公开(公告)号：US20070253984A1

公开(公告)日：2007-11-01

申请号：US11737674

申请日：2007-04-19

Applicant: Lakshmi Khandke ,  Ronald Malone ,  Xudong Yang ,  Hanyoung Han ,  Jee Look ,  Zhaowei Jin ,  Robert Seid ,  Ying Chen

Inventor： Lakshmi Khandke ,  Ronald Malone ,  Xudong Yang ,  Hanyoung Han ,  Jee Look ,  Zhaowei Jin ,  Robert Seid ,  Ying Chen

IPC: A61K39/09 ,  A61K39/095

CPC classification number: A61K47/26 ,  A61K39/09 ,  A61K39/092 ,  A61K39/095 ,  A61K47/646 ,  A61K2039/55505 ,  A61K2039/55583 ,  A61K2039/57 ,  A61K2039/6018 ,  A61K2039/6037

Abstract: The present invention addresses an ongoing need in the art to improve the stability of immunogenic compositions such as polysaccharide-protein conjugates and protein immunogens. The invention broadly relates to novel formulations which stabilize and inhibit precipitation of immunogenic compositions. More particularly, the invention described hereinafter, addresses a need in the art for formulations which stabilize and inhibit particulate formation (e.g., aggregation, precipitation) of immunogenic compositions which are processed, developed, formulated, manufactured and/or stored in container means such as fermentors, bioreactors, vials, flasks, bags, syringes, rubber stoppers, tubing and the like.

Abstract translation: 本发明解决了本领域持续的需要，以提高免疫原性组合物如多糖 - 蛋白质缀合物和蛋白质免疫原的稳定性。 本发明广泛涉及稳定和抑制免疫原性组合物沉淀的新型制剂。 更具体地说，下文描述的发明解决了本领域对于稳定和抑制在诸如以下的容器装置中加工，开发，配制，制造和/或储存的免疫原性组合物的颗粒形成（例如，聚集，沉淀）的制剂的需要。 发酵罐，生物反应器，小瓶，烧瓶，袋子，注射器，橡胶塞子，管道等。

公开(公告)号：US07266656B2

公开(公告)日：2007-09-04

申请号：US10835299

申请日：2004-04-28

Applicant: Ying Chen ,  Binny Sher Gill ,  Lan Huang

Inventor： Ying Chen ,  Binny Sher Gill ,  Lan Huang

IPC: G08F12/00

CPC classification number: G06F11/2076 ,  G06F11/2069 ,  Y10S707/99953

Abstract: A system for minimizing downtime in an appliance-based business continuance architecture is provided. The system includes at least one primary data storage and least one primary host machine. The system includes an intercept agent to intercept primary host machine data requests, and to collect information associated with the intercepted data requests. Moreover, at least one business continuance appliance in communication with the primary host machine and in communication with a remote backup site is provided. The appliance receives information associated with the intercepted data requests from the intercept agent. In addition, a local cache is included within the business continuance appliance. The local cache maintains copies of primary data storage according to the information received. Furthermore, the remote site is provided with the intercepted data requests via the business continuance appliance, wherein the remote site maintains a backup of the primary data storage.

Abstract translation: 提供了一种用于最小化基于设备的业务连续性架构中的停机时间的系统。 该系统包括至少一个主数据存储和至少一个主要主机。 该系统包括截取主机数据请求的拦截代理，并收集与拦截的数据请求相关的信息。 此外，提供了与主主机通信并与远程备份站点通信的至少一个业务连续性设备。 设备从拦截代理接收与拦截的数据请求相关联的信息。 此外，本地缓存包含在业务连续设备中。 本地缓存根据收到的信息维护主数据存储的副本。 此外，通过业务连续性设备向远程站点提供截获的数据请求，其中远程站点维护主数据存储的备份。

公开(公告)号：US20070124340A1

公开(公告)日：2007-05-31

申请号：US11291629

申请日：2005-11-30

Applicant: Ying Chen ,  Kenneth Day ,  Philip Doatmas ,  David Pease ,  John Wolfgang

Inventor： Ying Chen ,  Kenneth Day ,  Philip Doatmas ,  David Pease ,  John Wolfgang

IPC: G06F17/30

CPC classification number: G06F11/2097 ,  G06F11/1435 ,  G06F11/2094 ,  G06F17/30218 ,  Y10S707/99955

Abstract: An apparatus and method to replicate one or more files between non-symmetric storage systems are disclosed. The method supplies a first storage system comprising a first configuration, a first volume, a first file system, and a first replication appliance comprising first replication appliance memory. The method further supplies a second storage system comprising a second configuration, a second volume, a second file system, and a second replication appliance comprising second replication appliance memory, where the first configuration differs from the second configuration. The first storage system receives a dataset, writes that dataset to the first volume as a first file. Applicants' method then replicates the first file to the second volume as a second file, and maintains in the second replication appliance memory a second replication appliance mapping associating the first file with the second file.

Abstract translation: 公开了一种在非对称存储系统之间复制一个或多个文件的装置和方法。 该方法提供包括第一配置，第一卷，第一文件系统和包括第一复制设备存储器的第一复制设备的第一存储系统。 该方法还提供包括第二配置，第二卷，第二文件系统和包括第二复制设备存储器的第二复制设备的第二存储系统，其中第一配置与第二配置不同。 第一个存储系统接收数据集，将该数据集写入第一个卷作为第一个文件。 然后，申请人的方法将第一文件作为第二文件复制到第二卷，并在第二复制装置存储器中维护将第一文件与第二文件相关联的第二复制装置映射。

公开(公告)号：US07214673B2

公开(公告)日：2007-05-08

申请号：US10505805

申请日：2003-03-17

Applicant: Thomas Daniel Aicher ,  Zhaogen Chen ,  Joseph Herman Krushinski, Jr. ,  Yvan Le Huerou ,  Marta Maria Pineiro-Nunez ,  Kevin Michael Ruley ,  John Mehnert Schaus ,  Dennis Charles Thompson ,  David Edward Tupper ,  Ying Chen ,  Margaret Mary Faul ,  Vincent Patrick Rocco

Inventor： Thomas Daniel Aicher ,  Zhaogen Chen ,  Joseph Herman Krushinski, Jr. ,  Yvan Le Huerou ,  Marta Maria Pineiro-Nunez ,  Kevin Michael Ruley ,  John Mehnert Schaus ,  Dennis Charles Thompson ,  David Edward Tupper ,  Ying Chen ,  Margaret Mary Faul ,  Vincent Patrick Rocco

IPC: A61P25/00 ,  A61K31/55 ,  C07D243/10

CPC classification number: C07D487/04 ,  C07D243/38 ,  C07D495/04 ,  C07D513/04

Abstract: Described herein are antipyschotic compounds of formula (I) wherein, A is an optionally benzo-fused five or six member aromatic ring having zero to three hetero atoms independently selected from N, O, and S; Alk is (C1-4) alkylene optionally substituted with OH, methoxy, ethoxy, or F; Ar is optionally substituted phenyl, naphthyl, monocyclic heteroaromatic, or bicyclic heteroaromatic; R1 is hydrogen or (C1-4) alkyl optionally substituted with OH, OR3, or OCH2CH2OH, wherein R3 is (C1-2) alkyl; R2 is H, (C1-6) alkyl, halogen, fluorinated (C1-6) alkyl, OR4, SR4, NO2, CN, COR4, CONR5R6, SO2NR5R6, NR5R6, NR5COR4, NR5SO2R4, or optionally substituted phenyl, wherein R4 is hydrogen, (C1-6) alkyl, fluorinated (C1-6) alkyl, or optionally substituted phenyl, R5 and R6 are independently hydrogen, (C1-6) alkyl, or optionally substituted phenyl; Z is one or two substituents independently selected from hydrogen, halogen, (C1-6) alkyl, fluorinated (C1-6) alkyl, OR7, SR7, NO2, CN, COR7, CONR8R9, SO2NR8R9, NR8SO2R7, NR8R9, or optionally substituted phenyl, wherein R7 is hydrogen, (C1-6) alkyl, fluorinated alkyl, or optionally substituted phenyl, R8 and R9 are independently hydrogen, (C1-6) alkyl, or optionally substituted phenyl; and salts, solvates, and crystal forms thereof. Also described are the use of the compounds of formula (I) as antagonists of the dopamine D2 receptor and as agents for the treatment of psychosis and bipolar disorder, and pharmaceutical formulations of the compounds of formula (I).

公开(公告)号：US20070088717A1

公开(公告)日：2007-04-19

申请号：US11249920

申请日：2005-10-13

Applicant: Ying Chen

Inventor： Ying Chen

IPC: G06F7/00

CPC classification number: G06F16/35

Abstract: Embodiments herein present a method for a back-tracking decision tree classifier for a large reference data set. The method analyzes first data files having a higher usage than second data files and identifies file attribute sets that are common in the first data files. Next, the method associates associated qualifiers with each of the file attribute sets, wherein each of the associated qualifiers represents a corresponding first data file. The associated qualifiers are then counted to determine the number of associated qualifiers that are associated with each of the file attribute sets. Subsequently, the file attribute sets are sorted in descending order based on the number of associated qualifiers. The counting and sorting are initially performed on file attribute sets that only have a single file attribute.

Abstract translation: 本文的实施例提供了用于大参考数据集的反向跟踪决策树分类器的方法。 该方法分析具有比第二数据文件更高的使用的第一数据文件，并且识别第一数据文件中通用的文件属性集。 接下来，该方法将关联限定符与每个文件属性集相关联，其中每个相关联的限定符表示对应的第一数据文件。 然后将关联的限定符计数以确定与每个文件属性集相关联的关联限定符的数量。 随后，文件属性集根据关联限定符的数量按降序排列。 最初对仅具有单个文件属性的文件属性集执行计数和排序。

公开(公告)号：US20060211744A1

公开(公告)日：2006-09-21

申请号：US11295647

申请日：2005-12-05

Applicant: Zhigang He ,  Jing Wang ,  Ying Chen ,  Shijniro Kaneko

Inventor： Zhigang He ,  Jing Wang ,  Ying Chen ,  Shijniro Kaneko

IPC: G06Q10/00 ,  A61K31/455

CPC classification number: A61K31/465 ,  A61K31/455 ,  G06Q50/22

Abstract: Neural degeneration is reduced in a patient determined to be suffering from chronic neurodegeneration by administering to the patient an effective amount of 3-pyridinecarboxamide (nicotinamide) and detecting a resultant decrease in the neural degeneration.

Abstract translation: 通过向患者施用有效量的3-吡啶甲酰胺（烟酰胺）并检测神经变性的减少，确定患有慢性神经变性的患者的神经变性减少。

公开(公告)号：US20060106833A1

公开(公告)日：2006-05-18

申请号：US11255297

申请日：2005-10-20

Applicant: Ying Chen ,  Fang Rao ,  Knut Stolze

Inventor： Ying Chen ,  Fang Rao ,  Knut Stolze

IPC: G06F7/00

CPC classification number: G06F17/30333 ,  Y10S707/99933 ,  Y10S707/99934 ,  Y10S707/99942 ,  Y10S707/99943

Abstract: Systems, methods, and computer products that improve the techniques used to search multidimensional databases over techniques of the past. The preferred embodiment of the present invention advantageously improves the technique of determining a grid index that is used to locate a geometric shape in a spatial database. More particularly, the preferred embodiment of the present invention improves the technique of sampling data for defining the grid cell size in a grid for a given data set, thereby improving the grid indexing process that locates a particular minimum-bounding rectangle and the associated geometric shape.

公开(公告)号：US20050203296A1

公开(公告)日：2005-09-15

申请号：US10505805

申请日：2003-03-17

Applicant: Thomas Aicher ,  Zhaogen Chen ,  Joseph Krushinski ,  Yvan Le Huerou ,  Marta Pineiro-Nunez ,  Kevin Ruley ,  John Schaus ,  Dennis Thompson ,  David Tupper ,  Ying Chen ,  Margaret Faul ,  Vincent Rocco

Inventor： Thomas Aicher ,  Zhaogen Chen ,  Joseph Krushinski ,  Yvan Le Huerou ,  Marta Pineiro-Nunez ,  Kevin Ruley ,  John Schaus ,  Dennis Thompson ,  David Tupper ,  Ying Chen ,  Margaret Faul ,  Vincent Rocco

IPC: C07D333/62 ,  A61K31/551 ,  A61K31/5517 ,  A61P25/18 ,  A61P43/00 ,  C07D243/38 ,  C07D333/68 ,  C07D403/04 ,  C07D487/04 ,  C07D495/04 ,  C07D498/02 ,  C07D513/04

CPC classification number: C07D487/04 ,  C07D243/38 ,  C07D495/04 ,  C07D513/04

Abstract: Described herein are antipyschotic compounds of formula (I) wherein, A is an optionally benzo-fused five or six member aromatic ring having zero to three hetero atoms independently selected from N, O, and S; Alk is (C1-4) alkylene optionally substituted with OH, methoxy, ethoxy, or F; Ar is optionally substituted phenyl, naphthyl, monocyclic heteroaromatic, or bicyclic heteroaromatic; R1 is hydrogen or (C1-4) alkyl optionally substituted with OH, OR3, or OCH2CH2OH, wherein R3 is (C1-2) alkyl; R2 is H, (C1-6) alkyl, halogen, fluorinated (C1-6) alkyl, OR4, SR4, NO2, CN, COR4, CONR5R6, SO2NR5R6, NR5R6, NR5COR4, NR5SO2R4, or optionally substituted phenyl, wherein R4 is hydrogen, (C1-6) alkyl, fluorinated (C1-6) alkyl, benzyl, or optionally substituted phenyl, R5 and R6 are independently hydrogen, (C1-6) alkyl, or optionally substituted phenyl; Z is one or two substituents independently selected from hydrogen, halogen, (C1-6) alkyl, fluorinated (C1-6) alkyl, OR7, SR7, NO2, CN, COR7, CONR8R9, SO2NR8R9, NR8SO2R7, NR8R9, or optionally substituted phenyl, wherein R7 is hydrogen, (C1-6) alkyl, fluorinated alkyl, benzyl, or optionally substituted phenyl, R8 and R9 are independently hydrogen, (C1-6) alkyl, or optionally substituted phenyl; and salts, solvates, and crystal forms thereof. Also described are the use of the compounds of formula (a) as antagonists of the dopamine D2 receptor and as agents for the treatment of psychosis and bipolar disorders, and pharmaceutical formulations of the compounds of formula (I). Also described are compounds useful as intermediates for the synthesis of the compounds of formula (I).

公开(公告)号：US06940530B2

公开(公告)日：2005-09-06

申请号：US10442022

申请日：2003-05-20

Applicant: Ying Chen ,  Xiu Lan Yu ,  Fang Yan Rao

Inventor： Ying Chen ,  Xiu Lan Yu ,  Fang Yan Rao

IPC: G06F17/00 ,  G06T17/40 ,  G06T17/50 ,  G09B29/00 ,  G09B29/10 ,  G09G5/00

CPC classification number: G06T19/00 ,  G01C21/3673 ,  G06T17/05 ,  G06T2219/004 ,  G09B29/106

Abstract: Provides point label placement determining methods, apparatus and systems. A point label placement determining method and system are used in map browsing service based on session mode. In an example embodiment, initial label placement data in a scale is calculated by a static point label determining method. When a user requires a map browsing service, the requirement are met by using an incremental label placement method on the base of said initial label placement data. The incremental point label placement method dramatically reduces the cost for service process. Therefore, the simultaneous requirements of a large number of users can be met. The present invention is successfully used in location based service systems.

Abstract translation: 提供点标签放置确定方法，设备和系统。 基于会话模式的地图浏览服务使用点标签放置确定方法和系统。 在示例实施例中，通过静态点标签确定方法来计算标度中的初始标签放置数据。 当用户需要地图浏览服务时，通过在所述初始标签放置数据的基础上使用增量标签放置方法来满足要求。 增量点标签放置方法大大降低了服务过程的成本。 因此，可以满足大量用户的同时要求。 本发明成功地用于基于位置的服务系统。

公开(公告)号：US20050124596A1

公开(公告)日：2005-06-09

申请号：US10967601

申请日：2004-10-18

Applicant: X. Zhang ,  Ying Chen ,  Guang-yao Gao

Inventor： X. Zhang ,  Ying Chen ,  Guang-yao Gao

IPC: C07D487/22 ,  A61K31/58 ,  A61K31/422 ,  A61K31/555 ,  C07J43/00

CPC classification number: C07D487/22

Abstract: Novel methods of synthesizing heteroatom-containing chiral porphyrins and chiral metalloporphyrins and the novel chiral porphyrins and chiral metalloporphyrins themselves are disclosed. Metal complexes of the chiral porphyrins are prepared in high yields and shown to be active catalysts for highly enantioselective and diastereoselective cyclopropanation, aziridination, and epoxidation of alkenes under a practical one-pot protocol.

Abstract translation: 公开了合成含杂原子的手性卟啉和手性金属卟啉以及新型手性卟啉和手性金属卟啉的新方法。 手性卟啉的金属络合物以高产率制备，并且显示为用于在实际一锅法下高度对映选择性和非对映选择性环丙烷化，氮丙啶化和烯烃环氧化的活性催化剂。