公开(公告)号：US20210394081A1

公开(公告)日：2021-12-23

申请号：US17351084

申请日：2021-06-17

申请人： Agilent Technologies, Inc.

发明人： Jose-Angel Mora ,  Uwe Effelsberg ,  Lena Höninger

IPC分类号： B01D15/16 ,  G01N30/30 ,  B01D15/12

摘要： A thermal impact assembly for a sample separation apparatus for separating a fluidic sample in a mobile phase by a sample separation unit includes a thermal impact device configured for thermally impacting the fluidic sample and/or the mobile phase and the sample separation unit, and a control unit configured for controlling the thermal impact device for thermally impacting the fluidic sample and/or the mobile phase on the one hand and for thermally impacting the sample separation unit on the other hand independently from each other.

公开(公告)号：US20210389282A1

公开(公告)日：2021-12-16

申请号：US17288478

申请日：2018-10-26

申请人： Agilent Technologies, Inc.

发明人： Thomas Ortmann

IPC分类号： G01N30/20 ,  B01D15/18 ,  G01N30/22 ,  G01N30/46 ,  G01N30/60

摘要： An injector, for injecting a fluidic sample in at least one selected one of a first sample separation apparatus and a second sample separation apparatus, includes a valve arrangement fluidically connectable to the first sample separation apparatus and the second sample separation apparatus, a sample accommodation volume for accommodating the fluidic sample, and a control unit configured for controlling the valve arrangement so that fluidic sample in the sample accommodation volume is selectively injectable into the selected first sample separation apparatus and/or second sample separation apparatus.

公开(公告)号：US20210263043A1

公开(公告)日：2021-08-26

申请号：US17319868

申请日：2021-05-13

申请人： Agilent Technologies, Inc.

发明人： Michael J. Kimzey

IPC分类号： G01N33/68 ,  G01N33/53 ,  C09B19/00 ,  C09B57/02 ,  C09B57/08 ,  C12P19/04 ,  G01N33/58

摘要： The presence of mild electrophiles, such as aldehydes, during the denaturation of glycoproteins or glycopeptides and subsequent enzymatic deglycosylation reduces artifacts in subsequent analyses of the glycans released from the glycoproteins or gly-copeptides.

公开(公告)号：US11072829B2

公开(公告)日：2021-07-27

申请号：US16555683

申请日：2019-08-29

申请人： AGILENT TECHNOLOGIES, INC.

发明人： Dirk Goossens ,  Joachim De Schrijver ,  Jurgen Del Favero

IPC分类号： C12Q1/68 ,  C12Q1/6883 ,  C12Q1/6809

摘要： The present invention relates to the technical field of organ and tissue transplantation and specifically to methods allowing rejection of transplanted organs and tissues by a transplant patient. The present invention provides methods for non-invasive and ex vivo or in vitro detection of the presence or absence of transplant rejection, i.e. transplant health or rejection. The present methods allow for effective and continuous monitoring of transplant status with a minimal or absent discomfort for a transplant patent.

公开(公告)号：US11053546B2

公开(公告)日：2021-07-06

申请号：US15737105

申请日：2016-07-13

申请人： AGILENT TECHNOLOGIES, INC.

发明人： Jurgen Peter Lode Del Favero ,  Michaël Vyverman ,  Paul Vauterin

IPC分类号： G16B20/00 ,  G16H50/20 ,  C12Q1/6881 ,  C12Q1/6827 ,  G16H10/40 ,  G01N33/49 ,  G01N33/68

摘要： A method for estimating whether a female is pregnant, said method comprising measuring allele presences (D) for a plurality of genetic markers of at least one chromosome, different from the X and Y chromosome, in a sample of cell-free DNA from a potentially pregnant female; each allele presence representing the presence at a genetic marker of at least one of: a reference allele of maternal or foetal origin, and an alternative allele of maternal or foetal origin; based on said measured allele presences, determining a homozygous fraction (Fho) thereof which is associated with purely homozygous genetic markers; and estimating whether the female is pregnant based on said fraction.

公开(公告)号：US11022111B2

公开(公告)日：2021-06-01

申请号：US14633281

申请日：2015-02-27

申请人： AGILENT TECHNOLOGIES, INC.

发明人： Bernhard Dehmer ,  Arne Kurz ,  Lothar Mitzlaff

IPC分类号： F04B53/22 ,  F04B19/22 ,  F04B37/00 ,  F04B39/14 ,  F04B53/14 ,  F04B53/16 ,  B01D15/14 ,  B01D19/00 ,  F04B17/03

摘要： A pump for pumping fluid, wherein the pump comprises a pump head comprising a working chamber, a piston assembly configured for reciprocating within the working chamber to thereby displace fluid, a pump base accommodating a piston actuator being mechanically lockable to the piston assembly in a working mode of the pump to thereby transmit drive energy to the piston assembly to reciprocate, and a locking/unlocking mechanism configured to, upon unfastening the pump head from the pump base, mechanically unlock the piston actuator from the piston assembly in a maintenance mode of the pump.

公开(公告)号：US11016057B2

公开(公告)日：2021-05-25

申请号：US15634846

申请日：2017-06-27

申请人： Agilent Technologies, Inc.

发明人： Mark R. Ver Meer ,  Jolita J. Uthe ,  Wei Wei ,  Martin Chris Foster ,  Bruce R. Boeke

IPC分类号： G01N27/447 ,  C12N15/10 ,  C12Q1/6806

摘要： The invention is a multiplex, pulsed-field capillary electrophoresis instrument with the ability to analyze DNA fragments with sizes greater than 150,000 base pairs. The parallel capillary electrophoresis system allows for the simultaneous analysis of at least 12 samples while applying a pulse or varying electric field for separation. Sequences of pulse-field electric fields are iterated to achieve accurate separation of DNA smears.

公开(公告)号：US11002684B2

公开(公告)日：2021-05-11

申请号：US13718061

申请日：2012-12-18

申请人： AGILENT TECHNOLOGIES, INC.

发明人： Robert P. Rhodes

IPC分类号： G01N21/76

摘要： An apparatus for receiving a chemical species is disclosed. The apparatus includes an emission block configured to receive a vapor phase chemical species that is excited by chemical reaction in the emission block to provide an excited species that emits light. The emission block has an interior portion having a surface. A coating is disposed over the surface and the coating reduces adsorption of the excited species onto the surface.

公开(公告)号：US10953345B2

公开(公告)日：2021-03-23

申请号：US14252711

申请日：2014-04-14

申请人： AGILENT TECHNOLOGIES, INC.

发明人： Klaus Witt ,  Konstantin Shoykhet ,  Dwight Stoll

IPC分类号： B01D15/14 ,  G01N30/20 ,  G01N30/46

摘要： A sample dispatcher is disclosed and is configured for individually introducing a plurality of portions of one or more sample fluids into a flow of a mobile phase of a liquid separation system. The liquid separation system is configured for separating compounds of the sample fluids and comprises a mobile phase drive configured for driving the mobile phase through a separation unit configured for separating compounds of the sample fluids in the mobile phase. The sample dispatcher comprises one or more sample reservoirs, each configured for receiving and temporarily storing a respective sample fluid portion or at least a part thereof, and a bypass channel.

公开(公告)号：US10942176B2

公开(公告)日：2021-03-09

申请号：US15230876

申请日：2016-08-08

申请人： AGILENT TECHNOLOGIES, INC.

发明人： Mimi Healy ,  Xiyi Chen ,  Jinchun Wang ,  Weidong Wu ,  Sophia Petrichenko ,  Su Zhang ,  Stacie Frye

IPC分类号： G01N33/543 ,  G01N33/53 ,  G01N33/58 ,  G01N33/533 ,  B01L3/00 ,  G01N1/30 ,  G01N1/31 ,  G01N35/00

摘要： Provided herein are methods of using photocleavable labels for multiplex and serial antigen detection. The methods comprise detecting the presence of photocleavable labels, which are conjugated through functional linkers to antigen-binding complexes, which in turn non-covalently bind to antigens. The presence of a photocleavable label is indicative of the presence of an antigen specifically or selectively bound by an antigen-binding complex. Also provided are apparatuses for using photocleavable labels for multiplex and serial antigen detection.