公开(公告)号：US20230112993A1

公开(公告)日：2023-04-13

申请号：US17913313

申请日：2021-03-15

Applicant: Agilent Technologies, Inc.

Inventor： Dwight Robert Stoll ,  Stephan Buckenmaier ,  Sascha Lege ,  Thomas Ortmann ,  Konstantin Shoykhet

IPC: G01N30/34 ,  B01D15/14 ,  B01D15/16 ,  G01N30/20 ,  G01N30/46

Abstract: A sample separation device for separating a fluidic sample includes a fluid drive for driving a mobile phase and the fluidic sample when injected in the mobile phase, a sample separation unit for separating the fluidic sample in the mobile phase, and a control unit configured for bracketing the fluidic sample between two mobile phase portions of the mobile phase. At least one of the mobile phase portions is arranged directly next to the fluidic sample and has a higher solvent strength compared to a solvent of the fluidic sample.

公开(公告)号：US20220308019A1

公开(公告)日：2022-09-29

申请号：US17698732

申请日：2022-03-18

Applicant: Agilent Technologies, Inc.

Inventor： Lena Höninger ,  Uwe Effelsberg ,  Gerhart Metzler ,  Sascha Lege ,  Konstantin Shoykhet ,  Stephan Buckenmaier

IPC: G01N30/36 ,  G01N30/30

Abstract: A process of controlling a sample separation apparatus for separating a fluidic sample includes determining whether the sample separation apparatus is appropriate for carrying out a predefined operation, by simulating the operation of the sample separation apparatus, and taking an action depending on a result of the determining.

公开(公告)号：US20210389285A1

公开(公告)日：2021-12-16

申请号：US17348531

申请日：2021-06-15

Applicant: Agilent Technologies, Inc.

Inventor： Clemens Plachetka ,  Konstantin Shoykhet ,  Tony Ziegler ,  Joachim-Richard Wagner ,  Manfred Berndt

IPC: G01N30/36 ,  G01N30/20 ,  G01N30/32 ,  B01D15/14

Abstract: A fluid supply device for providing a mobile phase for a sample separating device includes, a supply conduit for providing a fluid which forms at least a part of the mobile phase, a fluid valve which is fluidically coupled with the supply conduit and, depending on its switching state, enables or prevents a passing of the fluid from the supply conduit, an elastic buffer unit which is fluidically coupled upstream of the fluid valve with the supply conduit and which is configured for buffering the fluid, and a fluid conveying unit for conveying the fluid which passes the fluid valve.

公开(公告)号：US20210324840A1

公开(公告)日：2021-10-21

申请号：US17322676

申请日：2021-05-17

Applicant: Agilent Technologies, Inc.

Inventor： Klaus Witt ,  Konstantin Shoykhet

IPC: F04B11/00 ,  F04B13/02

Abstract: A solvent supply system for supplying a composite includes a first supply path with a first pump unit, the first supply path being adapted for supplying a first solvent to a mixing unit, the first pump unit operating periodically, and a second supply path with a second pump unit, the second supply path being adapted for supplying a second solvent to the mixing unit, the second pump unit operating periodically. The mixing unit is adapted for mixing the first and the second solvent and for supplying a composite solvent. The solvent supply system further includes a control unit adapted for controlling operation of the first and the second pump unit.

公开(公告)号：US20200246724A1

公开(公告)日：2020-08-06

申请号：US16780366

申请日：2020-02-03

Applicant: Agilent Technologies, Inc.

Inventor： Konstantin Shoykhet

IPC: B01D19/00 ,  G01N30/14 ,  G01N30/10

Abstract: A degasser for at least partially degassing a gas-containing liquid, in particular for a sample separation device, includes a circulation path along which the liquid can be circulated between a liquid accommodation volume and one of an inlet to a consumer unit consuming degassed liquid or a conduit leading to the inlet, a drive unit configured for circulating the liquid in the circulation path, and a filter in the circulation path for filtering particles or debris out of the liquid, wherein the liquid is forced through the filter by the drive unit. The drive unit includes a movable body, in particular a movable piston or a movable membrane, configured for at least partially degassing the liquid by generating a negative pressure in the liquid.

公开(公告)号：US20170219540A1

公开(公告)日：2017-08-03

申请号：US15500706

申请日：2015-05-28

Applicant: Agilent Technologies, Inc.

Inventor： Herbert Anderer ,  Konstantin Shoykhet ,  Klaus Witt ,  Stephan Buckenmaier

IPC: G01N30/46

Abstract: In a method for processing successive fluidic sample portions provided by a sample source, sample reception volumes are filled successively temporarily with at least a respective one of the sample sections, and the sample sections are emptied successively out of the sample reception volumes in such a way, that, while emptying, it is avoided to bring two respective ones of the sample sections, which have not left the sample source directly adjacent to one another, in contact with one another.

公开(公告)号：US12055526B2

公开(公告)日：2024-08-06

申请号：US17045756

申请日：2019-04-05

Applicant: Agilent Technologies, Inc.

Inventor： Stephan Buckenmaier ,  Konstantin Shoykhet

IPC: G01N30/20 ,  G01N30/02 ,  G01N30/46 ,  G01N30/82 ,  G01N30/84 ,  B01D15/18

CPC classification number: G01N30/20 ,  G01N30/463 ,  G01N30/465 ,  G01N30/82 ,  B01D15/1878 ,  G01N2030/027 ,  G01N2030/202 ,  G01N2030/208 ,  G01N2030/8411

Abstract: A sampling unit for handling a sample fluid includes a sample container having a length and being configured for receiving and storing the sample fluid, and a sample segment dispatching unit configured for providing a plurality of individual sample packages of the fluidic sample, each contained in a respective volume segment along the length of the sample container, and for individually dispatching each of the plurality of individual sample packages for further processing in a fluid processing unit. The sample unit may be utilized, for example, for injecting the sample packages into a mobile phase stream for transporting to a sample separating unit such as a chromatography column.

公开(公告)号：US12000808B2

公开(公告)日：2024-06-04

申请号：US17348531

申请日：2021-06-15

Applicant: Agilent Technologies, Inc.

Inventor： Clemens Plachetka ,  Konstantin Shoykhet ,  Tony Ziegler ,  Joachim-Richard Wagner ,  Manfred Berndt

IPC: B01D15/14 ,  G01N30/02 ,  G01N30/20 ,  G01N30/32 ,  G01N30/36

CPC classification number: G01N30/36 ,  B01D15/14 ,  G01N30/20 ,  G01N30/32 ,  G01N2030/027 ,  G01N2030/201

Abstract: A fluid supply device for providing a mobile phase for a sample separating device includes, a supply conduit for providing a fluid which forms at least a part of the mobile phase, a fluid valve which is fluidically coupled with the supply conduit and, depending on its switching state, enables or prevents a passing of the fluid from the supply conduit, an elastic buffer unit which is fluidically coupled upstream of the fluid valve with the supply conduit and which is configured for buffering the fluid, and a fluid conveying unit for conveying the fluid which passes the fluid valve.

公开(公告)号：US11772012B2

公开(公告)日：2023-10-03

申请号：US16780366

申请日：2020-02-03

Applicant: Agilent Technologies, Inc.

Inventor： Konstantin Shoykhet

IPC: B01D19/00 ,  G01N30/14 ,  G01N30/10 ,  G01N30/60 ,  G01N30/02

CPC classification number: B01D19/0031 ,  G01N30/10 ,  G01N30/14 ,  G01N30/6091 ,  G01N2030/027 ,  G01N2030/146

Abstract: A degasser for at least partially degassing a gas-containing liquid, in particular for a sample separation device, includes a circulation path along which the liquid can be circulated between a liquid accommodation volume and one of an inlet to a consumer unit consuming degassed liquid or a conduit leading to the inlet, a drive unit configured for circulating the liquid in the circulation path, and a filter in the circulation path for filtering particles or debris out of the liquid, wherein the liquid is forced through the filter by the drive unit. The drive unit includes a movable body, in particular a movable piston or a movable membrane, configured for at least partially degassing the liquid by generating a negative pressure in the liquid.

公开(公告)号：US20230039500A1

公开(公告)日：2023-02-09

申请号：US17787107

申请日：2020-12-01

Applicant: Agilent Technologies, Inc.

Inventor： Stephan Buckenmaier ,  Sascha Lege ,  Thomas Ortmann ,  Konstantin Shoykhet

IPC: B01D15/18 ,  G01N30/46

Abstract: A fluid processing apparatus includes a first fluid separation apparatus including a first fluid pump, configured for driving a first mobile phase, and a first separation unit configured for separating a fluidic sample when within the first mobile phase. A sampling unit includes a modulation buffering unit and a modulation drive, wherein the modulation drive is configured for introducing fluid into the modulation buffering unit. A switching unit is configured, in a first switching state, for introducing fluid into the modulation buffering unit from downstream of the first separation unit, and, in a second switching state, for introducing fluid buffered in the modulation buffering unit in a first flow path between the first fluid pump and the first separation unit.