公开(公告)号：US07835493B2

公开(公告)日：2010-11-16

申请号：US12187222

申请日：2008-08-06

Applicant: Paul J. Keall ,  Yelin Suh ,  Elisabeth Weiss

Inventor： Paul J. Keall ,  Yelin Suh ,  Elisabeth Weiss

IPC: A61N5/10 ,  H05G1/08

CPC classification number: A61N5/1042 ,  A61N5/1036 ,  A61N5/1037

Abstract: A deliverable four dimensional (4D) intensity modulated radiation therapy (IMRT) planning method is disclosed, for delivery using a linear accelerator with a dynamic multi-leaf collimator (DMLC). A 4D computed tomography (CT) scan is used for segmenting tumor anatomy on a reference phase of periodic motion of the tumor. Deformable registration of the 4D CT data is used to generate corresponding anatomical structures on other phases. Preferably, the collimator for each beam position is aligned using the gross tumor volume (GTV) centroid motion corresponding to the periodic motion of the tumor, as determined from the two dimensional (2D) projection of a given beam position. A deliverable IMRT plan is created on the 4D CT image set in which the MLC leaf positions and beam on/off status can vary as a function of respiratory phase by solving a four dimensional optimization problem. The mechanical constraints of the MLC leaves are included in the optimization.

Abstract translation: 公开了一种可交付的四维（4D）强度调制放射治疗（IMRT）规划方法，用于使用具有动态多叶准直器（DMLC）的线性加速器的传送。 4D计算机断层扫描（CT）扫描用于在肿瘤周期性运动的参考期分割肿瘤解剖。 4D CT数据的变形注册用于在其他阶段产生相应的解剖结构。 优选地，根据给定束位置的二维（2D）投影确定，使用与肿瘤的周期性运动相对应的肿瘤总体积（GTV）质心运动来对准每个束位置的准直器。 在4D CT图像集上创建可交付的IMRT计划，其中MLC叶位置和束开/关状态可以通过解决四维优化问题作为呼吸相位的函数而变化。 MLC叶片的机械约束包括在优化中。

公开(公告)号：US20100046713A1

公开(公告)日：2010-02-25

申请号：US12196639

申请日：2008-08-22

Applicant: Janne Ilmari Nord ,  Sami Pekka Siljamaki ,  Tuomas Erik Torsti

Inventor： Janne Ilmari Nord ,  Sami Pekka Siljamaki ,  Tuomas Erik Torsti

IPC: G21K1/04 ,  H01J35/08

CPC classification number: A61N5/1042 ,  A61N5/1036 ,  G21K1/046

Abstract: A method of providing intensity modulated radiation therapy to a moving target is disclosed. The target moves periodically along a trajectory that is projected onto a multi-leaf collimator (MLC) plane. The MLC plane is divided into thin slices parallel to the movement of the target. The present invention optimizes the leaf sequence such that, within each slice, if a point receives radiation, all other points in that slice that receive the same amount or more fluence are also receiving radiation at the same time.

Abstract translation: 公开了一种向移动目标提供强度调制辐射治疗的方法。 目标沿着投影到多叶准直器（MLC）平面上的轨迹周期性移动。 MLC平面分为平行于目标运动的薄片。 本发明优化叶子序列，使得在每个切片内，如果点接收辐射，则该切片中接收相同量或更多注量的所有其它点也同时接收辐射。

公开(公告)号：US20080013687A1

公开(公告)日：2008-01-17

申请号：US11731145

申请日：2007-03-30

Applicant: Calvin Maurer ,  Jay West ,  John Allison

Inventor： Calvin Maurer ,  Jay West ,  John Allison

IPC: G21K1/00

CPC classification number: A61N5/103 ,  A61N5/1036 ,  A61N5/1042 ,  G21K1/046

Abstract: Systems and methods for automatically determining a beam parameter at each of a plurality of treatment nodes are disclosed. The beam parameter may include a beam shape, beam size and/or beam orientation. Systems and methods for automatically selecting multiple collimators in a radiation treatment system are also disclosed.

Abstract translation: 公开了用于在多个处理节点中的每一个处自动确定波束参数的系统和方法。 光束参数可以包括光束形状，光束尺寸和/或光束取向。 还公开了用于在辐射处理系统中自动选择多个准直器的系统和方法。

公开(公告)号：US20070086569A1

公开(公告)日：2007-04-19

申请号：US11249619

申请日：2005-10-13

Applicant: Stanley Johnsen

Inventor： Stanley Johnsen

IPC: A61N5/10

CPC classification number: A61N5/103 ,  A61N5/1036 ,  A61N5/1042

Abstract: A method of using a radiation system having a multileaf collimator (“MLC”) to adjust for unevenness in the radiation emitted by the system is disclosed. By appropriately controlling the MLC in accordance with the invention the system can be operated without a flattening filter. In addition, the invention allows the system user to vary the radiation beam energy in the course of a single treatment, without the need to use or change flattening filters. A map of the uneven radiation beam intensity in the treatment area is obtained, and the map information is combined with a treatment plan to control movement of the leaves of the MLC such that each area receives the correct radiation dose.

公开(公告)号：US07085348B2

公开(公告)日：2006-08-01

申请号：US10736023

申请日：2003-12-15

Applicant: Srijit Kamath ,  Sartaj Sahni ,  Jantinder Palta ,  Sanjay Ranka ,  Jonathan G. Li

Inventor： Srijit Kamath ,  Sartaj Sahni ,  Jantinder Palta ,  Sanjay Ranka ,  Jonathan G. Li

IPC: A61N5/10

CPC classification number: A61N5/103 ,  A61N5/1036 ,  A61N5/1042

Abstract: A method of delivering radiation treatment using multi-leaf collimation includes the step of providing a radiation fluence map which includes an intensity profile. The fluence map is converted into a preliminary leaf sequence, wherein the preliminary leaf sequence minimizes machine on-time and is generated without leaf movement constraints. The leaf movement constraint is imposed on the preliminary leaf sequence. At least one constraint elimination algorithm is then applied, the algorithm adjusting the preliminary leaf sequence to minimize violations of the constraint while providing the desired fluence map and minimized radiation on-time. The method can be applied to SMLC and DLMC systems, and can include adjustment for the tongue-and-groove effect.

Abstract translation: 使用多叶准直进行放射治疗的方法包括提供包括强度分布的辐射注量图的步骤。 注量图被转换成初步的叶子序列，其中初步叶子序列使机器准时最小化，并且不产生叶片运动限制。 叶片运动约束对初步叶序列施加。 然后应用至少一个约束消除算法，该算法调整初步叶序列以最小化对约束的违反，同时提供期望的通量图和最小化的辐射on-time。 该方法可以应用于SMLC和DLMC系统，并且可以包括对榫槽效应的调整。

公开(公告)号：US06907105B2

公开(公告)日：2005-06-14

申请号：US10253781

申请日：2002-09-25

Applicant: Karl Otto

Inventor： Karl Otto

IPC: A61N5/10 ,  G21K1/04

CPC classification number: G21K1/046 ,  A61N5/103 ,  A61N5/1036 ,  A61N5/1042

Abstract: A method and system for controlling the spatial distribution of radiation produced by a radiation device having a multi-leaf collimator can generate arbitrary intensity-modulated radiation fields. The methods control both angles and leaf configuration of the multi-leaf collimator for each of multiple sub-fields. The leaf positions, collimator angles, and individual sub-field contributions may be derived by optimization techniques.

Abstract translation: 用于控制由具有多叶准直器的辐射装置产生的辐射的空间分布的方法和系统可以产生任意强度调制的辐射场。 该方法控制多个子场中的每一个的多叶准直器的角度和叶子配置。 叶位置，准直器角度和单个子场贡献可以通过优化技术得到。

公开(公告)号：US06661871B2

公开(公告)日：2003-12-09

申请号：US09967673

申请日：2001-09-28

Applicant: Ramon Alfredo Carvalho Siochi

Inventor： Ramon Alfredo Carvalho Siochi

IPC: A61N510

CPC classification number: A61N5/1031 ,  A61N5/1036 ,  A61N5/1042

Abstract: A system and method of the present invention for controlling radiation delivery from a radiation source to an object are disclosed. The method generally includes defining a field on the object for radiation delivery. The field includes a plurality of cells, each having a defined treatment intensity level. The cells are grouped to form a matrix having at least one dimension approximately equal to a width of a collimator leaf capable of blocking radiation emitted from the radiation source. The method further includes decomposing the matrix into orthogonal matrices and optimizing delivery of the radiation by selecting a combination of orthogonal matrices to minimize junction effects.

公开(公告)号：US06314159B1

公开(公告)日：2001-11-06

申请号：US09457602

申请日：1999-12-08

Applicant: Ramon Alfredo Carvalho Siochi

Inventor： Ramon Alfredo Carvalho Siochi

IPC: A61N510

CPC classification number: A61N5/1042 ,  A61N5/1036

Abstract: A method for controlling radiation delivery from a radiation source to an object is disclosed. The method includes defining a field on the object for radiation delivery. The field includes a plurality of cells, each cell having a defined treatment intensity level. The cells are grouped to form a matrix having at least one dimension approximately equal to a width of a collimator leaf capable of blocking radiation emitted from the radiation source. The method further includes decomposing the matrix into orthogonal matrices and optimizing delivery of the radiation by selecting the orthogonal matrices having minimum vertical and horizontal gradients when combined with adjacent cells. A system for controlling radiation delivery from a radiation source to an object is also disclosed.

Abstract translation: 公开了一种用于控制从辐射源到物体的辐射传递的方法。 该方法包括定义用于辐射传送的物体上的场。 该场包括多个单元，每个单元具有确定的处理强度水平。 细胞被分组以形成具有至少一个尺寸的矩阵，该尺寸近似等于能够阻挡从辐射源发射的辐射的准直仪叶片的宽度。 所述方法还包括：当将所述矩阵分解为正交矩阵并且通过在与相邻小区组合时选择具有最小垂直和水平梯度的正交矩阵来优化辐射传递。 还公开了一种用于控制从辐射源到物体的辐射传递的系统。

公开(公告)号：US12053647B2

公开(公告)日：2024-08-06

申请号：US17056477

申请日：2019-05-24

Applicant: RaySearch Laboratories AB

Inventor： Rasmus Bokrantz

IPC: A61N5/10

CPC classification number: A61N5/1036 ,  A61N5/1047

Abstract: Automatic radiation therapy treatment planning for generating a plan to be delivered from at least one beam angle, using a collimator having a variable collimator angle. Delivery times are determined for a number of possible collimator angles, and the optimization problem is defined to take the delivery times into account when selecting the collimator angles to be used when delivering the radiation.

公开(公告)号：US20240173568A1

公开(公告)日：2024-05-30

申请号：US18480900

申请日：2023-10-04

Applicant: RefleXion Medical, Inc.

Inventor： Debashish PAL ,  Ayan MITRA ,  Christopher Eric BROWN ,  Peter Demetri OLCOTT ,  Yevgen VORONENKO ,  Rostem BASSALOW

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N5/1001 ,  A61N5/1045 ,  A61N5/1049 ,  A61N5/1065 ,  A61N5/1067 ,  A61N5/1069 ,  A61N5/107 ,  A61N5/1081 ,  A61N2005/1019 ,  A61N5/1036 ,  A61N5/1039 ,  A61N2005/1041 ,  A61N5/1075

Abstract: Systems and methods for shuttle mode radiation delivery are described herein. One method for radiation delivery comprises moving the patient platform through the patient treatment region multiple times during a treatment session. This may be referred to as patient platform or couch shuttling (i.e., couch shuttle mode). Another method for radiation delivery comprises moving the therapeutic radiation source jaw across a range of positions during a treatment session. The jaw may move across the same range of positions multiple times during a treatment session. This may be referred to as jaw shuttling (i.e., jaw shuttle mode). Some methods combine couch shuttle mode and jaw shuttle mode. Methods of dynamic or pipelined normalization are also described.