公开(公告)号：US20220323528A1

公开(公告)日：2022-10-13

申请号：US17807798

申请日：2022-06-20

申请人： CARGILL, INCORPORATED

发明人： Dan S. GASPARD ,  Adam T. ZARTH

IPC分类号： A61K36/28 ,  A23L2/56 ,  A23L2/60 ,  C07H15/256 ,  C07K1/18 ,  C07K1/16 ,  A23L27/30 ,  A23L2/68 ,  A23L27/00 ,  A23L5/40 ,  A23F3/34 ,  A61K31/192 ,  A61K31/235 ,  B01D15/36

摘要： A solubilized steviol glycoside composition including one or more steviol glycosides and one or more steviol glycoside solubility enhancers can be used as a sweetener composition to sweeten other compositions (sweetenable compositions) such as foods, beverages, medicines, oral hygiene compositions, pharmaceuticals, nutraceuticals, and the like.

公开(公告)号：US20220313646A1

公开(公告)日：2022-10-06

申请号：US17627391

申请日：2020-07-13

申请人： Rush University Medical Center

发明人： Kalipada Pahan

IPC分类号： A61K31/235 ,  A61K9/00 ,  A61K47/24 ,  A61P25/28

摘要： The present disclosure generally relates to improved pharmaceutical compositions useful for the treatment of diseases and disorders. More particularly, the disclosure relates to pharmaceutical compositions comprising glyceryl tribenzoate and/or glyceryl dibenzoate for the treatment of neurodegenerative disorders and peripheral diseases.

公开(公告)号：US20220304958A1

公开(公告)日：2022-09-29

申请号：US17611036

申请日：2020-06-04

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  THE UNIVERSITY OF NEW MEXICO

发明人： Alexandre GINGRAS ,  Mark GINSBERG, ,  Carlo BALLATORE ,  Larry SKLAR ,  Karol Rogelle Karagdag FRANCISCO

IPC分类号： A61K31/166 ,  A61K31/196 ,  A61K31/41 ,  A61K31/4196 ,  A61K31/4406 ,  A61K31/245 ,  A61K31/44 ,  A61K31/135 ,  A61K31/423 ,  A61K31/472 ,  A61K31/235 ,  A61K31/05 ,  A61K31/192 ,  A61K31/337 ,  A61K31/085 ,  A61K31/095 ,  A61K31/10 ,  A61K31/055 ,  A61K31/121 ,  A61K31/451 ,  A61K31/136 ,  A61K31/397 ,  A61K31/222 ,  A61K31/137 ,  A61K31/381 ,  A61K31/11 ,  A61P9/14 ,  C07C251/24 ,  C07D249/14 ,  C07D257/06 ,  C07D213/74 ,  C07C229/56 ,  C07C233/81 ,  C07C251/48 ,  C07D261/20 ,  C07D217/16 ,  C07C215/50 ,  C07C65/19 ,  C07C65/105 ,  C07D305/08 ,  C07C317/22 ,  C07C39/38 ,  C07C49/83 ,  C07D295/112 ,  C07D205/08 ,  C07C69/738 ,  C07C255/56 ,  C07C47/575 ,  C07D333/22

摘要： Compositions and methods for treating thrombosis, inflammation, and atherosclerosis by administration of a compound that binds to KRIT1 to inhibit binding with HEG1.

公开(公告)号：US20220175713A1

公开(公告)日：2022-06-09

申请号：US17442351

申请日：2020-03-24

申请人： SOCIETE DES PRODUITS NESTLE S.A.

发明人： Denis Marcel Barron ,  Benjamin Brinon ,  Jerome Feige ,  Sonia Karaz ,  Joris Michaud ,  Yann Ratinaud ,  Pascal Stuelsatz

IPC分类号： A61K31/235 ,  A23K20/111 ,  A23K50/40 ,  A23L33/10 ,  A61K45/06 ,  A61P21/06

摘要： The present invention relates to novel depside trimeric compounds for improving skeletal muscle plasticity regeneration to maintain or increase muscle function and/or muscle mass by modulating muscle stem cells. For example, the present invention is useful for subjects to promote muscle repair and/or subjects suffering from precachexia, cachexia, sarcopenia, myopathy, dystrophy and/or recovery after muscle injury or surgery.

公开(公告)号：US11344525B2

公开(公告)日：2022-05-31

申请号：US16896243

申请日：2020-06-09

申请人： University of Mississippi

发明人： Mahmoud A. ElSohly ,  Soumyajit Majumdar ,  Waseem Gul ,  Mohammad Khalid Ashfaq ,  Kenneth Joseph Sufka ,  Hannah Marie Harris

IPC分类号： A61K31/27 ,  A61K31/235 ,  A61K31/24 ,  C07C69/40 ,  C07C69/42 ,  C07C229/08 ,  A61K31/05 ,  A61K31/223 ,  A61K31/225 ,  C07C233/56 ,  C07C69/017 ,  C07C229/24 ,  C07C233/47 ,  C07C237/06

摘要： Biologically active cannabidiol analogs comprising a compound of the formula wherein one of R1 or R2 or both is/are the residue of a moiety formed by the reaction of an amino group of the amino acid ester of R1 or R2 or both with a dicarboxylic acid or a dicarboxylic acid derivative and the other R1 or R2 (in the case of the mono) is the residue of a dicarboxylic acid or dicarboxylic acid derivative or Hydrogen (H), (i.e. underivatized), and salts thereof. These CBD analogs are be useful in pain management in oncology and other clinical settings in which neuropathy is presented. Furthermore, these CBD-analogs are useful in blocking the addictive properties of opiates.

公开(公告)号：US20220152228A1

公开(公告)日：2022-05-19

申请号：US17432733

申请日：2020-03-01

申请人： Washington University ,  Cornell University

发明人： Daniel THOREK ,  Diane ABOU ,  Justin WILSON ,  Nikki THIELE

IPC分类号： A61K51/04 ,  A61K51/08 ,  A61K51/10 ,  A61K31/415 ,  A61K31/4965 ,  A61K31/18 ,  A61K31/496 ,  A61K31/196 ,  A61K31/4725 ,  A61K31/235 ,  A61K31/4166 ,  A61K31/4422 ,  A61K31/365 ,  A61P39/04 ,  A61P35/00

摘要： Among the various aspects of the present disclosure is the provision of compositions of isotope-ligand complexes, methods of use thereof, and methods of chelating isotopes. The present disclosure also provides for methods for modulating ion channel transportation of radiopharmaceuticals. For example, the inhibition of radiopharmaceutical transport comprises administering an ion channel transport modulating or inhibiting agent (e.g., a calcium channel inhibitor) in an amount effective to inhibit gastrointestinal uptake.

公开(公告)号：US20220062281A1

公开(公告)日：2022-03-03

申请号：US17268440

申请日：2019-08-13

申请人： NATIONAL CENTRE FOR BIOLOGICAL SCIENCES-TIFR ,  CENTRE FOR CELLULAR AND MOLECULAR PLATFORMS NCBS-TIFR ,  INDIAN INSTITUTE OF INTEGRATIVE MEDICINE ,  INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY

发明人： Satyajit MAYOR ,  Akankshi MUNJAL ,  Taslimarlf SAIYED ,  Anandl KARUMBATl ,  Ram Aysre VISHWAKARMA ,  Parvinder Pal SINGH ,  Shweta SHARMA ,  Gurunadham MUNAGALA ,  Kushalava Reddy YEMPALLA ,  Srinivas AMBALA ,  Shahid JAMEEL ,  Satyajit RATH

IPC分类号： A61K31/506 ,  A61K31/5377 ,  A61K31/167 ,  A61K31/235 ,  A61K31/192 ,  A61K31/4245 ,  A61K31/421 ,  A61K31/27 ,  A61P31/18

摘要： The compounds of Formula I, II, and III along with their stereoisomers, pharmaceutically acceptable salts, polymorphs, solvates and hydrates thereof are described in the present disclosure. The said compounds restore immune activation in case of infections or a disease associated with an HIV infection in a subject in need thereof.

公开(公告)号：US11241410B2

公开(公告)日：2022-02-08

申请号：US16945600

申请日：2020-07-31

申请人： Amanuel Tesfazion ,  Lydia Seifu ,  Meried Bezuneh

发明人： Amanuel Tesfazion ,  Lydia Seifu ,  Meried Bezuneh

IPC分类号： A61K31/235

摘要： A method for the treatment of a coronavirus disease, including administering to a subject in need thereof of an anti-pathogenic compound, such that the anti-pathogenic compound is derived from an herbal extract.

公开(公告)号：US20220016075A1

公开(公告)日：2022-01-20

申请号：US17375403

申请日：2021-07-14

申请人： University of South Florida

发明人： Bill J. Baker ,  Kyle Rohde ,  Bingjie Yang ,  Marisa Fuse

IPC分类号： A61K31/366 ,  A61K31/192 ,  A61K31/235 ,  A61K31/343 ,  A61K31/365 ,  A61K31/352 ,  A61K31/12 ,  A61K31/472 ,  A61K31/4015 ,  A61P31/06 ,  A61K31/4409 ,  A61K31/496 ,  A61K31/7036 ,  A61K31/145 ,  A61K31/454 ,  A61K31/4045 ,  A61K31/505 ,  A61K31/44 ,  A61K31/133 ,  A61K31/498

摘要： The present disclosure provides methods for the treatment of infections with Mycobacterium such as tuberculosis or leprosy.

公开(公告)号：US20220015338A1

公开(公告)日：2022-01-20

申请号：US17293991

申请日：2019-11-12

申请人： ZHUHAI QIWEI BIO-TECHNOLOGY LTD.

发明人： Yan ZHANG ,  Lai WEI ,  Hui OUYANG

IPC分类号： A01K67/00 ,  C12N1/20 ,  G01N33/50 ,  A61K31/12 ,  A61K31/085 ,  A61K31/235 ,  A61K31/437 ,  A61K31/704

摘要： Provided herein are screening methods and animal models related to intraocular diseases such as age-related macular degeneration (AMD), for example, for identifying candidate therapeutics for treating or preventing eye diseases, such as AMD. Also provided herein are compounds/compositions that are useful for killing or inhibiting the growth of a microorganism, such as Bacillus megaterium. Further provided herein are methods of using the compounds/compositions for treating infections with a microorganism, such as Bacillus megaterium and for treating or preventing diseases or disorders associated with such infections, such as AMD.