公开(公告)号：US11633410B2

公开(公告)日：2023-04-25

申请号：US17236258

申请日：2021-04-21

申请人： Azura Ophthalmics Ltd.

发明人： Yair Alster ,  Omer Rafaeli ,  Kirsten Angela Macfarlane ,  Cary Reich ,  Shimon Amselem ,  Doron Friedman

IPC分类号： A61K8/23 ,  A61K31/60 ,  A61K33/04 ,  A61K9/00 ,  A61K31/327 ,  A61K9/06 ,  A61K31/122 ,  A61K31/17 ,  A61K31/19 ,  A61K31/4015 ,  A61K31/555 ,  A61K35/04 ,  A61K8/22

摘要： Described herein are compositions and methods for the treatment of meibomian gland dysfunction. Said compositions and methods comprise keratolytic agents, such as salicylic acid, selenium disulfide, or the like. Topical administration of said compositions to the eyelid margin or surrounding areas provides therapeutic benefit to patients suffering from meibomian gland dysfunction.

公开(公告)号：US20230120577A1

公开(公告)日：2023-04-20

申请号：US17957607

申请日：2022-09-30

申请人： Lynne Deupree Yancey

发明人： Lynne Deupree Yancey

IPC分类号： A61K36/185 ,  A61K31/352 ,  A61K31/05 ,  A61K31/60 ,  A61K9/00

摘要： The present disclosure provides a raw cannabis composition, the raw cannabis composition comprises a cannabis biomass dispersed in a transdermal carrier, and the cannabis biomass composition comprises an anesthetically effective amount of a cannabinoid acid compound and is substantially free from the cannabinoid acid compound in its decarboxylated form. The cannabinoid acid compound comprises a major cannabinoid acid compound that is tetrahydrocannabinolic acid (“THCA”) and a minor cannabinoid acid compound other than THCA. Methods of making and using the raw cannabis composition are also disclosed.

公开(公告)号：US20230115784A1

公开(公告)日：2023-04-13

申请号：US18064676

申请日：2022-12-12

申请人： Dermala, Inc.

发明人： Lada RASOCHOVA ,  Michelle KEM

IPC分类号： A61K31/60 ,  A61P17/10 ,  A61K9/00 ,  A61K9/06 ,  A61K9/70 ,  A61K31/194 ,  A61K31/20 ,  A61K31/327 ,  A61K31/4402 ,  A61K33/30 ,  A61K35/745 ,  A61K35/747 ,  A61K36/752 ,  A61K36/886 ,  A61K45/06 ,  A61K47/44 ,  A61K47/10 ,  A61K8/36 ,  A61K8/362 ,  A61Q19/00

摘要： Disclosed are compositions, methods of treatment using the compositions and methods of preparing the compositions for the treatment of acne vulgaris. The compositions include succinic acid and an API selected from the group consisting of salicylic acid, azelaic acid, picolinic acid, benzoyl peroxide, antibiotic, retinoid and combinations thereof in a pharmaceutically acceptable preparation. The compositions that include the combination of succinic acid and another API produce improved efficacy in treating acne vulgaris.

公开(公告)号：US20230111238A1

公开(公告)日：2023-04-13

申请号：US17945010

申请日：2022-09-14

申请人： Nulixir Inc.

发明人： Ehsan Moaseri

IPC分类号： A61K9/51 ,  A61K36/28 ,  A61K36/67 ,  A61K36/53 ,  A61K36/9068 ,  A61K36/258 ,  A61K36/54 ,  A61K36/481 ,  A61K36/07 ,  A61K36/16 ,  A61K36/88 ,  A61K31/05 ,  A61K31/352 ,  A61K31/60 ,  A61K31/343 ,  A61K31/4458 ,  A61K31/137 ,  A61K31/522 ,  A61K31/465 ,  A61K31/165 ,  A61K36/37 ,  A61K31/4025 ,  A61K31/13 ,  A61K36/23

摘要： Provided is a composition, including: an aqueous suspension, comprising: a first plurality of active ingredients, and one or more nanoparticles, wherein: the one or more nanoparticles encapsulate a second plurality of active ingredients; the second plurality of active ingredients are insoluble in the aqueous suspension; the one or more nanoparticles solubilize the second plurality of active ingredients in the aqueous suspension; and the one or more nanoparticles have a Z-average diameter between 50 to 950 nanometers.

公开(公告)号：US11622937B2

公开(公告)日：2023-04-11

申请号：US15752006

申请日：2016-08-18

申请人： Mewa Singh

发明人： Mewa Singh

IPC分类号： A61K9/16 ,  A61K9/70 ,  A61K47/32 ,  A61K47/55 ,  A61K31/366 ,  A61K31/60 ,  A61K31/22 ,  A61K31/335 ,  A61K31/337 ,  A61K31/192 ,  A61K31/05 ,  A61K31/4745 ,  A61K31/5513 ,  A61K31/616 ,  A61K31/203 ,  A61K9/19

摘要： The subject invention relates to compositions of a polyphenolic Polymer and methods useful for the delivery of substantially water-insoluble drugs and agrochemicals, like Artemisinin, Aspirin, and Pyrethrin. The use of specific composition and preparation conditions enables the reproducible production of unusually water-soluble formulation, which can be sterile-filtered. The particulate system produced according to the invention can be converted into a re-dispersible dry powder comprising nanoparticles of drug. The innovation is also based on the fact that complementary polyphenolic partner is also an active drug but may have a different mode action with respect to primary molecule of the hybrid drug. The complementary polyphenol molecule has multiple properties like antioxidant, antimicrobial, anti-inflammatory, anti-allergic, cox-2 inhibitors, etc. This results in a unique delivery system, in which part of the pharmacologically active agent is readily bioavailable. More important the whole process and material used is GRAS approved and environmentally safe.

公开(公告)号：US11590211B2

公开(公告)日：2023-02-28

申请号：US17068722

申请日：2020-10-12

申请人： Nuvothera, Inc.

发明人： Arthur Clapp

IPC分类号： A61K38/48 ,  A61K33/00 ,  A61K31/12 ,  A61K9/06 ,  A61K31/14 ,  A61K31/60 ,  A61K9/00 ,  A61K31/08

摘要： The present invention is directed to novel systems and methods for treating dermal inflammatory disorders, such as psoriasis.

公开(公告)号：US20230049415A1

公开(公告)日：2023-02-16

申请号：US17758920

申请日：2021-01-14

申请人： CAN-FITE BIOPHARMA LTD.

发明人： Pnina FISHMAN ,  Inbal ITZHAK

IPC分类号： A61K36/185 ,  A61K31/352 ,  A61K31/05 ,  A61K31/60

摘要： Cannabinoids are used to treat diseases or disorders treatable by an activator of the A3 adenosine receptor (A3AR). The cannabinoid effect is exerted through the A3AR. The cannabinoids may be selected from natural, phytocannabinoids, synthetic derivatives of phytocannabinoids, extracts of cannabis plant, and others.

公开(公告)号：US11564901B2

公开(公告)日：2023-01-31

申请号：US13745740

申请日：2013-01-18

申请人： Zheng Tao Han ,  Hung-Fong Chen

发明人： Zheng Tao Han ,  Hung-Fong Chen

IPC分类号： A61K31/215 ,  A61K45/06 ,  A61K31/23 ,  A61K31/573 ,  A61K31/60 ,  A61K31/14 ,  A61K33/06

摘要： Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms or sequelae of disease. Chronic and acute conditions may be due to viral infections such as HIV and AIDS, neoplastic diseases stroke, kidney disease, urinary incontinence, autoimmune disorders, Parkinson's disease, prostate hypertrophy, aging, or the treatment of such diseases. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools against acute and chronic conditions in mammalian subjects.

公开(公告)号：US20220401431A1

公开(公告)日：2022-12-22

申请号：US17893147

申请日：2022-08-22

申请人： Alexza Pharmaceuticals, Inc.

发明人： Daniel J. MYERS ,  James CASSELLA

IPC分类号： A61K31/465 ,  A61M15/06 ,  A61K9/00 ,  A61K31/60 ,  A61M5/00 ,  A61M11/04 ,  A61M15/00 ,  A61M35/00 ,  A61M37/00 ,  C07D401/04 ,  A24B15/167 ,  A61M31/00 ,  C07C63/08 ,  H05B1/02 ,  C07C65/10

摘要： The present disclosure relates generally to the field of nicotine delivery. The disclosure teaches a nicotine meta-salicylate. More specifically, the disclosure teaches a condensation nicotine aerosol where nicotine meta-salicylate is vaporized. This disclosure relates to aerosol nicotine delivery devices. The delivery devices can be activated by actuation mechanisms to vaporize thin films comprising a nicotine meta-salicylate. More particularly, this disclosure relates to thin films of nicotine salt with meta salicylic acid for the treatment of nicotine craving and for effecting smoking cessation.

公开(公告)号：US20220401379A1

公开(公告)日：2022-12-22

申请号：US17675664

申请日：2022-02-18

申请人： Unigen, Inc.

发明人： Mei Feng Hong ,  Qi Jia ,  Lidia Alfaro Brownell

IPC分类号： A61K31/05 ,  A61K31/60 ,  A61Q19/02 ,  A61K8/34

摘要： Methods for treating excess pigmentation, including treatment of post inflammatory hyperpigmentation (PIH), are disclosed. The disclosed methods comprise administration of a composition comprising bakuchiol substantially free of furanocoumarins to a mammal. Compositions comprising bakuchiol and methods for their preparation are also disclosed.