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公开(公告)号：US09572807B2
公开(公告)日：2017-02-21
申请号：US14740070
申请日：2015-06-15
申请人： NEURALSTEM, INC.
发明人： Karl K. Johe
IPC分类号： A61K31/496 , A61K31/444
CPC分类号： A61K31/496 , A61K31/444
摘要： Although it is known that certain benzylpiperazine-aminopyridines or open chain forms thereof are effective in stimulating neural growth in in vitro tests, it has now been surprisingly found that administering these compounds in a dosage range of 10 mg/day-130 mg/day over 25-35 days is effective in treating Major Depressive Disorder (MDD) such that statistically significant results can be obtained with samples of only six subjects.
摘要翻译： 尽管已知某些苄基哌嗪 - 氨基吡啶或其开链形式在体外试验中刺激神经生长是有效的，但是现在已经令人惊奇地发现，以10mg /天-131mg /天的剂量范围施用这些化合物， 25-35天有效治疗重度抑郁症（MDD），使得只有6名受试者的样本可获得统计学显着的结果。
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公开(公告)号：US08674098B2
公开(公告)日：2014-03-18
申请号：US13744220
申请日：2013-01-17
申请人： Neuralstem, Inc.
IPC分类号： C07D471/00 , C07D211/32
CPC分类号： C07D239/48 , A61K31/437 , A61K31/4545 , A61K31/4985 , A61K31/505 , A61K35/12 , C07D239/49 , C07D471/04 , C07D487/04 , G01N33/5008 , G01N33/5058 , G01N33/5073 , G01N33/6896
摘要： Compositions containing neurogenic agents for inhibition of neuron death and inducing proliferation of neural cells are disclosed.
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公开(公告)号：US08460651B2
公开(公告)日：2013-06-11
申请号：US12404841
申请日：2009-03-16
IPC分类号： A01N63/00
CPC分类号： A61K35/30 , A61K9/0085 , C12N5/0623 , C12N2501/11 , C12N2501/113 , C12N2501/115 , C12N2501/148
摘要： The invention relates generally to methods of treating spasticity, rigidity, or muscular hyperactivity conditions by introducing a portion of an expanded population of neural stem cells into an area of a recipient spinal cord.
摘要翻译： 本发明一般涉及通过将一部分扩大的神经干细胞群引入受体脊髓的区域来治疗痉挛，僵硬或肌肉过度活动的方法。
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公开(公告)号：US08293488B2
公开(公告)日：2012-10-23
申请号：US11852922
申请日：2007-09-10
IPC分类号： G01N33/567
CPC分类号： G01N33/5058
摘要： A method for discovering neurogenic drugs is revealed. The method allows for systematic screening of test agents such as libraries of compounds. The method consists of exposing test agents to cultures of differentiating neural progenitor cells and measuring their effects on increasing the overall cell number and/or the number of neurons.
摘要翻译： 揭示了一种发现神经源性药物的方法。 该方法允许对诸如化合物文库的试剂进行系统筛选。 该方法包括将测试试剂暴露于分化神经祖细胞的培养物，并测量它们对增加总细胞数量和/或神经元数量的影响。
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公开(公告)号：US07858628B2
公开(公告)日：2010-12-28
申请号：US12500073
申请日：2009-07-09
IPC分类号： A61K31/497 , A61K31/44
CPC分类号： C07D239/48 , A61K31/437 , A61K31/4545 , A61K31/4985 , A61K31/505 , A61K35/12 , C07D239/49 , C07D471/04 , C07D487/04 , G01N33/5008 , G01N33/5058 , G01N33/5073 , G01N33/6896
摘要： The present invention provides a group of compounds found to increase the number of neurons derived from stem cells for use as a therapeutic agent in neurological conditions or diseases. In one embodiment of the present invention, the compounds are used to detect the mechanism by which the number of neurons is increased.
摘要翻译： 本发明提供一组化合物，其用于增加在干细胞中衍生的神经元数量，以用作神经病症或疾病中的治疗剂。 在本发明的一个实施方案中，化合物用于检测神经元数量增加的机制。
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公开(公告)号：US20100034784A1
公开(公告)日：2010-02-11
申请号：US12500073
申请日：2009-07-09
IPC分类号： A61K35/12 , A61K31/497 , A61K31/444
CPC分类号： C07D239/48 , A61K31/437 , A61K31/4545 , A61K31/4985 , A61K31/505 , A61K35/12 , C07D239/49 , C07D471/04 , C07D487/04 , G01N33/5008 , G01N33/5058 , G01N33/5073 , G01N33/6896
摘要： The present invention provides a group of compounds found to increase the number of neurons derived from stem cells for use as a therapeutic agent in neurological conditions or diseases. In one embodiment of the present invention, the compounds are used to detect the mechanism by which the number of neurons is increased.
摘要翻译： 本发明提供一组化合物，其用于增加在干细胞中衍生的神经元数量，以用作神经病症或疾病中的治疗剂。 在本发明的一个实施方案中，化合物用于检测神经元数量增加的机制。
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公开(公告)号：US10702555B2
公开(公告)日：2020-07-07
申请号：US15624959
申请日：2017-06-16
申请人： Neuralstem, Inc.
发明人： Thomas Hazel , Karl K. Johe
IPC分类号： C12N5/22 , A61K35/30 , A61K38/30 , C12N5/0797 , C12N5/079 , C12N5/10 , A61K48/00 , C07K14/65
摘要： The present disclosure provides a human neural stem cell comprising an exogenous polynucleotide coding for a growth factor such as IGF-1. Also disclosed are methods of using the human neural stem cells for the treatment of neurodegenerative diseases or disorders including, for example, ALS.
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公开(公告)号：US10413534B2
公开(公告)日：2019-09-17
申请号：US15895881
申请日：2018-02-13
申请人： NEURALSTEM, INC.
发明人： Karl K. Johe
IPC分类号： A61K31/444 , A61K31/496 , A61P25/28 , A61K9/00
摘要： Motor skill deficits and cognitive deficits associated with stroke and secondary neuronal cell death are ameliorated by treatment with pharmaceutically acceptable salts of 2-amino substituted nicotinamides.
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公开(公告)号：US10286010B2
公开(公告)日：2019-05-14
申请号：US15661281
申请日：2017-07-27
IPC分类号： C12N5/0735 , A61K35/30 , C12N5/0797 , A61K9/00
摘要： The invention relates generally to methods of treating spasticity, rigidity, or muscular hyperactivity conditions by introducing a portion of an expanded population of neural stem cells into an area of a recipient spinal cord.
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公开(公告)号：US09744194B2
公开(公告)日：2017-08-29
申请号：US14954105
申请日：2015-11-30
IPC分类号： A61K35/30 , C12N5/0797 , A61K9/00
CPC分类号： A61K35/30 , A61K9/0085 , C12N5/0623 , C12N2501/11 , C12N2501/113 , C12N2501/115 , C12N2501/148
摘要： The invention relates generally to methods of treating spasticity, rigidity, or muscular hyperactivity conditions by introducing a portion of an expanded population of neural stem cells into an area of a recipient spinal cord.
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