公开(公告)号：US06648609B2

公开(公告)日：2003-11-18

申请号：US10117984

申请日：2002-04-05

申请人： Terry A. Berger ,  Kimber D. Fogelman ,  Kenneth Klein ,  L. Thompson Staats, III ,  Mark Nickerson ,  Paul F. Bente, III

发明人： Terry A. Berger ,  Kimber D. Fogelman ,  Kenneth Klein ,  L. Thompson Staats, III ,  Mark Nickerson ,  Paul F. Bente, III

IPC分类号： F04B4908

CPC分类号： F04B11/0091 ,  F04B49/225 ,  Y10T137/7838 ,  Y10T137/87917 ,  Y10T137/88054 ,  G01N2030/326 ,  B01D15/40

摘要： The invention is a device and method in a high-pressure chromatography system, such as a supercritical fluid chromatography (SFC) system, that uses a pump as a pressure source for precision pumping of a compressible fluid. The preferred exemplary embodiment comprises a pressure regulation assembly installed downstream from a compressible fluid pump but prior to combining the compressible flow with a relatively incompressible modifier flow stream. The present invention allows the replacement of an high-grade SFC pump in the compressible fluid flow stream with an inexpensive and imprecise pump. The imprecise pump becomes capable of moving the compressible fluid flow stream in a precise flow rate and pattern. The assembly dampens the damaging effects of an imprecise pump, such as large pressure oscillations caused by flow ripples and noisy pressure signals that do not meet precise SFC pumping requirements.

摘要翻译： 本发明是高压色谱系统中的装置和方法，例如超临界流体色谱（SFC）系统，其使用泵作为精密泵送可压缩流体的压力源。 优选的示例性实施例包括安装在可压缩流体泵的下游但在将可压缩流与相对不可压缩的修饰剂流动流组合之前的压力调节组件。 本发明允许用便宜且不精确的泵替代可压缩流体流动中的高级SFC泵。 不精确的泵变得能够以精确的流速和模式移动可压缩流体流动流。 该组件会抑制不精确泵的破坏性影响，例如由流动波纹引起的大压力振荡和不符合精确SFC泵送要求的噪声压力信号。

公开(公告)号：US5804701A

公开(公告)日：1998-09-08

申请号：US731943

申请日：1996-10-22

申请人： Terry A. Berger

发明人： Terry A. Berger

IPC分类号： G01N30/02 ,  B01D15/08 ,  G01N30/30 ,  G01N30/54 ,  G01N30/60 ,  G01N30/88

CPC分类号： G01N30/30 ,  G01N30/88 ,  G01N2030/0095 ,  G01N2030/3084 ,  G01N2030/8881 ,  G01N30/6034 ,  G01N30/6095

摘要： An analytical instrument includes a control system, including a computer and a pneumatic controller responsive to the computer, and a planar chromatographic assembly. The planar chromatographic assembly includes a planar pneumatic manifold, a heater/fan assembly for establishing a temperature-controlled zone, an insulating enclosure for confining the temperature-controlled zone to an oven cavity and certain zones of the planar pneumatic manifold, a separation column having inlet and outlet ends attached to couplers at selected internal fluid-bearing conduits in the pneumatic manifold and located closely adjacent the planar manifold and within the temperature-controlled zone, and one or more fluid-handling functional devices attached to the pneumatic manifold for fluid-tight communication with respective internal etched channels provided within in the planar pneumatic manifold. The fluid-handling functional devices may be surface-mounted or edge-mounted to certain ones of the etched channels in the planar pneumatic manifold. The fluid-handling functional devices may include: a) passive devices such as an injector section, a fluid coupler, or a vent for coupling a fluid stream to or from a selected fluid-bearing conduit; b) active devices such as a valve, a fluid regulator, a fluid flow input device (fluid source), operable in response to a control signal from the control system for controlling fluid flow in one or more selected etched channels in the planar manifold, or c) signal generating devices such as a sensor or detector operable so as to provide sense or detection signal indicative of a characteristic of the fluid flow in an etched channel or in the separation column. The combination of the planar manifold and the edge- or surface-mounted fluid-handling functional devices allows the planar chromatographic assembly to be constructed in a compact, low-profile form factor.

摘要翻译： 分析仪器包括控制系统，包括响应于计算机的计算机和气动控制器以及平面色谱组件。 平面色谱组件包括平面气动歧管，用于建立温度控制区域的加热器/风扇组件，用于将温度控制区域限制在烤箱腔室和平面气动歧管的某些区域的绝缘外壳，具有 入口端和出口端连接到气动歧管中选定的内部流体承载导管处的耦合器并且紧邻平面歧管并位于温度控制区域内，以及连接到气动歧管的流体处理功能装置， 与设置在平面气动歧管内的相应的内部蚀刻通道紧密连通。 流体处理功能装置可以表面安装或边缘安装到平面气动歧管中的某些蚀刻通道。 流体处理功能装置可以包括：a）无源装置，例如喷射器部分，流体耦合器或用于将流体流耦合到选定的流体承载导管的通气口; b）有源装置，例如阀门，流体调节器，流体流动输入装置（流体源），其响应于来自控制系统的控制信号可操作，用于控制平面歧管中的一个或多个选定的蚀刻通道中的流体流动， 或c）诸如传感器或检测器的信号产生装置，其可操作以提供指示在蚀刻通道或分离柱中的流体流动的特性的感测或检测信号。 平面歧管和边缘或表面安装的流体处理功能装置的组合允许平面色谱组件以紧凑，薄型的形状因子构造。

公开(公告)号：US5744696A

公开(公告)日：1998-04-28

申请号：US814035

申请日：1997-03-10

申请人： Tak Kui Wang ,  James Ward Baker ,  Terry A. Berger

发明人： Tak Kui Wang ,  James Ward Baker ,  Terry A. Berger

IPC分类号： G01N30/54 ,  B01D53/22 ,  B01D69/10 ,  B01D71/02 ,  C01B3/50 ,  G01N30/02 ,  G01N30/30 ,  F25D23/06

CPC分类号： B01D53/228 ,  B01D69/10 ,  B01D71/022 ,  C01B3/505 ,  G01N30/30 ,  G01N2030/025 ,  G01N2030/3007 ,  G01N2030/3084

摘要： Sample analysis in a portable analytical instrument, preferably in the form of a gas chromatograph, benefits from temperature control of one or more thermal zones in the instrument by way of a thermal isolation system that includes a novel pumping assembly to effect a selective amount of thermal isolation of the thermal zone. The pumping assembly includes a pumping element in the form of a tubular or planar palladium structure. The pumping assembly makes use of the unique properties of palladium to allow selective control of a nominal gas pressure within a vacuum cavity. A component system, which may include a separation column and a thermal device for heating and/or cooling the component system, may be provided within the vacuum cavity. The thermal device and the pumping assembly are individually controlled by a control system. The pumping assembly may be operated to allow selective control of the thermal isolation of the thermal zone; alternatively, the component system may be subject to a controlled temperature by operating the thermal device. A sample mixture passing through the separation column may thereby be exposed to a desired temperature profile according to a selected program so that the sample will separate into its components for subsequent detection by a detector.

摘要翻译： 便携式分析仪器中的样品分析优选以气相色谱仪的形式受益于通过热隔离系统对仪器中的一个或多个热区进行温度控制，所述热隔离系统包括新颖的泵送组件以实现选择量的热 隔离热区。 泵送组件包括管状或平面钯结构形式的泵送元件。 泵送组件利用钯的独特性质来允许选择性地控制真空腔内的标称气体压力。 可以在真空腔内设置可包括分离塔和用于加热和/或冷却部件系统的热装置的部件系统。 热设备和泵组件由控制系统单独控制。 可以操作泵送组件以允许选择性地控制热区的热隔离; 或者，组件系统可以通过操作热装置而经受受控的温度。 因此，通过分离柱的样品混合物可以根据所选择的程序暴露于所需的温度分布，使得样品将分离成其组分以便随后由检测器检测。

公开(公告)号：US5663488A

公开(公告)日：1997-09-02

申请号：US456210

申请日：1995-05-31

申请人： Tak Kui Wang ,  James W. Baker ,  Terry A. Berger

发明人： Tak Kui Wang ,  James W. Baker ,  Terry A. Berger

IPC分类号： G01N30/54 ,  B01D53/22 ,  B01D69/10 ,  B01D71/02 ,  C01B3/50 ,  G01N30/02 ,  G01N30/30 ,  G01N7/00

CPC分类号： B01D53/228 ,  B01D69/10 ,  B01D71/022 ,  C01B3/505 ,  G01N30/30 ,  G01N2030/025 ,  G01N2030/3007 ,  G01N2030/3084

摘要： Sample analysis in a portable analytical instrument, preferably in the form of a gas chromatograph, benefits from temperature control of one or more thermal zones in the instrument by way of a thermal isolation system that includes a novel pumping assembly to effect a selective amount of thermal isolation of the thermal zone. The pumping assembly includes a pumping element in the form of a tubular or planar palladium structure. The pumping assembly makes use of the unique properties of palladium to allow selective control of a nominal gas pressure within a vacuum cavity. A component system, which may include a separation column and a thermal device for heating and/or cooling the component system, may be provided within the vacuum cavity. The thermal device and the pumping assembly are individually controlled by a control system. The pumping assembly may be operated to allow selective control of the thermal isolation of the thermal zone; alternatively, the component system may be subject to a controlled temperature by operating the thermal device. A sample mixture passing through the separation column may thereby be exposed to a desired temperature profile according to a selected program so that the sample will separate into its components for subsequent detection by a detector.

摘要翻译： 便携式分析仪器中的样品分析优选以气相色谱仪的形式受益于通过热隔离系统对仪器中的一个或多个热区进行温度控制，所述热隔离系统包括新颖的泵送组件以实现选择量的热 隔离热区。 泵送组件包括管状或平面钯结构形式的泵送元件。 泵送组件利用钯的独特性质来允许选择性地控制真空腔内的标称气体压力。 可以在真空腔内设置可包括分离塔和用于加热和/或冷却部件系统的热装置的部件系统。 热设备和泵组件由控制系统单独控制。 可以操作泵送组件以允许选择性地控制热区的热隔离; 或者，组件系统可以通过操作热装置而经受受控的温度。 因此，通过分离柱的样品混合物可以根据所选择的程序暴露于所需的温度分布，使得样品将分离成其组分以便随后由检测器检测。