公开(公告)号：US20230102047A1

公开(公告)日：2023-03-30

申请号：US17863135

申请日：2022-07-12

Applicant: UNIVERSITY OF KANSAS

Inventor： Brian S.J. BLAGG ,  Bhaskar Reddy KUSUMA ,  Teather SUNDSTROM

IPC: C07H15/207 ,  C07H15/203 ,  C07C211/17

Abstract: Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.

公开(公告)号：US11566555B2

公开(公告)日：2023-01-31

申请号：US17260102

申请日：2019-08-30

Applicant: University of Kansas

Inventor： Christopher Depcik ,  Matthew Cole

IPC: F01N9/00

Abstract: Systems, methods, and computer readable storage media for controlling oxidation of a particulate filter (PF) are closed. The oxidation of the PF may be controlled using a PF model. The PF model may be utilized to simulate operations of the PF based on various input data and/or derived data to determine an optimum time for initiating an oxidation event at the PF, and an oxidation event may be initiated at the PF based on the simulating.

公开(公告)号：US20230024611A1

公开(公告)日：2023-01-26

申请号：US17791079

申请日：2021-03-02

Applicant: University of Kansas

Inventor： Yong Zeng

IPC: G01N33/574 ,  G01N33/68 ,  G01N33/543 ,  C12Q1/37 ,  G01N21/64

Abstract: Provided herein are methods for inkjet printing objects, including objects which may be used as elements of microfluidic devices. The microfluidic devices incorporating the elements are also provided. Such microfluidic devices include those configured to quantify the expression and activity of exosomal matrix metalloprotease, MMP14. These microfluidic devices may be used in methods of monitoring breast cancer in patients having breast cancer.

公开(公告)号：US20220410134A1

公开(公告)日：2022-12-29

申请号：US17775540

申请日：2020-11-13

Applicant: University of Kansas

Inventor： Mark Brandon Shiflett ,  Rajkumar Kore ,  Aaron M. Scurto

IPC: B01J31/02 ,  C07C2/62

Abstract: An alkylation catalyst composition is provided which comprises an acid, an aromatic, and a third component selected from the group consisting of a base capable of forming an ionic liquid with the acid; and an ionic liquid. An alkylation process is also provided which comprises combining the alkylation catalyst composition with a feedstock under conditions to produce an alkylate product for a motor fuel additive. The alkylate product produced by the alkylation process is also provided.

公开(公告)号：US20220404466A1

公开(公告)日：2022-12-22

申请号：US17682973

申请日：2022-02-28

Applicant: University of Kansas

Inventor： Christian Curtis Jones ,  Lumumba Harnett ,  Charles Andrew Mohr ,  Shannon David Blunt

IPC: G01S7/41

Abstract: The present application provides techniques for reducing noise in sensor-based systems, such as radar systems. In particular, techniques referred to background supplemental cancellation (BaSC) and background supplemental loading (BaSL) are disclosed and facilitate improved detection of moving targets in certain types of radar systems, such as radar systems based on Reiterative minimum-mean square error (RMMSE) estimation formulations. The BaSC technique may utilize a hard cancellation, where clutter cancellation is performed prior to estimation, while the BaSL technique may utilize a “soft” cancellation technique whereby clutter cancellation is performed jointly with estimation. The clutter cancellation provided via the BaSC and BaSL techniques improves the accuracy of the radar system with respect to performing target detection.

公开(公告)号：US11510964B2

公开(公告)日：2022-11-29

申请号：US17072409

申请日：2020-10-16

Applicant: University of Kansas ,  University of Florida Research Foundation

Inventor： Jane Aldrich ,  Archana Mukhopadhyay ,  Laura E. Hanold

IPC: A61K38/12 ,  A61P35/00 ,  A61K9/00 ,  A61K9/08 ,  A61K47/02

Abstract: The present technology provides methods end medicaments useful for treating prostate cancer and breast cancer. Such methods include administering at least one of cyclo[Phe-D-Pro-Phe-Trp] and cyclo[Phe-D-Pro-Phe-D-Trp] to a subject suffering from prostate cancer or breast cancer.

公开(公告)号：US20220331749A1

公开(公告)日：2022-10-20

申请号：US17722825

申请日：2022-04-18

Applicant: University of Kansas

Inventor： Gibum Kwon ,  Bishwash Shrestha ,  Mohammadamin Ezazi

IPC: B01D71/40 ,  C10G25/00 ,  H01M8/0221

Abstract: A method of separating a mixture of fluids may comprise contacting an absorbent material with a mixture of fluids comprising a first fluid and a second fluid having different polarities, wherein the absorbent material selectively absorbs the first fluid to provide a permeate comprising the first fluid and a retentate comprising the second fluid. The absorbent material comprises a zwitterionic polymer, the zwitterionic polymer being a polymerization product of reactants comprising a zwitterionic monomer and a (meth)acrylate crosslinker. The zwitterionic monomer is selected from the group consisting of: a zwitterionic monomer of Formula I, R—(CH2)m—NR′2+—(CH2)n-A−, wherein R is selected from a carboxyamide, a (meth)acrylate, and an alkyl; m is an integer of from 0 to 5; each R′ is independently selected from hydrogen and an alkyl; n is an integer of from 1 to 5; and A− is SO3− or CO2−; a zwitterionic monomer of Formula II, R—(CH2)m-A−-(CH2)n—NR′3+, wherein R is an (meth)acrylate; m is an integer of from 1 to 5; A is PO4−; n is an integer of from 1 to 5; and each R′ is independently selected from hydrogen and an alkyl; carboxybetaine diacrylamide; (3-methacryloylamino-propyl)-(2-carboxy-ethyl)-dimethylammonium; 3-[Dimethyl-(2-hydroxyethyl)ammonio]-1-propanesulfonate; 1-methylpyridinium 3-sulfonate; and combinations thereof.

公开(公告)号：US11439700B2

公开(公告)日：2022-09-13

申请号：US17053544

申请日：2019-05-03

Applicant: UNIVERSITY OF KANSAS

Inventor： Wendy L. Picking ,  William D. Picking

IPC: A61K39/104 ,  A61K39/118 ,  A61K39/02

Abstract: Disclosed are methods and compositions related to polypeptides comprising a fusion of the needle tip protein and translocator protein of a type III secretion apparatus (T3SA) from a type III secretion system (T3SS) of a Gram negative bacteria. Disclosed herein are fusion polypeptides comprising a fusion of a needle tip protein, such as, Bsp22, LcrV, BipD, PcrV, CT053, or CT668, or anantigenic fragment thereof; and a translocator protein, such as, BopB, YopB, BipB, PopB, CopB, or CopB2, or anantigenic fragment thereof from a Type III secretion system (T3SS) of a Gram negative bacteria, such as, Bordetella, Burkholderia, Chlamydia, Pseudomonas, Vibrio, or Yersinia.

公开(公告)号：US11384279B2

公开(公告)日：2022-07-12

申请号：US17079877

申请日：2020-10-26

Applicant: CONOCOPHILLIPS COMPANY ,  University of Kansas

Inventor： Huili Guan ,  Cory Berkland ,  Ahmad Moradi-Araghi ,  Jenn-Tai Liang ,  Terry M. Christian ,  Riley B. Needham ,  Min Cheng

IPC: C09K8/588 ,  C09K8/50 ,  C09K8/512

Abstract: The disclosure is directed to methods and compositions delaying the gelation of polymers in water flooding by sequentially or co-injecting a carboxylate-containing polymer solution, a gel-delaying polymer, and gelation agent into a hydrocarbon reservoir. Delays of weeks are observed.

公开(公告)号：US11382944B2

公开(公告)日：2022-07-12

申请号：US16920127

申请日：2020-07-02

Applicant: CyDex Pharmaceuticals, Inc. ,  University of Kansas

Inventor： James D. Pipkin ,  Roger A. Rajewski ,  Beau Mainous

IPC: A61K36/28 ,  A61Q19/08 ,  A61K47/40 ,  A61K9/00 ,  A61K8/49 ,  A61K8/73 ,  A61K31/353 ,  A61K31/357 ,  A61K9/06 ,  A61P17/06 ,  A61P1/16 ,  A61K8/96 ,  A61Q17/04

Abstract: Cosmetic and dietary supplement compositions containing silymarin and sulfoalkyl ether cyclodextrin, particularly sulfobutyl ether cyclodextrin, are described. The compositions and methods are useful in reducing appearance of facial redness in rosacea-prone skin, rejuvenating skin, preventing skin aging, inhibiting oxidative stress in epidermal and dermal cells, increasing collagen production, reducing the likelihood of skin cancer, treating or reducing liver damage from a toxin, or treating a liver disease.