Bis-heteroaryl derivatives as modulators of protein aggregation

    公开(公告)号:US10913735B2

    公开(公告)日:2021-02-09

    申请号:US16480252

    申请日:2018-01-23

    申请人: UCB Biopharma SRL

    发明人: Adrian Hall

    摘要: The present invention relates to bis-heteroaryl compounds of formula (I), pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer including melanoma.

    Method employing bispecific antibodies

    公开(公告)号:US10829566B2

    公开(公告)日:2020-11-10

    申请号:US15779426

    申请日:2016-12-01

    摘要: The present invention relates to a method of identifying, separating and characterizing a cell or a population of cells, by capturing at the cell surface, secreted soluble substances (such as an immunoglobulin) that cell or population of cell secrete. This is achieved by combing on a heterodimerically-tethered multispecific protein complex combining a binding specificity for the secreted molecule and a binding specificity for a surface antigen specific for that cell or population of cells. This method may be used in research and experimental purposes, such as patients' stratification in preparation of clinical trials or personalized therapies by identifying cell populations relevant to a pathology and/or prognosis.

    Multispecific antibodies
    38.
    发明授权

    公开(公告)号:US10774157B2

    公开(公告)日:2020-09-15

    申请号:US15779424

    申请日:2016-12-01

    摘要: The present invention relates to heterodimerically-tethered bispecific protein complexes (according to the general formula of A(A1)n-X:Y-B(B1)m and libraries/multiplexes thereof for use in research and therapy and in particular an in vitro/ex vivo method of detecting synergistic biological function of otherwise unknown pairs of targets. Such complexes may be used to capture soluble molecules secreted from a particular cell, in therapy, in research and for experimental purposes such as in assays to characterise patient populations by identifying cell populations relevant to a pathology or prognosis.

    Method of generating, storing and mining data related to key opinion leaders in scientific fields and computer system configured for presenting an explorable graphical user interface

    公开(公告)号:US10748226B2

    公开(公告)日:2020-08-18

    申请号:US15258645

    申请日:2016-09-07

    申请人: UCB BIOPHARMA SRL

    摘要: A method of storing and ingesting data related to key opinion leaders is provided. The method includes extracting published works data, individual data, organization data and subject matter data for a plurality of published scientific works to identify entities for each of the published scientific works and storing the published works data, the individual data, the organization data and the subject matter data in a graph database as an explorable network in which each of the entities is represented by a respective node, the published scientific works including at least one of results of clinical trials and biomedical scientific publications, the entities including the published scientific works, individuals, organizations and subjects, the nodes including published work nodes representing the published scientific works, individual nodes representing the individuals, organization nodes representing the organizations and subject matter nodes representing the subjects, each of the individual nodes being linked to at least one of the other individual nodes, at least one of the organization nodes and at least one of the subject matter nodes, the graph database being configured such that the individual nodes, organization nodes and subject nodes are each displayable on a graphical user interface as a center node icon in a partial view of the explorable network with linked nodes being generated as outer node icons surrounding the center node icon. The method also includes mining the explorable network stored in the graph database to augment the explorable network with supplemental information for each individual in the explorable network. The supplemental information is relevant to each individual being a key opinion leader. The method also includes storing the supplemental information for each individual in the explorable network such that upon selection of a node icon representing one or more of the individual nodes the corresponding supplemental information for the one or more individuals represented by the one or more individual nodes is generated on the graphical user interface.