公开(公告)号：US11351103B2

公开(公告)日：2022-06-07

申请号：US15783151

申请日：2017-10-13

Applicant: Johnson & Johnson Consumer Inc. ,  Fertin Pharma A/S

Inventor： Anthony R. Geonnotti ,  Patricia L. Golas ,  Helle Wittorff ,  Heidi Ziegler Bruun ,  Dorthe Shackinger Boesen

IPC: A61K8/60 ,  A61Q11/00 ,  A61K9/20 ,  A61K8/02 ,  A61K9/00

Abstract: Provided are methods of providing at least one oral care benefit by introducing a tablet into the oral cavity to generate a fluid and forcing at least a portion of fluid generated around the oral cavity, for example, by swishing, rinsing, washing, etc., to provide an oral care benefit.

公开(公告)号：US11260030B2

公开(公告)日：2022-03-01

申请号：US17344373

申请日：2021-06-10

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff

IPC: A61K9/20 ,  A61K9/00 ,  A61K31/734 ,  A61K31/165 ,  A61K31/43 ,  A61K31/606 ,  A61K31/708

Abstract: An oral tablet for delivery of active ingredients to the gastrointestinal tract includes a population of particles and an active ingredient to be delivered to the gastrointestinal tract. The population of particles includes directly compressible (DC) and non-directly compressible (non-DC) sugar alcohol particles, the non-DC particles providing the tablet with a plurality of discrete non-DC areas, and the non-DC areas resulting in induced saliva generation upon mastication of the tablet, wherein the tablet is designed to be masticated and designed to deliver the active ingredient to the gastrointestinal tract as part of the saliva generated upon mastication of the tablet.

公开(公告)号：US20210346263A1

公开(公告)日：2021-11-11

申请号：US17245330

申请日：2021-04-30

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff ,  Christine Nøhr Pedersen

IPC: A61K8/37 ,  A61Q11/00 ,  A61K8/02

Abstract: A mouthwash and method for oral care benefits includes a swishable powder delivery system having a content of at least two types of sugar alcohol particles with different particle size distributions and one or more active ingredients, the powder delivery system being a dry and flowable population of particles suitable for resembling a liquid mouthwash by swishing the powder delivery system, thereby generating fluid in the oral cavity without adding water.

公开(公告)号：US20210299052A1

公开(公告)日：2021-09-30

申请号：US17344373

申请日：2021-06-10

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff

IPC: A61K9/20 ,  A61K9/00 ,  A61K31/165 ,  A61K31/43 ,  A61K31/606 ,  A61K31/708 ,  A61K31/734

Abstract: An oral tablet for delivery of active ingredients to the gastrointestinal tract includes a population of particles and an active ingredient to be delivered to the gastrointestinal tract. The population of particles includes directly compressible (DC) and non-directly compressible (non-DC) sugar alcohol particles, the non-DC particles providing the tablet with a plurality of discrete non-DC areas, and the non-DC areas resulting in induced saliva generation upon mastication of the tablet, wherein the tablet is designed to be masticated and designed to deliver the active ingredient to the gastrointestinal tract as part of the saliva generated upon mastication of the tablet.

公开(公告)号：US11096896B2

公开(公告)日：2021-08-24

申请号：US15982810

申请日：2018-05-17

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff

IPC: A61K9/20 ,  A61K9/00 ,  A61K45/06 ,  A61K31/465

Abstract: The invention relates to a tablet dosage form for buccal absorption of active ingredients comprising a population of particles and an active ingredient to be released in the oral cavity for absorption through the oral mucosa, the population of particles comprising directly compressible (DC) and non-directly compressible (non-DC) sugar alcohol particles, the non-DC particles providing the tablet with a plurality of discrete non-DC areas.

公开(公告)号：US11058641B2

公开(公告)日：2021-07-13

申请号：US15982510

申请日：2018-05-17

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff

IPC: A61K9/56 ,  A61K9/20 ,  A61K9/00 ,  A61K31/522

Abstract: The invention relates to an oral tablet for taste masking of active ingredients, the tablet comprising a population of particles and an active ingredient with off-note taste, the population of particles comprising directly compressible (DC) and non-directly compressible (non-DC) sugar alcohol particles, the non-DC particles providing the tablet with a plurality of discrete non-DC areas, and the non-DC areas resulting at least partly in induced taste masking of the active ingredient upon mastication of the tablet.

公开(公告)号：US11058633B2

公开(公告)日：2021-07-13

申请号：US15982556

申请日：2018-05-17

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff

IPC: A61K9/56 ,  A61K9/00 ,  A61K9/20

Abstract: The invention relates to a disintegrating oral tablet suitable for active pharmaceutical ingredients comprising a population of particles and at least one flavor ingredient, the population of particles comprising directly compressible (DC) and non-directly compressible (non-DC) sugar alcohol particles, the non-DC particles providing the tablet with a plurality of discrete non-DC areas, and the non-DC areas resulting in a burst of the at least one flavor ingredient upon mastication of the tablet.

公开(公告)号：US20210169808A1

公开(公告)日：2021-06-10

申请号：US17039185

申请日：2019-05-15

Applicant: Fertin Pharma A/S

Inventor： Helle Wittorff

IPC: A61K9/20 ,  A61K9/00 ,  A61K31/465

Abstract: The invention relates to a tablet dosage form for buccal absorption of active ingredients comprising a population of particles and an active ingredient to be released in the oral cavity for absorption through the oral mucosa, the population of particles comprising directly compressible (DC) and non-directly compressible (non-DC) sugar alcohol particles, the non-DC particles providing the tablet with a plurality of discrete non-DC areas.

公开(公告)号：US20210106521A1

公开(公告)日：2021-04-15

申请号：US16599629

申请日：2019-10-11

Applicant: Fertin Pharma A/S

Inventor： Dorthe Schackinger Boesen ,  Heidi Ziegler Bruun ,  Bruno Provstgaard Nielsen ,  Kent Albin Nielsen ,  Rikke Pranger-Rasmussen

IPC: A61K9/00 ,  A61K31/465 ,  A61K47/26 ,  A61K47/32

Abstract: A water-dissolvable compressed oral nicotine lozenge is disclosed, the oral nicotine lozenge comprising a first module and a second module, the first and the second modules being fused by compression, the first module being a lozenge module comprising at least one sugar alcohol and the second module being an FDT-module comprising at least one sugar alcohol and nicotine. Also, a method of manufacturing a water-dissolvable compressed oral nicotine lozenge is disclosed.

公开(公告)号：US10251426B2

公开(公告)日：2019-04-09

申请号：US15516324

申请日：2014-10-03

Applicant: FERTIN PHARMA A/S

Inventor： Bruno Provstgaard Nielsen

IPC: A24F47/00

Abstract: An electronic nicotine delivery system (ENDS) is disclosed, said electronic nicotine delivery system (ENDS) comprising a mouth piece (MP), an atomizer arrangement (AA), a power supply (PS), a nicotine container (NC), an additive container (AC), the atomizer arrangement (AA) comprising an inlet (NCI) from the nicotine container (NC) and an inlet (ACI) from the additive container (AC), the atomizer arrangement (AA) comprising two separate atomizers, a first atomizer (FA) and a second atomizer (SA), the first atomizer producing nicotine-containing aerosols having a first mass median aerodynamic diameter (FMMAD) and the second atomizer producing additive-containing aerosols having a second mass median aerodynamic diameter (SMMAD) and wherein the second mass median aerodynamic diameter (SMMAD) is greater than the first mass median aerodynamic diameter (FMMAD), the atomizers being electrically connected to the power supply (PS). Furthermore, a method of producing a mixture of aerosols, an aerosol mixture and a use of an electronic nicotine delivery system (ENDS) is disclosed.