公开(公告)号：US06982864B1

公开(公告)日：2006-01-03

申请号：US10864309

申请日：2004-06-09

Applicant: Srinivasan Sridharan ,  Umesh Kumar ,  Chandrashekhar S. Khadilkar

Inventor： Srinivasan Sridharan ,  Umesh Kumar ,  Chandrashekhar S. Khadilkar

IPC: H01G4/06

CPC classification number: H01G4/2325 ,  C03C3/066 ,  C03C8/04 ,  C03C8/14 ,  C03C8/16 ,  C03C8/18

Abstract: Lead-free and cadmium-free glass composition that is particularly suitable for use in conductive ink applications. The invention includes a capacitor comprising a copper termination, the copper termination is made by firing an ink including a glass component, the glass component may comprise up to about 65 mole % ZnO, up to about 51 mole % SrO, about 0.1 to about 61 mole % B2O3, up to about 17 mole % Al2O3, about 0.1 to about 63 mole % Sio2, up to about 40 mole % BaO+CaO, and up to about 20 mole % MgO.

Abstract translation: 无铅和无镉玻璃组合物，特别适用于导电油墨应用。 本发明包括一个包含铜终端的电容器，铜端接件是通过烧制包括玻璃组分的油墨制成的，该玻璃组分可以包括高达约65％（摩尔）的ZnO，至多约51％的SrO，约0.1-约61 摩尔％B 2 O 3 3，至多约17摩尔％的Al 2 O 3 3，约0.1至约 63摩尔％的SiO 2，至多约40摩尔％的BaO + CaO和至多约20摩尔％的MgO。

公开(公告)号：US5759432A

公开(公告)日：1998-06-02

申请号：US663729

申请日：1996-06-14

Applicant: Umesh Kumar ,  Wayne Huebner ,  Sea Fue Wang

Inventor： Umesh Kumar ,  Wayne Huebner ,  Sea Fue Wang

IPC: B06B1/06 ,  C04B35/499 ,  H01L41/187 ,  C04B35/495 ,  C04B35/472 ,  H02K47/04

CPC classification number: B06B1/06 ,  C04B35/499 ,  H01L41/187

Abstract: A relaxor ferroelectric composition that has the components lead magnesium niobate, lead titanate, and lead magnesium tungstate. The components are preferably present in relative molar amounts of (1-x-y) lead magnesium niobate, (x) lead titanate, and (y) lead magnesium tungstate, where 0.11.ltoreq.x.ltoreq.0.13 and 0.01.ltoreq.y.ltoreq.0.03. Also disclosed is a tunable ultrasonic transducer made of a relaxor ferroelectric composition that has the components lead magnesium niobate, lead titanate, and lead magnesium tunstate. A method of making a relaxor ferroelectric material comprising the step of adding an effective amount of lead magnesium tungstate to a lead magnesium niobate-lead titanate composition is also disclosed.

Abstract translation: 具有铅铌酸铅，钛酸铅和钨酸铅镁的组分的弛豫铁电组合物。 组分优选以（1-xy）铅铌酸铅，（x）钛酸铅和（y）钨酸铅镁的相对摩尔量存在，其中0.11≤x≤0.13和0.01 < /=0.03。 还公开了一种由弛豫铁电组合物制成的可调谐超声波换能器，其具有铌酸镁镁，钛酸铅和镁镁铅组分。 还公开了一种制备弛豫铁电材料的方法，其包括将有效量的钨酸铅镁添加到铅铌酸铅铅钛酸盐组合物的步骤。

公开(公告)号：US10765755B1

公开(公告)日：2020-09-08

申请号：US14548996

申请日：2014-11-20

Applicant: Umesh Kumar Jinwal ,  Vijaykumar Bhadabhai Sutariya

Inventor： Umesh Kumar Jinwal ,  Vijaykumar Bhadabhai Sutariya

IPC: A61K31/5415 ,  A61K47/48 ,  A61K9/51

Abstract: A delivery system of coated and uncoated nanoparticles (NP) for delivery of methylene blue (MB). The delivery system was developed using PLGA-based polymer that was repeatedly shown to be biocompatible and biodegradable. The parameters of synthesized NPs were within the suitable range for BBB permeation—specifically, the NPs were monodispersed, with slight negative charge, and with the size within 100-150 nm range suitable for intravenous delivery and delivery to the brain. The coating on the nanoparticle did not have a significant impact on the nanoparticle size and zeta potential. Based on the immunoblotting experiments using AD cellular model, the GSH coated NPs were better in reducing tau levels compared to MB solution. In vitro BBB Transwell permeation study showed eight fold higher MB-NP permeation compared to the MB solution over 24 hours.

公开(公告)号：US10758520B1

公开(公告)日：2020-09-01

申请号：US16271018

申请日：2019-02-08

Applicant: Vijaykumar Bhadabhai Sutariya ,  Umesh Kumar Jinwal

Inventor： Vijaykumar Bhadabhai Sutariya ,  Umesh Kumar Jinwal

IPC: A61K31/4439 ,  A61K9/51

Abstract: Nanoparticle based MKT formulation. MKT is encapsulated by poly(ethylene glycol)ylated (PEGylated) poly-(lactide-co-glycolide) (PLGA) to form nanoparticles (NPs). To induce trans-BBB permeability, glutathione (GSH) is coated on the resulting NPs. Newly generated MKT-NPs showed BBB permeability and tau reduction in experimental models. Specifically, brain-targeting MKT NPs were developed with a glutathione coating, characterized, and shown to permeate BBB permeation insert models as a therapeutic for Alzheimer's disease and related tauopathies.

公开(公告)号：US20190298663A1

公开(公告)日：2019-10-03

申请号：US16293535

申请日：2019-03-05

Applicant: Umesh Kumar Jinwal ,  Vetriselvan Manavalan

Inventor： Umesh Kumar Jinwal ,  Vetriselvan Manavalan

IPC: A61K31/055 ,  A61P25/28 ,  A61K9/00

Abstract: Disclosed herein are compositions and methods for treating tauopathies such as Alzheimer's disease (AD). Also provided herein are methods of reducing or disrupting tau aggregation in a subject, and methods of reducing tau protein in a subject. The methods may include administering to the subject a therapeutic amount of hexachlorophene, or a pharmaceutically acceptable salt thereof. Further provided herein are pharmaceutical compositions comprising hexachlorophene, or a pharmaceutically acceptable salt thereof, for the treatment of a tauopathy in a subject.

公开(公告)号：US20180250241A1

公开(公告)日：2018-09-06

申请号：US15905748

申请日：2018-02-26

Applicant: Umesh Kumar Jinwal ,  Vetriselvan Manavalan

Inventor： Umesh Kumar Jinwal ,  Vetriselvan Manavalan

IPC: A61K31/055 ,  A61K9/00 ,  A61P25/28

CPC classification number: A61K31/055 ,  A61K9/0019 ,  A61P25/28

Abstract: Disclosed herein are compositions and methods for treating tauopathies such as Alzheimer's disease (AD). Also provided herein are methods of reducing or disrupting tau aggregation in a subject, and methods of reducing tau protein in a subject. The methods may include administering to the subject a therapeutic amount of hexachlorophene, or a pharmaceutically acceptable salt thereof. Further provided herein are pharmaceutical compositions comprising hexachlorophene, or a pharmaceutically acceptable salt thereof, for the treatment of a tauopathy in a subject.

公开(公告)号：US09336188B2

公开(公告)日：2016-05-10

申请号：US13010900

申请日：2011-01-21

Applicant: Rohit Shetty ,  Umesh Kumar Balaraj

Inventor： Rohit Shetty ,  Umesh Kumar Balaraj

IPC: G06F17/00 ,  G06F17/22

CPC classification number: G06F17/2229 ,  G06F17/2247

Abstract: A method and apparatus for generating a statistical tree representing an extensible markup language Schema (XSD) is disclosed. Components of the XSD are prioritized according to predefined rules. A root node representing said XSD is created. Pairs of child nodes are generated from the root node. Each pair comprises at least one genuine node, and each pair of generated child nodes is appended to a parent node which is a genuine node. The path to each of said child nodes from a respective parent genuine node is represented with a binary sequence. At least one genuine node is allocated to a corresponding component of said XSD, the allocation being based on the prioritization of the component. Methods, apparatus and computer program products for generating a statistical tree representing an extensible markup language Schema (XSD), for encoding an extensible markup language (XML) document utilizing a statistical tree representing an extensible markup language Schema (XSD), and for decoding an XML document represented by a binary encoded sequence also are disclosed.

Abstract translation: 公开了一种用于生成表示可扩展标记语言模式（XSD）的统计树的方法和装置。 XSD的组件根据预定义的规则进行优先排序。 创建表示所述XSD的根节点。 从根节点生成成对的子节点。 每对包括至少一个正版节点，并且每对生成的子节点被附加到作为真实节点的父节点。 来自相应父母节点的每个所述子节点的路径用二进制序列表示。 至少一个正版节点被分配给所述XSD的相应组件，该分配基于组件的优先级。 用于生成表示可扩展标记语言模式（XSD）的统计树的方法，装置和计算机程序产品，用于使用表示可扩展标记语言模式（XSD）的统计树对可扩展标记语言（XML）文档进行编码， 还公开了由二进制编码序列表示的XML文档。

公开(公告)号：US20140050719A1

公开(公告)日：2014-02-20

申请号：US13491810

申请日：2012-06-08

Applicant: Stephen Anthony Burbidge ,  Jonathan Henry Ellis ,  Susannah K. Ford ,  Volker Germaschewski ,  Umesh Kumar ,  Karen Louise Philpott ,  Peter Ernest Soden

Inventor： Stephen Anthony Burbidge ,  Jonathan Henry Ellis ,  Susannah K. Ford ,  Volker Germaschewski ,  Umesh Kumar ,  Karen Louise Philpott ,  Peter Ernest Soden

IPC: C07K16/18

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/71 ,  C07K2317/92 ,  C07K2317/94

Abstract: Antibodies that bind human β-amyloid peptide, methods of treating diseases or disorders characterised by elevated β-amyloid levels or β-amyloid deposits with said antibodies, pharmaceutical compositions comprising said antibodies and methods of manufacture.

Abstract translation: 结合人β-淀粉样蛋白肽的抗体，用所述抗体治疗特征为升高的β-淀粉样蛋白水平或β-淀粉样沉积物的疾病或病症的方法，包含所述抗体的药物组合物和制备方法。

公开(公告)号：US08147659B2

公开(公告)日：2012-04-03

申请号：US11943363

申请日：2007-11-20

Applicant: Rakesh K. Lal ,  Likun Shen ,  Umesh Kumar Mishra

Inventor： Rakesh K. Lal ,  Likun Shen ,  Umesh Kumar Mishra

IPC: C25B9/04 ,  C25D17/00

CPC classification number: C25B1/003 ,  C25B11/0447 ,  Y02P20/135

Abstract: A gated electrode structure for altering a potential and electric field in an electrolyte near at least one working electrode is disclosed. The gated electrode structure may comprise a gate electrode biased appropriately with respect to a working electrode. Applying an appropriate static or dynamic (time varying) gate potential relative to the working electrode modifies the electric potential and field in an interfacial region between the working electrode and the electrolyte, and increases electron emission to and from states in the electrolyte, thereby facilitating an electrochemical, electrolytic or electrosynthetic reaction and reducing electrode overvoltage/overpotential.

Abstract translation: 公开了一种用于改变靠近至少一个工作电极的电解质中的电场和电场的选通电极结构。 门电极结构可以包括相对于工作电极适当地偏置的栅电极。 施加相对于工作电极的适当的静态或动态（时变）门电位改变了工作电极和电解质之间的界面区域中的电位和场，并且增加了电解质中的电子发射，从而促进了 电化学，电解或电合成反应和还原电极过电压/超电势。

公开(公告)号：US20110119315A1

公开(公告)日：2011-05-19

申请号：US13010900

申请日：2011-01-21

Applicant: Rohit Shetty ,  Umesh Kumar Balaraj

Inventor： Rohit Shetty ,  Umesh Kumar Balaraj

IPC: G06F17/30

CPC classification number: G06F17/2229 ,  G06F17/2247

Abstract: A method and apparatus for generating a statistical tree representing an extensible markup language Schema (XSD) is disclosed. Components of the XSD are prioritized according to predefined rules. A root node representing said XSD is created. Pairs of child nodes are generated from the root node. Each pair comprises at least one genuine node, and each pair of generated child nodes is appended to a parent node which is a genuine node. The path to each of said child nodes from a respective parent genuine node is represented with a binary sequence. At least one genuine node is allocated to a corresponding component of said XSD, the allocation being based on the prioritization of the component. Methods, apparatus and computer program products for generating a statistical tree representing an extensible markup language Schema (XSD), for encoding an extensible markup language (XML) document utilizing a statistical tree representing an extensible markup language Schema (XSD), and for decoding an XML document represented by a binary encoded sequence also are disclosed.

Abstract translation: 公开了一种用于生成表示可扩展标记语言模式（XSD）的统计树的方法和装置。 XSD的组件根据预定义的规则进行优先排序。 创建表示所述XSD的根节点。 从根节点生成成对的子节点。 每对包括至少一个正版节点，并且每对生成的子节点被附加到作为真实节点的父节点。 来自相应父母节点的每个所述子节点的路径用二进制序列表示。 至少一个正版节点被分配给所述XSD的相应组件，该分配基于组件的优先级。 用于生成表示可扩展标记语言模式（XSD）的统计树的方法，装置和计算机程序产品，用于使用表示可扩展标记语言模式（XSD）的统计树对可扩展标记语言（XML）文档进行编码， 还公开了由二进制编码序列表示的XML文档。