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公开(公告)号:US20210140972A1
公开(公告)日:2021-05-13
申请号:US17072665
申请日:2020-10-16
申请人: UCB BIOPHARMA SRL
发明人: James Philip O'CONNELL , John Robert PORTER , Alastair LAWSON , Boris KROEPLIEN , Stephen Edward RAPECKI , Timothy John NORMAN , David James MCMILLAN , Graham John WARRELLOW , Daniel Christopher BROOKINGS , Rikki Peter ALEXANDER
IPC分类号: G01N33/68 , C07D401/14 , C07K14/525 , C07D471/00 , C07K14/705 , C07K16/24 , C07D213/72 , C07D235/04 , C07D239/26 , C07D471/04 , A61K47/64 , A61P37/00 , A61P35/00
摘要: The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy.
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公开(公告)号:US20210101964A1
公开(公告)日:2021-04-08
申请号:US16772043
申请日:2018-12-13
申请人: UCB Biopharma SRL
发明人: Patrick DOWNEY , Kerry Louise TYSON , Marco KRIEK , Lorenzo DE LICHTERVELDE , Daniel John LIGHTWOOD , David James MCMILLAN , Peter Charles ELLIOTT , Terence Seward BAKER
摘要: The present invention relates to alpha synuclein binding antibodies and fragments thereof capable of binding alpha synuclein as a monomer and in fibrils and preventing alpha synuclein aggregation induced by alpha synuclein fibrils. The antibodies of the present invention are for use in the treatment of alpha synucleinopathies, including Parkinson's disease.
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公开(公告)号:US10969393B2
公开(公告)日:2021-04-06
申请号:US15736535
申请日:2015-10-22
申请人: UCB Biopharma SRL
发明人: James Philip O'Connell , John Robert Porter , Alastair Lawson , Daniel John Lightwood , Rebecca Jayne Munro
IPC分类号: C07D401/14 , C07K14/525 , C07D471/00 , C07K14/705 , C07K16/24 , C07D213/72 , C07D235/04 , C07D239/26 , C07D471/04 , A61K47/64 , A61P37/00 , A61P35/00 , G01N33/68
摘要: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.
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公开(公告)号:US20210088530A1
公开(公告)日:2021-03-25
申请号:US17013326
申请日:2020-09-04
申请人: UCB BIOPHARMA SRL
发明人: James Philip O'CONNELL , John Robert PORTER , Alastair LAWSON , Boris KROEPLIEN , Stephen Edward RAPECKI , Timothy John NORMAN , Graham John WARRELLOW , Tracy Lynn ARAKAKI , Alex Buntin BURGIN , William Ross PITT , Mark Daniel CALMIANO , David Andreas SCHUBERT , Daniel John LIGHTWOOD , Rebecca Jayne MUNRO
IPC分类号: G01N33/68 , C07D401/14 , C07K14/525 , C07D471/00 , C07K14/705 , C07K16/24 , C07D213/72 , C07D235/04 , C07D239/26 , C07D471/04 , A61K47/64 , A61P37/00 , A61P35/00
摘要: A new, stable trimeric TNFα structure is disclosed with distorted symmetry which can bind to the TNFR1 receptor to attenuate signalling therefrom, which can be used in the treatment and/or prevention of diseases associated with the soluble TNFα/TNFR1 interaction. Membrane-bound TNFα is not affected in its ability to signal through TNFR2, and thus the new structure of TNFα may be used in therapies which do not significantly raise the risk of infection or malignancy.
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公开(公告)号:US20210053952A1
公开(公告)日:2021-02-25
申请号:US16959339
申请日:2019-01-10
申请人: UCB Biopharma SRL
发明人: Gareth Neil Brace , Rose Elizabeth Chappell , Gregory Foulkes , James Richard Frost , Helen Tracey Horsley , Elizabeth Pearl Jones , Fabien Claude Lecomte , James Thomas Reuberson , Monika-Sarah Elizabeth Dorothea Schulze , Richard David Taylor , Wei Tsung Yau , Zhaoning Zhu
IPC分类号: C07D407/14 , C07D413/12 , C07D413/14 , C07D235/16 , C07D401/14
摘要: A series of substituted fused bicyclic imidazole derivatives, including benzimidazole derivatives and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.
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公开(公告)号:US10913735B2
公开(公告)日:2021-02-09
申请号:US16480252
申请日:2018-01-23
申请人: UCB Biopharma SRL
发明人: Adrian Hall
IPC分类号: C07D417/14 , A61K31/496 , A61K31/501 , A61K31/506 , A61P25/28 , A61P25/16
摘要: The present invention relates to bis-heteroaryl compounds of formula (I), pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, Lewy body disease, Parkinson's disease with dementia, fronto-temporal dementia, Huntington's Disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer including melanoma.
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公开(公告)号:US10829566B2
公开(公告)日:2020-11-10
申请号:US15779426
申请日:2016-12-01
申请人: UCB BIOPHARMA SPRL
摘要: The present invention relates to a method of identifying, separating and characterizing a cell or a population of cells, by capturing at the cell surface, secreted soluble substances (such as an immunoglobulin) that cell or population of cell secrete. This is achieved by combing on a heterodimerically-tethered multispecific protein complex combining a binding specificity for the secreted molecule and a binding specificity for a surface antigen specific for that cell or population of cells. This method may be used in research and experimental purposes, such as patients' stratification in preparation of clinical trials or personalized therapies by identifying cell populations relevant to a pathology and/or prognosis.
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公开(公告)号:US10774157B2
公开(公告)日:2020-09-15
申请号:US15779424
申请日:2016-12-01
申请人: UCB BIOPHARMA SPRL
发明人: Michael John Wright
摘要: The present invention relates to heterodimerically-tethered bispecific protein complexes (according to the general formula of A(A1)n-X:Y-B(B1)m and libraries/multiplexes thereof for use in research and therapy and in particular an in vitro/ex vivo method of detecting synergistic biological function of otherwise unknown pairs of targets. Such complexes may be used to capture soluble molecules secreted from a particular cell, in therapy, in research and for experimental purposes such as in assays to characterise patient populations by identifying cell populations relevant to a pathology or prognosis.
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公开(公告)号:US10748226B2
公开(公告)日:2020-08-18
申请号:US15258645
申请日:2016-09-07
申请人: UCB BIOPHARMA SRL
IPC分类号: G16H70/40 , G16H10/20 , G16H70/60 , G16H70/00 , G06Q50/22 , G06F16/22 , G06F16/25 , G06F16/2458 , G06F16/901 , G06F19/00 , G06Q30/02
摘要: A method of storing and ingesting data related to key opinion leaders is provided. The method includes extracting published works data, individual data, organization data and subject matter data for a plurality of published scientific works to identify entities for each of the published scientific works and storing the published works data, the individual data, the organization data and the subject matter data in a graph database as an explorable network in which each of the entities is represented by a respective node, the published scientific works including at least one of results of clinical trials and biomedical scientific publications, the entities including the published scientific works, individuals, organizations and subjects, the nodes including published work nodes representing the published scientific works, individual nodes representing the individuals, organization nodes representing the organizations and subject matter nodes representing the subjects, each of the individual nodes being linked to at least one of the other individual nodes, at least one of the organization nodes and at least one of the subject matter nodes, the graph database being configured such that the individual nodes, organization nodes and subject nodes are each displayable on a graphical user interface as a center node icon in a partial view of the explorable network with linked nodes being generated as outer node icons surrounding the center node icon. The method also includes mining the explorable network stored in the graph database to augment the explorable network with supplemental information for each individual in the explorable network. The supplemental information is relevant to each individual being a key opinion leader. The method also includes storing the supplemental information for each individual in the explorable network such that upon selection of a node icon representing one or more of the individual nodes the corresponding supplemental information for the one or more individuals represented by the one or more individual nodes is generated on the graphical user interface.
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公开(公告)号:US20240352083A1
公开(公告)日:2024-10-24
申请号:US18647911
申请日:2024-04-26
申请人: UCB Biopharma SRL
发明人: Ralph Adams , Terence Seward Baker , Xiaofeng Liu
IPC分类号: C07K14/54 , C07K14/505 , C07K14/535 , C07K14/55 , C07K16/18 , C07K16/24 , C07K16/28
CPC分类号: C07K14/5443 , C07K14/505 , C07K14/535 , C07K14/5428 , C07K14/55 , C07K16/18 , C07K16/244 , C07K16/248 , C07K16/2809 , C07K16/2818 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/567 , C07K2317/569 , C07K2317/622 , C07K2317/76
摘要: The present invention provides antibodies comprising a variable (V) domain and an insert polypeptide, wherein the insert polypeptide is within the framework 3 region of the V domain.
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