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    Method for Identifying Compounds of Therapeutic Interest
    38.
    发明申请
    Method for Identifying Compounds of Therapeutic Interest 审中-公开
    识别治疗兴趣化合物的方法

    公开(公告)号：US20150219635A1

    公开(公告)日：2015-08-06

    申请号：US14409424

    申请日：2013-06-28

    Applicant: UCB PHARMA S.A.

    Inventor： Alastair David Griffiths Lawson ,  Alistair James Henry

    IPC: G01N33/53 ,  G06F19/16

    CPC classification number: G01N33/5308 ,  C07K16/4291 ,  C07K2299/00 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2317/92 ,  C40B30/04 ,  G01N33/542 ,  G01N2500/02 ,  G01N2500/04 ,  G01N2500/20 ,  G06F19/16

    Abstract: The present invention relates to an improved method for drug discovery. In particular the present invention provides a method of identifying compounds capable of binding to a functional conformational state of a protein of interest or protein fragment thereof, said method comprising the steps of: (a) Binding a function-modifying antibody to the target protein of interest or a fragment thereof to provide an antibody-constrained protein or fragment, wherein the antibody has binding kinetics with the protein or fragment which are such that it has a low dissociation rate constant, (b) Providing a test compound which has a low molecular weight, (c) Evaluating whether the test compound of step b) binds the antibody constrained protein or fragment, and (d) Select a compound from step c) based on the ability to bind to the protein or fragment thereof.

    Abstract translation: 本发明涉及药物发现的改进方法。 特别地，本发明提供了鉴定能够结合目标蛋白质或其蛋白质片段的功能构象状态的化合物的方法，所述方法包括以下步骤：（a）将功能修饰抗体与靶蛋白的结合 提供抗体约束蛋白或片段，其中抗体与蛋白质或片段具有结合动力学，使得其具有低解离速率常数，（b）提供具有低分子量的测试化合物 （c）评估步骤b）的测试化合物是否结合抗体约束蛋白或片段，和（d）基于与蛋白质或其片段结合的能力从步骤c）中选择化合物。

    Analytical method for fab and fab′ molecules
    39.
    发明授权
    Analytical method for fab and fab′ molecules 有权
    晶圆和晶圆分子的分析方法

    公开(公告)号：US09096887B2

    公开(公告)日：2015-08-04

    申请号：US14275055

    申请日：2014-05-12

    Applicant: UCB PHARMA, S.A.

    Inventor： Bryan John Smith ,  Helen Marie Kirke

    IPC: C12Q1/37 ,  G01N33/68

    CPC classification number: C12Q1/37 ,  G01N33/6857 ,  G01N2333/96433

    Abstract: A method of measuring acidic species generated by degradation of a Fab or Fab′ component of a Fab-PEG or a Fab′-PEG is provided. The method involves: a) cleaving PEG and a linker from the Fab-PEG or Fab′-PEG with an enzyme; b) optionally separating the PEG and linker from the Fab or Fab′ to provide isolated Fab or Fab′; and c) quantitatively analyzing acidic species associated with the cleaved Fab or Fab′ and/or the cleaved PEG.

    Abstract translation: 提供了测量由Fab-PEG或Fab'-PEG的Fab或Fab'成分降解而产生的酸性物质的方法。 该方法包括：a）用酶切割PEG和Fab-PEG或Fab'-PEG的接头; b）任选地将PEG和接头与Fab或Fab'分离以提供分离的Fab或Fab'; 和c）定量分析与切割的Fab或Fab'和/或切割的PEG相关的酸性物质。

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