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1.发明申请公开(公告)号：US20070253984A1
公开(公告)日：2007-11-01
申请号：US11737674
申请日：2007-04-19
申请人： Lakshmi Khandke , Ronald Malone , Xudong Yang , Hanyoung Han , Jee Look , Zhaowei Jin , Robert Seid , Ying Chen
发明人： Lakshmi Khandke , Ronald Malone , Xudong Yang , Hanyoung Han , Jee Look , Zhaowei Jin , Robert Seid , Ying Chen
IPC分类号： A61K39/09 , A61K39/095
CPC分类号： A61K47/26 , A61K39/09 , A61K39/092 , A61K39/095 , A61K47/646 , A61K2039/55505 , A61K2039/55583 , A61K2039/57 , A61K2039/6018 , A61K2039/6037
摘要： The present invention addresses an ongoing need in the art to improve the stability of immunogenic compositions such as polysaccharide-protein conjugates and protein immunogens. The invention broadly relates to novel formulations which stabilize and inhibit precipitation of immunogenic compositions. More particularly, the invention described hereinafter, addresses a need in the art for formulations which stabilize and inhibit particulate formation (e.g., aggregation, precipitation) of immunogenic compositions which are processed, developed, formulated, manufactured and/or stored in container means such as fermentors, bioreactors, vials, flasks, bags, syringes, rubber stoppers, tubing and the like.
摘要翻译： 本发明解决了本领域持续的需要，以提高免疫原性组合物如多糖 - 蛋白质缀合物和蛋白质免疫原的稳定性。 本发明广泛涉及稳定和抑制免疫原性组合物沉淀的新型制剂。 更具体地说，下文描述的发明解决了本领域对于稳定和抑制在诸如以下的容器装置中加工，开发，配制，制造和/或储存的免疫原性组合物的颗粒形成（例如，聚集，沉淀）的制剂的需要。 发酵罐，生物反应器，小瓶，烧瓶，袋子，注射器，橡胶塞子，管道等。
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2.发明授权Neisseria meningitidis serogroup B glycoconjugates and methods of producing the same 失效脑膜炎奈瑟氏球菌血清群B糖缀合物及其制备方法公开(公告)号：US07169392B2
公开(公告)日：2007-01-30
申请号：US10643349
申请日：2003-08-19
申请人： Robert Seid
发明人： Robert Seid
IPC分类号： A61K39/385 , A61K39/116 , A61K39/02 , A61K39/00 , A61K39/095 , A61K31/70 , C07H1/00
CPC分类号： A61K39/095 , A61K2039/6037 , Y10S424/831 , Y10S424/832 , Y10S977/917
摘要： The present invention pertains generally to novel Neisseria meningitidis serogroup B glycoconjugates. More particularly, the invention pertains to glycoconjugates formed from a Neisseria meningitidis serogroup B capsular oligosaccharide derivative (MenB OS derivative) in which sialic acid residue N-acetyl groups are replaced with N-acyl groups. The invention also pertains to vaccine formulations containing the glycoconjugates, methods of making the vaccine formulations, and methods of using the vaccine formulations to treat or prevent Neisseria meningitidis serogroup B or E. coli K1 disease in a mammalian subject.
摘要翻译： 本发明一般涉及脑膜炎奈瑟氏球菌血清群B糖缀合物。 更具体地说，本发明涉及由唾液酸残基N-乙酰基被N-酰基取代的脑膜炎奈瑟氏球菌血清群B荚膜寡糖衍生物（MenB OS衍生物）形成的糖缀合物。 本发明还涉及含有糖缀合物的疫苗制剂，制备疫苗制剂的方法，以及使用疫苗制剂在哺乳动物受试者中治疗或预防脑膜炎奈瑟氏球菌血清群B或大肠杆菌K1疾病的方法。
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公开(公告)号：US08765148B2
公开(公告)日：2014-07-01
申请号：US13578686
申请日：2011-02-21
申请人： Benjamin Wizel , Karin Riedl , Karen Lingnau , Ursula Schlosser , Jürgen Wruss , Robert Schlegl , Michael Weber , Christoph Reinisch , Ljubomir Paucz , Christoph Klade , Jee Loon Look , Christian Ruiz , Robert Seid
发明人： Benjamin Wizel , Karin Riedl , Karen Lingnau , Ursula Schlosser , Jürgen Wruss , Robert Schlegl , Michael Weber , Christoph Reinisch , Ljubomir Paucz , Christoph Klade , Jee Loon Look , Christian Ruiz , Robert Seid
CPC分类号： A61K39/39 , A61K9/0019 , A61K9/08 , A61K9/10 , A61K9/14 , A61K9/51 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K39/092 , A61K39/118 , A61K39/12 , A61K39/145 , A61K39/40 , A61K39/42 , A61K48/00 , A61K2039/55516 , A61K2039/55555 , A61K2039/55561 , A61K2039/70 , C12N7/00 , C12N2760/16134 , C12N2760/16171 , C12N2760/16234 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396 , Y02A50/401 , Y02A50/412 , Y02A50/47
摘要： The invention discloses pharmaceutical compositions in liquid form comprising a peptide with the amino acid sequence KLKL5KLK and an oligodeoxynucleotide with the nucleic acid sequence (dIdC)13 and wherein the peptide and the oligodeoxynucleotide are present as sterile-filterable nanoparticles in the composition, thereby forming a suspension, characterized in that the mean particle size of the solid particles is less than 1 μm.
摘要翻译： 本发明公开了液体形式的药物组合物，其包含具有氨基酸序列KLKL5KLK的肽和具有核酸序列（dIdC）13的寡脱氧核苷酸的肽，并且其中肽和寡脱氧核苷酸作为无菌可过滤纳米粒子存在于组合物中，由此形成 悬浮液，其特征在于固体颗粒的平均粒径小于1μm。
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公开(公告)号：US08293275B2
公开(公告)日：2012-10-23
申请号：US12807343
申请日：2010-09-01
IPC分类号： A61K9/14
CPC分类号： A61K9/0075 , A01N1/02 , A01N1/0252 , A61K9/1694 , A61K9/19
摘要： This invention provides methods and compositions to preserve bioactive materials, such as viruses, bacteria, cells, or liposomes, in freeze dried particles suitable for pulmonary administration. Methods provide spray freeze drying of formulations to form stable freeze dried particles.
摘要翻译： 本发明提供了在适于肺部施用的冷冻干燥颗粒中保存生物活性物质如病毒，细菌，细胞或脂质体的方法和组合物。 方法提供喷雾冷冻干燥制剂以形成稳定的冻干颗粒。
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公开(公告)号：US06638513B2
公开(公告)日：2003-10-28
申请号：US08908262
申请日：1997-08-07
申请人： Robert Seid
发明人： Robert Seid
IPC分类号： A61K39385
CPC分类号： A61K39/095 , A61K2039/6037 , Y10S424/831 , Y10S424/832 , Y10S977/917
摘要： The present invention pertains generally to Neisseria meningitidis serogroup B glycoconjugates. More particularly, the invention pertains to glycoconjugates formed from a Neisseria meningitidis serogroup B capsular oligosaccharide derivative (MenB OS derivative) in which sialic acid residue N-acetyl groups are replaced with N-acyl groups. The invention also pertains to vaccine formulations containing the glycoconjugates, methods of making the vaccine formulations, and methods of using the vaccine formulations to treat or prevent Neisseria meningitidis serogroup B or E. coli K1 disease in a mammalian subject.
摘要翻译： 本发明一般涉及脑膜炎奈瑟氏球菌血清群B糖缀合物。 更具体地说，本发明涉及由唾液酸残基N-乙酰基被N-酰基取代的脑膜炎奈瑟氏球菌血清群B荚膜寡糖衍生物（MenB OS衍生物）形成的糖缀合物。 本发明还涉及含有糖缀合物的疫苗制剂，制备疫苗制剂的方法，以及使用疫苗制剂在哺乳动物受试者中治疗或预防脑膜炎奈瑟氏球菌血清群B或大肠杆菌K1疾病的方法。
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公开(公告)号：US20110243996A1
公开(公告)日：2011-10-06
申请号：US13065965
申请日：2011-04-01
CPC分类号： A61K9/0043 , A61K9/1617 , A61K9/1623 , A61K9/1658 , A61K9/1694
摘要： This invention provides methods and compositions to preserve bioactive materials, such as peptides, nucleic acids, viruses, bacteria, cells, or liposomes, in freeze dried particles suitable for intranasal administration. Methods provide spray freeze drying of formulations to form stable freeze dried particles for intranasal administration.
摘要翻译： 本发明提供在适于鼻内给药的冷冻干燥颗粒中保存生物活性物质如肽，核酸，病毒，细菌，细胞或脂质体的方法和组合物。 方法提供制剂的喷雾冷冻干燥以形成用于鼻内给药的稳定的冷冻干燥颗粒。
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公开(公告)号：US20100330162A1
公开(公告)日：2010-12-30
申请号：US12807343
申请日：2010-09-01
IPC分类号： A61K9/127 , A61K39/145 , A61K9/14 , A61P31/12 , A61P31/04
CPC分类号： A61K9/0075 , A01N1/02 , A01N1/0252 , A61K9/1694 , A61K9/19
摘要： This invention provides methods and compositions to preserve bioactive materials, such as viruses, bacteria, cells, or liposomes, in freeze dried particles suitable for pulmonary administration. Methods provide spray freeze drying of formulations to form stable freeze dried particles.
摘要翻译： 本发明提供了在适于肺部给药的冷冻干燥颗粒中保存生物活性物质如病毒，细菌，细胞或脂质体的方法和组合物。 方法提供喷雾冷冻干燥制剂以形成稳定的冻干颗粒。
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公开(公告)号：US20120308618A1
公开(公告)日：2012-12-06
申请号：US13578686
申请日：2011-02-21
申请人： Benjamin Wizel , Karin Riedl , Karen Lingnau , Ursula Schlosser , Jürgen Wruss , Robert Schlegl , Michael Weber , Christoph Reinisch , Ljubomir Paucz , Christoph Klade , Jee Loon Look , Christian Ruiz , Robert Seid
发明人： Benjamin Wizel , Karin Riedl , Karen Lingnau , Ursula Schlosser , Jürgen Wruss , Robert Schlegl , Michael Weber , Christoph Reinisch , Ljubomir Paucz , Christoph Klade , Jee Loon Look , Christian Ruiz , Robert Seid
IPC分类号： A61K39/39 , A61P31/14 , A61P31/18 , A61P31/20 , A61P35/00 , A61P33/00 , A61P33/02 , A61P31/04 , A61P31/10 , A61K9/14 , A61P31/22
CPC分类号： A61K39/39 , A61K9/0019 , A61K9/08 , A61K9/10 , A61K9/14 , A61K9/51 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K39/092 , A61K39/118 , A61K39/12 , A61K39/145 , A61K39/40 , A61K39/42 , A61K48/00 , A61K2039/55516 , A61K2039/55555 , A61K2039/55561 , A61K2039/70 , C12N7/00 , C12N2760/16134 , C12N2760/16171 , C12N2760/16234 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396 , Y02A50/401 , Y02A50/412 , Y02A50/47
摘要： The invention discloses pharmaceutical compositions in liquid form comprising a peptide with the amino acid sequence KLKL5KLK and an oligodeoxynucleotide with the nucleic acid sequence (dIdC)13 and wherein the peptide and the oligodeoxynucleotide are present as sterile-filterable nanoparticles in the composition, thereby forming a suspension, characterized in that the mean particle size of the solid particles is less than 1 μm.
摘要翻译： 本发明公开了液体形式的药物组合物，其包含具有氨基酸序列KLKL5KLK的肽和具有核酸序列（dIdC）13的寡脱氧核苷酸的肽，并且其中肽和寡脱氧核苷酸作为无菌可过滤纳米粒子存在于组合物中，由此形成 悬浮液，其特征在于固体颗粒的平均粒径小于1μm。
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公开(公告)号：US07923029B2
公开(公告)日：2011-04-12
申请号：US10412644
申请日：2003-04-10
CPC分类号： A61K9/0075 , A01N1/02 , A01N1/0252 , A61K9/1694 , A61K9/19
摘要： This invention provides methods and compositions to preserve bioactive materials, such as viruses, bacteria, cells, or liposomes, in freeze dried particles suitable for pulmonary administration. Methods provide spray freeze drying of formulations to form stable freeze dried particles.
摘要翻译： 本发明提供了在适于肺部施用的冷冻干燥颗粒中保存生物活性物质如病毒，细菌，细胞或脂质体的方法和组合物。 方法提供喷雾冷冻干燥制剂以形成稳定的冻干颗粒。
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