公开(公告)号：US20240335491A1

公开(公告)日：2024-10-10

申请号：US18708128

申请日：2022-06-30

Applicant: KOHKAN PHARMACEUTICAL INSTITUTE CO., LTD. ,  TOKUSHIMA UNIVERSITY

Inventor： Akiteru GO ,  Yoshihiro UTO

IPC: A61K36/258 ,  A61K9/00 ,  A61P21/00

CPC classification number: A61K36/258 ,  A61K9/0056 ,  A61P21/00

Abstract: The present invention provides a method for producing a sarcopenia-inhibiting food product readily available to general consumers, the sarcopenia-inhibiting food product, and a muscle-enhancing food product. In order to solve this problem, this method for producing the sarcopenia-inhibiting food product performs production by fermentation of American ginseng using a microbial group containing at least one of lactic acid bacteria and bifidobacteria. The microbial group preferably contains lactic acid bacteria capable of growing in human intestines. The fermentation is preferably performed for 36-120 hours, inclusive. This sarcopenia-inhibiting food product and this muscle-enhancing food product contain a fermented product of American ginseng using a microbial group containing at least one of lactic acid bacteria and bifidobacteria.

公开(公告)号：US20240092734A1

公开(公告)日：2024-03-21

申请号：US18261383

申请日：2021-10-08

Applicant: Tokushima University ,  AICHI STEEL CORPORATION

Inventor： Kosuke NAMBA ,  Akane MERA ,  Motofumi SUZUKI

IPC: C07D207/16

CPC classification number: C07D207/16

Abstract: Provided is a simple method for producing a heterocycle-containing amino acid compound. A heterocycle-containing amino acid compound is produced by a method comprising step A of reacting a compound represented by the following formula (2) or a salt thereof:




wherein R4 is a hydrogen atom or a carboxyl-protecting group, and n is an integer of 1 to 3,

acrolein, a cyanating agent, and a compound represented by the following formula (3) or a salt thereof:





wherein R1a is a hydrogen atom or CO2R1b, R1b is a hydrogen atom or a carboxyl-protecting group, R2a is a hydrogen atom or OR2b, R2b i s a hydrogen atom or a hydroxyl-protecting group, and R3 is a hydrogen atom or an amino-protecting group.

公开(公告)号：US20230374479A1

公开(公告)日：2023-11-23

申请号：US18030704

申请日：2021-10-07

Applicant: Tokushima University

Inventor： Keishi OSAKABE ,  Yuriko Osakabe ,  Naoki Wada

IPC: C12N9/22 ,  C12N15/63 ,  C12N15/10

CPC classification number: C12N9/22 ,  C12N15/63 ,  C12N15/102 ,  C12N2310/20 ,  C12N2750/14143

Abstract: Provided are a method for targeting a target nucleotide sequence, etc. said method comprising introducing into a cell: (i) CRISPR type I-D Cas proteins Cas5d, Cas6d and Cas7d and a polypeptide containing the N-terminal HD domain of Cas10d, or nucleic acids encoding the proteins and the polypeptide; (ii) a polypeptide that contains not the N-terminal HD domain of Cas10d but the C-terminal partial sequence of Cas10d, or a nucleic acid encoding the polypeptide; and (iii) a crRNA that contains a sequence capable of forming a base pair with the target nucleotide sequence, or a DNA encoding the crRNA.

公开(公告)号：US11453931B2

公开(公告)日：2022-09-27

申请号：US17607397

申请日：2020-09-24

Applicant: TANAKA KIKINZOKU KOGYO K.K. ,  TOKUSHIMA UNIVERSITY

Inventor： Michimasa Okubo ,  Kenji Goto ,  Kunihiro Tanaka ,  Kojiro Shiraishi ,  Kunihiro Shima ,  Yuya Kato ,  Kenichi Hamada ,  Eiichi Honda ,  Emi Takegawa

IPC: C22C5/02 ,  C22C1/02

Abstract: The present invention relates to a medical Au—Pt—Pd alloy including Au, Pt, Pd, and inevitable impurities. The alloy has an alloy composition inside a polygon (A1-A2-A3-A4-A5-A6) surrounded by straight lines connected at point A1 (Au: 37.9 atom %, Pt: 0.1 atom %, and Pd: 62 atom %), point A2 (Au: 79.9 atom %, Pt: 0.1 atom %, and Pd: 20 atom %), point A3 (Au: 79.9 atom %, Pt: 20 atom %, and Pd: 0.1 atom %), point A4 (Au: 69.9 atom %, Pt: 30 atom %, and Pd: 0.1 atom %), point A5 (Au: 49 atom %, Pt: 30 atom %, and Pd: 21 atom %), and point A6 (Au: 39 atom %, Pt: 40 atom %, and Pd: 21 atom %) in a Au—Pt—Pd ternary state diagram. The metal structure of the alloy is optimized, and the metal structure is close to a single-phase structure, and has little precipitation of a Au-rich phase and a Pt-rich phase different in composition from a mother phase.

公开(公告)号：US20220257676A1

公开(公告)日：2022-08-18

申请号：US17626622

申请日：2020-07-17

Applicant: Asahi Group Holdings, Ltd. ,  Tokushima University

Inventor： Daisuke SAWADA ,  Shigeru FUJIWARA ,  Tomonori SUGAWARA ,  Kazuhito ROKUTAN ,  Kensei NISHIDA ,  Yuki KUWANO

IPC: A61K35/747 ,  A61P15/00 ,  A61P17/10 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24

Abstract: [Problem] The purpose of the present invention is to provide a novel technology capable of regulating female hormone secretion. [Solution] Provided is an agent for regulating female hormone secretion, which contains the lactobacillus strain Lactobacillus gasseri strain CP2305 (accession No.: FERM PB-11331), a treated product of said lactobacillus strain, or extracts thereof.

公开(公告)号：US20220220234A1

公开(公告)日：2022-07-14

申请号：US17608591

申请日：2020-05-08

Applicant: SEKISUI CHEMICAL CO., LTD. ,  TOKUSHIMA UNIVERSITY

Inventor： Yohei NISHIMURA ,  Risa YAMAZAKI ,  Koichi UTE ,  Miyuki OSHIMURA ,  Tomohiro HIRANO ,  Ryo KAGITANI

IPC: C08F16/06 ,  C08F16/38 ,  C08F8/30

Abstract: The present invention provides a vinyl alcohol-amino acid ester copolymer that is excellent in properties such as cell culture properties, biocompatibility, antibacterial properties, and solubility in organic solvents, and is applicable to the medical field, the biomaterial field, and the agricultural field (medical and life science fields). Provided is a vinyl alcohol-amino acid ester copolymer including a unit represented by the following formula (1) and a unit represented by the following formula (2): where, in the formula (2), R1 represents a hydrocarbon group that may optionally have a substituent, R2 and R3 each independently represent a hydrogen atom or a hydrocarbon group, and R1 and R2, or R2 and R3, may optionally be bonded together to form a cyclic structure.

公开(公告)号：US20210253522A1

公开(公告)日：2021-08-19

申请号：US17270334

申请日：2019-08-22

Applicant: TOKUSHIMA UNIVERSITY ,  AICHI STEEL CORPORATION

Inventor： Kosuke NAMBA ,  Motofumi SUZUKI ,  Akane MERA

IPC: C07D207/16 ,  C05C11/00 ,  A01N59/16 ,  A01N43/36 ,  C07F15/02

Abstract: The present invention is a heterocycle-containing amino acid compound represented by a general formula (1): wherein R1 and R2 are identical with or different from each other, and each represent a hydrogen atom or a carboxy-protecting group; R3 represents a carboxyl group or a hydroxyl group; and n is 1 or 2, or a salt thereof.

公开(公告)号：US10732099B2

公开(公告)日：2020-08-04

申请号：US16068087

申请日：2016-12-20

Applicant: TOKUSHIMA UNIVERSITY

Inventor： Yoshihiro Deguchi

IPC: G01N21/27 ,  G01N21/39 ,  G01N21/3504 ,  G01N21/03

Abstract: A gas analysis device includes a laser light source configured to output a laser beam, an irradiation unit configured to irradiate a measurement region including measurement target gas with the laser beams in plural directions, plural photoreceivers each configured to receive a laser beam having passed through the measurement region and output an electric signal according to intensity of the received laser beam, and an analyzer configured to analyze the physical state of the measurement target gas based on the electric signal output from each photoreceiver. The analyzer sets a function (e.g. two-dimensional polynomial f(X,Y)) representing the physical state (e.g. concentration, temperature) of the target gas at least in the measurement region, and measures the physical state of the target gas by determining a coefficient of each of terms included in the function based on a measured value obtained from the electric signal output from the photoreceiver.

公开(公告)号：US20200181579A1

公开(公告)日：2020-06-11

申请号：US16341175

申请日：2017-10-06

Applicant: Tokushima University

Inventor： Hideharu ABE

IPC: C12N5/071 ,  G01N33/50

Abstract: A novel tissue usable for a kidney tissue model is provided. A method for producing a kidney-like tissue includes co-culturing a cell group containing mesenchymal stem cells, vascular endothelial cells, and clonal embryonic kidney cells.

公开(公告)号：US10400226B2

公开(公告)日：2019-09-03

申请号：US14436833

申请日：2013-10-17

Applicant: TOKUSHIMA UNIVERSITY ,  MEIJI PHARMACEUTICAL UNIVERSITY

Inventor： Koji Ito ,  Hitoshi Sakuraba ,  Daisuke Tsuji

IPC: C12N9/24 ,  A61K38/47 ,  A61K38/00

Abstract: Provided is a modified β-subunit of human β-hexosaminidase which has the activity derived from the α-subunit of wild-type human β-hexosaminidase and has the resistance to protease. A protein comprising an amino acid sequence having substitutions of the 312th to the 318th amino acids with glycine, serine, glutamic acid, proline, serine, glycine and threonine in order, respectively, in an amino acid sequence of a β-subunit of wild-type human β-hexosaminidase.