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公开(公告)号：US20250027113A1
公开(公告)日：2025-01-23
申请号：US18774322
申请日：2024-07-16
Inventor： Steve Wanjara , Elena Ivanova , The Hong Phong Nguyen , Tharushi Perera , Rodney Croft , Denver Linklater , Saulius Joudkazis
IPC: C12N15/87
Abstract: Provided herein are methods for introducing a foreign substance into a cell using high frequency electromagnetic energy. Provided are methods for delivery substances to both prokaryotic and to eukaryotic cells. Also provided are cells generated with the methods disclosed herein.
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公开(公告)号：US12152047B2
公开(公告)日：2024-11-26
申请号：US17595019
申请日：2020-05-07
Applicant: Royal Melbourne Institute of Technology
Inventor： Nedaossadat Mirzadeh , Suresh Bhargava , Steven Priver , Srinivasa Reddy Telukutla
Abstract: A compound according to Formula (I), or a pharmaceutically acceptable salt thereof: wherein R1 and R2 are each independently selected from optionally substituted C1-6-alkyl and optionally substituted aryl; R3, R4, R5, and R6 are each independently selected from the group consisting of H, halo, optionally substituted C1-6-alkyl, and optionally substituted C1-6 alkoxy; and R7 is a phosphorus containing moiety, wherein a phosphorus atom is bonded to Au.
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33.发明公开公开(公告)号：US20240288397A1
公开(公告)日：2024-08-29
申请号：US18572665
申请日：2022-06-23
Inventor： Taimur AHMED , Ganganath PERERA , Sumeet WALIA , Madhu BHASKARAN , Sharath SRIRAM , Stephen FOX , Andrew FELLOWES
IPC: G01N27/327
CPC classification number: G01N27/3275 , G01N27/3272
Abstract: The invention provides a sensor for detecting a nucleic acid, comprising: a substrate; a pair of terminal electrodes disposed on the substrate in mutually spaced apart and opposing relation; and a sensing element, between and in electrical contact with the pair of terminal electrodes, wherein the sensing element comprises: (i) a semiconducting portion of the substrate, wherein a conduction path between the terminal electrodes passes through the semiconducting portion; and (ii) an oligonucleotide on a surface of the semiconducting portion, the oligonucleotide being complementary to the nucleic acid to be detected, wherein hybridisation of the nucleic acid with the oligonucleotide leads to a change in resistance of the sensor.
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公开(公告)号：US12054395B2
公开(公告)日：2024-08-06
申请号：US17433438
申请日：2020-02-24
Applicant: Royal Melbourne Institute of Technology
Inventor： Baohua Jia , Han Lin
IPC: C01B32/198 , C01B32/194 , H01G11/38 , H01G11/86 , H01M4/133 , H01M4/1393 , H01M4/02
CPC classification number: C01B32/198 , C01B32/194 , H01G11/38 , H01G11/86 , H01M4/133 , H01M4/1393 , C01B2204/04 , C01B2204/22 , C01P2002/82 , C01P2002/84 , C01P2002/85 , C01P2004/03 , H01M2004/021
Abstract: A composition comprising reduced graphene oxide in the form of sheets that are interconnected to define pores between the sheets.
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公开(公告)号：US20240093093A1
公开(公告)日：2024-03-21
申请号：US18521452
申请日：2023-11-28
Applicant: ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY
Inventor： Kalpit SHAH
CPC classification number: C10B49/22 , C10B47/24 , C10B49/10 , C10B53/02 , F23B90/06 , F23G5/027 , F23G5/245 , F23G2201/303
Abstract: The invention provides a pyrolysis reaction system, the system comprising: a pyrolysis chamber comprising a feed inlet, a gas inlet and a product outlet, wherein the pyrolysis chamber is configured i) to receive a pyrolysable organic feed and an inert gas via the feed inlet and gas inlet respectively, ii) to pyrolyse the organic feed at a pyrolysis temperature to produce a carbonaceous pyrolysis product and a pyrolysis gas, wherein the pyrolysis gas will combine with the inert gas to form a gas mixture having a pyrolysis chamber pressure in the pyrolysis chamber, and iii) to discharge the carbonaceous pyrolysis product via the product outlet; a gas reactor configured to react the pyrolysis gas by combustion and/or carbon deposition at a gas reaction temperature and a gas reactor pressure; and a first partition defining a boundary between the pyrolysis chamber and the gas reactor, the first partition comprising a plurality of first apertures to provide fluid communication between the pyrolysis chamber and the gas reactor, wherein the pyrolysis reaction system is operable with the gas reactor pressure less than the pyrolysis chamber pressure such that the gas mixture flows from the pyrolysis chamber to the gas reactor through the first apertures, thereby providing at least a portion of the pyrolysis gas for reaction in the gas reactor.
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Patent Agency Ranking
公开(公告)号：US20230265378A1
公开(公告)日：2023-08-24
申请号：US18041238
申请日：2021-08-10
Applicant: ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY
Inventor： Lizebona August AMBATTU , Shwathy RAMESAN , Leslie YEO
CPC classification number: C12M35/04 , C12M23/12 , A61K9/5068 , C12N5/0693 , C12N2521/10
Abstract: Embodiments relate to a method and apparatus for stimulating the production of extracellular vesicles (EVs) from a population of cells. Some embodiments relate to a method for stimulating the production of extracellular vesicles (EVs) from a population of cells, the method comprising: (i) exposing a culture media comprising the population of cells to acoustic wave energy and (ii) harvesting the EVs produced from the population of cells following the exposure. Some embodiments relate to an apparatus for use in stimulating the production of EVs from a population of cells, the apparatus comprising: (i) an acoustic wave generator configured to generate acoustic energy at a selected power and frequency; and (ii) a receptacle for accommodating a population of cells in a culture media, the receptacle being configured to receive acoustic energy generated by the acoustic wave generator.
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公开(公告)号：US20230061342A1
公开(公告)日：2023-03-02
申请号：US17759155
申请日：2021-01-20
Applicant: Royal Melbourne Institute of Technology
Inventor： Sumeet WALIA , Aaron ELBOURNE , Vi Khanh TRUONG , Sruthi KURIAKOSE
Abstract: An article comprising a substrate and an anti-microbial coating, wherein the anti-microbial coating comprises at least one solvent-free black phosphorus flake.
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公开(公告)号：US20230045427A1
公开(公告)日：2023-02-09
申请号：US17757700
申请日：2020-12-18
Applicant: Royal Melbourne Institute of Technology
Inventor： Taimur AHMED , Mortiz DOERING , Ganganath PERERA , Sumeet WALIA , Madhu BHASKARAN , Sharath SRIRAM
IPC: G01N27/327 , G01N33/543 , G01N33/563 , G01N33/552
Abstract: The present invention provides a sensor for detecting a bioanalyte, comprising: a substrate; a pair of terminal electrodes disposed on the substrate in mutually spaced apart and opposing relation; and a non-insulating sensing element applied to a surface of the substrate, between and in electrical contact with the pair of terminal electrodes wherein the sensing element provides a conduction path between the terminal electrodes, wherein the sensing element comprises an oxygen-deficient metal oxide layer and a bioanalyte binding site, and wherein when a voltage is applied across the sensor, an electrical signal is generated that is proportional to a change in conductance of the sensing element corresponding to binding of a bioanalyte to the bioanalyte binding site.
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公开(公告)号：US20220411698A1
公开(公告)日：2022-12-29
申请号：US17779357
申请日：2020-11-27
Applicant: ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY
Inventor： Kalpit SHAH , Kumar Sazal KUNDU , Rajnikantbhai Savankumar PATEL , David John WINTER
IPC: C10B51/00 , C10B47/24 , C10B49/10 , C10B57/10 , C10B53/02 , C02F11/10 , B09B3/40 , C10J3/02 , C10J3/72 , F23G7/14 , F23G5/027
Abstract: The invention provides a system for pyrolysis, comprising: (i) a gas producer comprising a gasification zone and a producer gas outlet, wherein the gas producer is configured to: oxidise at least one carbon-containing feed in the presence of an oxidising gas in the gasification zone to form a producer gas; and discharge the producer gas from the gasification zone via the producer gas outlet, wherein a residual oxygen content of the producer gas is substantially depleted or maintained below a maximum predetermined amount by controlling a ratio of oxygen fed to the gasification zone to the carbon-containing feed, (ii) a pyrolyzer comprising a pyrolysis zone and one or more pyrolyzer gas outlets, wherein the pyrolyzer is configured to: feed the producer gas discharged from the gasification zone to the pyrolysis zone; pyrolyze a pyrolyzable organic feed in the pyrolysis zone in the presence of the producer gas to produce a carbonaceous pyrolysis product and a gas mixture comprising combustible components comprising pyrolysis gas; and discharge the gas mixture from the pyrolysis zone via the one or more pyrolyzer gas outlets, and (iii) a first combustor comprising a combustion zone, wherein the first combustor is configured to: receive the gas mixture discharged from the pyrolysis zone in the combustion zone; feed an oxygen-containing gas to the combustion zone; and combust at least a portion of the combustible components present in the gas mixture in the combustion zone to produce a combustion product gas.
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公开(公告)号：US11319343B2
公开(公告)日：2022-05-03
申请号：US16624367
申请日：2018-06-29
Applicant: ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY , UNIVERSITY OF SOUTH AUSTRALIA , THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN , MONASH UNIVERSITY
Inventor： Stavros Selemidis , Doug A. Brooks , John O'Leary
Abstract: The present invention relates generally to the field of immunomodulation. Taught herein is an agent for inhibiting immunostimulation mediated by a Toll-like receptor useful in the treatment of viral and microbial pathogenesis, diseases involving elements of autoimmunity and inflammation as well as cancer. The agent antagonizes disulfide bond formation between C98 and C475 of Toll-like receptor 7 (TLR7) thereby preventing TLR7 activation. Pharmaceutical compositions are also enabled herein.
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