10S514/866 , Y10S514/909
摘要： The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
摘要翻译： 本发明涉及新型醚化合物，包含醚化合物的组合物和用于治疗和预防心血管疾病，血脂异常，dysproteinemias和葡萄糖代谢紊乱的方法，包括施用包含醚化合物的组合物。 本发明的化合物，组合物和方法还可用于治疗和预防阿尔茨海默病，综合征X，过氧化物酶体增殖物激活受体相关病症，败血症，血栓形成障碍，肥胖症，胰腺炎，高血压，肾脏疾病，癌症，炎症和 阳。 在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。
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公开(公告)号：US06974702B2
公开(公告)日：2005-12-13
申请号：US10657810
申请日：2003-09-08
申请人： Jean-Louis H. Dasseux , Roger S. Newton , Thomas J. Rea , Charles L. Bisgaier , Michael E. Pape
发明人： Jean-Louis H. Dasseux , Roger S. Newton , Thomas J. Rea , Charles L. Bisgaier , Michael E. Pape
CPC分类号： G01N33/5011 , G01N33/5008 , G01N33/502 , G01N33/5038 , G01N33/5091 , Y02A90/26 , Y10T436/24
摘要： The present invention relates to methods for high information content (HIC) analysis or screening of complex biological systems using Fourier transform mass spectrometry (FTMS). The present methods are useful for analyzing complex biological mixtures containing both high molecular weight molecules (e.g., polynucleotides, proteins, polysaccharides) and low molecular weight molecules (e.g., oligonucleotides, peptides, lipids, oligosaccharides, steroid hormones, catabolic and metabolic intermediates) permit the elucidation of molecular differences between complex biological samples, and permit the identification of biologically active molecules (e.g. therapeutically active drugs, etc.).
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公开(公告)号：US06953840B2
公开(公告)日：2005-10-11
申请号：US10629892
申请日：2003-07-29
CPC分类号： A61K38/1709 , A61K47/543 , A61K47/6905 , A61K2300/00
摘要： The invention provides methods and compositions for treating disorders using non-human animal Apolipoprotein A-I (ApoA-I) protein. The invention provides methods and compositions for treating disorders in animals, including humans, associated with dyslipidemia, including hyperlipidemia, hyperlipoproteinemia, hypertriglyceridemia, hypercholesterolemia, HDL deficiency, ApoA-I deficiency, cardiovascular disease, atherosclerosis, restenosis, and other disorders such as septic shock and viral infections.
摘要翻译： 本发明提供了使用非人动物载脂蛋白A-I（ApoA-I）蛋白治疗病症的方法和组合物。 本发明提供了用于治疗与血脂异常相关的动物（包括人）的疾病的方法和组合物，包括高脂血症，高脂蛋白血症，高甘油三酯血症，高胆固醇血症，HDL缺乏症，ApoA-I缺乏症，心血管疾病，动脉粥样硬化，再狭窄和其它疾病如败血性休克 和病毒感染。
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公开(公告)号：US20050004082A1
公开(公告)日：2005-01-06
申请号：US10893791
申请日：2004-07-16
申请人： Jean-Louis Dasseux , Carmen Oniciu
发明人： Jean-Louis Dasseux , Carmen Oniciu
IPC分类号： C07D233/74 , A61K31/08 , A61K31/6615 , A61P1/18 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/08 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/12 , A61P13/12 , A61P15/10 , A61P25/28 , A61P29/00 , A61P35/00 , A61P43/00 , C07C31/20 , C07C31/36 , C07C41/01 , C07C41/18 , C07C43/13 , C07C59/125 , C07C311/04 , C07C311/24 , C07D233/72 , C07F9/09 , A61K31/66 , A61K31/185 , A61K31/19
CPC分类号： C07D233/72 , C07C43/132 , C07C59/125 , C07C311/04 , C07F9/091 , Y10S514/866 , Y10S514/909
摘要： The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
摘要翻译： 本发明涉及新型醚化合物，包含醚化合物的组合物和用于治疗和预防心血管疾病，血脂异常，dysproteinemias和葡萄糖代谢紊乱的方法，包括施用包含醚化合物的组合物。 本发明的化合物，组合物和方法还可用于治疗和预防阿尔茨海默病，综合征X，过氧化物酶体增殖物激活受体相关病症，败血症，血栓形成障碍，肥胖症，胰腺炎，高血压，肾脏疾病，癌症，炎症和 阳。 在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。
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公开(公告)号：US20040082548A1
公开(公告)日：2004-04-29
申请号：US10656974
申请日：2003-09-05
IPC分类号： A61K031/66 , A61K031/365 , A61K031/366
CPC分类号： C07D233/72 , C07C43/132 , C07C59/125 , C07C311/04 , C07F9/091 , Y10S514/866 , Y10S514/909
摘要： The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
摘要翻译： 本发明涉及新型醚化合物，包含醚化合物的组合物和用于治疗和预防心血管疾病，血脂异常，dysproteinemias和葡萄糖代谢紊乱的方法，包括施用包含醚化合物的组合物。 本发明的化合物，组合物和方法还可用于治疗和预防阿尔茨海默病，综合征X，过氧化物酶体增殖物激活受体相关病症，败血症，血栓形成障碍，肥胖症，胰腺炎，高血压，肾脏疾病，癌症，炎症和 阳。 在某些实施方案中，本发明的化合物，组合物和方法可用于与其它治疗剂如降胆固醇和降血糖药物组合治疗。
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29.发明申请APOLIPOPROTEIN A-I AGONISTS AND THEIR USE TO TREAT DYSLIPIDEMIC DISORDERS 失效APOLIPOPROTEIN A-I AGONISTS及其用于治疗感染性疾病公开(公告)号：US20040029807A9
公开(公告)日：2004-02-12
申请号：US09865989
申请日：2001-05-25
IPC分类号： A61K038/10 , C07K007/08
CPC分类号： A61K38/10 , A61K38/16 , C07K14/775
摘要： The present invention provides peptides and peptide analogues that mimic the structural and pharmacological properties of human ApoA-I. The peptides and peptide analogues are useful to treat a variety of disorders associated with dyslipidemia.
摘要翻译： 本发明提供模拟人ApoA-I的结构和药理学性质的肽和肽类似物。 肽和肽类似物可用于治疗与血脂异常相关的各种障碍。
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公开(公告)号：US6090921A
公开(公告)日：2000-07-18
申请号：US912387
申请日：1997-08-15
申请人： Stefan Winge , Sara Wiklund
发明人： Stefan Winge , Sara Wiklund
IPC分类号： C07K14/755 , C07K14/775 , A61K35/14 , C07K3/02
CPC分类号： C07K14/775 , C07K14/755
摘要： The present invention relates to a process for purifying apolipoprotein A (ApoA) or apolipoprotein E (ApoE) from human plasma, by obtaining a fraction of human plasma containing said ApoA or ApoE, prepurifying said fraction in at least one step, binding said ApoA or ApoE to an anion-exchange chromatography gel, and thereafter eluting said ApoA or ApoE from said anion-exchange chromatography gel. The thus produced ApoA or ApoE can be used for the manufacture of a medicament in the treatment of atherosclerosis and cardiovascular diseases, or peripheral atherosclerosis and sepsis as well as in a method for treatment of atherosderosis and cardiovascular diseases, or peripheral atherosclerosis and sepsis when administered in a therapeutically effective amount.
摘要翻译： 本发明涉及通过获得含有所述ApoA或ApoE的人血浆级分来纯化来自人血浆的载脂蛋白A（ApoA）或载脂蛋白E（ApoE）的方法，在至少一个步骤中将所述级分预先完成，结合所述ApoA或 ApoE转移到阴离子交换色谱凝胶上，然后从所述阴离子交换色谱凝胶中洗脱所述ApoA或ApoE。 由此产生的ApoA或ApoE可用于制备治疗动脉粥样硬化和心血管疾病或外周动脉粥样硬化和败血症的药物，以及用于治疗动脉粥样硬化和心血管疾病或外周动脉粥样硬化和败血症的方法 治疗有效量。
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