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公开(公告)号：US20070048260A1
公开(公告)日：2007-03-01
申请号：US11551362
申请日：2006-10-20
申请人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
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公开(公告)号：US20070041974A1
公开(公告)日：2007-02-22
申请号：US11549868
申请日：2006-10-16
申请人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
IPC分类号： A61K39/395 , C07K16/24 , C12P21/04
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
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公开(公告)号：US20050003475A1
公开(公告)日：2005-01-06
申请号：US09745792
申请日：2000-12-22
申请人： Donald Foster , Wenfeng Xu , Karen Madden , James Kelly , Cindy Sprecher , Cameron Brandt , Mark Rixon , Scott Presnell , Brian Fox
发明人： Donald Foster , Wenfeng Xu , Karen Madden , James Kelly , Cindy Sprecher , Cameron Brandt , Mark Rixon , Scott Presnell , Brian Fox
IPC分类号： A61K38/00 , C07K14/715 , A61K38/17 , C07H21/04
CPC分类号： C07K16/2866 , A61K38/00 , C07K14/7155 , C07K2319/00
摘要： A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
摘要翻译： 具有两个多肽亚单位IL-20RA（以前称为ZcytoR7）和IL-20RB（以前称为DIRS1）的IL-20的可溶性受体。 两个亚基优选连接在一起。 在一个实施方案中，一个亚基与免疫球蛋白的轻链的恒定区融合，另一个亚基与免疫球蛋白的重链的恒定区融合。 轻链和重链通过二硫键连接。
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公开(公告)号：US20070166794A1
公开(公告)日：2007-07-19
申请号：US11551811
申请日：2006-10-23
申请人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
摘要翻译： 描述了与SEQ ID NO：2所示的包含zalpha11配体的序列的多肽和肽结合的抗体。 抗体可以结合162个氨基酸残基或其片段的全长序列，包括131个氨基酸残基的成熟多肽和较小的多肽和肽序列。 抗体可以包括多克隆，单克隆，鼠，人源化或中和的抗体。 还描述了产生抗体的方法。
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公开(公告)号：US20070140964A1
公开(公告)日：2007-06-21
申请号：US11553241
申请日：2006-10-26
申请人： Cindy Sprecher , Zeren Gao , Joseph Kuijper , Maria Dasovich , Francis Grant , Scott Presnell , Theodore Whitmore , Angela Hammond , Julia Novak , Jane Gross , Stacey Dillon
发明人： Cindy Sprecher , Zeren Gao , Joseph Kuijper , Maria Dasovich , Francis Grant , Scott Presnell , Theodore Whitmore , Angela Hammond , Julia Novak , Jane Gross , Stacey Dillon
IPC分类号： A61K51/00 , A61K39/395 , A61K38/17
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
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公开(公告)号：US20070105777A1
公开(公告)日：2007-05-10
申请号：US11620994
申请日：2007-01-08
申请人： Cindy Sprecher , Scott Presnell , Zeren Gao , Theodore Whitmore , Joseph Kuijper , Mark Maurer
发明人： Cindy Sprecher , Scott Presnell , Zeren Gao , Theodore Whitmore , Joseph Kuijper , Mark Maurer
IPC分类号： A61K38/17 , C07K14/715 , C07H21/04 , C12P21/06
CPC分类号： C07K14/715
摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17, a novel cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytorl7, are located on chromosome 5, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zcytor17，一种新的细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zcytor17的多核苷酸位于染色体5上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。
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公开(公告)号：US20070098682A1
公开(公告)日：2007-05-03
申请号：US11551136
申请日：2006-10-19
申请人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
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公开(公告)号：US20070092485A1
公开(公告)日：2007-04-26
申请号：US11551807
申请日：2006-10-23
申请人： JULIA NOVAK , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： JULIA NOVAK , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
CPC分类号： A61K38/17
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
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公开(公告)号：US20070059825A1
公开(公告)日：2007-03-15
申请号：US11551127
申请日：2006-10-19
申请人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
发明人： Julia Novak , Scott Presnell , Cindy Sprecher , Donald Foster , Richard Holly , Jane Gross , Janet Johnston , Andrew Nelson , Stacey Dillon , Angela Hammond
IPC分类号： C12N5/08
CPC分类号： C07K14/001 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A61K38/00 , A61K38/18 , C07K14/52 , C07K14/535 , C07K14/54 , C07K14/5406 , C07K14/715 , C07K16/24 , C07K16/2866 , C07K2317/73 , C07K2319/00 , C07K2319/21 , C07K2319/24 , C07K2319/30 , C07K2319/55 , C12N15/62 , C12N15/8509 , C12N2799/026 , G01N2333/52 , A61K2300/00
摘要： Antibodies that bind to polypeptides and peptides comprising the sequence of zalpha11 Ligand as shown in SEQ ID NO: 2 are described. The antibodies may bind the full length sequence of 162 amino acid residues or a fragment thereof, including a mature polypeptide of 131 amino acid residues and smaller polypeptide and peptide sequences. The antibodies may include antibodies that are polyclonal, monoclonal, murine, humanized or neutralizing. Methods for producing the antibodies are also described.
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公开(公告)号：US20070049530A1
公开(公告)日：2007-03-01
申请号：US11552653
申请日：2006-10-25
申请人： Cindy Sprecher , Zeren Gao , Joseph Kuijper , Maria Dasovich , Francis Grant , Scott Presnell , Theodore Whitmore , Angela Hammond , Julia Novak , Jane Gross , Stacey Dillon
发明人： Cindy Sprecher , Zeren Gao , Joseph Kuijper , Maria Dasovich , Francis Grant , Scott Presnell , Theodore Whitmore , Angela Hammond , Julia Novak , Jane Gross , Stacey Dillon
IPC分类号： A61K38/17 , C07K14/705 , C07H21/04 , C12P21/06
CPC分类号： C07K16/2866 , A01K2217/05 , A61K38/00 , C07K14/52 , C07K14/715 , C07K2317/24 , C07K2317/76
摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.
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