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公开(公告)号：US10544429B2
公开(公告)日：2020-01-28
申请号：US15106555
申请日：2014-12-19
摘要： The present invention relates to a nucleic acid sequence comprising a binding site operably linked to a nucleotide of interest, wherein the binding site is capable of interacting with an RNA-binding protein such that translation of the nucleotide of interest is repressed in a viral vector production cell.
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公开(公告)号：US10525100B2
公开(公告)日：2020-01-07
申请号：US16239217
申请日：2019-01-03
摘要： Provided are activating transcription factor 5 (ATF5) peptides having a truncated ATF5 leucine zipper region and, optionally, a cell-penetrating region, compositions comprising the ATF5 peptides, and methods of inhibiting proliferation of and promoting cytotoxicity in a neoplastic cell using the ATF5 peptides.
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公开(公告)号：US10155023B2
公开(公告)日：2018-12-18
申请号：US15424107
申请日：2017-02-03
IPC分类号： C12N7/00 , A61K39/12 , A61K38/16 , C07K14/005 , C12P21/00 , G01N33/569
摘要： The present invention provides methods of making engineered viral proteins and protein complexes that are useful as vaccine immunogens, engineered viral proteins and protein complexes made using such methods, and pharmaceutical compositions comprising such engineered viral proteins and protein complexes. Such engineered viral proteins and protein complexes may comprise one or more cross-links that stabilize the conformation of an antibody epitope, such as a quaternary neutralizing antibody, and may exhibit an enhanced ability to elicit a protective immune response when administered to a subject as a component of a vaccine.
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公开(公告)号：US09863954B2
公开(公告)日：2018-01-09
申请号：US14763023
申请日：2014-01-23
发明人： Johan Aarum , Denise Schwarz
IPC分类号： C40B30/00 , C40B30/02 , C40B30/04 , C40B30/06 , C40B30/08 , C40B30/10 , C40B40/00 , G01N33/68 , C12Q1/34 , C12Q1/68
CPC分类号： G01N33/6803 , C12Q1/34 , C12Q1/6869 , C12Q1/6883 , G01N33/6896 , G01N2333/922 , G01N2500/04
摘要： The present invention provides the use of RNA removal to initiate protein aggregation of a plurality of proteins in a cell or cell lysate. This may be used to create an in vitro model of a disease, such as a neurodegenerative disease. The present invention also provides a method for determining the efficacy of a potential anti-protein aggregation agent comprising the following steps: i) using RNA removal to initiate the aggregation of a protein in a cell or cell lysate, ii) treating the cell or cell lysate with the potential anti-protein aggregation agent before, after or during RNA removal; and iii) comparing protein aggregation in equivalent samples with and without step ii) treatment in which a decrease in protein aggregation associated with step ii) treatment indicates that the potential anti-protein aggregation agent is effective in preventing and/or reversing protein aggregation.
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公开(公告)号：US09541555B2
公开(公告)日：2017-01-10
申请号：US14615045
申请日：2015-02-05
发明人： Dawn Coverley
IPC分类号： C12Q1/68 , G01N33/574 , C07K14/47
CPC分类号： G01N33/57496 , C07K14/4702 , C12Q1/6883 , C12Q2600/158 , G01N33/57407 , G01N33/57426 , G01N33/5743 , G01N33/57438 , G01N2333/47
摘要： This invention relates to a screening method for the identification of agents which modulate the activity of a DNA replication protein as a target for intervention in cancer therapy and includes agents which modulate said activity. The invention also relates to the use of the DNA replication protein, and its RNA transcripts in the prognosis and diagnosis of proliferative disease e.g., cancer.
摘要翻译： 本发明涉及一种筛选方法，用于鉴定调节作为癌症治疗干预的靶标的DNA复制蛋白的活性的试剂，并且包括调节所述活性的试剂。 本发明还涉及DNA复制蛋白及其RNA转录物在增殖性疾病例如癌症的预后和诊断中的用途。
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公开(公告)号：US12054735B2
公开(公告)日：2024-08-06
申请号：US16714516
申请日：2019-12-13
CPC分类号： C12N15/86 , C12N7/00 , C12N2710/10343 , C12N2710/10351 , C12N2740/15043 , C12N2740/15051 , C12N2740/15052 , C12N2740/16043 , C12N2740/16051 , C12N2750/14143 , C12N2750/14151 , C12N2840/102 , C12N2840/55
摘要： The present invention relates to a nucleic acid sequence comprising a binding site operably linked to a nucleotide of interest, wherein the binding site is capable of interacting with an RNA-binding protein such that translation of the nucleotide of interest is repressed in a viral vector production cell.
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公开(公告)号：US11964027B2
公开(公告)日：2024-04-23
申请号：US16606633
申请日：2018-04-20
发明人： Anna Christina Kajaste-Rudnitski , Carolina Petrillo , Bernhard Rudolf Gentner , Luigi Naldini , Pietro Genovese , Giulia Schiroli
IPC分类号： A61K48/00 , C07K7/64 , C12N5/0789 , C12N15/69 , C12N15/86
CPC分类号： A61K48/0008 , C07K7/645 , C12N5/0647 , C12N15/69 , C12N15/86 , C12N2740/15043
摘要： Use of cyclosporin H (CsH) or a derivative thereof for increasing the efficiency of transduction of an isolated population of cells by a viral vector and/or increasing the efficiency of gene editing of an isolated population of cells when transduced by a viral vector.
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公开(公告)号：US11895994B2
公开(公告)日：2024-02-13
申请号：US17011292
申请日：2020-09-03
发明人： Jun Xu , Lu Cheng , Yeheng Liu , Jiawei Yi , Xuefeng Zhou
IPC分类号： A01K67/027 , C12N5/0735 , C12N15/85
CPC分类号： A01K67/0278 , A01K67/0276 , C12N5/0606 , C12N15/8509 , A01K2207/15 , A01K2217/052 , A01K2227/105 , A01K2267/03 , C12N2015/8527
摘要： Provided is a genetically modified non-human animal, in which at least one copy of the endogenous nucleotide sequence encoding Protein C in the genome of said the non-human animal has been replaced by a nucleotide sequence encoding human Protein C or a functional fragment or variant thereof. Also provided are vectors, cells, and methods for the production of such non-human animals. Further provided are methods of testing agents for their ability to alter to the level and/or functional activity of human protein C, for example, to test their potential therapeutic efficacy.
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公开(公告)号：US11673943B2
公开(公告)日：2023-06-13
申请号：US17104848
申请日：2020-11-25
IPC分类号： A61K49/00 , A61K49/16 , A61K39/395 , A61K39/00 , C07K16/18 , G01N33/53 , G01N33/68 , C07K14/47 , A61P25/28 , G01N33/533 , C12Q1/37
CPC分类号： C07K16/18 , A61K39/3955 , A61P25/28 , C07K14/4711 , G01N33/6896 , A01K2267/0312 , A61K39/395 , A61K49/00 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , C12Q1/37 , G01N33/533 , G01N2333/4709 , G01N2333/96425 , G01N2800/2814 , G01N2800/2821
摘要： The invention provides an antibody or antigen binding fragments thereof that binds to 3pE Aβ and methods of making and using the antibody or antigen binding fragment thereof, including use for formulations, administration and kits. The antibody and antigen binding fragments thereof and methods disclosed are useful for diagnosis, prognosis and treatment of Alzheimer's disease or other β-amyloid-related diseases.
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公开(公告)号：US11279954B2
公开(公告)日：2022-03-22
申请号：US16454024
申请日：2019-06-26
摘要： Provided is a construct comprising (i) a nucleotide sequence which encodes tyrosine hydroxylase (TH), (ii) a nucleotide sequence which encodes GTP-cyclohydrolase I (CH1) and (iii) a nucleotide sequence which encodes Aromatic Amino Acid Dopa Decarboxylase (AADC) wherein the nucleotide sequence encoding TH is linked to the nucleotide sequence encoding CH1 such that they encode a fusion protein TH-CH1. Also provided is a construct comprising (i) a nucleotide sequence which encodes tyrosine hydroxylase (TH), (ii) a nucleotide sequence which encodes GTP-cyclohydrolase I (CH1) and (iii) a nucleotide sequence which encodes Aromatic Amino Acid Dopa Decarboxylase (AADC) wherein the nucleotide sequence encoding AADC is linked to the nucleotide sequence encoding TH such that they encode a fusion protein AADC-TH or TH-AADC. Further provided is a viral vector comprising such nucleotide sequences and its use in the treatment and/or prevention of Parkinson's disease.
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