公开(公告)号：US08365087B2

公开(公告)日：2013-01-29

申请号：US12420237

申请日：2009-04-08

申请人： Karlheinz Glaser-Seidnitzer ,  Johannes Kling ,  Diana Martin

发明人： Karlheinz Glaser-Seidnitzer ,  Johannes Kling ,  Diana Martin

IPC分类号： G06F3/048 ,  A61B5/05

CPC分类号： G06F19/321 ,  G06F19/00 ,  G16H40/63

摘要： A method and a user interface for the implementation of a medical examination with at least one imaging device operated by determination and input of a group of measurement parameters via an input device of the user interface, generation of spatially resolved image information with the at least one imaging device depending on the group of measurement parameters, and storage of the image information on a storage medium, presentation of the image information as a data symbol on a screen of the user interface, Multiple data symbols are presented in a predetermined arrangement on the screen for a medical assessment. In order to be able to clearly present all data of a patient that are acquired in imaging methods in an accessible and manipulable manner, the data symbols are arranged on the screen by a control unit depending on at least three display parameters.

摘要翻译： 一种用于通过至少一个成像装置实施医疗检查的方法和用户界面，所述至少一个成像装置通过经由用户界面的输入装置的一组测量参数的确定和输入来操作，产生具有至少一个的空间分辨图像信息 成像装置，取决于测量参数组，以及将图像信息存储在存储介质上，将图像信息作为数据符号呈现在用户界面的屏幕上，多个数据符号以预定布置呈现在屏幕上 进行医学评估。 为了能够以可访问和可操作的方式清楚地呈现在成像方法中获取的患者的所有数据，根据至少三个显示参数，数据符号由控制单元布置在屏幕上。

公开(公告)号：US20110190164A1

公开(公告)日：2011-08-04

申请号：US12991689

申请日：2008-05-09

申请人： Thomas Zurcher ,  Juan Jose Bernal ,  Cayetano von Kobbe ,  Ignacio JimenezTorres ,  Ana Diaz Blázquez ,  Diana Martin Lorenzo ,  Gloria Calderita Lucas ,  Arcadio Garcia de Castro

发明人： Thomas Zurcher ,  Juan Jose Bernal ,  Cayetano von Kobbe ,  Ignacio JimenezTorres ,  Ana Diaz Blázquez ,  Diana Martin Lorenzo ,  Gloria Calderita Lucas ,  Arcadio Garcia de Castro

IPC分类号： C40B30/06 ,  C07K19/00 ,  C07H21/00 ,  C12N15/63 ,  C40B40/02 ,  C12P21/00 ,  C12N1/00 ,  C12N5/10

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K2039/5256 ,  A61K2039/5258 ,  C07K2319/40 ,  C12N2720/10022 ,  C12N2720/10023

摘要： The field of the invention refers to chimeric Virus Like Particles (VLP) derived from Birnavirus chimeric VP2 protein. In particular, the invention refers to chimeric VP2 fusion proteins which incorporate insertions and/or substitutions with one or more amino acids or particular peptide of interest while maintaining the capacity to assemble in the form of VLP. The invention identifies particular insertion and/or substitutions sites within VP2 P loop regions and outside said P loop regions. The invention also incorporates methods for the identification of preferred insertion and substitution sites within VP2 for the incorporation of particular amino acids and peptides of interest. The resulting chimeric VLP are of interest in the design of therapeutic and prophylactic vaccines as well as in the design of drug delivery systems, carriers for DNA and RNA in gene therapy, as targeted agents, in the development of antitoxins, and as diagnostic reagents.

摘要翻译： 本发明的领域是指衍生自Birnavirus嵌合VP2蛋白的嵌合病毒样颗粒（VLP）。 特别地，本发明涉及嵌合VP2融合蛋白，其掺入一个或多个氨基酸或特定感兴趣肽的插入和/或取代，同时保持以VLP形式组装的能力。 本发明鉴定VP2P环区域内的所述P环区域内的特定插入和/或取代位点。 本发明还包括用于鉴定VP2内优选的插入和取代位点以便并入特定的目的氨基酸和肽的方法。 所产生的嵌合VLP在治疗和预防性疫苗的设计以及药物递送系统的设计，基因治疗中的DNA和RNA的载体，靶向剂，抗毒素的开发和诊断试剂方面都是感兴趣的。

公开(公告)号：US07835781B2

公开(公告)日：2010-11-16

申请号：US11882693

申请日：2007-08-03

申请人： Ralf Ladebeck ,  Diana Martin ,  Norbert Rietsch

发明人： Ralf Ladebeck ,  Diana Martin ,  Norbert Rietsch

IPC分类号： A61B5/05 ,  A61B6/00

CPC分类号： G01R33/481 ,  A61B6/037 ,  G01T1/1603

摘要： A device is disclosed for superposed MRI and PET imaging and includes an MRI tube that has a first field of view along its longitudinal direction, and a multiplicity of PET detection units arranged opposite one another in pairs about the longitudinal direction. In at least one embodiment the many PET detection units define a second field of view along the longitudinal direction, and their arrangement density along the longitudinal direction is optimized such that the second field of view substantially corresponds to the first field of view.

摘要翻译： 公开了一种用于重叠的MRI和PET成像的装置，并且包括沿着其纵向方向具有第一视场的MRI管和多个相对于纵向方向成对布置的PET检测单元。 在至少一个实施例中，许多PET检测单元沿着纵向方向限定第二视场，并且优化其沿着纵向方向的排列密度，使得第二视场基本上对应于第一视场。

公开(公告)号：US20090105583A1

公开(公告)日：2009-04-23

申请号：US12232522

申请日：2008-09-18

申请人： Diana Martin ,  Gunther Platsch ,  Martin Requardt ,  Sebastian Schmidt ,  Kristin Schmiedehausen ,  Michael Szimtenings

发明人： Diana Martin ,  Gunther Platsch ,  Martin Requardt ,  Sebastian Schmidt ,  Kristin Schmiedehausen ,  Michael Szimtenings

IPC分类号： A61B5/055 ,  A61G7/00 ,  G06Q50/00

CPC分类号： G01T1/1603 ,  A61B6/037 ,  A61B6/4494 ,  G01T7/005 ,  G06F19/00 ,  G06Q50/22 ,  G06Q50/24

摘要： A method is disclosed for determining attenuation values for PET data of a patient. In at least one embodiment, the method includes detecting at least one accessory of a magnetic resonance imaging scanner and detecting the position and/or alignment of the accessory by way of an imaging measuring method; comparing the detected accessory with data from a database; and assigning an attenuation map, which is contained in the database, to attenuation values of the detected accessory and adapting the attenuation map to the detected position and/or alignment of the accessory.

摘要翻译： 公开了一种用于确定患者PET数据的衰减值的方法。 在至少一个实施例中，该方法包括检测磁共振成像扫描仪的至少一个附件，并通过成像测量方法检测附件的位置和/或对准; 将检测到的附件与来自数据库的数据进行比较; 以及将包含在所述数据库中的衰减图分配给所检测到的附件的衰减值，并将所述衰减图适配到所述检测到的位置和/或所述附件的对准。

公开(公告)号：US20090041318A1

公开(公告)日：2009-02-12

申请号：US12219613

申请日：2008-07-24

申请人： Thorsten Feiweier ,  Ralf Ladebeck ,  Diana Martin ,  Hartwig Newiger ,  Josef Pfeuffer ,  Michael Szimtenings ,  Harald Werthner

发明人： Thorsten Feiweier ,  Ralf Ladebeck ,  Diana Martin ,  Hartwig Newiger ,  Josef Pfeuffer ,  Michael Szimtenings ,  Harald Werthner

IPC分类号： G01R33/56 ,  G01R33/54

CPC分类号： A61B6/032 ,  A61B5/11 ,  A61B5/7285 ,  A61B6/037 ,  A61B6/541 ,  A61B8/00 ,  A61B8/4416 ,  G06F19/00

摘要： A method is disclosed for recording measured data of a patient while taking account of movement operations by way of a medical device that is designed both for recording movement-related measured data, in particular measured data of high temporal resolution and/or measured data that can be interpolated with regard to movement operations, with the aid of an imaging method and/or by means of at least one sensor element, and also for recording nuclear medicine measured data, in particular of lower temporal resolution. In at least one embodiment, the method includes recording nuclear medicine measured data with the aid of the medical device; simultaneously recording movement-related measured data with the aid of the medical device; determining at least one item of movement information relating to at least one movement operation of the patient and/or in the body of the patient by evaluating at least a portion of the recorded measured data of high temporal resolution on the part of a computing device of the medical device; and adapting at least one item of attenuation correction information available for the computing device and serving for reconstructing the nuclear medicine measured data, doing so as a function of the at least one determined item of movement information.

摘要翻译： 公开了一种用于记录患者的测量数据的方法，同时考虑到通过设计用于记录运动相关测量数据的医疗设备，特别是高时间分辨率的测量数据和/或可测量数据的测量数据， 借助于成像方法和/或通过至少一个传感器元件，以及用于记录核医学测量数据，特别是用于记录较低时间分辨率的内插关于移动操作。 在至少一个实施例中，该方法包括借助医疗装置记录核医学测量数据; 借助医疗设备同时记录运动相关测量数据; 通过在计算设备的一部分上评估所记录的高时间分辨率测量数据的至少一部分来确定与患者的至少一个移动操作和/或患者身体有关的至少一个移动信息项 医疗器械; 以及修改可用于所述计算设备的至少一项衰减校正信息，并且用于重构所述核医学测量数据，作为所述至少一个确定的运动信息项的函数。

公开(公告)号：US20090018431A1

公开(公告)日：2009-01-15

申请号：US12216293

申请日：2008-07-02

申请人： Thorsten Feiweier ,  Diana Martin ,  Gunther Platsch ,  Sebastian Schmidt ,  Kristin Schmiedehausen ,  Michael Szimtenings

发明人： Thorsten Feiweier ,  Diana Martin ,  Gunther Platsch ,  Sebastian Schmidt ,  Kristin Schmiedehausen ,  Michael Szimtenings

IPC分类号： A61B5/05

CPC分类号： G01R33/481 ,  A61B5/0035 ,  A61B5/04008 ,  A61B5/4094 ,  A61B6/037 ,  A61B6/501 ,  A61B6/5247

摘要： A method and an apparatus are disclosed for imaging functional processes in the brain. In order to be able to correlate the results of MEG examinations with anatomical information and metabolic data, a positron emission tomography measurement is recorded in at least one embodiment by at least one radiation detector, a magnetic resonance imaging measurement is recorded by a coil and a radio-frequency antenna device and a magnetoencephalography measurement is recorded by a plurality of magnetic field sensors, the positron emission tomography measurement and the magnetic resonance imaging measurement being substantially undertaken at the same time, so that the records of the positron emission tomography measurement and the magnetic resonance tomography measurement are isocentric. In at least one embodiment, an evaluation apparatus is provided for carrying out a spatial correlation between the magnetoencephalography measurement and the magnetic resonance imaging measurement, so that registration between the magnetoencephalography measurement and the positron emission tomography measurement results.

摘要翻译： 公开了一种用于成像脑中的功能过程的方法和装置。 为了能够将MEG检查的结果与解剖信息和代谢数据相关联，在至少一个实施例中通过至少一个辐射检测器记录正电子发射断层摄影测量，磁共振成像测量由线圈和 射频天线装置和脑磁图测量由多个磁场传感器记录，正电子发射断层摄影测量和磁共振成像测量基本上同时进行，使得正电子发射断层摄影测量和 磁共振断层扫描测量是同中心的。 在至少一个实施例中，提供了一种用于执行脑磁图测量和磁共振成像测量之间的空间相关性的评估装置，从而导致脑磁图测量与正电子发射断层摄影测量之间的配准。

公开(公告)号：US20090005678A1

公开(公告)日：2009-01-01

申请号：US12213745

申请日：2008-06-24

申请人： Kristin Schmiedehausen ,  Gunther Platsch ,  Thorsten Feiweier ,  Diana Martin ,  Sebastian Schmidt ,  Michael Szimtenings

发明人： Kristin Schmiedehausen ,  Gunther Platsch ,  Thorsten Feiweier ,  Diana Martin ,  Sebastian Schmidt ,  Michael Szimtenings

IPC分类号： A61B6/03

CPC分类号： A61B6/501 ,  A61B6/037 ,  A61B6/507 ,  A61B34/10 ,  A61B90/36 ,  A61B2090/364 ,  A61B2090/374

摘要： A computer-implemented method is disclosed for determining and displaying an access corridor to a target area in the brain of a patient, as well as an imaging arrangement suited to this. In at least one embodiment, the method includes a) generating a first image of the brain via positron emission tomography, b) discriminating the target area relative to its surroundings via electronic image processing, c) generating a second image of the brain via magnetic resonance imaging while acquiring at least one anatomical structure, d) generating a third image of the brain via an imaging method displaying physiological processes for identifying at least one functional area of the brain that must not be injured in any circumstances, e) determining an access corridor to the target area while omitting the at least one functional area of the brain, and f) generating and displaying a fourth image of the brain in which the target area, the at least one functional area of the brain, the at least one anatomical structure and the access corridor are displayed, wherein steps a) to d) are carried out, one after another in quick succession, in a single frame of reference without repositioning the patient, or are even carried out simultaneously.

摘要翻译： 公开了一种计算机实现的方法，用于确定和显示患者脑中的目标区域的通道走廊以及适合于此的成像装置。 在至少一个实施例中，该方法包括：a）通过正电子发射断层摄影术产生脑的第一图像，b）通过电子图像处理区分相对于其周围的目标区域，c）通过磁共振产生大脑的第二图像 成像，同时获取至少一个解剖结构，d）通过显示生理过程的成像方法产生大脑的第三图像，用于识别在任何情况下不得受伤的脑的至少一个功能区域，e）确定通路走廊 到目标区域，同时省略脑的至少一个功能区域，以及f）产生和显示脑的第四图像，其中目标区域，脑的至少一个功能区域，至少一个解剖结构 并且显示进入通道，其中步骤a）至d）在一个单独的参考框架中以快速连续的方式相继地执行而不重新定位 或者甚至同时进行。

公开(公告)号：US20080319305A1

公开(公告)日：2008-12-25

申请号：US12153557

申请日：2008-05-21

申请人： Diana Martin ,  Wolfgang Bielmeier

发明人： Diana Martin ,  Wolfgang Bielmeier

IPC分类号： G01R33/48 ,  A61B5/055

CPC分类号： G01R33/481 ,  A61B6/037 ,  A61B6/5247 ,  A61B6/545 ,  G01R33/543 ,  G01T1/1603

摘要： A method is disclosed for determining at least one PET parameter for a PET examination in a combined magnetic resonance/PET scanner designed for isocentric measurement. In at least one embodiment, at least one acquisition time for the PET examination is determined as a PET parameter from magnetic resonance data, recorded for determining patient-specific examination parameters for a magnetic resonance examination, and/or from at least one patient-specific information value derived therefrom, and is displayed and/or used for controlling the scanner.

摘要翻译： 公开了一种用于在为等中心测量设计的组合磁共振/ PET扫描仪中确定用于PET检查的至少一个PET参数的方法。 在至少一个实施例中，PET检查的至少一个采集时间被确定为来自磁共振数据的PET参数，记录用于确定用于磁共振检查的患者特异性检查参数，和/或从至少一个患者特异性 从其导出的信息值，并显示和/或用于控制扫描仪。

公开(公告)号：US20080298664A1

公开(公告)日：2008-12-04

申请号：US12153556

申请日：2008-05-21

申请人： Diana Martin ,  Kirstin Jattke ,  Horst Winder

发明人： Diana Martin ,  Kirstin Jattke ,  Horst Winder

IPC分类号： G06K9/00

CPC分类号： G01R33/481 ,  A61B5/055 ,  A61B6/501 ,  A61B6/5247 ,  A61B2090/364 ,  G01R33/5608 ,  G06F19/00 ,  G06F19/321 ,  G06T7/30 ,  G06T11/008 ,  G06T2207/10072 ,  G06T2207/30004 ,  G06T2211/412

摘要： A method is disclosed for data evaluation of first and second measured data records acquired substantially simultaneously with the aid of a combined medical examination device suitable for simultaneous and isocentric acquisition of first measured data, specifically magnetic resonance or computed tomography measured data, and second nuclear medicine measured data, specifically PET measured data or SPECT measured data. In at least one embodiment, the method includes reconstructing a first image data record from the measured data of the at least one first measured data record, reconstructing a second image data record from the measured data of the at least one second measured data record, fusing the image data records as a function of registering the coordinate systems of the first measured data record and of the second measured data record to form a fusion image data record, and displaying and/or storing the fusion image data record.

摘要翻译： 公开了一种用于数据评估的方法，用于借助于适于同时和等中心获取第一测量数据，特别是磁共振或计算机断层摄影测量数据的组合医疗检查装置和第二核医学药物基本上同时获得的第一和第二测量数据记录 测量数据，特别是PET测量数据或SPECT测量数据。 在至少一个实施例中，该方法包括从所述至少一个第一测量数据记录的测量数据中重构第一图像数据记录，从所述至少一个第二测量数据记录的测量数据重构第二图像数据记录， 所述图像数据记录作为登记所述第一测量数据记录和所述第二测量数据记录的坐标系以形成融合图像数据记录的函数，以及显示和/或存储所述融合图像数据记录。

公开(公告)号：US20080156994A1

公开(公告)日：2008-07-03

申请号：US12000836

申请日：2007-12-18

申请人： Diana Martin ,  Sebastian Schmidt

发明人： Diana Martin ,  Sebastian Schmidt

IPC分类号： G01T1/166

CPC分类号： G01T1/1603

摘要： A method is disclosed for operating a hybrid medical imaging unit including a first imaging device of relatively high spatial resolution and a second nuclear medicine imaging device of relatively high sensitivity that respectively acquire imaging measurement signals from a common examination volume. In at least one embodiment, the method includes determining the duration of the measurement signal acquisition of one imaging device as a function of the duration of the measurement signal acquisition of the other imaging device, which is defined by the occurrence of a specific truncation criterion.

摘要翻译： 公开了一种用于操作混合医疗成像单元的方法，所述混合医学成像单元包括相对高的空间分辨率的第一成像装置和相对高灵敏度的第二核医学成像装置，其分别从共同检查体积获取成像测量信号。 在至少一个实施例中，该方法包括根据特定截断标准的出现来定义作为另一成像装置的测量信号获取的持续时间的函数来确定一个成像装置的测量信号采集的持续时间。