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公开(公告)号：US20200338136A1
公开(公告)日：2020-10-29
申请号：US16959175
申请日：2019-01-07
Inventor： Sue KIM , Jin Ho YU , Yeon Mok OH
IPC: A61K35/545 , A61K35/28 , A61P17/10 , A61K8/98 , A61Q19/00
Abstract: The present invention may provide a pharmaceutical composition for preventing or treating skin diseases, a cosmetic composition for preventing or improving skin diseases, and a stem cell therapeutic agent, which comprise an induced pluripotent stem cell-derived mesenchymal stem cell (iMSC), a culture thereof, or an exosome isolated from an iMSC or iMSC culture as active ingredients. When the composition of the present invention, etc. is used, it is possible to provide a composition for improving, preventing or treating skin diseases and a stem cell therapeutic agent which have an improved immunomodulating function over conventional mesenchymal stem cells.
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公开(公告)号：US10677806B2
公开(公告)日：2020-06-09
申请号：US16233695
申请日：2018-12-27
Applicant: MEDICINAL BIOCONVERGENCE RESEARCH CENTER , THE ASAN FOUNDATION , UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
Inventor： Sunghoon Kim , Won Suk Yang , Kyunggon Kim , Won Gu Kim
IPC: G01N33/53 , G01N33/78 , G01N33/573 , G01N33/574
Abstract: A method for diagnosing follicular thyroid carcinoma is described. The method measures protein expression levels of an aminoacyl-tRNA synthetase (ARS) or an aminoacyl-tRNA synthetase complex-interacting multifunctional protein (AIMP) in a sample, such as a thyroid tissue sample, from a subject suspected of having follicular thyroid carcinoma. The protein expression levels of ARS or AIMP are compared to the measured protein expression levels in a control.
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公开(公告)号：US20200022997A1
公开(公告)日：2020-01-23
申请号：US16435680
申请日：2019-06-10
Applicant: Seoul National university R&DB Foundation , University of Ulsan Foundation For Industry Cooperation , The Asia Foundation
Inventor： Youngro BYUN , Sang Yoon KIM , Seongwoo CHUNG , Young Seok CHO
IPC: A61K31/704 , A61K31/337 , A61K47/54 , A61K47/55 , A61K47/64 , A61P35/00
Abstract: Described herein are anticancer complexes suitable for oral administration comprising an anticancer prodrug moiety comprising (i) a caspase-cleavable peptide, attached directly or through a linker, to (ii) an anticancer chemotherapeutic agent; and (b) a bile acid moiety, wherein the bile acid moiety is non-covalently complexed to the anticancer prodrug moiety. Also described is the preparation of such anticancer complexes and their use in combination with a treatment that induces apoptosis (e.g., radiotherapy) for inducing amplified apoptosis of tumor cells and treating cancer.
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34.发明授权公开(公告)号：US10521969B2
公开(公告)日：2019-12-31
申请号：US15552560
申请日：2016-02-23
Applicant: OSSTEMIMPLANT CO., LTD. , SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
Inventor： Namkug Kim , Mooyong Park , Seongyun Lee , Byunghee Han , Il-Hyung Yang , In-Sung Yeo
Abstract: The present invention relates to method for simulating mandibular movements, device for the same and recording medium for recording the same. With the method for simulating mandible movements according to the present invention, it is possible to perform the simulation directly on the medical image of the patient and thus simulate the mandibular movements more closely to the actual situation. Therefore, the inaccurate mechanical approximation of the mandibular movement with the articulator according to the conventional art is overcome. In addition, according to the present invention, it is possible to simulate mandibular movements customized to the various states of the patient and specific clinical cases.
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公开(公告)号：US20190277865A1
公开(公告)日：2019-09-12
申请号：US16233695
申请日：2018-12-27
Applicant: MEDICINAL BIOCONVERGENCE RESEARCH CENTER , THE ASAN FOUNDATION , UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
Inventor： Sunghoon Kim , Won Suk Yang , Kyunggon Kim , Won Gu Kim
IPC: G01N33/78 , G01N33/573
Abstract: The present invention relates to a method for detecting markers for diagnosis of follicular thyroid carcinoma using an expression level of aminoacyl-tRNA synthetase-related protein. More specifically, the present invention relates to a method for detecting markers of follicular carcinoma in order to provide necessary for the diagnosis of follicular thyroid carcinoma in a patient suspected of having follicular thyroid carcinoma, the method comprising; (a) a step of providing a sample from a subject suspected of having follicular thyroid carcinoma; (b) a step of measuring the protein expression of an aminoacyl-tRNA synthetase or an aminoacyl-tRNA synthetase complex-interacting multifunctional protein in the sample; and (c) a step of comparing the measured protein expression level with that of a control, and determining that the subject having a confirmed change in the protein expression level has follicular thyroid carcinoma. Specifically, the types of proteins disclosed in the present invention can be used to diagnose follicular thyroid carcinoma simply and clearly without surgical tissue retrieval, and have high diagnostic sensitivity and specificity
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Patent Agency Ranking
公开(公告)号：US20190269359A1
公开(公告)日：2019-09-05
申请号：US16417159
申请日：2019-05-20
Inventor： Namkug KIM , Hyun Na LEE , Sung Won HAM , Dong Wha KANG
Abstract: The present disclosure relates to a system and a method for estimating an acute cerebral infarction onset time. The method according to the present disclosure includes at least: receiving a first image and a second image of a first patient whose acute cerebral infarction onset time is not identified; extracting an infarction area image from the second image; aligning the second image with the first image; defining an infarction area in the first image, based on a result of the alignment of the second image with the first image; extracting feature information of the first patient, from the infarction area in the first image; comparing the extracted feature information with reference data; and calculating an amount of time that has elapsed since the acute cerebral infarction onset time, based on a result of the comparison of the extracted feature information with reference data.
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公开(公告)号：US20190217046A1
公开(公告)日：2019-07-18
申请号：US16363884
申请日：2019-03-25
Inventor： Dong Wha KANG , Dong Ho KIM
CPC classification number: A61M21/00 , A61B3/113 , A61B5/162 , A61M2021/005 , A61M2205/3303 , A61M2209/088 , A61M2230/63
Abstract: Disclosed are a device, a method, and a program for training memory using brain stimulation. The method includes at least: displaying a first problem on a task display portion of a screen; receiving a first response corresponding to the first problem; and evaluating a memory state of a user based on the first response. The first problem includes one or more output images to be displayed at a specific location within the task display portion, and the first response includes a result of comparing a previous first problem that was displayed before N times (N is a natural number) of executing the method, with the displayed first problem.
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公开(公告)号：US20190204321A1
公开(公告)日：2019-07-04
申请号：US16314253
申请日：2017-07-20
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , THE ASAN FOUNDATION , UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
Inventor： Kwan Hyi LEE , Min Hong JEUN , Sung Wook PARK , Seung Jae MYUNG , Choung Soo KIM , Sang Yeob KIM , Eun Ju DO , Ja Young KANG
IPC: G01N33/574 , G01N33/543 , G01N27/414
CPC classification number: G01N33/57419 , A61B5/00 , G01N27/414 , G01N27/4145 , G01N27/4146 , G01N33/543 , G01N33/5438 , G01N33/54386 , G01N33/574 , G01N33/57484 , G01N2800/50
Abstract: The present invention relates to a high-sensitivity liquid field-effect sensor for colon cancer, applicable to a sample such as blood or stool. The sensor according to one aspect enables ultra-high precision/low-concentration detection of colon cancer biomarkers, thereby having an effect of enabling early diagnosis of colon cancer even with a very small amount of a sample.
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公开(公告)号：US20190183900A1
公开(公告)日：2019-06-20
申请号：US16310450
申请日：2017-03-09
Inventor： Seong-Who KIM , Sang-Yoon KIM , Hyang-Ju LEE
IPC: A61K31/519 , A61K31/541 , A61K35/28 , A61P37/02
CPC classification number: A61K31/519 , A61K31/541 , A61K35/28 , A61P37/02
Abstract: Disclosed is a composition for proliferation, differentiation promotion, and senescence inhibition of stem cells, including a JAK1 inhibitor as an active ingredient, wherein JAK1 inhibitor-treated stem cells or JAK1 knockout stem cells have an activity for decreasing senescence and increasing the survival rate of the stem cells, thereby being usable in a composition for proliferation, differentiation promotion, and senescence inhibition of stem cells.
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公开(公告)号：US20190018014A1
公开(公告)日：2019-01-17
申请号：US16149142
申请日：2018-10-02
Inventor： Eun Kyung CHOI , Seong-Yun JEONG , Si Yeol SONG , Kyoung Jin LEE , Seol Hwa SHIN , Eun Jin JU
Abstract: Provided is a peptide for targeting gastric cancer, a composition for diagnosing radioresponsiveness-dependent gastric cancer using the peptide, and a drug delivery use of the peptide, wherein a functional peptide capable of targeting cancer has been discovered so as to implement personalized diagnosis and treatment for individual patients having cancer, consideration of problems occurring during treatment in which treatment cases of respective patients differ due to different therapeutic responses resulting from genetic differences in the individual patients.
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