公开(公告)号：US20220338471A1

公开(公告)日：2022-10-27

申请号：US17762994

申请日：2020-09-23

Applicant: Kansas State University Research Foundation ,  The United States of America, as represented by the Secretary of Agriculture ,  Board of Regents of The University of Nebraska

Inventor： Yoonseong Park ,  Ronald Nachman ,  Troy Anderson

IPC: A01N25/32 ,  A01N25/02 ,  A01N25/12 ,  A01P7/00

Abstract: Described herein are bee-safe acaricides that target the varroa mite-specific neuropeptidergic system regulated by proctolin, and methods of use. The acaricides comprise a peptide analog or peptidomimetic of varroa mite proctolin for selective targeting of this pest in a bee colony. The compounds are also effective against other pests, such as ticks. The peptide analog or peptidomimetic generally comprises one or two amino acid residue substitutions or insertions. Also described herein are methods of screening compounds for activity on a proctolin receptor.

公开(公告)号：US11447753B2

公开(公告)日：2022-09-20

申请号：US16868243

申请日：2020-05-06

Applicant: Northwestern University ,  Board of Regents of the University of Nebraska ,  Trustees of Tufts College (AKA Tufts University)

Inventor： Gregory A. Smith ,  Patricia Jane Sollars ,  Gary Edward Pickard ,  Ekaterina E. Heldwein

IPC: A61K39/245 ,  A61K39/25 ,  C12N7/00 ,  C07K14/005 ,  A61K39/12 ,  A61K35/763 ,  A61K39/00

Abstract: Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.

公开(公告)号：US20220294449A1

公开(公告)日：2022-09-15

申请号：US17827744

申请日：2022-05-29

Applicant: Board of Regents of the University of Nebraska

Inventor： Nishtha Sharma GAUL ,  Andrew MARSHALL ,  Peter A. DOWBEN ,  Dmitri E. NIKONOV

IPC: H03K19/16 ,  H01L29/423 ,  H03K19/10 ,  H03K19/21

Abstract: A magneto-electric (ME) majority gate device includes a conducting device and a plurality of ME transistors coupled to the conducting device. In one implementation, the plurality of ME transistors include a ME AND gate device with downward interface polarization, a ME-transmission gate device with downward interface polarization, and a ME-XNOR gate device. In another implementation, the plurality of ME transistors is five single-input ME-FETs.

公开(公告)号：US11419317B2

公开(公告)日：2022-08-23

申请号：US16615578

申请日：2019-03-18

Applicant: Central Institute for Experimental Animals ,  the Board of Regents of the University of Nebraska

Inventor： Larisa Poluektova ,  Santhi Gorantla ,  Mamoru Ito ,  Ikumi Katano

IPC: A01K67/027 ,  C12N5/079

Abstract: The present invention provides a non-human animal having human interleukin-34 (IL-34) in the body thereof; a method for producing a non-human animal having human microglia, which includes transplanting human CD34-positive hematopoietic stem cells into the non-human animal having human IL-34 in the body; and a method for producing human microglia, which includes obtaining human microglia from the non-human animal having human microglia.

公开(公告)号：US20220194990A1

公开(公告)日：2022-06-23

申请号：US17310245

申请日：2020-01-31

Applicant: Board of Regents of the University of Nebraska

Inventor： Howard E. Gendelman ,  Jonathan Herskovitz ,  Mahmudul Hasan ,  Bhavesh Kevadiya

IPC: C07K14/005

Abstract: The present invention provides virus-like particles and methods of manufacture and use thereof. In accordance with the instant invention, virus-like particles (VLPs), particularly human immunodeficiency virus (HIV) VLPs, are provided. The HIV VLPs comprise at least one HIV structural protein and the HIV envelope protein, but lacks the HIV genome and lacks functional reverse transcriptase and integrase.

公开(公告)号：US11351153B2

公开(公告)日：2022-06-07

申请号：US16474173

申请日：2017-12-27

Applicant: Board of Regents of the University of Nebraska

Inventor： Thomas McDonald ,  Steven M. Tracy

IPC: A61K31/4166 ,  A61P31/04 ,  A61P31/10 ,  A61K9/00 ,  A61K31/4164

Abstract: An antimicrobial composition containing a synergistic combination of an imidazole antifungal agent and activated creatinine is provided, wherein the imidazole antifungal agent represents in the range of about 0.5 mol % to about 30 mol % of the combination of the antifungal agent and the activated creatinine in the composition. Methods for treating bacterial infections, fungal infections, viral infections, and wounds are also provided, as are other methods of use, including methods for disinfecting inert surfaces, methods for preserving food products, and methods for treating plants. In addition, the invention provides a method for enhancing the antifungal effect of an imidazole antifungal agent as well as a method for enhancing the antibacterial effect of activated creatinine. Compositions and methods involving use of activated 2-amino-imidazol-4-one analogs other than activated creatinine are also provided.

公开(公告)号：US20220152457A1

公开(公告)日：2022-05-19

申请号：US17533837

申请日：2021-11-23

Applicant: Board of Regents of the University of Nebraska

Inventor： William Denton ,  Molly Schieber ,  Casey Wiens

IPC: A63B24/00 ,  A63B22/02 ,  A63B21/00

Abstract: Disclosed herein are examples of user-paced exercise equipment, as well as related circuitry, methods, and computer-readable media. For example, disclosed herein is a user-paced treadmill, including a belt, a motor coupled to the belt, and control circuitry communicatively coupled to the motor. The control circuitry may be configured to change a velocity of the belt based at least in part on a body velocity and a leg swing velocity of a user of the user-paced treadmill.

公开(公告)号：US11317889B2

公开(公告)日：2022-05-03

申请号：US16971988

申请日：2019-02-22

Applicant: Board of Regents of the University of Nebraska

Inventor： Irving H. Zucker ,  Ioannis Chatzizisis ,  Han-Jun Wang ,  Alicia M. Schiller ,  Peter Ricci Pellegrino

IPC: A61B8/06 ,  A61B90/00 ,  A61B8/04 ,  A61B8/00 ,  A61B5/026 ,  A61B5/022

Abstract: Technology is described that can be used for continuous measurements of blood pressure and arterial blood flow to automatically derive time-varying estimates of multiple factors pertaining to a patients vascular system. Such factors can include, but are not limited to, resistive flow, capacitive flow, vascular resistance, and arterial capacitance. Determination of such factors can allow for the meaningful assessment of the control of vascular resistance and capacitance in real time.

公开(公告)号：US20220008543A1

公开(公告)日：2022-01-13

申请号：US17288814

申请日：2019-10-27

Applicant: Board of Regents of the University of Nebraska

Inventor： Dong Wang ,  Steven R. Goldring ,  Gang Zhao ,  Rongguo Ren ,  Zhenshan Jia ,  Xin Wei

IPC: A61K47/58 ,  A61K47/69 ,  A61K47/54 ,  A61K47/55

Abstract: This application discloses prodrug-based thermosensitive gel (“ProGel”) comprised of conjugates of dmg molecules with water-soluble polymeric carriers, which are capable of controlled release of the dmg molecules into the tissue of a subject. Use of the ProGel-Drug conjugates for treatment of various diseases or disorders and methods of preparing them are also disclosed.

公开(公告)号：US20210393654A1

公开(公告)日：2021-12-23

申请号：US17332324

申请日：2021-05-27

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA ,  UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Sarah Holstein ,  David Wiemer

IPC: A61K31/683 ,  A61K45/06 ,  C07F9/6518

Abstract: Disclosed herein are inhibitors of the GGDPS enzyme, and methods for their use in treating or preventing diseases, such as multiple myeloma. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: wherein the substituents are described.