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    Real-time nucleic acid detection processes and compositions
    31.
    发明授权
    Real-time nucleic acid detection processes and compositions 有权
    实时核酸检测方法和组合物

    公开(公告)号：US09261460B2

    公开(公告)日：2016-02-16

    申请号：US10096076

    申请日：2002-03-12

    Applicant: Elazar Rabbani ,  Jannis G. Stavrianopoulos ,  James J. Donegan ,  Jack Coleman ,  Dakai Liu

    Inventor： Elazar Rabbani ,  Jannis G. Stavrianopoulos ,  James J. Donegan ,  Jack Coleman ,  Dakai Liu

    IPC: C12P19/34 ,  G01N21/64 ,  C12Q1/68

    CPC classification number: C12Q1/6818 ,  C12Q1/6834 ,  C12Q1/6844 ,  C12Q1/6853 ,  C12Q1/686 ,  G01N21/64 ,  G01N21/6486 ,  C12Q2565/101 ,  C12Q2533/101 ,  C12Q2561/113

    Abstract: This invention provides compositions for use in real time nucleic acid detection processes. Such real time nucleic acid detection processes are carried out with energy transfer elements attached to nucleic acid primers, nucleotides, nucleic acid probes or nucleic acid binding agents. Real time nucleic acid detection allows for the qualitative or quantitative detection or determination of single-stranded or double-stranded nucleic acids of interest in a sample. Other processes are provided by this invention including processes for removing a portion of a homopolymeric sequence, e.g., poly A sequence or tail, from an analyte or library of analytes. Compositions useful in carrying out such removal processes are also described and provided.

    Abstract translation: 本发明提供用于实时核酸检测过程的组合物。 这种实时核酸检测方法是用连接于核酸引物，核苷酸，核酸探针或核酸结合剂的能量转移元件进行的。 实时核酸检测允许定性或定量检测或测定样品中感兴趣的单链或双链核酸。 本发明提供了其它方法，包括从被分析物或分析物库中除去一部分均聚物序列，例如聚A序列或尾部的方法。 还描述和提供了用于进行这种去除方法的组合物。

    Property effecting and/or property exhibiting compositions for therapeutic and diagnostic uses
    32.
    发明授权
    Property effecting and/or property exhibiting compositions for therapeutic and diagnostic uses 失效
    性能影响和/或性能表现出用于治疗和诊断用途的组合物

    公开(公告)号：US08742090B2

    公开(公告)日：2014-06-03

    申请号：US08978632

    申请日：1997-11-25

    Applicant: Elazar Rabbani ,  Jannis G. Stavrianopoulos ,  James J. Donegan ,  Dakai Liu ,  Norman E. Kelker ,  Dean L. Engelhardt

    Inventor： Elazar Rabbani ,  Jannis G. Stavrianopoulos ,  James J. Donegan ,  Dakai Liu ,  Norman E. Kelker ,  Dean L. Engelhardt

    IPC: C07H21/04

    CPC classification number: C12N15/1132 ,  C07K14/005 ,  C07K14/62 ,  C12N9/1247 ,  C12N15/87 ,  C12N2740/16322 ,  C12Q1/6897 ,  C12Q1/703 ,  C12Q2525/301 ,  C12Q2525/307

    Abstract: The present invention provides an array of compositions useful for effecting and/or exhibiting changes in biological functioning and processing within cells and in biological systems containing such cells. In effect, these compositions combine chemical modifications and/or ligand additions with biological functions. The chemical modifications and/or ligand additions provide additional characteristics to the compositions without interfering substantially with their biological function. Such additional characteristics include nuclease resistance, targeting specific cells or specific cell receptors localizing to specific sites within cells and augmenting interactions between the compositions and target cells of interest as well as decreasing such interactions when desired. Also provided by the present invention are processes and kits.

    Abstract translation: 本发明提供了一组组合物，其用于在细胞内和含有这种细胞的生物系统中实现和/或表现出生物功能和加工中的变化。 实际上，这些组合物将化学修饰和/或配体添加与生物学功能相结合。 化学修饰和/或配体添加为组合物提供额外的特征，而不会基本上干扰它们的生物学功能。 这样的附加特征包括核酸酶抗性，靶向特定细胞或定位于细胞内特定位点的特定细胞受体，并且增加组合物和靶细胞之间的相互作用，并且当需要时减少这种相互作用。 本发明还提供了方法和试剂盒。

    Label target and labeling reagents comprising backbones with at least two consecutive peptide bonds
    34.
    发明授权
    Label target and labeling reagents comprising backbones with at least two consecutive peptide bonds 有权
    标记靶标和标记试剂，其包含具有至少两个连续肽键的骨架

    公开(公告)号：US08357793B2

    公开(公告)日：2013-01-22

    申请号：US10763104

    申请日：2004-01-22

    Applicant: Jannis G. Stavrianopoulos ,  Flazar Rabbani

    Inventor： Jannis G. Stavrianopoulos ,  Flazar Rabbani

    IPC: C07H19/04 ,  C07H21/00 ,  G01N33/532 ,  C12Q1/68

    CPC classification number: C07H21/00 ,  C09B23/02 ,  C09B47/00 ,  C09B57/00 ,  Y10S436/80

    Abstract: This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or targets, including nucleic acids and proteins. These reagents can be usefully applied to protein and nucleic acid probe based assays. They are also applicable to real-time detection processes.

    Abstract translation: 本发明提供标记试剂，标记的靶标和制备标记试剂的方法。 标记试剂可以采用花青染料，呫吨染料，卟啉染料，香豆素染料或复合染料的形式。 这些标记试剂可用于标记探针或靶标，包括核酸和蛋白质。 这些试剂可用于基于蛋白质和基于核酸探针的测定。 它们也适用于实时检测过程。

    Fluorescent dye composition and target labeled therewith
    37.
    发明授权
    Fluorescent dye composition and target labeled therewith 有权
    荧光染料组合物和标记的靶标

    公开(公告)号：US07553959B2

    公开(公告)日：2009-06-30

    申请号：US10764417

    申请日：2004-01-23

    Applicant: Jannis G. Stavrianopoulos ,  Elazar Rabbani

    Inventor： Jannis G. Stavrianopoulos ,  Elazar Rabbani

    IPC: C07H19/04 ,  C07D213/00 ,  C07D221/18 ,  C07F15/00 ,  C07H21/02 ,  C12Q1/68

    CPC classification number: C07H21/00 ,  C09B23/02 ,  C09B47/00 ,  C09B57/00 ,  Y10S436/80

    Abstract: This invention provides for labeling reagents, labeled targets and processes for preparing labeling reagents. The labeling reagents can take the form of cyanine dyes, xanthene dyes, porphyrin dyes, coumarin dyes or composite dyes. These labeling reagents are useful for labeling probes or targets, including nucleic acids and proteins. These reagents can be usefully applied to protein and nucleic acid probe based assays. They are also applicable to real-time detection processes.

    Abstract translation: 本发明提供标记试剂，标记的靶标和制备标记试剂的方法。 标记试剂可以采用花青染料，呫吨染料，卟啉染料，香豆素染料或复合染料的形式。 这些标记试剂可用于标记探针或靶标，包括核酸和蛋白质。 这些试剂可用于基于蛋白质和基于核酸探针的测定。 它们也适用于实时检测过程。

    NOVEL PROPERTY EFFECTING AND/OR PROPERTY EXHIBITING COMPOSITIONS FOR THERAPEUTIC AND DIAGNOSTIC USES
    40.
    发明申请
    NOVEL PROPERTY EFFECTING AND/OR PROPERTY EXHIBITING COMPOSITIONS FOR THERAPEUTIC AND DIAGNOSTIC USES 有权
    用于治疗和诊断用途的新型物业效果和/或物业展示组合物

    公开(公告)号：US20080248564A1

    公开(公告)日：2008-10-09

    申请号：US11929897

    申请日：2007-10-30

    Applicant: Elazar Rabbani ,  Jannis G. Stavrianopoulos ,  James J. Donegan ,  Dakai Liu ,  Norman E. Kelker ,  Dean L. Engelhardt

    Inventor： Elazar Rabbani ,  Jannis G. Stavrianopoulos ,  James J. Donegan ,  Dakai Liu ,  Norman E. Kelker ,  Dean L. Engelhardt

    IPC: C12N15/00

    CPC classification number: C12N15/1132 ,  C07K14/005 ,  C07K14/62 ,  C12N9/1247 ,  C12N15/87 ,  C12N2740/16322 ,  C12Q1/6897 ,  C12Q1/703 ,  C12Q2525/301 ,  C12Q2525/307

    Abstract: The present invention provides an array of compositions useful for effecting and/or exhibiting changes in biological functioning and processing within cells and in biological systems containing such cells. In effect, these compositions combine chemical modifications and/or ligand additions with biological functions. The chemical modifications and/or ligand additions provide additional characteristics to the compositions without interfering substantially with their biological function. Such additional characteristics include nuclease resistance, targeting specific cells or specific cell receptors localizing to specific sites within cells and augmenting interactions between the compositions and target cells of interest as well as decreasing such interactions when desired. Also provided by the present invention are processes and kits.

    Abstract translation: 本发明提供了一组组合物，其用于在细胞内和含有这种细胞的生物系统中实现和/或表现出生物功能和加工中的变化。 实际上，这些组合物将化学修饰和/或配体添加与生物学功能相结合。 化学修饰和/或配体添加为组合物提供额外的特征，而不会基本上干扰它们的生物学功能。 这样的附加特征包括核酸酶抗性，靶向特定细胞或定位于细胞内特定位点的特定细胞受体，并且增加组合物和靶细胞之间的相互作用，并且当需要时减少这种相互作用。 本发明还提供了方法和试剂盒。

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