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1.发明授权公开(公告)号：US11988633B2
公开(公告)日：2024-05-21
申请号：US16644467
申请日：2018-09-20
IPC分类号： G01N27/447 , C08B37/00 , C08G73/02 , C08L79/02
CPC分类号： G01N27/44747 , C08B37/0003 , C08B37/0087 , C08G73/0206 , C08G73/0273 , C08L79/02 , G01N27/44791
摘要： The present disclosure provides methods of improving the resolution of labeled glycans in capillary electrophoresis techniques using a gel as a sieving matrix, by incorporating polyamines in the gel.
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公开(公告)号：US20210223253A1
公开(公告)日：2021-07-22
申请号：US17222741
申请日：2021-04-05
IPC分类号： G01N33/58 , C07D207/46
摘要： The invention relates to an activated form of procaine, and the use of the activated procaine, or salts or solvates thereof, to label amine-containing compounds. In some embodiments, the amine-containing compound is an N-glycan.
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公开(公告)号：US20210333269A1
公开(公告)日：2021-10-28
申请号：US17369768
申请日：2021-07-07
发明人： Francis T. Haxo , Michael J. Kimzey
IPC分类号： G01N33/533 , C07D207/46 , C07D213/24 , C12Q1/6806 , C07H1/00
摘要： Bispyridines improve the labeling of nucleophiles, including amines and thiols and are particularly useful for improving labeling with acidic and basic labels. Use of bispyridines with such labels dramatically increases labeling compared to protocols without a bispyridine. The labeled nucleophile can then be subjected to standard analytical methods.
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公开(公告)号：US11815488B2
公开(公告)日：2023-11-14
申请号：US16960307
申请日：2019-01-11
IPC分类号： G01N27/447 , C12N15/10
CPC分类号： G01N27/44747 , C12N15/101 , G01N27/44791
摘要： The present disclosure provides methods of improving the resolution of analytes by in electrophoretic separations using a gel by incorporating into the gel an effective amount of one or more tri- or tetra-hydroxyl quaternary ammonium compounds, or a mixture of such compounds.
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公开(公告)号：US11092595B2
公开(公告)日：2021-08-17
申请号：US16072816
申请日：2017-02-24
发明人： Francis T. Haxo , Michael J. Kimzey
IPC分类号： G01N33/533 , C07D207/46 , C07D213/24 , C12Q1/6806 , C07H1/00
摘要： Bispyridines improve the labeling of nucleophiles, including amines and thiols and are particularly useful for improving labeling with acidic and basic labels. Use of bispyridines with such labels dramatically increases labeling compared to protocols without a bispyridine. The labeled nucleophile can then be subjected to standard analytical methods.
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公开(公告)号：US11858961B2
公开(公告)日：2024-01-02
申请号：US17398763
申请日：2021-08-10
CPC分类号： C07K1/1136 , C07K1/113 , C11D1/62 , C11D17/00
摘要： Ammonium cation detergents comprising a quaternary or tertiary ammonium cation can be used as detergents to denature proteins and are particularly useful in denaturing glycoproteins or glycopeptides prior to enzymatic deglycosylation. Ammonium cation detergents with sulfate or sulfonate anions are particularly useful.
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公开(公告)号：US20210263043A1
公开(公告)日：2021-08-26
申请号：US17319868
申请日：2021-05-13
发明人： Michael J. Kimzey
摘要： The presence of mild electrophiles, such as aldehydes, during the denaturation of glycoproteins or glycopeptides and subsequent enzymatic deglycosylation reduces artifacts in subsequent analyses of the glycans released from the glycoproteins or gly-copeptides.
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