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    Dentifrice composition
    31.
    发明授权
    Dentifrice composition 有权
    牙粉组合物

    公开(公告)号：US08865137B2

    公开(公告)日：2014-10-21

    申请号：US13266998

    申请日：2010-05-25

    Applicant: Andre Morgan ,  Venda Porter ,  Melissa Martinetti ,  Michael Prencipe

    Inventor： Andre Morgan ,  Venda Porter ,  Melissa Martinetti ,  Michael Prencipe

    IPC: A61Q11/00 ,  A61K8/73 ,  A61K8/365 ,  A61K8/27

    CPC classification number: A61Q11/00 ,  A61K8/27 ,  A61K8/365 ,  A61K8/731

    Abstract: Disclosed are dentifrice compositions comprising an orally acceptable vehicle and at least one source of metal ions in a polymer matrix, the metal being selected from zinc, stannous, copper or combinations thereof, the at least one source of metal ions comprising from 10 to 75 wt % of the total weight of the polymer matrix and the at least one source of metal ions, and wherein the dentifrice composition comprises less than 10 wt % water based on the total weight of the dentifrice composition. Also disclosed is a method of stabilizing at least one source of metal ions in a dentifrice compositions.

    Abstract translation: 公开了包含口腔可接受的载体和聚合物基质中的至少一种金属离子源的洁牙剂组合物，所述金属选自锌，亚锡，铜或其组合，所述至少一种金属离子源包含10至75wt 基于聚合物基质和至少一种金属离子源的总重量的百分比，并且其中所述洁牙剂组合物包含基于洁齿剂组合物的总重量小于10重量％的水。 还公开了一种在洁牙剂组合物中稳定至少一种金属离子源的方法。

    Oral care regimen
    33.
    发明授权
    Oral care regimen 有权
    口腔护理方案

    公开(公告)号：US08501161B2

    公开(公告)日：2013-08-06

    申请号：US11745158

    申请日：2007-05-07

    Applicant: Michael Prencipe ,  Isabelle Van Rycke ,  Richard Lovell

    Inventor： Michael Prencipe ,  Isabelle Van Rycke ,  Richard Lovell

    IPC: A61K8/00

    CPC classification number: A61K8/25 ,  A61K2800/28 ,  A61K2800/412 ,  A61K2800/88 ,  A61K2800/884 ,  A61Q11/00

    Abstract: The invention includes methods of cleaning an oral surface, maintaining oral health and/or increasing oral health. Such methods encompass contacting an oral surface with a primary oral care composition at least once daily, and contacting the oral surface with a periodic oral care composition at least once within a period of about 42 days. The periodic oral care compositions suitable for use in the method comprise a first abrasive having an Einlehner hardness of greater than about 5 mg loss per 100,000 revolutions and a second abrasive having an Einlehner hardness of less than about 5 mg loss per 100,000 revolutions. In the periodic oral care compositions, the ratio of the first abrasive to the second abrasive is about 1:1.6 to about 1.6:1. The periodic oral care compositions are characterized by a pellicle cleaning ratio of greater than about 100 and a radioactive dentin abrasion of less than about 200. Additionally or alternatively, the methods may include those where the second abrasive comprises silica and has an oil of absorption of greater than about 90 cm3/100 g and/or an Einlehner hardness of less than about 5 mg loss per 100,000 revolutions. The ratio of the first abrasive to the second abrasive may be about 1:1.6 to about 1.6:1. The total amount of the first and second abrasives present in the oral composition may be greater than about 25% by weight of the composition and/or the oral composition has a pellicle cleaning ratio of greater than about 100 and a radioactive dentin abrasion of less than about 200.

    Abstract translation: 本发明包括清洁口腔表面，维持口腔健康和/或增加口腔健康的方法。 这样的方法包括使口腔表面与初级口腔护理组合物每天至少接触一次接触，并在约42天的时间内将口腔表面与周期性口腔护理组合物接触至少一次。 适用于该方法的定期口腔护理组合物包括具有大于约5毫克损失/ 100,000次旋转的爱因纳氏硬度的第一研磨剂，以及每100,000次旋转具有小于约5毫克损失的爱因纳氏硬度的第二磨料。 在定期口腔护理组合物中，第一研磨剂与第二研磨剂的比例为约1:1.6至约1.6:1。 定期口腔护理组合物的特征在于大于约100的防护薄膜清洁率和小于约200的放射性牙本质磨损。另外或替代地，所述方法可以包括其中第二磨料包含二氧化硅并具有吸收油的那些 大于约90cm 3 / 100g和/或Einlehner硬度，每100,000次旋转损失小于约5mg。 第一研磨剂与第二研磨剂的比例可以为约1:1.6至约1.6:1。 存在于口腔组合物中的第一和第二研磨剂的总量可以大于组合物的约25重量％，和/或口腔组合物具有大于约100的防护薄膜清洁率和低于约100的放射性牙本质磨损 约200。

    DUAL ACTION DENTIFRICE COMPOSITIONS TO PREVENT HYPERSENSITIVITY AND PROMOTE REMINERALIZATION
    35.
    发明申请
    DUAL ACTION DENTIFRICE COMPOSITIONS TO PREVENT HYPERSENSITIVITY AND PROMOTE REMINERALIZATION 审中-公开
    双重作用DENTIFRICE组合物，以防止高度敏感性和促进重新定位

    公开(公告)号：US20120021031A1

    公开(公告)日：2012-01-26

    申请号：US13262010

    申请日：2010-04-01

    Applicant: Suman K. Chopra ,  Lynette Zaidel ,  Michael Prencipe

    Inventor： Suman K. Chopra ,  Lynette Zaidel ,  Michael Prencipe

    IPC: A61K8/25 ,  A61K8/21 ,  A61Q11/00 ,  A61K8/02

    CPC classification number: A61Q11/00 ,  A61K8/19 ,  A61K8/20 ,  A61K8/25 ,  A61K2800/412

    Abstract: The invention encompasses combinations of bioactive glass composition and potassium salts that are useful in conjunction with delivery agent such as, for example, toothpastes, mouthwashes, and oral gels. In certain embodiments, the compositions of the invention form a rapid and continuous reaction with body fluids (e.g., saliva) to promote the immediate and long-tem release of Ca and P ions to produce a stable crystalline layer deposited onto and into the dentin tubules for the immediate and long term reduction of dentin hypersensitivity and tooth surface remineralization.

    Abstract translation: 本发明包括与递送剂例如牙膏，漱口剂和口服凝胶一起使用的生物活性玻璃组合物和钾盐的组合。 在某些实施方案中，本发明的组合物与体液（例如唾液）形成快速且连续的反应，以促进Ca和P离子的即时和长期释放，以产生沉积在牙质小管上和之上的稳定的晶体层 用于立即和长期减少牙质过敏和牙齿表面再矿化。

    Dual Component Dental Composition Containing Enzyme
    39.
    发明申请
    Dual Component Dental Composition Containing Enzyme 审中-公开
    含有酶的双组分牙科组合物

    公开(公告)号：US20100266514A9

    公开(公告)日：2010-10-21

    申请号：US12042870

    申请日：2008-03-05

    Applicant: Malcolm Williams ,  Michael Prencipe ,  James G. Masters

    Inventor： Malcolm Williams ,  Michael Prencipe ,  James G. Masters

    IPC: A61K8/66

    CPC classification number: A61Q11/00 ,  A61K8/66 ,  A61K2800/88

    Abstract: A two component desensitizing dentifrice composition is disclosed which comprises a first dentifrice component containing an enzyme such as papain and a second dentifrice component containing an ionic surfactant such as sodium lauryl sulfate, the first and second dentifrice components being maintained separate from the other until dispensed for application to teeth whereby enzyme activity is maintained with improved dentifrice foaming characteristics.

    Abstract translation: 公开了一种双组分脱敏洁牙剂组合物，其包含含有酶如木瓜蛋白酶的第一洁齿剂组分和含有离子表面活性剂如十二烷基硫酸钠的第二洁齿剂组分，第一和第二洁齿剂组分彼此分离直到分配 应用于牙齿，由此保持酶活性并提高洁牙剂发泡特性。

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