中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

53 records (took 0.024 seconds)

    Topical Application of Lactobacillus Crispatus to Ameliorate Barrier Damage and Inflammation
    31.
    发明申请
    Topical Application of Lactobacillus Crispatus to Ameliorate Barrier Damage and Inflammation 有权

    公开(公告)号：US20230131201A1

    公开(公告)日：2023-04-27

    申请号：US18087545

    申请日：2022-12-22

    Applicant: SEED HEALTH, INC.

    Inventor： Sheri Simmons ,  Shanthi Parkar ,  Erin A. Miller ,  Joseph E. Kovarik

    IPC: A61K35/74 ,  A61K31/715 ,  A61K31/58 ,  A61K38/17

    Abstract: Compositions, systems and methods of improving the health of the microbiome of an individual's skin relate to the provision of skin contacting formulations containing beneficial bacteria and other microbe components to foster the growth and maintenance of a healthy skin microbiome. A topical application of Lactobacillus crispatus is employed to ameliorate skin barrier damage and inflammation using unique combinations of probiotics, prebiotics, and other skin-beneficial ingredients, effectively treating inflammatory skin diseases, such as atopic dermatitis, psoriasis and acne. The topical application of Lactobacillus crispatus to an individual's skin reduces inflammation through the production of tryptophan metabolites that act as AHR agonists.

    Method and system for reducing the likelihood of developing colorectal cancer in an individual human being
    32.
    发明授权
    Method and system for reducing the likelihood of developing colorectal cancer in an individual human being 有权

    公开(公告)号：US11529379B2

    公开(公告)日：2022-12-20

    申请号：US17835204

    申请日：2022-06-08

    Applicant: SEED HEALTH, INC.

    Inventor： Joseph E. Kovarik

    IPC: A61K35/74 ,  A61K31/715 ,  A61K31/58 ,  A61K38/17 ,  A61K35/00

    Abstract: A method for reducing the likelihood of an individual developing colorectal cancer includes the use of a CRISPR system to selectively kill pathogenic bacteria, such as Klebsiella and E coli, within the individual. Preferrably, the growth of a beneficial bacteria, such as Akkermansia, Bacteroides, Bifidobacterium, Clostridium, Enterococcus, Fusobacterium, Coprococcus, Lactobacillus, Propionibacterium, Ruminococcus, Veillonella, Prevotella, and Streptococcus bacteria, is also enhanced. Reduction of certain virulence factors, such as colibactin, using a CRISPR system, as well the employment of immune checkpoint inhibitors, is effective in treating individuals with cancer and who suffer from a chronic infectious disease.

    Method and System to Modify an Individual's Gut-Brain Axis to Provide Neurocognitive Protection
    35.
    发明公开
    Method and System to Modify an Individual's Gut-Brain Axis to Provide Neurocognitive Protection 审中-公开

    公开(公告)号：US20240024382A1

    公开(公告)日：2024-01-25

    申请号：US18234132

    申请日：2023-08-15

    Applicant: Seed Health, Inc.

    Inventor： Sherri Simmons ,  Joseph E. Kovarik

    IPC: A61K35/741 ,  C12N15/11 ,  C12N9/22 ,  C12N1/20 ,  C12N15/74 ,  A61K9/48 ,  A61K35/747 ,  A61K35/745

    CPC classification number: A61K35/741 ,  C12N15/11 ,  C12N9/22 ,  C12N1/20 ,  C12N15/74 ,  A61K9/4808 ,  A61K35/747 ,  A61K35/745 ,  C12N2310/20 ,  C12N2800/80 ,  A61K2035/115

    Abstract: The present invention is directed to beneficially directing the bidirectional communication that exists between the brain and the gut so as to influence brain physiology, psychological responses and ultimately behavior in a positive manner by regulating an individual's mood, psychological symptoms, such as anxiety and depression and stress-related changes in brain function, by modifying the gut microbiome of an individual. An various embodiments, an individual's microbiome is modified in a manner to reduce the likelihood of stress, to reduce or treat symptoms affecting mental health and to promote the mental health of the individual. In certain embodiments, administration to an individual of at least three different bacteria species are combined to modify an individual's microbiome, selected from the group of Lacticaseibacillus paracasei, Coprococcus, Roseburia, Bifidobacterium, L. casei and Faecalibacterium prausnitzii, to reduce adverse psychological and/or physiological responses attendant to psychological stress. Other embodiments reduce certain bacterial populations, such as Veillonella and Megasphaer, while in other embodiments, bacteria that produce hydrogen sulfide, methane and acetate are reduced to beneficially affect an individual's mental health.

    Method and system to reduce the likelihood of dental caries and halitosis
    38.
    发明授权
    Method and system to reduce the likelihood of dental caries and halitosis 有权

    公开(公告)号：US11844720B2

    公开(公告)日：2023-12-19

    申请号：US18103768

    申请日：2023-01-31

    Applicant: SEED HEALTH, INC.

    Inventor： Tye Jensen ,  Joseph E. Kovarik

    IPC: A61F5/56

    CPC classification number: A61F5/566

    Abstract: A method to facilitate the growth of desired bacteria in a human's mouth to reduce the likelihood of dental caries and halitosis and other oral diseases, and for inhibiting oral biofilm formation, gingivitis, periodontitis and halitosis via the employment of one or more probiotic bacterial, bioactive flavonoid, and zinc compound compositions effective in providing prevention and treatment options.

    Topical application of CRISPR-modified bacteria to treat acne vulgaris
    39.
    发明授权
    Topical application of CRISPR-modified bacteria to treat acne vulgaris 有权

    公开(公告)号：US11839632B2

    公开(公告)日：2023-12-12

    申请号：US18178847

    申请日：2023-03-28

    Applicant: Seed Health, Inc.

    Inventor： Tye Jensen ,  Joseph E. Kovarik

    IPC: A61K35/74 ,  A61K31/715 ,  A61K31/58 ,  A61K38/17 ,  A61K35/00

    CPC classification number: A61K35/74 ,  A61K31/58 ,  A61K31/715 ,  A61K38/1709 ,  A61K38/1758 ,  A61K2035/11

    Abstract: Compositions, systems and methods of improving the health of the microbiome of an individual's skin relate to the provision of skin contacting formulations containing beneficial bacteria and other microbe components to foster the growth and maintenance of a healthy skin microbiome. Embodiments include methods for treating an individual suffering from acne vulgaris by topically administering a composition that includes live bacteria selected from the group consisting of L. reuteri, L. johnsonii, L. crispatus, C. acnes, and Nitrosomonas eutropha, that have been modified by using a using a clustered regularly interspaced short palindromic repeats (CRISPR) CRISPR associated protein (Cas) system or a CRISPR from Prevotella and Francisella 1(Cpf1) system to reduce the production of a virulence factor of the bacteria.

    Topical application of
    40.
    发明授权
    Topical application of 有权

    公开(公告)号：US11826388B2

    公开(公告)日：2023-11-28

    申请号：US18087545

    申请日：2022-12-22

    Applicant: SEED HEALTH, INC.

    Inventor： Sheri Simmons ,  Shanthi Parkar ,  Erin A. Miller ,  Joseph E. Kovarik

    IPC: A61K35/74 ,  A61K31/715 ,  A61K31/58 ,  A61K38/17 ,  A61K35/00

    CPC classification number: A61K35/74 ,  A61K31/58 ,  A61K31/715 ,  A61K38/1709 ,  A61K38/1758 ,  A61K2035/11

    Abstract: Compositions, systems and methods of improving the health of the microbiome of an individual's skin relate to the provision of skin contacting formulations containing beneficial bacteria and other microbe components to foster the growth and maintenance of a healthy skin microbiome. A topical application of Lactobacillus crispatus is employed to ameliorate skin barrier damage and inflammation using unique combinations of probiotics, prebiotics, and other skin-beneficial ingredients, effectively treating inflammatory skin diseases, such as atopic dermatitis, psoriasis and acne. The topical application of Lactobacillus crispatus to an individual's skin reduces inflammation through the production of tryptophan metabolites that act as AHR agonists.

Patent Agency Ranking