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公开(公告)号：US20070270434A1
公开(公告)日：2007-11-22
申请号：US11749742
申请日：2007-05-16
申请人： James W. Malecha , Stewart A. Noble , Sergio G. Duron , Andrew Lindstrom , Andrew Shiau , Steven Govek
发明人： James W. Malecha , Stewart A. Noble , Sergio G. Duron , Andrew Lindstrom , Andrew Shiau , Steven Govek
IPC分类号： A61K31/496 , A61K31/495
CPC分类号： C07D295/26
摘要： The present invention relates to compounds and methods useful as inhibitors of PPAR, particularly PPARδ, and for the treatment or prevention of PPAR-mediated diseases, including metabolic diseases.
摘要翻译： 本发明涉及可用作PPAR抑制剂，特别是PPARδ的化合物和方法，以及用于治疗或预防PPAR介导的疾病，包括代谢疾病。
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![8-ETHYL-6-(ARYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF NERVOUS SYSTEM DISORDERS AND CANCER](/abs-image/US/2014/06/12/US20140163026A1/abs.jpg.150x150.jpg)
32.发明申请8-ETHYL-6-(ARYL)PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES FOR THE TREATMENT OF NERVOUS SYSTEM DISORDERS AND CANCER 审中-公开用于治疗神经系统疾病和癌症的8-乙基-6-（ARYL）吡啶并[2,3-D]嘧啶-2（8H） - 酮公开(公告)号：US20140163026A1
公开(公告)日：2014-06-12
申请号：US14110670
申请日：2012-04-09
申请人： David Campbell , Sergio G. Duron
发明人： David Campbell , Sergio G. Duron
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0043 , A61K9/0048 , A61K9/0056 , A61K9/0078 , A61K9/06 , A61K9/2054 , A61K9/4866 , A61K45/06 , C07D519/00
摘要： Provided herein are PAK inhibitors and methods of utilizing PAK inhibitors for the treatment of CNS disorders such as neuropsychiatric disorders or neurofibromatosis. Also described herein are methods of utilizing PAK inhibitors for the treatment of cancer.
摘要翻译： 本文提供PAK抑制剂和利用PAK抑制剂治疗CNS疾病如神经精神障碍或神经纤维瘤病的方法。 本文还描述了利用PAK抑制剂治疗癌症的方法。
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公开(公告)号：US20130225575A1
公开(公告)日：2013-08-29
申请号：US13703326
申请日：2011-06-16
IPC分类号： A61K45/06 , C07D401/04 , A61K31/506 , C07D471/04 , A61K31/5377 , A61K31/519
CPC分类号： A61K45/06 , A61K31/38 , A61K31/426 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , C07D401/04 , C07D471/04 , A61K2300/00
摘要： Provided herein are PAK inhibitors. Also provided herein are compositions and methods for treating an individual suffering from certain neurological conditions.
摘要翻译： 本文提供PAK抑制剂。 本文还提供了用于治疗患有某些神经病症状况的个体的组合物和方法。
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34.发明授权Controlled release ion channel modulator compositions and methods for the treatment of otic disorders 有权控释离子通道调节剂组合物和治疗耳部疾病的方法公开(公告)号：US08399018B2
公开(公告)日：2013-03-19
申请号：US12506664
申请日：2009-07-21
申请人： Jay Lichter , Benedikt Vollrath , Sergio G. Duron , Carl Lebel , Fabrice Piu , Qiang Ye , Luis A. Dellamary , Andrew M. Trammel , Michael Christopher Scaife , Jeffrey P. Harris
发明人： Jay Lichter , Benedikt Vollrath , Sergio G. Duron , Carl Lebel , Fabrice Piu , Qiang Ye , Luis A. Dellamary , Andrew M. Trammel , Michael Christopher Scaife , Jeffrey P. Harris
IPC分类号： A61K9/14
CPC分类号： A61K9/0046 , A61K9/0019 , A61K9/06 , A61K9/122 , A61K9/127 , A61K9/1647 , A61K9/5153 , A61K9/7007 , A61K31/24 , A61K31/27 , A61K31/44 , A61K31/444 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/40
摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with ion channel modulators. In these methods, the ion channel modulator compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the ion channel modulator compositions and formulations onto the auris interna target areas, or via perfusion into the auris interna structures.
摘要翻译： 本文公开了用离子通道调节剂治疗耳部疾病的组合物和方法。 在这些方法中，离子通道调节剂组合物和制剂通过将离子通道调节剂组合物和制剂直接施用到内耳目标区域上，或通过灌注到内耳结构中而局部施用于患有耳科疾病的个体。
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35.发明申请CONTROLLED-RELEASE APOPTOSIS MODULATING COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS 审中-公开控制释放调节组合物和治疗情绪障碍的方法公开(公告)号：US20100016218A1
公开(公告)日：2010-01-21
申请号：US12500486
申请日：2009-07-09
申请人： Jay Lichter , Benedikt Vollrath , Sergio G. Duron , Carl Lebel , Fabrice PIU , Qiang Ye , Luis A. Dellamary , Michael Christopher Scaife , Andrew M. Trammel , Jeffrey P. Harris
发明人： Jay Lichter , Benedikt Vollrath , Sergio G. Duron , Carl Lebel , Fabrice PIU , Qiang Ye , Luis A. Dellamary , Michael Christopher Scaife , Andrew M. Trammel , Jeffrey P. Harris
CPC分类号： A61K38/1709 , A61K9/0046 , A61K9/06 , A61K9/14 , A61K38/005 , A61K38/162 , A61K38/1761 , A61K47/36 , C12N7/00 , C12N2740/16322
摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with anti-apoptotic agent or pro-apoptotic agent compositions and compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).
摘要翻译： 本文公开的是通过将这些组合物和组合物直接施用于灌注或通过灌注至本发明的，通过将抗凋亡剂或促凋亡剂组合物和组合物局部施用于患有耳科疾病的个体来治疗耳部病症的组合物和方法， 目标耳结构。
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36.发明申请CONTROLLED RELEASE AURIS SENSORY CELL MODULATOR COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS 有权控制释放的感染细胞调节剂组合物和治疗卵巢疾病的方法公开(公告)号：US20100015263A1
公开(公告)日：2010-01-21
申请号：US12504553
申请日：2009-07-16
申请人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Carl LEBEL , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Andrew M. TRAMMEL , Michael Christopher SCAIFE , Jeffrey P. HARRIS
发明人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Carl LEBEL , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Andrew M. TRAMMEL , Michael Christopher SCAIFE , Jeffrey P. HARRIS
CPC分类号： A61K31/517 , A61K9/0046 , A61K31/135 , A61K31/137 , A61K31/4535 , A61K31/47 , A61K47/10 , A61K47/32 , A61K47/34
摘要： Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with auris sensory cell modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
摘要翻译： 本文公开了用于治疗耳科疾病或病症的组合物和方法，其中耳蜗感觉细胞调节剂组合物和制剂在局部施用于患有耳科疾病或病症的个体，通过将这些组合物和制剂直接施用于或经由灌注至 目标耳结构。
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37.发明申请CONTROLLED RELEASE IMMUNOMODULATOR COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS 有权受控释放的免疫调节剂组合物和治疗口臭的方法公开(公告)号：US20090297533A1
公开(公告)日：2009-12-03
申请号：US12472034
申请日：2009-05-26
申请人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Michael Christopher SCAIFE , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Carl LEBEL , Jeffrey P. Harris , Andrew M. TRAMMEL
发明人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Michael Christopher SCAIFE , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Carl LEBEL , Jeffrey P. Harris , Andrew M. TRAMMEL
IPC分类号： A61K39/395 , A61K31/4353 , A61P27/16
CPC分类号： C07K16/241 , A61K9/0046 , A61K39/39591 , A61K47/34
摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agent compositions and formulations administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
摘要翻译： 本文公开了通过将免疫调节剂组合物和制剂局部施用于患有耳科疾病的个体，通过将这些组合物和制剂直接施用到或经由灌注到目标耳结构中来治疗耳部疾病的组合物和方法。
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公开(公告)号：US20090264417A1
公开(公告)日：2009-10-22
申请号：US12204489
申请日：2008-09-04
申请人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steven P. Govek
发明人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steven P. Govek
IPC分类号： A61K31/551 , C07D295/26 , A61K31/495 , A61K31/496 , C07K1/107 , C07D401/04 , C07D403/12
CPC分类号： C07D213/74 , C07D209/08 , C07D211/96 , C07D257/04 , C07D295/26 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
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公开(公告)号：US20090029971A1
公开(公告)日：2009-01-29
申请号：US12204459
申请日：2008-09-04
申请人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steve P. Govek
发明人： Stewart A. Noble , Guy Oshiro , James W. Malecha , Cunxiang Zhao , Carmen Robinson , Sergio G. Duron , Michael Sertic , Andrew K. Lindstrom , Andrew K. Shiau , Christopher D. Bayne , Mehmet Kahraman , Boliang Lou , Steve P. Govek
IPC分类号： A61K31/496 , C07D241/04 , C07D401/04 , C07D211/70 , A61K31/4418 , A61K31/551 , A61K31/495 , C07D401/12 , C07D409/14
CPC分类号： C07D213/74 , C07D209/08 , C07D211/96 , C07D257/04 , C07D295/26 , C07D333/60 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/12 , C07D487/08
摘要： Compounds as modulators of peroxisome proliferator activated receptors, pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed.
摘要翻译： 公开了作为过氧化物酶体增殖物激活受体的调节剂的化合物，包含其的药物组合物和使用其的治疗疾病的方法。
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