公开(公告)号：US20240011949A1

公开(公告)日：2024-01-11

申请号：US18371405

申请日：2023-09-21

申请人： Agilent Technologies, Inc.

发明人： Bettina Schuhn ,  Uwe Effelsberg ,  Manuel van Venrooy ,  Matthias Kamuf

IPC分类号： G01N30/34 ,  G01N30/74 ,  B01D15/16

CPC分类号： G01N30/34 ,  G01N30/74 ,  B01D15/163 ,  G01N2030/027

摘要： In a sample separation apparatus for separating a fluidic sample, a mobile phase container is identified by determining a weight and volume characteristic of the mobile phase container, and identifying the mobile phase container based on a comparison of the determined weight and volume characteristic of the mobile phase container with a pre-known reference weight and volume characteristic of one or more reference mobile phase containers with pre-known identity. A mobile phase is identified by determining a weight and volume reduction behavior according to which weight and volume of mobile phase in a mobile phase container are reduced during conveying mobile phase from the mobile phase container in the sample separation apparatus, and identifying the mobile phase based on a comparison of the determined weight and volume reduction behavior with pre-known reference weight and volume reduction behavior of one or more reference mobile phase materials with pre-known identity.

公开(公告)号：US20210302399A1

公开(公告)日：2021-09-30

申请号：US17215872

申请日：2021-03-29

申请人： Agilent Technologies, Inc.

发明人： Bettina Schuhn ,  Uwe Effelsberg

IPC分类号： G01N30/86 ,  G01N30/16

摘要： A process of determining a modified separation method for a sample separation apparatus based on an initial separation method, including carrying out the initial separation method on a sample separation apparatus, detecting sensor data at the sample separation apparatus during carrying out the initial separation method, and carrying out a numerical analysis for determining the modified separation method by modifying at least one operation parameter of the initial separation method and by using the detected sensor data.

公开(公告)号：US20240011953A1

公开(公告)日：2024-01-11

申请号：US18371392

申请日：2023-09-21

申请人： Agilent Technologies, Inc.

发明人： Bettina Schuhn ,  Uwe Effelsberg ,  Manuel van Venrooy ,  Matthias Kamuf

IPC分类号： G01N30/34 ,  G01N30/74 ,  B01D15/16

CPC分类号： G01N30/34 ,  G01N30/74 ,  B01D15/163 ,  G01N2030/027

摘要： In a sample separation apparatus for separating a fluidic sample using a mobile phase provided from at least one mobile phase container, a method of determining a density of the mobile phase includes determining a weight and volume reduction behavior according to which weight and volume of mobile phase in a mobile phase container are reduced during conveying mobile phase from the mobile phase container in the sample separation apparatus. The density of the mobile phase is determined based on the determined weight and volume reduction behavior.

公开(公告)号：US20220317102A1

公开(公告)日：2022-10-06

申请号：US17706184

申请日：2022-03-28

申请人： Agilent Technologies, Inc.

发明人： Kyle Robert Busch ,  Uwe Effelsberg

IPC分类号： G01N30/86 ,  G01N30/16 ,  G01N30/80

摘要： A process which, on the basis of a provided test sample including a mix of a plurality of preknown sample components and on the basis of provided absolute sample separation properties for each of the sample components, includes experimentally determining a real sample separation result by executing a sample separation method for separating the test sample by a sample separation apparatus, and determining a real value of at least one operation parameter based on a comparison between the absolute sample separation properties and the real sample separation result for characterizing a real course of the sample separation method.

公开(公告)号：US20220308019A1

公开(公告)日：2022-09-29

申请号：US17698732

申请日：2022-03-18

申请人： Agilent Technologies, Inc.

发明人： Lena Höninger ,  Uwe Effelsberg ,  Gerhart Metzler ,  Sascha Lege ,  Konstantin Shoykhet ,  Stephan Buckenmaier

IPC分类号： G01N30/36 ,  G01N30/30

摘要： A process of controlling a sample separation apparatus for separating a fluidic sample includes determining whether the sample separation apparatus is appropriate for carrying out a predefined operation, by simulating the operation of the sample separation apparatus, and taking an action depending on a result of the determining.

公开(公告)号：US20220236235A1

公开(公告)日：2022-07-28

申请号：US17584250

申请日：2022-01-25

申请人： Agilent Technologies, Inc.

发明人： Daniela Loraing ,  Lena Höninger ,  Uwe Effelsberg ,  Andreas Otto ,  Ansgar Waldbaur ,  Armin Steinke ,  Thomas Ortmann ,  Michael Lang

IPC分类号： G01N30/60

摘要： A mounting device for mounting a sample separation unit configured for separating, preferably chromatographically separating, compounds in a fluidic sample includes a first fluid connector configured for being mechanically and fluidically coupled with a first fluid interface of the sample separation unit, a second fluid connector configured for being mechanically and fluidically coupled with a second fluid interface of the sample separation unit, and a swivel mechanism configured for swivelling the first fluid connector between a mounting orientation for mounting the first fluid interface of the sample separation unit at the first fluid connector and an alignment orientation for aligning the second fluid interface of the mounted sample separation unit with the second fluid connector for subsequently coupling the second fluid interface with the second fluid connector.

公开(公告)号：US12085545B2

公开(公告)日：2024-09-10

申请号：US17215872

申请日：2021-03-29

申请人： Agilent Technologies, Inc.

发明人： Bettina Schuhn ,  Uwe Effelsberg

IPC分类号： G01N30/86 ,  G01N30/16 ,  G01N30/02

CPC分类号： G01N30/8658 ,  G01N30/16 ,  G01N2030/027

摘要： A process of determining a modified separation method for a sample separation apparatus based on an initial separation method, including carrying out the initial separation method on a sample separation apparatus, detecting sensor data at the sample separation apparatus during carrying out the initial separation method, and carrying out a numerical analysis for determining the modified separation method by modifying at least one operation parameter of the initial separation method and by using the detected sensor data.

公开(公告)号：US11921093B2

公开(公告)日：2024-03-05

申请号：US17584250

申请日：2022-01-25

申请人： Agilent Technologies, Inc.

发明人： Daniela Loraing ,  Lena Höninger ,  Uwe Effelsberg ,  Andreas Otto ,  Ansgar Waldbaur ,  Armin Steinke ,  Thomas Ortmann ,  Michael Lang

IPC分类号： G01N30/60

CPC分类号： G01N30/6047

摘要： A mounting device for mounting a sample separation unit configured for separating, preferably chromatographically separating, compounds in a fluidic sample includes a first fluid connector configured for being mechanically and fluidically coupled with a first fluid interface of the sample separation unit, a second fluid connector configured for being mechanically and fluidically coupled with a second fluid interface of the sample separation unit, and a swivel mechanism configured for swivelling the first fluid connector between a mounting orientation for mounting the first fluid interface of the sample separation unit at the first fluid connector and an alignment orientation for aligning the second fluid interface of the mounted sample separation unit with the second fluid connector for subsequently coupling the second fluid interface with the second fluid connector.

公开(公告)号：US20210394081A1

公开(公告)日：2021-12-23

申请号：US17351084

申请日：2021-06-17

申请人： Agilent Technologies, Inc.

发明人： Jose-Angel Mora ,  Uwe Effelsberg ,  Lena Höninger

IPC分类号： B01D15/16 ,  G01N30/30 ,  B01D15/12

摘要： A thermal impact assembly for a sample separation apparatus for separating a fluidic sample in a mobile phase by a sample separation unit includes a thermal impact device configured for thermally impacting the fluidic sample and/or the mobile phase and the sample separation unit, and a control unit configured for controlling the thermal impact device for thermally impacting the fluidic sample and/or the mobile phase on the one hand and for thermally impacting the sample separation unit on the other hand independently from each other.

公开(公告)号：US20240288408A1

公开(公告)日：2024-08-29

申请号：US18284491

申请日：2021-03-30

申请人： Agilent Technologies, Inc.

发明人： Lena Höninger ,  Uwe Effelsberg ,  Gerhart Metzler

IPC分类号： G01N30/86 ,  G01N30/02

CPC分类号： G01N30/8658 ,  G01N30/8693 ,  G01N2030/027

摘要： A device for determining a target separation method for separating a fluidic sample by a target sample separation apparatus modifies an initial separation method for an initial sample separation apparatus. The device includes a data provision unit configured for providing a first initial data set characterizing the initial separation method, a second initial data set characterizing properties of the target sample separation apparatus, a third initial data set characterizing properties of the fluidic sample, a fourth initial data set characterizing properties of the initial sample separation apparatus, and a determining unit configured for determining a target data set characterizing the target separation method by carrying out a numerical analysis based on the first initial data set, the second initial data set, the third initial data set, and the fourth initial data set.