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    Intermediates and process for the production of optically active quinolonecarboxylic acid derivatives
    22.
    发明授权
    Intermediates and process for the production of optically active quinolonecarboxylic acid derivatives 失效
    用于制备光学活性喹诺酮羧酸衍生物的中间体和方法

    公开(公告)号：US07915418B2

    公开(公告)日：2011-03-29

    申请号：US10559499

    申请日：2004-06-04

    申请人： Makoto Muto ,  Manabu Miura ,  Yutaka Kitagawa

    发明人： Makoto Muto ,  Manabu Miura ,  Yutaka Kitagawa

    IPC分类号： C07D215/38

    CPC分类号： C07D215/56 ,  A01N43/42 ,  C07C51/00 ,  C07C65/21 ,  C07C225/16 ,  C07C255/43 ,  C07C2601/02 ,  C07D215/54

    摘要： Provision of a commercially advantageous method for producing an intermediate which is important for producing the antibacterial and which has a mother nucleus common to the antibacterial, and intermediates produced by such method.A method for producing a compound represented by formula (VI): which comprises the steps of treating a compound represented by formula (IV): with a base in the presence of a base to produce a compound represented by formula (V): and hydrolyzing this compound; a compound represented by formula (II): a compound represented by formula (Ia): a compound represented by formula (V): and a compound represented by formula (VI).

    摘要翻译： 提供一种商业上有利的生产中间体的方法，其对于生产抗菌剂是重要的，并且具有抗细菌共有的母核和通过这种方法制备的中间体。 一种制备由式（VI）表示的化合物的方法：其包括在碱的存在下用碱处理式（IV）表示的化合物以制备由式（V）表示的化合物的步骤：水解 这种化合物 由式（II）表示的化合物：由式（Ia）表示的化合物：由式（V）表示的化合物和由式（VI）表示的化合物。

    Process for Production of Optically Active Benzylamine Derivatives
    25.
    发明申请
    Process for Production of Optically Active Benzylamine Derivatives 审中-公开
    光活性苄胺衍生物的制备方法

    公开(公告)号：US20100081845A1

    公开(公告)日：2010-04-01

    申请号：US11993821

    申请日：2006-06-20

    申请人： Teruaki Sugiyama ,  Akinori Fujishima ,  Atsushi Umetani ,  Nobutaka Matsunaga ,  Yoshiyuki Omori ,  Norihiko Seko

    发明人： Teruaki Sugiyama ,  Akinori Fujishima ,  Atsushi Umetani ,  Nobutaka Matsunaga ,  Yoshiyuki Omori ,  Norihiko Seko

    IPC分类号： C07C221/00

    CPC分类号： C07B55/00 ,  C07B57/00 ,  C07C221/00 ,  C07C225/16

    摘要： A benzylamine derivative has a structure represented by the following formula (1): In a method for optical resolution of the benzylamine derivative, optically active mandelic acid is used as an optical resolving agent. In an optical resolution step in a production method of the optically active benzylamine derivative, an optically active (S)-benzylamine derivative represented by the formula (3) is precipitated as (S)-mandelic acid salt from a solution containing the benzylamine derivative and (S)-mandelic acid: wherein Ar represents an aryl group that has 6 to 15 carbon atoms and may have a substituent, and *1 represents an asymmetric carbon atom.

    摘要翻译： 苄胺衍生物具有由下式（1）表示的结构：在用于光学拆分苄胺衍生物的方法中，使用光学活性扁桃酸作为光学拆分剂。 在光学活性苄胺衍生物的制造方法中的光学拆分工序中，将由式（3）表示的光学活性（S） - 苄基胺衍生物从含有苄胺衍生物的溶液中析出为（S） - 扁桃酸盐， （S） - 扁桃酸：其中Ar表示具有6至15个碳原子并可以具有取代基的芳基，* 1表示不对称碳原子。